All Stories

  1. Novel insights on the DNA interaction of calicheamicin γ 1 I

    Article • Biopolymers, May 2015, Wiley

    Professor Claudia Sissi

  2. Interactions of selected gold(iii) complexes with DNA G quadruplexes

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Professor Claudia Sissi

  3. Telomeric G-Quadruplex Architecture and Interactions with Potential Drugs

    Article • Current Pharmaceutical Design, October 2014, Bentham Science Publishers

    Professor Claudia Sissi

  4. DNA Targeting by Cationic Porphyrin-Ruthenium(II) Conjugates

    Article • ChemPlusChem, September 2014, Wiley

    Professor Claudia Sissi

  5. Sequencing and G-Quadruplex Folding of the Canine Proto-Oncogene KIT Promoter Region: Might Dog Be Used as a Model for Human Disease?

    Article • PLoS ONE, August 2014, PLOS

    Professor Claudia Sissi

  6. Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

    Article • Archiv der Pharmazie, July 2014, Wiley

    Professor Claudia Sissi

  7. Pt-based drugs: the spotlight will be on proteins

    Article • Metallomics, January 2014, Oxford University Press (OUP)

    Professor Claudia Sissi

  8. Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Claudia Sissi

  9. Exploring the Chemical Space of G-Quadruplex Binders: Discovery of a Novel Chemotype Targeting the Human Telomeric Sequence

    Article • Journal of Medicinal Chemistry, December 2013, American Chemical Society (ACS)

    Professor Claudia Sissi

  10. Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents

    Article • Bioorganic & Medicinal Chemistry, November 2013, Elsevier

    Professor Claudia Sissi

  11. Metal ion and inter-domain interactions as functional networks in E. coli topoisomerase I

    Article • Gene, July 2013, Elsevier

    Professor Claudia Sissi

  12. Platinum-based drugs and proteins: Reactivity and relevance to DNA adduct formation

    Article • Journal of Inorganic Biochemistry, May 2013, Elsevier

    Professor Claudia Sissi

  13. Effect of G-Quadruplex Polymorphism on the Recognition of Telomeric DNA by a Metal Complex

    Article • PLoS ONE, March 2013, PLOS

    Professor Claudia Sissi

  14. Identification and Characterization of New DNA G-Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches

    Article • Journal of Medicinal Chemistry, February 2013, American Chemical Society (ACS)

    Professor Claudia Sissi

  15. Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Claudia Sissi

  16. Molecular Recognition of Human Telomeric DNA by Phenanthroline-Based G-Quadruplex Ligands

    Article • Open Journal of Medicinal Chemistry, January 2013, Scientific Research Publishing, Inc,

    Professor Claudia Sissi

  17. Structure–activity relationships of novel substituted naphthalene diimides as anticancer agents

    Article • European Journal of Medicinal Chemistry, November 2012, Elsevier

    Professor Claudia Sissi

  18. Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

    Article • Autophagy, August 2012, Taylor & Francis

    Professor Claudia Sissi

  19. Spectroscopic, Molecular Modeling, and NMR-Spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-Quadruplex DNA

    Article • ACS Chemical Biology, June 2012, American Chemical Society (ACS)

    Professor Claudia Sissi

  20. Folding Versus Charge: Understanding Selective Target Recognition by the Thrombin Aptamers

    Article • Current Pharmaceutical Design, March 2012, Bentham Science Publishers

    Professor Claudia Sissi

  21. Heterocyclic Dications as a New Class of Telomeric G-Quadruplex Targeting Agents

    Article • Current Pharmaceutical Design, March 2012, Bentham Science Publishers

    Professor Claudia Sissi

  22. Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Sara Richter, Professor Claudia Sissi

  23. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases

    Article • Bioorganic & Medicinal Chemistry Letters, December 2011, Elsevier

    Professor Claudia Sissi

  24. Tuning G-Quadruplex vs Double-Stranded DNA Recognition in Regioisomeric Lysyl-Peptidyl-Anthraquinone Conjugates

    Article • Bioconjugate Chemistry, October 2011, American Chemical Society (ACS)

