All Stories

  1. A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

    Article • Nature Communications, September 2015, Nature

    Dr Fan Yang

  2. Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

    Article • Nature Methods, June 2015, Nature

    Dr Fan Yang

  3. Application of fluorescence resonance energy transfer in protein studies

    Article • Journal of Molecular Structure, December 2014, Elsevier

    Dr Fan Yang

  4. The Tetramerization Domain Potentiates Kv4 Channel Function by Suppressing Closed-State Inactivation

    Article • Biophysical Journal, September 2014, Elsevier

    Dr Fan Yang, Professor Jie Zheng

  5. High temperature sensitivity is intrinsic to voltage-gated potassium channels

    Article • eLife, July 2014, eLife

    Dr Fan Yang, Professor Jie Zheng

  6. Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold

    Article • The Journal of General Physiology, December 2013, Rockefeller University Press

    Dr Fan Yang

  7. Divalent cations activate TRPV1 through promoting conformational change of the extracellular region

    Article • The Journal of General Physiology, December 2013, Rockefeller University Press

    Dr Fan Yang

  8. Patch Fluorometry

    Article • September 2013, Wiley

    Dr Fan Yang, Professor Jie Zheng

  9. A TRPV4 Channel C-terminal Folding Recognition Domain Critical for Trafficking and Function

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Fan Yang

  10. Screening for TRPV1 Temperature-Sensing Domains with Peptide Insertion

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Fan Yang

  11. Modeling Temperature-Dependent Ion Channel Protein Structural Changes with Rosetta

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Fan Yang, Professor Jie Zheng

  12. Intracellular Proton-mediated Activation of TRPV3 Channels Accounts for the Exfoliation Effect of  -Hydroxyl Acids on Keratinocytes

    Article • Journal of Biological Chemistry, June 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Fan Yang

  13. Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

    Article • The Journal of General Physiology, March 2012, Rockefeller University Press

    Dr Fan Yang

  14. Heteromeric Heat-Sensitive TRP Channels Exhibit Distinct Temperature and Chemical Response

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Fan Yang

  15. Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Fan Yang

  16. Identification of a Tetrameric Assembly Domain in the C Terminus of Heat-activated TRPV1 Channels

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Fan Yang

  17. Extracellular Cation Gates TRPV1 via the Heat Activation Pathway

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Fan Yang

  18. Extracellular Ethanol Modulates Thermotrp Channels

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Fan Yang

  19. The Pore Turret of ThermoTRP Channels is a Portable Domain Contributing to Temperature Sensing

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Fan Yang

  20. Identification of a Tetrameric Assembly Domain in the C-Terminus of Heat-Activated TRPV Channels

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Fan Yang

  21. Reply to Yao et al.: Is the pore turret just thermoTRP channels’ appendix?

    Article • Proceedings of the National Academy of Sciences, July 2010, Proceedings of the National Academy of Sciences

    Dr Fan Yang

  22. Thermosensitive TRP channel pore turret is part of the temperature activation pathway

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Dr Fan Yang

  23. Temperature-Driven Activation of Thermotrps: A Distinct Pathway Involved

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Fan Yang

  24. Heat and Capsaicin Activate TRPV1 Channels to Different Open States:

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Fan Yang

  25. Study Heat-Induced TRP Channel Activation Using Near-Infrared Laser As a Heat Source

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Fan Yang

  26. Activation of Thermosensitive TRP Channels

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Fan Yang

  27. Temperature-dependent Activation of Neurons by Continuous Near-infrared Laser

    Article • Cell Biochemistry and Biophysics, November 2008, Springer Science + Business Media

    Dr Fan Yang

  28. Thermosensitive TRPV Channel Subunits Coassemble into Heteromeric Channels with Intermediate Conductance and Gating Properties

    Article • The Journal of General Physiology, February 2007, Rockefeller University Press

    Dr Fan Yang

  29. Subunit Assembly of N-Methyl-D-aspartate Receptors Analyzed by Fluorescence Resonance Energy Transfer

    Article • Journal of Biological Chemistry, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Fan Yang