All Stories

  1. N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection

    Article • Molecular & Cellular Proteomics, May 2023, Elsevier

    Dr Heung-Chin Cheng

  2. CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

    Article • Oncogene, March 2021, Springer Science + Business Media

    Dr Heung-Chin Cheng

  3. Src family kinases and their role in hematological malignancies

    Article • Leukemia & Lymphoma, January 2015, Taylor & Francis

    Dr Heung-Chin Cheng

  4. C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.

    Article • Journal of Biological Chemistry, January 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng, Professor Anthony W Purcell

  5. Dual role of Src kinase in governing neuronal survival

    Article • Brain Research, January 2015, Elsevier

    Dr Heung-Chin Cheng

  6. Global Analysis of Human Nonreceptor Tyrosine Kinase Specificity Using High-Density Peptide Microarrays

    Article • Journal of Proteome Research, August 2014, American Chemical Society (ACS)

    Dr Vesa P Hytönen, Dr Heung-Chin Cheng

  7. Activation of Src family tyrosine kinases by ferric ions

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2014, Elsevier

    Dr Heung-Chin Cheng

  8. Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)

    Article • Human Mutation, February 2014, Wiley

    Dr Heung-Chin Cheng

  9. A Truncated Fragment of Src Protein Kinase Generated by Calpain-mediated Cleavage Is a Mediator of Neuronal Death in Excitotoxicity

    Article • Journal of Biological Chemistry, February 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng

  10. Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations

    Article • Biochemical Society Transactions, October 2012, Portland Press Ltd.

    Dr Heung-Chin Cheng

  11. Aberrant regulation and function of Src family tyrosine kinases: Their potential contributions to glutamate-induced neurotoxicity

    Article • Clinical and Experimental Pharmacology and Physiology, July 2012, Wiley

    Dr Heung-Chin Cheng

  12. Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)

    Article • Human Mutation, July 2012, Wiley

    Dr Heung-Chin Cheng

  13. Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of β-Synuclein as a Potential CHK Physiological Substrate

    Article • Biochemistry, August 2011, American Chemical Society (ACS)

    Dr Heung-Chin Cheng, Professor Anthony W Purcell

  14. Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

    Article • Biochemical Journal, March 2011, Portland Press Ltd.

    Dr Heung-Chin Cheng

  15. A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases

    Article • Bioorganic & Medicinal Chemistry Letters, January 2011, Elsevier

    Dr Heung-Chin Cheng

  16. Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): Comparison of the catalytic activities of CHK and CSK

    Article • Protein Expression and Purification, December 2010, Elsevier

    Dr Heung-Chin Cheng

  17. Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN—Demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, September 2010, Elsevier

    Dr Heung-Chin Cheng

  18. Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases

    Article • Growth Factors, May 2010, Taylor & Francis

    Dr Heung-Chin Cheng

  19. Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: Implications for disease-associated kinases

    Article • Clinical and Experimental Pharmacology and Physiology, January 2010, Wiley

    Dr Heung-Chin Cheng

  20. Common and differential recognition of structural features in synthetic peptides by the catalytic domain and the Src-Homology 2 (SH2) domain of pp60c-src

    Article • Journal of Peptide Research, January 2009, Wiley

    Dr Heung-Chin Cheng

  21. Synthesis and receptor binding activity of elephant β-endorphin, a β-endorphin homolog with highly potent analgesic activity#

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr Heung-Chin Cheng

  22. Chemical synthesis of human β-endorphin(1-27) analogs by peptide segment coupling

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr Heung-Chin Cheng

  23. Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

    Article • Journal of Neurochemistry, April 2008, Wiley

    Dr Heung-Chin Cheng

  24. Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2)

    Article • Nucleic Acids Research, November 2007, Oxford University Press (OUP)