    Professor Claudia Sissi

  25. The evolving world of protein-G-quadruplex recognition: A medicinal chemist’s perspective

    Article • Biochimie, August 2011, Elsevier

    Professor Claudia Sissi

  26. DNA Reactivity Profile of trans-Platinum Planar Amine Derivatives

    Article • ChemMedChem, April 2011, Wiley

    Professor Claudia Sissi

  27. Modeling and Biological Investigations of an Unusual Behavior of Novel Synthesized Acridine-Based Polyamine Ligands in the Binding of Double Helix and G-Quadruplex DNA

    Article • ChemMedChem, October 2010, Wiley

    Professor Claudia Sissi

  28. Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer

    Article • Biochemical Pharmacology, June 2010, Elsevier

    Professor Claudia Sissi

  29. Rational Design, Synthesis, Biophysical and Antiproliferative Evaluation of Fluorenone Derivatives with DNA G-Quadruplex Binding Properties

    Article • ChemMedChem, April 2010, Wiley

    Professor Claudia Sissi, Dr Francesco Paduano, Dr Francesco Paduano

  30. Phosphate diesters and DNA hydrolysis by dinuclear Zn(II) complexes featuring a disulfide bridge and H-bond donors

    Article • Tetrahedron, March 2010, Elsevier

    Professor Claudia Sissi

  31. In front of and behind the replication fork: bacterial type IIA topoisomerases

    Article • Cellular and Molecular Life Sciences, February 2010, Springer Science + Business Media

    Professor Claudia Sissi

  32. Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting

    Article • Bioorganic & Medicinal Chemistry Letters, February 2010, Elsevier

    Professor Claudia Sissi

  33. Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

    Article • Journal of the American Chemical Society, September 2009, American Chemical Society (ACS)

    Professor Claudia Sissi

  34. Metal ion-mediated assembly of effective phenanthroline-based G-quadruplex ligands

    Article • Dalton Transactions, January 2009, Royal Society of Chemistry

    Professor Claudia Sissi

  35. Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst

    Article • Journal of the American Chemical Society, November 2008, American Chemical Society (ACS)

    Professor Claudia Sissi

  36. Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences

    Article • Bioorganic & Medicinal Chemistry, October 2008, Elsevier

    Professor Claudia Sissi

  37. DNA Gyrase Requires DNA for Effective Two-Site Coordination of Divalent Metal Ions: Further Insight into the Mechanism of Enzyme Action †

    Article • Biochemistry, August 2008, American Chemical Society (ACS)

    Professor Claudia Sissi

  38. Effective DNA Inhibitors of Cathepsin G by In Vitro Selection

    Article • International Journal of Molecular Sciences, June 2008, MDPI AG

    Professor Claudia Sissi

  39. Tuning the Activity of Zn(II) Complexes in DNA Cleavage: Clues for Design of New Efficient Metallo-Hydrolases

    Article • Inorganic Chemistry, June 2008, American Chemical Society (ACS)

    Professor Claudia Sissi

  40. Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives

    Article • Bioorganic & Medicinal Chemistry, January 2008, Elsevier

    Professor Claudia Sissi, Professor Diego Dal Ben

  41. DNA Binding by a New Metallointercalator that Contains a Proflavine Group Bearing a Hanging Chelating Unit

    Article • Chemistry - A European Journal, December 2007, Wiley

    Antonio Bianchi, Professor Claudia Sissi

  42. Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G

    Article • Biochemical Pharmacology, January 2006, Elsevier

    Professor Claudia Sissi

  43. Efficient Plasmid DNA Cleavage by a Mononuclear Copper(II) Complex

    Article • Inorganic Chemistry, April 2005, American Chemical Society (ACS)

    Professor Claudia Sissi

  44. Toward Efficient Zn(II)-Based Artificial Nucleases

    Article • Journal of the American Chemical Society, April 2004, American Chemical Society (ACS)

    Professor Claudia Sissi

  45. Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers

    Article • Biochemical Pharmacology, February 2004, Elsevier

    Professor Claudia Sissi

  46. Antitumor Potential of Aza-bioisosterism in Anthracenedione-based Drugs

    Article • Current Topics in Medicinal Chemistry, January 2004, Bentham Science Publishers

