All Stories

  1. Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization

    Article • Clinical Chemistry, January 2015, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  2. DNA Ligase-Based Strategy for Quantifying Heterogeneous DNA Methylation without Sequencing

    Article • Clinical Chemistry, January 2015, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  3. Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors

    Article • Clinical Epidemiology, November 2014, Taylor & Francis

    Professor Alexander Dobrovic

  4. Methylation profiling of ductal carcinoma in situand its relationship to histopathological features

    Article • October 2014, Springer Science + Business Media

    Professor Alexander Dobrovic

  5. Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer

    Article • Modern Pathology, September 2014, Elsevier

    Professor Alexander Dobrovic

  6. Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma

    Article • Pigment Cell & Melanoma Research, August 2014, Wiley

    Professor Alexander Dobrovic

  7. Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

    Article • BMC Medical Genomics, May 2014, Springer Science + Business Media

    Professor Alexander Dobrovic

  8. The Clinical Relevance of Pathologic Subtypes in Metastatic Lung Adenocarcinoma

    Article • Journal of Thoracic Oncology, May 2014, Elsevier

    Professor Alexander Dobrovic

  9. Bioinformatics Pipelines for Targeted Resequencing and Whole-Exome Sequencing of Human and Mouse Genomes: A Virtual Appliance Approach for Instant Deployment

    Article • PLoS ONE, April 2014, PLOS

    Professor Alexander Dobrovic

  10. Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

    Article • Pigment Cell & Melanoma Research, March 2014, Wiley

    Professor Alexander Dobrovic

  11. Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC

    Article • Asia-Pacific Journal of Clinical Oncology, February 2014, Wiley

    Professor Alexander Dobrovic

  12. A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

    Article • Scientific Reports, February 2014, Springer Science + Business Media

    Professor Alexander Dobrovic

  13. Reassessing Locus-Specific DNA Methylation in Head-and-Neck Squamous Cell Carcinoma (HNSCC) With Quantitative Methodology and Correlation With Patient Outcome

    Article • International Journal of Radiation Oncology*Biology*Physics, February 2014, Elsevier

    Professor Alexander Dobrovic

  14. Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome

    Article • International Journal of Cancer, January 2014, Wiley

    Professor Alexander Dobrovic

  15. Candidate methylation profiling of ductal carcinoma in situ and its relationship to phenotype

    Article • Pathology, January 2014, Elsevier

    Professor Alexander Dobrovic

  16. EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma

    Article • Pathology, January 2014, Elsevier

    Professor Alexander Dobrovic

  17. Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours

    Article • Scientific Reports, December 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  18. The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

    Article • Leukemia Research, December 2013, Elsevier

    Professor Alexander Dobrovic

  19. Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors

    Article • BMC Medical Genomics, October 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  20. Characterization of a Novel Tumorigenic Esophageal Adenocarcinoma Cell Line: OANC1

    Article • Digestive Diseases and Sciences, September 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  21. Reducing Sequence Artifacts in Amplicon-Based Massively Parallel Sequencing of Formalin-Fixed Paraffin-Embedded DNA by Enzymatic Depletion of Uracil-Containing Templates

    Article • Clinical Chemistry, September 2013, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  22. PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

    Article • August 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  23. DNA methylation in ductal carcinoma in situof the breast

    Article • June 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  24. Quantitative threefold allele-specific PCR (QuanTAS-PCR) for highly sensitive JAK2V617F mutant allele detection

    Article • BMC Cancer, April 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  25. A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma

    Article • Scientific Reports, April 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  26. No evidence for PALB2 methylation in high-grade serous ovarian cancer

    Article • Journal of Ovarian Research, April 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  27. A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

    Article • Journal of Hematology & Oncology, January 2013, Springer Science + Business Media

    Professor Alexander Dobrovic

  28. DNA methylation biomarkers in cancer: progress towards clinical implementation

    Article • Expert Review of Molecular Diagnostics, June 2012, Taylor & Francis

    Professor Alexander Dobrovic, Dr Christoph Bock

  29. Abstract 2098: Reducing sequence artefacts from FFPE DNA for cancer diagnostics

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Professor Alexander Dobrovic

  30. Abstract LB-377: Promoter methylation of the DAPK1 CLL predisposition gene is associated with chronic lymphocytic leukaemia risk

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Professor Alexander Dobrovic

