All Stories

  1. Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses

    Article • Proceedings of the National Academy of Sciences, September 2021, Proceedings of the National Academy of Sciences

    Professor Luis Martinez-Sobrido

  2. A Highly Potent and Broadly Neutralizing H1 Influenza-Specific Human Monoclonal Antibody

    Article • Scientific Reports, March 2018, Nature

    Professor Luis Martinez-Sobrido

  3. Development of a novel equine influenza virus live-attenuated vaccine

    Article • Virology, March 2018, Elsevier

    Professor Luis Martinez-Sobrido

  4. Antigenicity of the 2015–2016 seasonal H1N1 human influenza virus HA and NA proteins

    Article • PLoS ONE, November 2017, PLOS

    Professor Luis Martinez-Sobrido

  5. Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus

    Article • AJP Lung Cellular and Molecular Physiology, November 2017, American Physiological Society

    Professor Luis Martinez-Sobrido

  6. Influenza A Virus Studies in a Mouse Model of Infection

    Article • Journal of Visualized Experiments, September 2017, MyJove Corporation

    Professor Luis Martinez-Sobrido

  7. Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo

    Article • Scientific Reports, September 2017, Nature

    Professor Luis Martinez-Sobrido

  8. The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression

    Article • Journal of Virology, August 2017, ASM Journals

    Professor Luis Martinez-Sobrido

  9. A bivalent live-attenuated influenza vaccine for the control and prevention of H3N8 and H3N2 canine influenza viruses

    Article • Vaccine, August 2017, Elsevier

    Professor Luis Martinez-Sobrido

  10. Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses

    Article • Journal of Virology, June 2017, ASM Journals

    Professor Luis Martinez-Sobrido, David Topham

  11. Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus

    Article • Journal of Virology, June 2017, ASM Journals

    Professor Luis Martinez-Sobrido

  12. A live-attenuated influenza vaccine for H3N2 canine influenza virus

    Article • Virology, April 2017, Elsevier

    Professor Luis Martinez-Sobrido

  13. Avian Interferons and Their Antiviral Effectors

    Article • Frontiers in Immunology, January 2017, Frontiers

    Professor Luis Martinez-Sobrido

  14. Lassa Virus Reverse Genetics

    Article • January 2017, Springer Science + Business Media

    Professor Luis Martinez-Sobrido

  15. Reverse Genetics of Influenza B Viruses

    Article • January 2017, Springer Science + Business Media

    Professor Luis Martinez-Sobrido

  16. Development of Recombinant Arenavirus-Based Vaccines

    Article • January 2017, Springer Science + Business Media

    Professor Luis Martinez-Sobrido

  17. Plasmid-Based Reverse Genetics of Influenza A Virus

    Article • January 2017, Springer Science + Business Media

    Professor Luis Martinez-Sobrido

  18. 46: Gestational age differences in susceptibility of the human placenta to viral infection

