All Stories

  1. The tale of proteolysis targeting chimeras (PROTACs) for leucine‐rich repeat kinase 2 (LRRK2)

    Article • ChemMedChem, December 2020, Wiley

    Arjan Kortholt

  2. The neuroprotective action of lenalidomide on rotenone model of Parkinson's Disease: Neurotrophic and supportive actions in the substantia nigra pars compacta

    Article • Neuroscience Letters, November 2020, Elsevier

    Arjan Kortholt

  3. Allosteric inhibition of LRRK2, where are we now

    Article • Biochemical Society Transactions, October 2020, Portland Press Ltd.

    Arjan Kortholt

  4. Complex Analysis of Fluorescence Intensity Fluctuations of Molecular Compounds

    Article • Journal of Applied Spectroscopy, September 2020, Springer Science + Business Media

    Arjan Kortholt

  5. Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria

    Article • Current Biology, August 2020, Elsevier

    Arjan Kortholt

  6. Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

    Article • Biochemical Journal, April 2020, Portland Press Ltd.

    Arjan Kortholt

  7. Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity

    Article • Biomedicine & Pharmacotherapy, October 2019, Elsevier

    Arjan Kortholt

  8. Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein

    Article • Biochemical Journal, January 2019, Portland Press Ltd.

    Arjan Kortholt

  9. Roco Proteins: GTPases with a Baroque Structure and Mechanism

    Article • International Journal of Molecular Sciences, January 2019, MDPI AG

    Arjan Kortholt

  10. Biochemical and kinetic properties of the complex Roco G-protein cycle

    Article • Biological Chemistry, November 2018, De Gruyter

    Arjan Kortholt, Wim Versées

  11. The cytoskeleton regulates symmetry transitions in moving amoeboid cells

    Article • Journal of Cell Science, February 2018, The Company of Biologists

    Arjan Kortholt

  12. The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2

    Article • Biological Chemistry, February 2018, De Gruyter

    Arjan Kortholt

  13. GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis

    Article • Proceedings of the National Academy of Sciences, November 2017, Proceedings of the National Academy of Sciences

    Arjan Kortholt, Xuehua Xu

  14. A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

    Article • Nature Communications, October 2017, Springer Science + Business Media

    Arjan Kortholt

  15. The LRR-Roc-COR module of theChlorobium tepidumRoco protein: crystallization and X-ray crystallographic analysis

    Article • Acta Crystallographica Section F Structural Biology Communications, August 2017, International Union of Crystallography

    Arjan Kortholt, Wim Versées

  16. Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection

    Article • Small GTPases, June 2017, Taylor & Francis

    Arjan Kortholt

  17. Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

    Article • Molecular Biology of the Cell, April 2017, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  18. The unconventional G-protein cycle of LRRK2 and Roco proteins

    Article • Biochemical Society Transactions, December 2016, Portland Press Ltd.

    Arjan Kortholt

  19. Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization

    Article • Small GTPases, October 2016, Taylor & Francis

    Arjan Kortholt

  20. Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

    Article • Proceedings of the National Academy of Sciences, June 2016, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  21. A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

    Article • PLoS ONE, June 2016, PLOS

    Arjan Kortholt

  22. A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis

    Article • Developmental Cell, June 2016, Elsevier

    Arjan Kortholt

  23. The small GTPases Ras and Rap1 bind to and control TORC2 activity

    Article • Scientific Reports, May 2016, Springer Science + Business Media

    Arjan Kortholt

  24. Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

    Article • International Journal of Molecular Sciences, January 2016, MDPI AG

    Arjan Kortholt

  25. Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

    Article • BMC Cell Biology, January 2016, Springer Science + Business Media

    Arjan Kortholt

  26. Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

    Article • Parkinson s Disease, January 2016, Hindawi Publishing Corporation

    Arjan Kortholt

  27. Abstract B48: Homer3 regulates the establishment of neutrophil polarity

    Article • Cancer Immunology Research, October 2015, American Association for Cancer Research (AACR)

    Arjan Kortholt

  28. Conformational heterogeneity of the Roc domains in C. tepidum Roc–COR and implications for human LRRK2 Parkinson mutations

    Article • Bioscience Reports, October 2015, Portland Press Ltd.

