Professor Reuben J Peters

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Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis

Article • Proceedings of the National Academy of Sciences, June 2023, Proceedings of the National Academy of Sciences

Professor Reuben J Peters
A (conditional) role for labdane‐related diterpenoid natural products in rice stomatal closure

Article • New Phytologist, February 2021, Wiley

Professor Reuben J Peters
Probing the specificity of CYP112 in bacterial gibberellin biosynthesis

Article • Biochemical Journal, June 2018, Portland Press Ltd.

Professor Reuben J Peters
Catalytic Bases and Stereocontrol in Lamiaceae Class II Diterpene Cyclases

Article • Biochemistry, May 2018, American Chemical Society (ACS)

Professor Reuben J Peters
Diverging Mechanisms: Cytochrome-P450-Catalyzed Demethylation and γ-Lactone Formation in Bacterial Gibberellin Biosynthesis

Article • Angewandte Chemie International Edition, April 2018, Wiley

Professor Reuben J Peters
Inferring Roles in Defense from Metabolic Allocation of Rice Diterpenoids

Article • The Plant Cell, April 2018, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Direct production of dihydroxylated sesquiterpenoids by a maize terpene synthase

Article • The Plant Journal, April 2018, Wiley

Professor Reuben J Peters
Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase

Article • ACS Catalysis, March 2018, American Chemical Society (ACS)

Professor Reuben J Peters
Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase

Article • Organic Letters, February 2018, American Chemical Society (ACS)

Professor Reuben J Peters
Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii

Article • The Plant Journal, December 2017, Wiley

Professor Reuben J Peters
Biosynthesis of Diterpenoids in Tripterygium Adventitious Root Cultures

Article • PLANT PHYSIOLOGY, July 2017, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Investigating the Phylogenetic Range of Gibberellin Biosynthesis in Bacteria

Article • Molecular Plant-Microbe Interactions, April 2017, Scientific Societies

Professor Reuben J Peters
Characterizing the enzyme that catalyzes the final step bacterial gibberellin biosynthesis

Article • ACS Chemical Biology, February 2017, American Chemical Society (ACS)

Professor Reuben J Peters, Dr. Ryan Stephan Nett
A Pair of Residues That Interactively Affect Diterpene Synthase Product Outcome

Article • ACS Chemical Biology, February 2017, American Chemical Society (ACS)

Professor Reuben J Peters
Probing Labdane-Related Diterpenoid Biosynthesis in the Fungal Genus Aspergillus

Article • Journal of Natural Products, January 2017, American Chemical Society (ACS)

Professor Reuben J Peters
Production of gibberellin, a plant hormone, by Xanthomonas oryzae, a bacterial pathogen of rice

Article • New Phytologist, January 2017, Wiley

Professor Reuben J Peters, Dr. Ryan Stephan Nett
cis or trans with class II diterpene cyclases

Article • Organic & Biomolecular Chemistry, January 2017, Royal Society of Chemistry

Professor Reuben J Peters
18O2labeling experiments illuminate the oxidation of ent-kaurene in bacterial gibberellin biosynthesis

Article • Organic & Biomolecular Chemistry, January 2017, Royal Society of Chemistry

Professor Reuben J Peters
Identification of a Dolabellane Type Diterpene Synthase and other Root-Expressed Diterpene Synthases in Arabidopsis

Article • Frontiers in Plant Science, November 2016, Frontiers

Professor Reuben J Peters
Extending a Single Residue Switch for Abbreviating Catalysis in Plant ent-Kaurene Synthases

Article • Frontiers in Plant Science, November 2016, Frontiers

Professor Reuben J Peters
Insight into the mechanism of the ring contraction reaction in bacterial gibberellin biosynthesis

Article • Organic Letters, November 2016, American Chemical Society (ACS)

Professor Reuben J Peters, Dr. Ryan Stephan Nett
A biosynthetic gene cluster in rhizobia is responsible for producing gibberellin phytohormones

Article • Nature Methods, November 2016, Springer Science + Business Media

Professor Reuben J Peters, Professor Trevor C Charles, Dr. Ryan Stephan Nett
Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha

Article • The Plant Cell, September 2016, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis

Article • Metabolic Engineering, September 2016, Elsevier

Professor Reuben J Peters
Investigating inducible short-chain alcohol dehydrogenases/reductases clarifies rice oryzalexin biosynthesis

Article • The Plant Journal, September 2016, Wiley

Professor Reuben J Peters
Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza

Article • Molecular Plant, June 2016, Elsevier

Professor Reuben J Peters
Product Rearrangement from Altering a Single Residue in the Ricesyn-Copalyl Diphosphate Synthase

Article • Organic Letters, March 2016, American Chemical Society (ACS)

Professor Reuben J Peters
Probing the promiscuity of ent -kaurene oxidases via combinatorial biosynthesis

Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

Professor Reuben J Peters
Characterization of CYP71Z18 indicates a role in maize zealexin biosynthesis

Article • Phytochemistry, January 2016, Elsevier

Professor Reuben J Peters
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones

Article • New Phytologist, December 2015, Wiley

Professor Reuben J Peters
A Tandem Array of ent -Kaurene Synthases in Maize with Roles in Gibberellin and More Specialized Metabolism

Article • PLANT PHYSIOLOGY, November 2015, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Blocking Deprotonation with Retention of Aromaticity in a Plant ent -Copalyl Diphosphate Synthase Leads to Product Rearrangement

Article • Angewandte Chemie International Edition, November 2015, Wiley

Professor Reuben J Peters
Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza Bunge

Article • PLANT PHYSIOLOGY, June 2015, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Full‐length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of S alvia miltiorrhiza and tanshinone biosynt...

Article • The Plant Journal, May 2015, Wiley

Professor Reuben J Peters
Investigation of the Chemical Interface in the Soybean–Aphid and Rice–Bacteria Interactions Using MALDI-Mass Spectrometry Imaging

Article • Analytical Chemistry, May 2015, American Chemical Society (ACS)

Professor Reuben J Peters
Biosynthesis of the Diterpenoid Lycosantalonol via Nerylneryl Diphosphate in Solanum lycopersicum

Article • PLoS ONE, March 2015, PLOS

Professor Reuben J Peters
Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis

Article • Applied Microbiology and Biotechnology, March 2015, Springer Science + Business Media

Professor Reuben J Peters
Efficient heterocyclisation by (di)terpene synthases

Article • Chemical Communications, January 2015, Royal Society of Chemistry

Professor Reuben J Peters
The Application of Synthetic Biology to Elucidation of Plant Mono-, Sesqui-, and Diterpenoid Metabolism

Article • Molecular Plant, January 2015, Elsevier

Professor Reuben J Peters
Investigation of terpene diversification across multiple sequenced plant genomes

Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

Professor Reuben J Peters
Biosynthesis of Lycosantalonol, acis-Prenyl Derived Diterpenoid

Article • Journal of the American Chemical Society, December 2014, American Chemical Society (ACS)

Professor Reuben J Peters
Anent-kaurene-derived diterpenoid virulence factor fromXanthomonas oryzaepv. oryzicola

Article • New Phytologist, November 2014, Wiley

Professor Reuben J Peters
Characterization of an Orphan Diterpenoid Biosynthetic Operon fromSalinispora arenicola

Article • Journal of Natural Products, September 2014, American Chemical Society (ACS)

Professor Reuben J Peters
Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization

Article • Phytochemistry, July 2014, Elsevier

Professor Reuben J Peters
Novel Product Chemistry from Mechanistic Analysis ofent-Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis

Article • Angewandte Chemie International Edition, May 2014, Wiley

Professor Reuben J Peters
To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism

Article • Annual Review of Plant Biology, April 2014, Annual Reviews

Professor Reuben J Peters
Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins

Article • The Plant Journal, March 2014, Wiley

Professor Reuben J Peters
1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis

Article • Biochimica et Biophysica Acta (BBA) - General Subjects, January 2014, Elsevier

Professor Reuben J Peters
Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza

Article • BMC Genomics, January 2014, Springer Science + Business Media

Professor Reuben J Peters
Functional Conservation of the Capacity for ent-Kaurene Biosynthesis and an Associated Operon in Certain Rhizobia

Article • Journal of Bacteriology, October 2013, ASM Journals

Professor Reuben J Peters
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis

Article • Biochemical Journal, September 2013, Portland Press Ltd.

Professor Reuben J Peters
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts

Article • Proceedings of the National Academy of Sciences, June 2013, Proceedings of the National Academy of Sciences

Professor Reuben J Peters
The Role of Momilactones in Rice Allelopathy

Article • Journal of Chemical Ecology, February 2013, Springer Science + Business Media

Professor Reuben J Peters
Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae

Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

Professor Reuben J Peters
A Single Residue Change Leads to a Hydroxylated Product from the Class II Diterpene Cyclization Catalyzed by Abietadiene Synthase

Article • Organic Letters, December 2012, American Chemical Society (ACS)

Professor Reuben J Peters
Functional characterization of wheat copalyl diphosphate synthases sheds light on the early evolution of labdane-related diterpenoid metabolism in the cereals

Article • Phytochemistry, December 2012, Elsevier

Professor Reuben J Peters
Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals

Article • Phytochemistry, December 2012, Elsevier

Professor Reuben J Peters
Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry

Article • Journal of the American Chemical Society, July 2012, American Chemical Society (ACS)

Professor Reuben J Peters
CYP701A8: A Rice ent-Kaurene Oxidase Paralog Diverted to More Specialized Diterpenoid Metabolism