    Article • American Journal of Obstetrics and Gynecology, January 2017, Elsevier

    Professor Luis Martinez-Sobrido

  19. Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines

    Article • Virology, January 2017, Elsevier

    Professor Luis Martinez-Sobrido

  20. Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein

    Article • Virology, January 2017, Elsevier

    Professor Luis Martinez-Sobrido

  21. Reverse Genetics Approaches for the Development of Influenza Vaccines

    Article • International Journal of Molecular Sciences, December 2016, MDPI AG

    Professor Luis Martinez-Sobrido

  22. NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses

    Article • Journal of Virology, December 2016, ASM Journals

    Professor Luis Martinez-Sobrido, David Topham

  23. Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine

    Article • Journal of Virology, December 2016, ASM Journals

    Professor Luis Martinez-Sobrido

  24. Antisense Oligonucleotides Targeting Influenza A Segment 8 Genomic RNA Inhibit Viral Replication

    Article • Nucleic Acid Therapeutics, October 2016, Mary Ann Liebert Inc

    Professor Luis Martinez-Sobrido

  25. Mutations at highly conserved residues in influenza A(H1N1)pdm09 virus affect neuraminidase activity

    Article • Virus Research, October 2016, Elsevier

    Professor Luis Martinez-Sobrido, PhD Guadalupe Ayora Talavera

  26. NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses

    Article • Journal of Virology, August 2016, ASM Journals

    Professor Luis Martinez-Sobrido, David Topham

  27. Reporter-Expressing, Replicating-Competent Recombinant Arenaviruses

    Article • Viruses, July 2016, MDPI AG

    Professor Luis Martinez-Sobrido

  28. Replication-Competent Influenza A Viruses Expressing Reporter Genes

    Article • Viruses, June 2016, MDPI AG

    Professor Luis Martinez-Sobrido

  29. Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell Culture

    Article • PLoS ONE, June 2016, PLOS

    Professor Luis Martinez-Sobrido

  30. Novel strategies for development of hemorrhagic fever arenavirus live-attenuated vaccines

    Article • Expert Review of Vaccines, May 2016, Taylor & Francis

    Professor Luis Martinez-Sobrido

  31. Development and applications of single-cycle infectious influenza A virus (sciIAV)

    Article • Virus Research, May 2016, Elsevier

    Professor Luis Martinez-Sobrido

  32. Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines

    Article • Journal of Virology, April 2016, ASM Journals

    Professor Luis Martinez-Sobrido

  33. Replication-competent fluorescent-expressing influenza B virus

    Article • Virus Research, February 2016, Elsevier

    Professor Daniel R Perez, Professor Luis Martinez-Sobrido

  34. Replication-Competent Influenza A and B Viruses Expressing a Fluorescent Dynamic Timer Protein for In Vitro and In Vivo Studies

    Article • PLoS ONE, January 2016, PLOS

    Professor Luis Martinez-Sobrido

  35. Reverse Genetics Approaches to Control Arenavirus

    Article • January 2016, Springer Science + Business Media

    Professor Luis Martinez-Sobrido

  36. Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA)

    Article • Vaccine, July 2015, Elsevier

    Professor Luis Martinez-Sobrido

  37. Downregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines

    Article • Future Virology, June 2015, Future Medicine

    Professor Luis Martinez-Sobrido

  38. An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein

    Article • Journal of Biopharmaceutical Statistics, May 2015, Taylor & Francis

    Professor Luis Martinez-Sobrido

  39. Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines

    Article • Journal of Virology, May 2015, ASM Journals

    Professor Luis Martinez-Sobrido, Juan C de la Torre

  40. Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS

    Article • Journal of Virology, April 2015, ASM Journals

    Professor Luis Martinez-Sobrido

  41. Replication-competent influenza A viruses expressing a red fluorescent protein

    Article • Virology, February 2015, Elsevier

    Professor Luis Martinez-Sobrido

  42. Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization

    Article • Journal of Virology, January 2015, ASM Journals

    Professor Luis Martinez-Sobrido, Juan C de la Torre

  43. Innate Immunity against RNA viruses☆

    Article • January 2015, Elsevier

    Professor Luis Martinez-Sobrido

  44. Development of a Mouse-Adapted Live Attenuated Influenza Virus That PermitsIn VivoAnalysis of Enhancements to the Safety of Live Attenuated Influenza Virus Vaccine

    Article • Journal of Virology, December 2014, ASM Journals

    Professor Luis Martinez-Sobrido

  45. Comparison of Serum Hemagglutinin and Neuraminidase Inhibition Antibodies After 2010-2011 Trivalent Inactivated Influenza Vaccination in Healthcare Personnel

    Article • Open Forum Infectious Diseases, December 2014, Oxford University Press (OUP)

    Professor Luis Martinez-Sobrido

  46. Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP–sugar synthesis to support viral protein glycosylation

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Professor Luis Martinez-Sobrido

  47. The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?

    Article • The Journal of Immunology, November 2014, The American Association of Immunologists