  31. No evidence for DNA methylation of theATMpromoter CpG island in chronic lymphocytic leukemia

    Article • Leukemia & Lymphoma, January 2012, Taylor & Francis

    Professor Alexander Dobrovic

  32. Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis

    Article • Leukemia & Lymphoma, January 2012, Taylor & Francis

    Professor Alexander Dobrovic

  33. Sensitive Quantification of Somatic Mutations Using Molecular Inversion Probes

    Article • Analytical Chemistry, October 2011, American Chemical Society (ACS)

    Professor Alexander Dobrovic

  34. 1.31 Investigating Methylation of the Pro-Apoptotic CLL Tumour Suppressor Gene, Death Associated Protein Kinase 1 (DAPK1)

    Article • Clinical Lymphoma Myeloma & Leukemia, October 2011, Elsevier

    Professor Alexander Dobrovic

  35. 1.29 Development of Highly Accurate RT-qPCR Assays for Profiling the Expression of DNA Repair and Apoptosis Genes in CLL

    Article • Clinical Lymphoma Myeloma & Leukemia, October 2011, Elsevier

    Professor Alexander Dobrovic

  36. 1.30 Caspase 10 is Down-Regulated in Chronic Lymphocytic Leukemia

    Article • Clinical Lymphoma Myeloma & Leukemia, October 2011, Elsevier

    Professor Alexander Dobrovic

  37. Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer

    Article • Breast Cancer Research and Treatment, July 2011, Springer Science + Business Media

    Professor Alexander Dobrovic

  38. A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2genes

    Article • BMC Cancer, June 2011, Springer Science + Business Media

    Professor Alexander Dobrovic

  39. Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma

    Article • Pigment Cell & Melanoma Research, June 2011, Wiley

    Professor Alexander Dobrovic

  40. Assessing combined methylation–sensitive high resolution melting and pyrosequencing for the analysis of heterogeneous DNA methylation

    Article • Epigenetics, April 2011, Taylor & Francis

    Professor Alexander Dobrovic

  41. Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer

    Article • BMC Cancer, March 2011, Springer Science + Business Media

    Professor Alexander Dobrovic

  42. Investigating the Potential Role of Genetic and Epigenetic Variation of DNA Methyltransferase Genes in Hyperplastic Polyposis Syndrome

    Article • PLoS ONE, February 2011, PLOS

    Professor Alexander Dobrovic

  43. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

    Article • February 2011, Springer Science + Business Media

    Professor Alexander Dobrovic

  44. Analysing DNA Methylation Using Bisulphite Pyrosequencing

    Article • January 2011, Springer Science + Business Media

    Professor Alexander Dobrovic

  45. Closed-Tube PCR Methods for Locus-Specific DNA Methylation Analysis

    Article • January 2011, Springer Science + Business Media

    Professor Alexander Dobrovic, Alexander Dobrovic

  46. A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues

    Article • BMC Biotechnology, December 2010, Springer Science + Business Media

    Professor Alexander Dobrovic

  47. Rarity ofAKT1andAKT3E17K mutations in squamous cell carcinoma of lung

    Article • Cell Cycle, November 2010, Taylor & Francis

    Professor Alexander Dobrovic

  48. Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer

    Article • Cancer Prevention Research, October 2010, American Association for Cancer Research (AACR)

    Professor Alexander Dobrovic

  49. Assessing Gene-Specific Methylation Using HRM-Based Analysis

    Article • September 2010, Springer Science + Business Media

    Professor Alexander Dobrovic

  50. DNA methylation analysis of the HIF‐1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas

    Article • Histopathology, August 2010, Wiley

    Professor Alexander Dobrovic

  51. No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer

    Article • Breast Cancer Research and Treatment, August 2010, Springer Science + Business Media

    Professor Alexander Dobrovic

  52. The implications of heterogeneous DNA methylation for the accurate quantification of methylation

    Article • Epigenomics, August 2010, Future Medicine

    Professor Alexander Dobrovic

  53. HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

    Article • July 2010, Springer Science + Business Media

    Professor Alexander Dobrovic

  54. DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast

    Article • Breast Cancer Research and Treatment, June 2010, Springer Science + Business Media

    Professor Alexander Dobrovic

  55. T1715 The Role of Genetic and Epigenetic Variation of DNA Methyltransferases in Hyperplastic Polyposis Syndrome

    Article • Gastroenterology, May 2010, Elsevier

    Professor Alexander Dobrovic

  56. Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure

    Article • Pigment Cell & Melanoma Research, January 2010, Wiley

    Professor Alexander Dobrovic

  57. A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical Setting

    Article • Journal of Molecular Diagnostics, November 2009, Elsevier

    Professor Alexander Dobrovic

  58. Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism

    Article • Cancer Prevention Research, September 2009, American Association for Cancer Research (AACR)