Article • PLANT PHYSIOLOGY, January 2012, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis

Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

Professor Reuben J Peters
Characterization of CYP76M5-8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster

Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

Professor Reuben J Peters
Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis

Article • MedChemComm, January 2012, Royal Society of Chemistry

Professor Reuben J Peters
Terpenoid synthase structures: a so far incomplete view of complex catalysis

Article • Natural Product Reports, January 2012, Royal Society of Chemistry

Professor Reuben J Peters
Gibberellin Phytohormone Metabolism

Article • January 2012, Springer Science + Business Media

Professor Reuben J Peters
Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria

Article • Frontiers in Microbiology, January 2012, Frontiers

Professor Reuben J Peters
Genetic evidence for natural product-mediated plant-plant allelopathy in rice (Oryza sativa)

Article • New Phytologist, December 2011, Wiley

Professor Reuben J Peters
Domain loss has independently occurred multiple times in plant terpene synthase evolution

Article • The Plant Journal, October 2011, Wiley

Professor Reuben J Peters
Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7

Article • FEBS Letters, October 2011, Wiley

Professor Reuben J Peters
A Novel Labda-7,13E-dien-15-ol-Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii

Article • ChemBioChem, July 2011, Wiley

Professor Reuben J Peters
Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase

Article • Nature Chemical Biology, May 2011, Springer Science + Business Media

Dr Huayou Hu, Professor Reuben J Peters
Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals

Article • Biochemical Journal, May 2011, Portland Press Ltd.

Professor Reuben J Peters
Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis

Article • Molecular Microbiology, January 2011, Wiley

Professor Reuben J Peters
Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis inMycobacterium tuberculosis

Article • FEBS Letters, January 2011, Wiley

Professor Reuben J Peters
Electrostatic effects on (di)terpene synthase product outcome

Article • Chemical Communications, January 2011, Royal Society of Chemistry

Professor Reuben J Peters
CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice

Article • The Plant Journal, November 2010, Wiley

Professor Reuben J Peters
Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis

Article • Biochemical Journal, November 2010, Portland Press Ltd.

Professor Reuben J Peters
Diterpenoid biopolymers: New directions for renewable materials engineering

Article • Biopolymers, September 2010, Wiley

Professor Reuben J Peters
Edaxadiene: A New Bioactive Diterpene fromMycobacterium tuberculosis

Article • Journal of the American Chemical Society, August 2010, American Chemical Society (ACS)

Professor Reuben J Peters
Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene) and (±)-Tuberculosinol

Article • Organic Letters, June 2010, American Chemical Society (ACS)

Professor Reuben J Peters
A Single Residue Switch for Mg2+-dependent Inhibition Characterizes Plant Class II Diterpene Cyclases from Primary and Secondary Metabolism

Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

Professor Reuben J Peters
Diterpene cyclases and the nature of the isoprene fold

Article • Proteins Structure Function and Bioinformatics, April 2010, Wiley

Professor Reuben J Peters
Two rings in them all: The labdane-related diterpenoids

Article • Natural Product Reports, January 2010, Royal Society of Chemistry

Professor Reuben J Peters
Edaxadiene: A New Bioactive Diterpene fromMycobacterium tuberculosis

Article • Journal of the American Chemical Society, December 2009, American Chemical Society (ACS)

Professor Reuben J Peters
A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

Article • Organic Letters, November 2009, American Chemical Society (ACS)

Professor Reuben J Peters
CYP76M7 Is an ent-Cassadiene C11 -Hydroxylase Defining a Second Multifunctional Diterpenoid Biosynthetic Gene Cluster in Rice

Article • The Plant Cell, October 2009, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering

Article • Applied Microbiology and Biotechnology, September 2009, Springer Science + Business Media

Professor Reuben J Peters
Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis: IMPLICATIONS FOR TUBERCULOSIS

Article • Journal of Biological Chemistry, July 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

Professor Reuben J Peters, Dr Huayou Hu
Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants

Article • Phytochemistry, February 2009, Elsevier

Professor Reuben J Peters
Gibberellin biosynthesis in bacteria: Separateent-copalyl diphosphate andent-kaurene synthases inBradyrhizobium japonicum

Article • FEBS Letters, December 2008, Wiley

Professor Reuben J Peters
Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch

Article • Journal of the American Chemical Society, April 2008, American Chemical Society (ACS)

Professor Reuben J Peters
A Single Residue Switch Converts Abietadiene Synthase into a Pimaradiene Specific Cyclase

Article • Journal of the American Chemical Society, December 2007, American Chemical Society (ACS)

Professor Reuben J Peters
16-Aza- ent -beyerane and 16-Aza- ent -trachylobane: Potent Mechanism-Based Inhibitors of Recombinant ent -Kaurene Synthase from Arabidopsis thaliana