    Professor Luis Martinez-Sobrido

  48. The Human Cytomegalovirus UL26 Protein Antagonizes NF- B Activation

    Article • Journal of Virology, October 2014, ASM Journals

    Professor Luis Martinez-Sobrido

  49. Corrigendum to “Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies” [J. Virol. Methods 197 (2014) 47–50)]

    Article • Journal of Virological Methods, September 2014, Elsevier

    Professor Luis Martinez-Sobrido

  50. Induction of CD8 T Cell Heterologous Protection by a Single Dose of Single-Cycle Infectious Influenza Virus

    Article • Journal of Virology, August 2014, ASM Journals

    Professor Luis Martinez-Sobrido, David Topham

  51. Influenza A and B Virus Intertypic Reassortment through Compatible Viral Packaging Signals

    Article • Journal of Virology, July 2014, ASM Journals

    Professor Luis Martinez-Sobrido

  52. Influenza A Virus Attenuation by Codon Deoptimization of the NS Gene for Vaccine Development

    Article • Journal of Virology, June 2014, ASM Journals

    Professor Luis Martinez-Sobrido

  53. Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies

    Article • Journal of Virological Methods, March 2014, Elsevier

    Professor Luis Martinez-Sobrido

  54. Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis Inhibitor

    Article • Journal of Virology, November 2013, ASM Journals

    Professor Luis Martinez-Sobrido, Juan C de la Torre

  55. Rescue of Recombinant Newcastle Disease Virus from cDNA

    Article • Journal of Visualized Experiments, October 2013, MyJove Corporation

    Professor Luis Martinez-Sobrido

  56. Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

    Article • ACS Chemical Biology, September 2013, American Chemical Society (ACS)

    Professor Luis Martinez-Sobrido

  57. Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

    Article • Journal of Visualized Experiments, August 2013, MyJove Corporation

    Professor Luis Martinez-Sobrido

  58. Protection against Lethal Influenza with a Viral Mimic

    Article • Journal of Virology, May 2013, ASM Journals

    Professor Luis Martinez-Sobrido, Dr Randy A Albrecht, David Topham

  59. Arenavirus reverse genetics for vaccine development

    Article • Journal of General Virology, January 2013, Society for General Microbiology

    Professor Luis Martinez-Sobrido

  60. D471G Mutation in LCMV-NP Affects Its Ability to Self-associate and Results in a Dominant Negative Effect in Viral RNA Synthesis

    Article • Viruses, October 2012, MDPI AG

    Professor Luis Martinez-Sobrido

  61. Arenavirus Nucleoproteins Prevent Activation of Nuclear Factor Kappa B

    Article • Journal of Virology, May 2012, ASM Journals

    Professor Luis Martinez-Sobrido

  62. Arenavirus Nucleoprotein Targets Interferon Regulatory Factor-Activating Kinase IKK 

    Article • Journal of Virology, April 2012, ASM Journals

    Professor Luis Martinez-Sobrido

  63. Self-Association of Lymphocytic Choriomeningitis Virus Nucleoprotein Is Mediated by Its N-Terminal Region and Is Not Required for Its Anti-Interferon Function

    Article • Journal of Virology, January 2012, ASM Journals

    Professor Luis Martinez-Sobrido

  64. Host-Range Restriction of Vaccinia Virus E3L Deletion Mutant Can Be Overcome In Vitro, but Not In Vivo, by Expression of the Influenza Virus NS1 Protein

    Article • PLoS ONE, December 2011, PLOS

    Professor Luis Martinez-Sobrido

  65. The C-Terminal Region of Lymphocytic Choriomeningitis Virus Nucleoprotein Contains Distinct and Segregable Functional Domains Involved in NP-Z Interaction and Counteraction of the Type I Interferon Response

    Article • Journal of Virology, October 2011, ASM Journals

    Professor Luis Martinez-Sobrido

  66. Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

    Article • mBio, August 2011, ASM Journals

    Professor Luis Martinez-Sobrido, Dr Randy A Albrecht

  67. Corrigendum to “Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes” [Virology 410 (2011) 240–247]

    Article • Virology, May 2011, Elsevier

    Professor Luis Martinez-Sobrido

  68. Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring

    Article • Journal of Neuroscience, February 2011, Society for Neuroscience

    Professor Luis Martinez-Sobrido

  69. The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease

    Article • Journal of Translational Medicine, January 2011, Springer Science + Business Media