    Professor Alexander Dobrovic

  59. Identification of circulating tumour cells in early stage breast cancer patients using multi marker immunobead RT-PCR

    Article • Journal of Hematology & Oncology, June 2009, Springer Science + Business Media

    Professor Alexander Dobrovic

  60. Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B‐Raf

    Article • International Journal of Cancer, April 2009, Wiley

    Professor Alexander Dobrovic

  61. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

    Article • Journal of Clinical Investigation, April 2009, American Society for Clinical Investigation

    Professor Alexander Dobrovic, Natalie A Sims

  62. DNA Methylation of the ABO Promoter Underlies Loss of ABO Allelic Expression in a Significant Proportion of Leukemic Patients

    Article • PLoS ONE, March 2009, PLOS

    Professor Alexander Dobrovic

  63. Melting Curve Assays for DNA Methylation Analysis

    Article • January 2009, Springer Science + Business Media

    Professor Alexander Dobrovic

  64. DNA methylation, epimutations and cancer predisposition

    Article • The International Journal of Biochemistry & Cell Biology, January 2009, Elsevier

    Professor Alexander Dobrovic, Alexander Dobrovic

  65. Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies

    Article • Molecular Cancer, January 2009, Springer Science + Business Media

    Professor Alexander Dobrovic

  66. Validation of a primer optimisation matrix to improve the performance of reverse transcription – quantitative real-time PCR assays

    Article • BMC Research Notes, January 2009, Springer Science + Business Media

    Professor Alexander Dobrovic

  67. No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer

    Article • BMC Research Notes, January 2009, Springer Science + Business Media

    Professor Alexander Dobrovic

  68. Methylation-sensitive high-resolution melting

    Article • Nature Protocols, November 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  69. Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene

    Article • Epigenetics & Chromatin, November 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  70. Rapid detection of methylation change at H19 in human imprinting disorders using methylation-sensitive high-resolution melting

    Article • Human Mutation, October 2008, Hindawi Publishing Corporation

    Professor Alexander Dobrovic

  71. Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia

    Article • Journal of Hematology & Oncology, July 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  72. High resolution melting allows sensitive high-throughput assessment of methylation in tumour samples

    Article • European Journal of Cancer Supplements, July 2008, Elsevier

    Professor Alexander Dobrovic

  73. High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

    Article • BMC Cancer, May 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  74. Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting

    Article • BMC Research Notes, May 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  75. Direct Genotyping of Single Nucleotide Polymorphisms in Methyl Metabolism Genes Using Probe-Free High-Resolution Melting Analysis

    Article • Cancer Epidemiology Biomarkers & Prevention, May 2008, American Association for Cancer Research (AACR)

    Professor Alexander Dobrovic

  76. Rapid detection of carriers with BRCA1 and BRCA2mutations using high resolution melting analysis

    Article • BMC Cancer, February 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  77. Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection

    Article • Nucleic Acids Research, February 2008, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  78. BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1tumour phenotype

    Article • February 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  79. Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail

    Article • BMC Biotechnology, January 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  80. A new approach to primer design for the control of PCR bias in methylation studies

    Article • BMC Research Notes, January 2008, Springer Science + Business Media

    Professor Alexander Dobrovic

  81. Complete molecular response of e6a2 BCR-ABL-positive acute myeloid leukemia to imatinib then dasatinib

    Article • Blood, December 2007, American Society of Hematology

    Professor Alexander Dobrovic

  82. High resolution melting for mutation scanning of TP53exons 5–8

    Article • BMC Cancer, August 2007, Springer Science + Business Media

    Professor Alexander Dobrovic

  83. P3-002: High resolution melting analysis for rapid and sensitive EGFR mutation detection

    Article • Journal of Thoracic Oncology, August 2007, Elsevier

    Professor Alexander Dobrovic

  84. A Simple, Rapid, and Sensitive Method for the Detection of the JAK2 V617F Mutation

    Article • American Journal of Clinical Pathology, June 2007, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  85. Distinct Clinical and Pathological Features Are Associated with the BRAFT1799A(V600E) Mutation in Primary Melanoma

    Article • Journal of Investigative Dermatology, April 2007, Elsevier

    Professor Alexander Dobrovic

  86. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation

    Article • Nucleic Acids Research, March 2007, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  87. Sensitive Detection of KIT D816V in Patients with Mastocytosis

    Article • Clinical Chemistry, December 2006, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  88. Polyclonal Resistance in Gastrointestinal Stromal Tumor Treated with Sequential Kinase Inhibitors

    Article • Clinical Cancer Research, October 2006, American Association for Cancer Research (AACR)