Article • Journal of the American Chemical Society, October 2007, American Chemical Society (ACS)

Professor Reuben J Peters
Probing the Role of the DXDD Motif in Class II Diterpene Cyclases

Article • ChemBioChem, May 2007, Wiley

Professor Reuben J Peters
A Modular Approach for Facile Biosynthesis of Labdane-Related Diterpenes

Article • Journal of the American Chemical Society, May 2007, American Chemical Society (ACS)

Professor Reuben J Peters
Following evolution's lead to a single residue switch for diterpene synthase product outcome

Article • Proceedings of the National Academy of Sciences, May 2007, Proceedings of the National Academy of Sciences

Professor Reuben J Peters
Synergistic Substrate Inhibition of ent-Copalyl Diphosphate Synthase: A Potential Feed-Forward Inhibition Mechanism Limiting Gibberellin Metabolism

Article • PLANT PHYSIOLOGY, March 2007, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Functional characterization of the rice kaurene synthase-like gene family

Article • Phytochemistry, February 2007, Elsevier

Professor Reuben J Peters
Uncovering the complex metabolic network underlying diterpenoid phytoalexin biosynthesis in rice and other cereal crop plants

Article • Phytochemistry, November 2006, Elsevier

Professor Reuben J Peters
An unexpected diterpene cyclase from rice: Functional identification of a stemodene synthase

Article • Archives of Biochemistry and Biophysics, April 2006, Elsevier

Professor Reuben J Peters
The Maize An2 Gene is Induced by Fusarium Attack and Encodes an ent-Copalyl Diphosphate Synthase

Article • Plant Molecular Biology, December 2005, Springer Science + Business Media

Professor Reuben J Peters
Rice Contains Two Disparate ent-Copalyl Diphosphate Synthases with Distinct Metabolic Functions

Article • PLANT PHYSIOLOGY, December 2004, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Functional identification of ricesyn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products

Article • The Plant Journal, August 2004, Wiley

Professor Reuben J Peters
Identification of Syn-Pimara-7,15-Diene Synthase Reveals Functional Clustering of Terpene Synthases Involved in Rice Phytoalexin/Allelochemical Biosynthesis

Article • PLANT PHYSIOLOGY, August 2004, American Society of Plant Biologists (ASPB)

Professor Reuben J Peters
Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases

Article • Archives of Biochemistry and Biophysics, September 2003, Elsevier

Professor Reuben J Peters
Monoterpene biosynthesis pathway construction in Escherichia coli

Article • Phytochemistry, September 2003, Elsevier

Professor Reuben J Peters
Bifunctional Abietadiene Synthase: Mutual Structural Dependence of the Active Sites for Protonation-Initiated and Ionization-Initiated Cyclizations†

Article • Biochemistry, March 2003, American Chemical Society (ACS)

Professor Reuben J Peters
Mechanism of Abietadiene Synthase Catalysis: Stereochemistry and Stabilization of the Cryptic Pimarenyl Carbocation Intermediates

Article • Journal of the American Chemical Society, June 2002, American Chemical Society (ACS)

Professor Reuben J Peters
Abietadiene Synthase Catalysis: Conserved Residues Involved in Protonation-Initiated Cyclization of Geranylgeranyl Diphosphate to (+)-Copalyl Diphosphate†

Article • Biochemistry, February 2002, American Chemical Society (ACS)

Professor Reuben J Peters
Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement

Article • Proceedings of the National Academy of Sciences, January 2002, Proceedings of the National Academy of Sciences

Professor Reuben J Peters
The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus1

Article • FEBS Letters, November 2001, Wiley

Professor Reuben J Peters
Bifunctional Abietadiene Synthase: Free Diffusive Transfer of the (+)-Copalyl Diphosphate Intermediate between Two Distinct Active Sites

Article • Journal of the American Chemical Society, September 2001, American Chemical Society (ACS)

Professor Reuben J Peters
Abietadiene Synthase from Grand Fir (Abies grandis): Characterization and Mechanism of Action of the “Pseudomature” Recombinant Enzyme†

Article • Biochemistry, December 2000, American Chemical Society (ACS)

Professor Reuben J Peters
α-Lytic Protease Precursor: Characterization of a Structured Folding Intermediate †

Article • Biochemistry, April 1999, American Chemical Society (ACS)

Professor Reuben J Peters
Pro Region C-Terminus:Protease Active Site Interactions Are Critical in Catalyzing the Folding of α-Lytic Protease †

Article • Biochemistry, September 1998, American Chemical Society (ACS)

Professor Reuben J Peters
Activation of a Retroviral Membrane Fusion Protein: Soluble Receptor-induced Liposome Binding of the ALSV Envelope Glycoprotein

Article • The Journal of Cell Biology, December 1997, Rockefeller University Press

Professor Reuben J Peters

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