    Professor Luis Martinez-Sobrido, Dr Randy A Albrecht

  70. Use of Single-Cycle Infectious Lymphocytic Choriomeningitis Virus To Study Hemorrhagic Fever Arenaviruses

    Article • Journal of Virology, December 2010, ASM Journals

    Professor Luis Martinez-Sobrido

  71. Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals

    Article • BMC Molecular Biology, November 2010, Springer Science + Business Media

    Professor Luis Martinez-Sobrido

  72. Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection

    Article • Viruses, November 2010, MDPI AG

    Professor Luis Martinez-Sobrido

  73. Induction of Type I Interferon Secretion through Recombinant Newcastle Disease Virus Expressing Measles Virus Hemagglutinin Stimulates Antibody Secretion in the Presence of Maternal Antibodies

    Article • Journal of Virology, October 2010, ASM Journals

    Professor Luis Martinez-Sobrido, Professor Changsun Choi

  74. Glycine 184 in Nonstructural Protein NS1 Determines the Virulence of Influenza A Virus Strain PR8 without Affecting the Host Interferon Response

    Article • Journal of Virology, October 2010, ASM Journals

    Professor Luis Martinez-Sobrido

  75. Generation of Recombinant Influenza Virus from Plasmid DNA

    Article • Journal of Visualized Experiments, August 2010, MyJove Corporation

    Professor Luis Martinez-Sobrido

  76. Murine Coronavirus Delays Expression of a Subset of Interferon-Stimulated Genes

    Article • Journal of Virology, March 2010, ASM Journals

    Professor Luis Martinez-Sobrido

  77. Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies

    Article • Journal of Virology, November 2009, ASM Journals

    Professor Luis Martinez-Sobrido

  78. Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor

    Article • Journal of General Virology, October 2009, Society for General Microbiology

    Professor Luis Martinez-Sobrido, Friedemann Weber

  79. Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene

    Article • Journal of General Virology, September 2009, Society for General Microbiology

    Professor Luis Martinez-Sobrido

  80. Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus

    Article • Journal of Virology, August 2009, ASM Journals

    Professor Luis Martinez-Sobrido

  81. Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation

    Article • Journal of General Virology, July 2009, Society for General Microbiology

    Professor Luis Martinez-Sobrido, Friedemann Weber

  82. A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery

    Article • Biotechnology and Bioengineering, July 2009, Wiley

    Professor Luis Martinez-Sobrido

  83. Influenza B Virus Ribonucleoprotein Is a Potent Activator of the Antiviral Kinase PKR

    Article • PLoS Pathogens, June 2009, PLOS

    Professor Luis Martinez-Sobrido

  84. Enhancement of Oncolytic Properties of Recombinant Newcastle Disease Virus Through Antagonism of Cellular Innate Immune Responses

    Article • Molecular Therapy, April 2009, Elsevier

    Professor Luis Martinez-Sobrido

  85. Mice Lacking the ISG15 E1 Enzyme UbE1L Demonstrate Increased Susceptibility to both Mouse-Adapted and Non-Mouse-Adapted Influenza B Virus Infection

    Article • Journal of Virology, November 2008, ASM Journals

    Professor Luis Martinez-Sobrido

  86. Influenza B Virus NS1-Truncated Mutants: Live-Attenuated Vaccine Approach

    Article • Journal of Virology, September 2008, ASM Journals

    Professor Luis Martinez-Sobrido

  87. 236 SARS-coronavirus inhibits interferon induction both at pre- and post-transcriptional levels

    Article • Cytokine, September 2008, Elsevier

    Professor Luis Martinez-Sobrido

  88. 292 p53 Transcriptionally activates IRF9 to enhance antiviral immunity

    Article • Cytokine, September 2008, Elsevier

    Professor Luis Martinez-Sobrido

  89. Transcriptional role of p53 in interferon-mediated antiviral immunity

    Article • The Journal of Experimental Medicine, July 2008, Rockefeller University Press

