All Stories

  1. Gain-of-function Shh mutants activate Smo cell-autonomously independent of Ptch1/2 function

    Article • Mechanisms of Development, October 2018, Elsevier

    Dr Henk Roelink

  2. Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life

    Article • Journal of Developmental Biology, June 2018, MDPI AG

    Dr Henk Roelink

  3. Skin-Derived Vitamin D 3 Protects against Basal Cell Carcinoma

    Article • Journal of Investigative Dermatology, December 2017, Elsevier

    Dr Henk Roelink

  4. ShhN-mediated activation of Smo in the absence of Ptch1/2 function

    Article • August 2017, Cold Spring Harbor Laboratory Press

    Dr Henk Roelink

  5. Patched1 and Patched2 inhibit Smoothened non-cell autonomously

    Article • eLife, August 2016, eLife

    Dr Henk Roelink

  6. Sonic Hedgehog and Neural Patterning☆

    Article • January 2015, Elsevier

    Dr Henk Roelink

  7. Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling

    Article • Nature Communications, September 2014, Springer Science + Business Media

    Dr Henk Roelink

  8. Ptch2 mediates the Shh response in Ptch1-/- cells

    Article • Development, August 2014, The Company of Biologists

    Dr Henk Roelink

  9. Core promoter factor TAF9B regulates neuronal gene expression

    Article • eLife, July 2014, eLife

    Dr Henk Roelink

  10. Assessment of the stromal contribution to Sonic Hedgehog‐dependent pancreatic adenocarcinoma

    Article • Molecular Oncology, August 2013, Wiley

    Dr Henk Roelink

  11. Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium

    Article • Science Signaling, August 2012, American Association for the Advancement of Science

    Dr Henk Roelink

  12. Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube

    Article • Developmental Dynamics, October 2010, Wiley

    Dr Henk Roelink

  13. Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets

    Article • Expert Opinion on Therapeutic Targets, June 2010, Informa Healthcare

    Dr Henk Roelink

  14. Evidence for a role of vertebrate Disp1 in long-range Shh signaling

    Article • Development, December 2009, The Company of Biologists

    Dr Henk Roelink

  15. Sonic Hedgehog and Neural Patterning

    Article • January 2009, Elsevier

    Dr Henk Roelink

  16. Sonic hedgehog is required for the assembly and remodeling of branchial arch blood vessels

    Article • Developmental Dynamics, June 2008, Wiley

    Dr Henk Roelink

  17. Leukotriene Synthesis Is Required for Hedgehog‐Dependent Neurite Projection in Neuralized Embryoid Bodies but Not for Motor Neuron Differentiation

    Article • Stem Cells, May 2008, Oxford University Press (OUP)

    Dr Henk Roelink, Arnold Spek

  18. Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites

    Article • Cellular Signalling, December 2007, Elsevier

    Dr Henk Roelink, Arnold Spek

  19. The Notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell‐derived embryoid bodies independently of sonic hedgehog signaling

    Article • Developmental Dynamics, February 2007, Wiley

    Dr Henk Roelink

  20. Inhibition of cGMP-Dependent Protein Kinase Reduces the Response to Sonic Hedgehog in Neuralized Embryoid Bodies

    Article • Stem Cells and Development, October 2006, Mary Ann Liebert Inc

    Dr Henk Roelink

  21. Threshold-Dependent BMP-Mediated Repression: A Model for a Conserved Mechanism That Patterns the Neuroectoderm

    Article • PLoS Biology, September 2006, PLOS

    Dr Henk Roelink

  22. Nude thymic rudiment lacking functional foxn1 resembles respiratory epithelium

    Article • Developmental Dynamics, June 2005, Wiley

    Dr Henk Roelink

  23. Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3‐like signal

    Article • Developmental Dynamics, January 2004, Wiley

    Dr Henk Roelink

  24. The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord

    Article • Developmental Biology, May 2003, Elsevier

    Dr Henk Roelink

  25. Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

    Article • Current Biology, June 2002, Elsevier

    Dr Henk Roelink

  26. Protein Kinase A Deficiency Causes Axially Localized Neural Tube Defects in Mice

    Article • Journal of Biological Chemistry, March 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Henk Roelink