    Professor Alexander Dobrovic

  89. Methods for Analysis of DNA Methylation

    Article • January 2006, Springer Science + Business Media

    Professor Alexander Dobrovic, Alexander Dobrovic

  90. DNA repair gene inactivation in non-Hodgkin's lymphoma

    Article • Leukemia & Lymphoma, January 2006, Taylor & Francis

    Professor Alexander Dobrovic

  91. Screening for and analysis of methylation differences using methylation-sensitive single-strand conformation analysis

    Article • Methods, June 2002, Elsevier

    Professor Alexander Dobrovic

  92. Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer

    Article • Carcinogenesis, February 2002, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  93. Clustering of 1p36 breakpoints distal to 1p36.2 in hematological malignancies

    Article • Cancer Genetics and Cytogenetics, February 2001, Elsevier

    Professor Alexander Dobrovic

  94. Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease

    Article • International Journal of Cancer, January 2000, Wiley

    Professor Alexander Dobrovic

  95. Molecular detection of blood-borne epithelial cells in colorectal cancer patients and in patients with benign bowel disease

    Article • International Journal of Cancer, January 2000, Wiley

    Professor Alexander Dobrovic

  96. Methylation-sensitive, single-strand conformation analysis (MS-SSCA): A rapid method to screen for and analyze methylation

    Article • Human Mutation, October 1999, Hindawi Publishing Corporation

    Professor Alexander Dobrovic

  97. Somatic mutations, acetylator status, and prognosis in colorectal cancer

    Article • Gut, May 1998, BMJ

    Professor Alexander Dobrovic, Professor David Roder

  98. Characterization of a KRAB Family Zinc Finger Gene,ZNF195,Mapping to Chromosome Band 11p15.5

    Article • Genomics, October 1997, Elsevier

    Professor Alexander Dobrovic

  99. A rapid and reliable PCR method for genotyping the ABO blood group. II: A2 and O2 alleles

    Article • Human Mutation, January 1996, Wiley

    Professor Alexander Dobrovic

  100. A rapid and reliable PCR method for genotyping the ABO blood group. II: A2 and O2 alleles

    Article • Human Mutation, January 1996, Hindawi Publishing Corporation

    Professor Alexander Dobrovic

  101. 57. Detection of circulating tumour cells in patients with breast cancer using immunobead-PCR

    Article • The Breast, September 1995, Elsevier

    Professor Alexander Dobrovic

  102. Localization of the human growth arrest-specific gene ( GAS1 ) to chromosome bands 9q21.3-q22, a region frequently deleted in myeloid malignancies

    Article • Genomics, December 1993, Elsevier

    Professor Alexander Dobrovic

  103. Mapping of the chromosome 11 breakpoint of the t(4;11)(q21;p14–15) translocation

    Article • Cancer Genetics and Cytogenetics, September 1993, Elsevier

    Professor Alexander Dobrovic

  104. A rapid and reliable PCR method for genotyping the ABO blood group

    Article • Human Mutation, January 1993, Hindawi Publishing Corporation

    Professor Alexander Dobrovic

  105. A rare translocation (4;11)(q21;p14–15) in an acute lymphoblastic leukemia expressing T-cell and myeloid markers

    Article • Cancer Genetics and Cytogenetics, October 1991, Elsevier

    Professor Alexander Dobrovic

  106. Review: Molecular analysis of the Philadelphia chromosome

    Article • Chromosoma, September 1991, Springer Science + Business Media

    Professor Alexander Dobrovic

  107. Detection of minimal residual tumour cells in stem cell harvests using molecular markers

    Article • European Journal of Cancer and Clinical Oncology, January 1991, Elsevier

    Professor Alexander Dobrovic

  108. The significance of oncogene amplification in primary breast cancer

    Article • International Journal of Cancer, February 1989, Wiley

    Professor Alexander Dobrovic

  109. DNA methylation and genetic inactivation at thymidine kinase locus: Two different mechanisms for silencing autosomal genes

    Article • January 1988

    Professor Alexander Dobrovic

  110. A frequent HindIII RFLP on chromosome 3p21–25 detected by a genomic erbA β sequence

    Article • Nucleic Acids Research, January 1988, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  111. A Hin dIII RFLP for the HPRT pseudogene on chromosome 3 (HPRTP1)

    Article • Nucleic Acids Research, January 1987, Oxford University Press (OUP)

    Professor Alexander Dobrovic

  112. Gene mapping in marsupials and monotremes

    Article • Cytogenetic and Genome Research, January 1986, Karger Publishers

    Professor Alexander Dobrovic