All Stories

  1. A molecular diagnostic approach able to detect the recurrent genetic prognostic factors typical of presenting myeloma

    Article • Genes Chromosomes and Cancer, October 2014, Wiley

    Dr Brian A Walker

  2. B-cell malignancies: capture-sequencing strategies for identification of gene rearrangements and translocations into immunoglobulin gene loci

    Article • Blood and Lymphatic Cancer Targets and Therapy, October 2014, Taylor & Francis

    Dr Brian A Walker

  3. A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue

    Article • Leukemia & Lymphoma, August 2014, Taylor & Francis

    Dr Brian A Walker, Professor Daniel S. Brewer

  4. Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients

    Article • Blood Cancer Journal, March 2014, Springer Science + Business Media

    Dr Brian A Walker

  5. Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma

    Article • Leukemia, January 2014, Springer Science + Business Media

    Dr Brian A Walker

  6. Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms

    Article • Leukemia, July 2013, Springer Science + Business Media

    Dr Brian A Walker

  7. Identification of a novel t(7;14) translocation in multiple myeloma resulting in overexpression of EGFR

    Article • Genes Chromosomes and Cancer, June 2013, Wiley

    Dr Brian A Walker

  8. Improved risk stratification in myeloma using a microRNA‐based classifier

    Article • British Journal of Haematology, May 2013, Wiley

    Dr Brian A Walker, Professor Daniel S. Brewer

  9. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma

    Article • Blood, May 2013, American Society of Hematology

    Dr Brian A Walker

  10. MMSET is the key molecular target in t(4;14) myeloma

    Article • Blood Cancer Journal, May 2013, Springer Science + Business Media

    Dr Brian A Walker

  11. Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells

    Article • Blood, February 2013, American Society of Hematology

    Dr Brian A Walker

  12. Characterization of a Novel Mouse Model of Multiple Myeloma and Its Use in Preclinical Therapeutic Assessment

    Article • PLoS ONE, February 2013, PLOS

    Dr Brian A Walker

  13. A TC classification-based predictor for multiple myeloma using multiplexed real-time quantitative PCR

    Article • Leukemia, January 2013, Springer Science + Business Media

    Dr Brian A Walker

  14. Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma

    Article • Blood, May 2012, American Society of Hematology

    Dr Brian A Walker

  15. The genetic architecture of multiple myeloma

    Article • Nature Reviews Cancer, April 2012, Springer Science + Business Media

    Dr Brian A Walker

  16. Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma

    Article • Haematologica, November 2011, Ferrata Storti Foundation (Haematologica)

    Dr Brian A Walker, Dr Jerome Moreaux

  17. Mapping of Chromosome 1p Deletions in Myeloma Identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as Being Genes in Regions Associated with Adverse Survival

    Article • Clinical Cancer Research, October 2011, American Association for Cancer Research (AACR)

    Dr Brian A Walker

  18. The Reconstruction of Transcriptional Networks Reveals Critical Genes with Implications for Clinical Outcome of Multiple Myeloma

    Article • Clinical Cancer Research, September 2011, American Association for Cancer Research (AACR)

    Dr Brian A Walker

  19. A Gene Expression-Based Predictor for Myeloma Patients at High Risk of Developing Bone Disease on Bisphosphonate Treatment

    Article • Clinical Cancer Research, August 2011, American Association for Cancer Research (AACR)

    Dr Brian A Walker, Professor Daniel S. Brewer

  20. A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial

    Article • Leukemia, August 2011, Springer Science + Business Media

    Dr Brian A Walker

  21. The clinical impact and molecular biology of del(17p) in multiple myeloma treated with conventional or thalidomide‐based therapy

    Article • Genes Chromosomes and Cancer, July 2011, Wiley

    Dr Brian A Walker

  22. Gender Disparities in the Tumor Genetics and Clinical Outcome of Multiple Myeloma

    Article • Cancer Epidemiology Biomarkers & Prevention, June 2011, American Association for Cancer Research (AACR)

    Dr Brian A Walker

  23. Could DNA methylation become a useful measure for multiple myeloma prognoses?

    Article • Expert Review of Hematology, April 2011, Taylor & Francis

    Dr Brian A Walker

  24. Genetic Factors Underlying the Risk of Thalidomide-Related Neuropathy in Patients With Multiple Myeloma

    Article • Journal of Clinical Oncology, January 2011, American Society of Clinical Oncology (ASCO)

    Dr Brian A Walker

  25. Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myeloma

    Article • Blood, October 2010, American Society of Hematology

    Dr Brian A Walker

  26. High expression levels of the mammalian target of rapamycin inhibitorDEPTORare predictive of response to thalidomide in myeloma

    Article • Leukemia & Lymphoma, September 2010, Taylor & Francis

    Dr Brian A Walker

  27. A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value

    Article • Blood, July 2010, American Society of Hematology

    Dr Brian A Walker

  28. XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments

    Article • Blood, April 2010, American Society of Hematology

    Dr Brian A Walker

  29. Abstract 4737: Genetic determinants associated with multiple myeloma risk in three large population sets

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Dr Brian A Walker

  30. Homozygous Deletion Mapping in Myeloma Samples Identifies Genes and an Expression Signature Relevant to Pathogenesis and Outcome

    Article • Clinical Cancer Research, March 2010, American Association for Cancer Research (AACR)

    Dr Brian A Walker

  31. Aminopeptidase inhibition as a targeted treatment strategy in myeloma

    Article • Molecular Cancer Therapeutics, April 2009, American Association for Cancer Research (AACR)

    Dr Brian A Walker

  32. B455 A Molecular Characterization of 17p Deletion in Myeloma, Related to Maintenance Thalidomide Outcome

    Article • Clinical Lymphoma & Myeloma, February 2009, Elsevier

    Dr Brian A Walker

  33. MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

    Article • Haematologica, January 2009, Ferrata Storti Foundation (Haematologica)

    Dr Brian A Walker

  34. Deletions of CDKN2C in Multiple Myeloma: Biological and Clinical Implications

    Article • Clinical Cancer Research, October 2008, American Association for Cancer Research (AACR)

    Dr Brian A Walker

  35. Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

    Article • Blood, November 2007, American Society of Hematology

    Dr Brian A Walker

  36. Use of Single Nucleotide Polymorphism–Based Mapping Arrays to Detect Copy Number Changes and Loss of Heterozygosity in Multiple Myeloma

    Article • Clinical Lymphoma & Myeloma, November 2006, Elsevier

    Dr Brian A Walker

  37. Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma

    Article • Blood, May 2006, American Society of Hematology

    Dr Brian A Walker