  27. cGMP Enhances the Sonic Hedgehog Response in Neural Plate Cells

    Article • Developmental Biology, October 2001, Elsevier

    Dr Henk Roelink

  28. The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly

    Article • Cellular and Molecular Life Sciences, November 2000, Springer Science + Business Media

    Dr Henk Roelink

  29. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

    Article • Proceedings of the National Academy of Sciences, October 2000, Proceedings of the National Academy of Sciences

    Dr Henk Roelink

  30. Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport

    Article • Developmental Biology, August 2000, Elsevier

    Dr Henk Roelink

  31. Hippocampus formation: An intriguing collaboration

    Article • Current Biology, April 2000, Elsevier

    Dr Henk Roelink

  32. Mechanistic Investigation of Veratrum Alkaloid-Induced Mammalian Teratogenesis

    Article • December 1999, American Chemical Society (ACS)

    Dr Henk Roelink

  33. Analysis of chicken Wnt13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction

    Article • Developmental Dynamics, July 1999, Wiley

    Dr Henk Roelink

  34. Analysis of chickenWnt-13 expression demonstrates coincidence with cell division in the developing eye and is consistent with a role in induction

    Article • Developmental Dynamics, July 1999, Wiley

    Dr Henk Roelink

  35. WNT Signaling in the Control of Hair Growth and Structure

    Article • Developmental Biology, March 1999, Elsevier

    Dr Henk Roelink

  36. Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

    Article • Cell, November 1996, Elsevier

    Dr Henk Roelink

  37. Determination of Neuroepithelial Cell Fate: Induction of the Oligodendrocyte Lineage by Ventral Midline Cells and Sonic Hedgehog

    Article • Developmental Biology, July 1996, Elsevier

    Dr Henk Roelink

  38. Sonic hedgehog: a mediator of inductive signaling in the neural ventral tube

    Article • Seminars in Cell and Developmental Biology, February 1996, Elsevier

    Dr Henk Roelink

  39. Tripartite signaling of pattern: interactions between Hedgehogs, BMPs and Wnts in the control of vertebrate development

    Article • Current Opinion in Neurobiology, February 1996, Elsevier

    Dr Henk Roelink

  40. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

    Article • Cell, September 1995, Elsevier

    Dr Henk Roelink

  41. Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation

    Article • Current Biology, June 1995, Elsevier

    Dr Henk Roelink

  42. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

    Article • Cell, May 1995, Elsevier

    Dr Henk Roelink

  43. Restrictions to Floor Plate Induction by hedgehog and Winged-Helix Genes in the Neural Tube of Frog Embryos

    Article • Molecular and Cellular Neuroscience, April 1995, Elsevier

    Dr Henk Roelink

  44. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

    Article • Cell, February 1994, Elsevier

    Dr Henk Roelink

  45. Molecular Cloning and Chromosomal Localization to 17q21 of the Human WNT3 Gene

    Article • Genomics, September 1993, Elsevier

    Dr Henk Roelink

  46. Using mRNA in Situ Hybridization to Localize Wnt-3 and Wnt-3A Expression in Developing Neural Tube

    Article • January 1992, Elsevier

    Dr Henk Roelink

  47. Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.

    Article • Genes & Development, March 1991, Cold Spring Harbor Laboratory Press

    Dr Henk Roelink

  48. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

    Article • Proceedings of the National Academy of Sciences, June 1990, Proceedings of the National Academy of Sciences

    Dr Henk Roelink

  49. Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.

    Article • Molecular and Cellular Biology, March 1989, ASM Journals

    Dr Henk Roelink

  50. Making a Morphogenetic Gradient

    Article • Springer Science + Business Media

    Dr Henk Roelink