    Dr Heung-Chin Cheng, Dr Dilantha D Gunawardana

  25. Decreased CHK protein levels are associated with Src activation in colon cancer cells

    Article • Oncogene, October 2007, Springer Science + Business Media

    Dr Heung-Chin Cheng

  26. Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase

    Article • Protein Expression and Purification, October 2007, Elsevier

    Dr Heung-Chin Cheng

  27. PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid — Mechanistic analysis of a familial Cowden disease-associated PTEN mutation

    Article • Cellular Signalling, July 2007, Elsevier

    Dr Heung-Chin Cheng

  28. C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1

    Article • Human Molecular Genetics, September 2006, Oxford University Press (OUP)

    Dr Heung-Chin Cheng

  29. C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases

    Article • Journal of Biological Chemistry, September 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng, Professor Anthony W Purcell

  30. PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis

    Article • Neuroscience Letters, September 2006, Elsevier

    Dr Heung-Chin Cheng

  31. Csk homologous kinase

    Article • AfCS-Nature Molecule Pages, June 2006, Springer Science + Business Media

    Dr Heung-Chin Cheng

  32. C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)—endogenous negative regulators of Src-family protein kinases

    Article • Growth Factors, January 2005, Taylor & Francis

    Dr Heung-Chin Cheng

  33. Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction

    Article • Cellular and Molecular Life Sciences, July 2004, Springer Science + Business Media

    Dr Heung-Chin Cheng

  34. A Novel Non-catalytic Mechanism Employed by the C-terminal Src-homologous Kinase to Inhibit Src-family Kinase Activity

    Article • Journal of Biological Chemistry, February 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng

  35. Modulation of the Catalytic Activity of the Src Family Tyrosine Kinase Hck by Autophosphorylation at a Novel Site in the Unique Domain

    Article • Journal of Biological Chemistry, August 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng

  36. Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530

    Article • Oncogene, February 1999, Springer Science + Business Media

    Dr Heung-Chin Cheng

  37. Common in Vitro Substrate Specificity and Differential Src Homology 2 Domain Accessibility Displayed by Two Members of the Src Family of Protein-tyrosine Kinases, c-Src and Hck

    Article • Journal of Biological Chemistry, July 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng

  38. Purification of Bovine Thymus Cytosolic C-Terminal Src Kinase (CSK) and Demonstration of Differential Efficiencies of Phosphorylation and Inactivation of p56 lyn and pp60 c-src by CSK †

    Article • Biochemistry, January 1996, American Chemical Society (ACS)

    Dr Heung-Chin Cheng

  39. Autophosphorylation Induces Autoactivation and a Decrease in the Src Homology 2 Domain Accessibility of the Lyn Protein Kinase

    Article • Journal of Biological Chemistry, December 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng

  40. Characterization of Two Activated Mutants of Human pp60c-src That Escape c-Src Kinase Regulation by Distinct Mechanisms

    Article • Journal of Biological Chemistry, October 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Heung-Chin Cheng

  41. PRELIMINARY STUDY ON THE ANTINOCICEPTIVE EFFECT OF ELEPHANT ?-ENDORPHIN

    Article • Clinical and Experimental Pharmacology and Physiology, January 1990, Wiley

    Dr Heung-Chin Cheng

  42. [16] Peptide inhibitors of CAMP-dependent protein kinase

    Article • January 1988, Elsevier

    Dr Heung-Chin Cheng

  43. Circular dichroic investigations of secondary structure in synthetic peptide inhibitors for cAMP-dependent protein kinase: a model for inhibitory potential

    Article • Biochemistry, December 1987, American Chemical Society (ACS)

    Dr Heung-Chin Cheng

  44. Identification of Functional Domains of the Inhibitor Protein of Camp-Dependent Protein Kinase

    Article • January 1987, Springer Science + Business Media

    Dr Heung-Chin Cheng

  45. Circular dichroic evidence for an ordered sequence of ligand/binding site interactions in the catalytic reaction of the cAMP-dependent protein kinase

    Article • Biochemistry, June 1985, American Chemical Society (ACS)

    Dr Heung-Chin Cheng