    Professor Claudia Sissi

  47. The Quinolone Family: From Antibacterial to Anticancer Agents

    Article • Current Medicinal Chemistry - Anti-Cancer Agents, November 2003, Bentham Science Publishers

    Professor Claudia Sissi

  48. Sequence-specific interactions of drugs interfering with the topoisomerase–DNA cleavage complex

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, July 2002, Elsevier

    Professor Claudia Sissi

  49. Effects of Calcium Ions on the Interactions between Antithrombin and Factor Xa Mediated by Variously Sulfated, Semisynthetic Low-Molecular-Weight Heparins

    Article • Seminars in Thrombosis and Hemostasis, January 2002, Thieme Publishing Group

    Professor Claudia Sissi

  50. Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions

    Article • Journal of Molecular Biology, August 2001, Elsevier

    Professor Claudia Sissi

  51. Dinuclear Zn2+Complexes of Synthetic Heptapeptides as Artificial Nucleases

    Article • Journal of the American Chemical Society, April 2001, American Chemical Society (ACS)

    Professor Claudia Sissi

  52. Effects of Sulfation on Antithrombin-Thrombin/Factor Xa Interactions in Semisynthetic Low Molecular Weight Heparins

    Article • Seminars in Thrombosis and Hemostasis, January 2001, Thieme Publishing Group

    Professor Claudia Sissi

  53. A Novel 9-Aza-Anthrapyrazole Effective against Human Prostatic Carcinoma Xenografts

    Article • Oncology, January 2001, Karger Publishers

    Professor Claudia Sissi

  54. 6-Hydroxy Derivative as New Desfluoroquinolone (DFQ): Synthesis and DNA-Binding Study

    Article • Nucleosides Nucleotides & Nucleic Acids, August 2000, Taylor & Francis

    Professor Claudia Sissi

  55. DNA Phosphodiester Bond Hydrolysis Mediated by Cu(II) and Zn(II) Complexes of 1,3,5,-Triamino-cyclohexane Derivatives

    Article • Nucleosides Nucleotides & Nucleic Acids, August 2000, Taylor & Francis

    Professor Claudia Sissi

  56. Design and Synthesis of Modified Quinolones as Antitumoral Acridones 1

    Article • Journal of Medicinal Chemistry, June 1999, American Chemical Society (ACS)

    Professor Claudia Sissi, Prof Giuseppe Nocentini

  57. Further insight into the Zn2+-mediated binding of streptonigrin to DNA

    Article • Il Farmaco, November 1998, Elsevier

    Professor Claudia Sissi

  58. Mg2+-mediated binding of 6-Substituted quinolones to DNA: relevance to biological activity

    Article • Bioorganic & Medicinal Chemistry, September 1998, Elsevier

    Professor Claudia Sissi

  59. New Peptidyl-Anthraquinones: Synthesis and DNA Binding

    Article • Nucleosides and Nucleotides, September 1998, Taylor & Francis

    Professor Claudia Sissi

  60. Preferred interaction of d-peptidyl-anthraquinones with double-stranded B-DNA

    Article • International Journal of Biological Macromolecules, December 1997, Elsevier

    Professor Claudia Sissi

  61. Physicochemical properties, cytotoxic activity and topoisomerase ii inhibition of 2,3-diaza-anthracenediones

    Article • Biochemical Pharmacology, January 1997, Elsevier

    Professor Claudia Sissi

  62. Peptidyl Anthraquinones as Potential Antineoplastic Drugs:  Synthesis, DNA Binding, Redox Cycling, and Biological Activity

    Article • Journal of Medicinal Chemistry, January 1996, American Chemical Society (ACS)

    Professor Claudia Sissi

  63. Potent 6-Desfluoro-8-methylquinolones as New Lead Compounds in Antibacterial Chemotherapy 1

    Article • Journal of Medicinal Chemistry, January 1996, American Chemical Society (ACS)

    Professor Claudia Sissi

  64. Chromophore-Modified Antitumor Anthracenediones: Synthesis, DNA Binding, and Cytotoxic Activity of 1,4-Bis[(aminoalkyl)amino]benzo[g]phthalazine-5,10-diones

    Article • Journal of Medicinal Chemistry, February 1995, American Chemical Society (ACS)

    Professor Claudia Sissi