    Arjan Kortholt

  29. Structural Characterization of LRRK2 Inhibitors

    Article • Journal of Medicinal Chemistry, May 2015, American Chemical Society (ACS)

    Arjan Kortholt

  30. Homer3 regulates the establishment of neutrophil polarity

    Article • Molecular Biology of the Cell, May 2015, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  31. Revisiting the Roco G-protein cycle

    Article • Biochemical Journal, January 2015, Portland Press Ltd.

    Arjan Kortholt

  32. Rap1-dependent pathways coordinate cytokinesis in Dictyostelium

    Article • Molecular Biology of the Cell, December 2014, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  33. Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

    Article • Frontiers in Molecular Neuroscience, May 2014, Frontiers

    Arjan Kortholt

  34. Ras activation and symmetry breaking during Dictyostelium chemotaxis

    Article • Journal of Cell Science, July 2013, The Company of Biologists

    Arjan Kortholt

  35. Reply to Tall et al.: Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  36. Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

    Article • Proceedings of the National Academy of Sciences, April 2013, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  37. Simple system – substantial share: The use of Dictyostelium in cell biology and molecular medicine

    Article • European Journal of Cell Biology, February 2013, Elsevier

    Professor Ludwig Eichinger, Arjan Kortholt

  38. Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

    Article • Molecular Biology of the Cell, January 2013, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  39. GxcC connects Rap and Rac signaling during Dictyostelium development

    Article • BMC Cell Biology, January 2013, Springer Science + Business Media

    Arjan Kortholt

  40. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

    Article • Proceedings of the National Academy of Sciences, June 2012, Proceedings of the National Academy of Sciences

    Arjan Kortholt

  41. Dictyostelium discoideum: A Model System to Study LRRK2-Mediated Parkinson Disease

    Article • February 2012, IntechOpen

    Arjan Kortholt

  42. Multiple Regulatory Mechanisms for theDictyosteliumRoco Protein GbpC

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  43. Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

    Article • EMBO Reports, November 2011, Wiley

    Arjan Kortholt

  44. A Rap/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation

    Article • Molecular Biology of the Cell, March 2010, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  45. Intramolecular Activation Mechanism of theDictyosteliumLRRK2 Homolog Roco Protein GbpC

    Article • Journal of Biological Chemistry, August 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  46. Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

    Article • Cellular Signalling, August 2008, Elsevier

    Arjan Kortholt

  47. Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

    Article • The EMBO Journal, July 2008, Wiley

    Arjan Kortholt

  48. Phospholipase C Regulation of Phosphatidylinositol 3,4,5-trisphosphate-mediated Chemotaxis

    Article • Molecular Biology of the Cell, December 2007, American Society for Cell Biology (ASCB)

    Arjan Kortholt

  49. Essential role of PI3-kinase and phospholipase A2 inDictyostelium discoideumchemotaxis

    Article • The Journal of Cell Biology, May 2007, Rockefeller University Press

    Arjan Kortholt

  50. Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

    Article • The Journal of Cell Biology, May 2007, Rockefeller University Press

    Arjan Kortholt

  51. Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

    Article • EMBO Reports, March 2007, EMBO

    Profesor Robert Insall, Arjan Kortholt

  52. Regulation of Phagocytosis in Dictyostelium by the Inositol 5-Phosphatase OCRL Homolog Dd5P4

    Article • Traffic, March 2007, Wiley

    Arjan Kortholt

  53. SevenDictyostelium discoideumphosphodiesterases degrade three pools of cAMP and cGMP

    Article • Biochemical Journal, February 2007, Portland Press Ltd.

    Arjan Kortholt

  54. Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity inDictyostelium discoideum

    Article • Journal of Biological Chemistry, June 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  55. DdPDE4, a Novel cAMP-specific Phosphodiesterase at the Surface of Dictyostelium Cells

    Article • Journal of Biological Chemistry, April 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Arjan Kortholt

  56. Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins

    Article • The EMBO Journal, October 2003, Wiley

    Arjan Kortholt