    Professor Luis Martinez-Sobrido

  90. Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response

    Article • Journal of Medical Virology, January 2008, Wiley

    Professor Luis Martinez-Sobrido, Friedemann Weber

  91. Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

    Article • Journal of Virology, October 2007, ASM Journals

    Professor Luis Martinez-Sobrido

  92. Differential Inhibition of Type I Interferon Induction by Arenavirus Nucleoproteins

    Article • Journal of Virology, September 2007, ASM Journals

    Professor Luis Martinez-Sobrido

  93. Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines

    Article • Immunology, September 2007, Wiley

    Professor Luis Martinez-Sobrido

  94. Use of Reverse Genetics to Enhance the Oncolytic Properties of Newcastle Disease Virus

    Article • Cancer Research, September 2007, American Association for Cancer Research (AACR)

    Professor Luis Martinez-Sobrido, Dr Jerome Cros

  95. Recombinant influenza virus vectors

    Article • Future Virology, July 2007, Future Medicine

    Professor Luis Martinez-Sobrido

  96. The intracellular sites of early replication and budding of SARS-coronavirus

    Article • Virology, May 2007, Elsevier

    Professor Luis Martinez-Sobrido, Friedemann Weber

  97. Inhibition of the Alpha/Beta Interferon Response by Mouse Hepatitis Virus at Multiple Levels

    Article • Journal of Virology, April 2007, ASM Journals

    Professor Luis Martinez-Sobrido

  98. Multiple Anti-Interferon Actions of the Influenza A Virus NS1 Protein

    Article • Journal of Virology, April 2007, ASM Journals

    Professor Luis Martinez-Sobrido

  99. Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene

    Article • Proceedings of the National Academy of Sciences, April 2007, Proceedings of the National Academy of Sciences

    Professor Luis Martinez-Sobrido

  100. Identification of Cellular Interaction Partners of the Influenza Virus Ribonucleoprotein Complex and Polymerase Complex Using Proteomic-Based Approaches

    Article • Journal of Proteome Research, February 2007, American Chemical Society (ACS)

    Professor Luis Martinez-Sobrido

  101. Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame (ORF) 3b, ORF 6, and Nucleocapsid Proteins Function as Interferon Antagonists

    Article • Journal of Virology, November 2006, ASM Journals

    Professor Luis Martinez-Sobrido

  102. Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus

    Article • Journal of Virology, November 2006, ASM Journals

    Professor Luis Martinez-Sobrido

  103. Inhibition of the Type I Interferon Response by the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus

    Article • Journal of Virology, September 2006, ASM Journals

    Professor Luis Martinez-Sobrido

  104. Ebola Virus VP35 Protein Binds Double-Stranded RNA and Inhibits Alpha/Beta Interferon Production Induced by RIG-I Signaling

    Article • Journal of Virology, June 2006, ASM Journals

    Erica Ollmann Saphire, Professor Luis Martinez-Sobrido

  105. Protection against Respiratory Syncytial Virus by a Recombinant Newcastle Disease Virus Vector

    Article • Journal of Virology, February 2006, ASM Journals

    Professor Luis Martinez-Sobrido, Dr Jerome Cros

  106. 7a Protein of Severe Acute Respiratory Syndrome Coronavirus Inhibits Cellular Protein Synthesis and Activates p38 Mitogen-Activated Protein Kinase

    Article • Journal of Virology, January 2006, ASM Journals

    Professor Luis Martinez-Sobrido

  107. Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses

    Article • Journal of Virology, July 2005, ASM Journals

    Professor Luis Martinez-Sobrido

  108. Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3

    Article • Journal of Virology, February 2005, ASM Journals

    Professor Luis Martinez-Sobrido, Friedemann Weber, Dr Jerome Cros

  109. Thogoto virus ML protein suppresses IRF3 function

    Article • Virology, January 2005, Elsevier

    Professor Luis Martinez-Sobrido, Friedemann Weber

  110. Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge

    Article • Virology, August 2004, Elsevier

    Professor Luis Martinez-Sobrido

  111. The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3

    Article • Journal of Virology, July 2003, ASM Journals

    Professor Luis Martinez-Sobrido