All Stories

  1. Structural basis for acyl-group discrimination by human Gcn5L2
  2. The Substrate Specificity of Sirtuins
  3. Uncovering the Role of Sgf73 in Maintaining SAGA Deubiquitinating Module Structure and Activity
  4. Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia
  5. Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2
  6. Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198
  7. The Bromodomain of Gcn5 Regulates Site Specificity of Lysine Acetylation on Histone H3
  8. New insights into ubiquitin E3 ligase mechanism
  9. Mechanisms for regulating deubiquitinating enzymes
  10. Corrigendum to “The Structure and Conformation of Lys63-Linked Tetraubiquitin” [J. Mol. Biol. 392 (2009) 1117–1124]
  11. Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase
  12. A New RING Tossed into an Old HAT
  13. E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1
  14. A New DUB Makes Linear Ubiquitin a Party to Its Own Destruction
  15. A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants
  16. Sirtuin on a high-fat diet
  17. A conserved asparagine has a structural role in ubiquitin-conjugating enzymes
  18. RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage
  19. A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity
  20. Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2
  21. The mechanism of OTUB1-mediated inhibition of ubiquitination
  22. Proteins: histones and chromatin
  23. A new chapter in the transcription SAGA
  24. A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins
  25. Structure of Sir2Tm bound to a propionylated peptide
  26. Side chain specificity of ADP-ribosylation by a sirtuin
  27. The Structure and Conformation of Lys63-Linked Tetraubiquitin
  28. Structure-based Mechanism of ADP-ribosylation by Sirtuins
  29. Highly Cooperative Recruitment of Ets-1 and Release of Autoinhibition by Pax5
  30. Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1
  31. Arm-domain interactions can provide high binding cooperativity
  32. Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism
  33. Structural Insights into Intermediate Steps in the Sir2 Deacetylation Reaction
  34. Structural and Functional Studies of the Rap1 C-Terminus Reveal Novel Separation-of-Function Mutants
  35. Identification of a New Nicotinamide Binding Site in a Sirtuin: A Reassessment
  36. Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme
  37. A conserved catalytic residue in the ubiquitin-conjugating enzyme family
  38. N-Lysine Propionylation Controls the Activity of Propionyl-CoA Synthetase
  39. The crystal structure of the tumor suppressor protein pp32 (Anp32a): Structural insights into Anp32 family of proteins
  40. Crystal Structure and Solution NMR Studies of Lys48-linked Tetraubiquitin at Neutral pH
  41. Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation
  42. SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
  43. Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide
  44. Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme
  45. The Structural Basis of Sirtuin Substrate Affinity † , ‡
  46. The Biochemistry of Sirtuins
  47. How does the histone code work?
  48. Getting a grip on O-acetyl-ADP-ribose
  49. Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD+ Cosubstrate Specificity of a Sir2 Enzyme
  50. A conserved catalytic residue in the ubiquitin-conjugating enzyme family
  51. Regulated nucleosome mobility and the histone code
  52. Structural Basis for the Mechanism and Regulation of Sir2 Enzymes
  53. Insights into nonspecific binding of homeodomains from a structure of MATα2 bound to DNA
  54. A core nucleosome surface crucial for transcriptional silencing
  55. Structure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide
  56. Structural and Thermodynamic Characterization of the DNA Binding Properties of a Triple Alanine Mutant of MATα2
  57. Protein–nucleic acid interactions
  58. SIR2 Family of NAD+-Dependent Protein Deacetylases
  59. Structural Studies of Ets-1/Pax5 Complex Formation on DNA
  60. Recognition of Specific DNA Sequences
  61. A standard reference frame for the description of nucleic acid base-pair geometry
  62. Molecular Insights into Polyubiquitin Chain Assembly
  63. Crystallization of Protein-DNA Complexes
  64. Characterization of the Oligomeric States of Wild Type and Mutant AraC†
  65. A phylogenetically conserved NAD + -dependent protein deacetylase activity in the Sir2 protein family
  66. NMR studies of the pbx1 TALE homeodomain protein free in solution and bound to DNA: proposal for a mechanism of HoxB1-pbx1-DNA complex assembly 1 1Edited by P. E. Wright
  67. MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION
  68. Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA
  69. Combinatorial transcription factors
  70. The 1.6 Å crystal structure of the AraC sugar-binding and dimerization domain complexed with d-fucose
  71. Homeodomain interactions
  72. Crystal Structure of the MATa1/MATalpha2 Homeodomain Heterodimer Bound to DNA
  73. Altered DNA Recognition and Bending by Insertions in the alpha2 Tail of the Yeast a1/alpha2 Homeodomai n Heterodimer
  74. Crystallization and preliminary X-ray diffraction studies of an a1/α2/DNA ternary complex
  75. b/HLH without the zip
  76. Transcription factor structure and DNA binding
  77. Structure and DNA Binding of the Yeast MAT 2 Homeodomain
  78. Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions
  79. Crystallization and preliminary X-ray diffraction studies of a MATα2-DNA complex
  80. Structure of phage 434 cro protein at 2.35 Å resolution
  81. Structure of a phage 434 Cro/DNA complex
  82. Recognition of DNA sequences by the repressor of bacteriophage 434
  83. Crystallization and X-ray diffraction studies of a 434 Cro-DNA complex