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  1. a rat model mimicking potential Alzheimer's disease

    Article • November 2019, Springer Science + Business Media

    Professor Karim A Alkadhi

  2. Neuroprotective Effects of Nicotine on Hippocampal Long-Term Potentiation in Brain Disorders

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Karim A Alkadhi

  3. Exercise decreases BACE and APP levels in the hippocampus of a rat model of Alzheimer's disease

    Article • Molecular and Cellular Neuroscience, January 2018, Elsevier

    Professor Karim A Alkadhi

  4. Correction to: Moderate Treadmill Exercise Protects Synaptic Plasticity of the Dentate Gyrus and Related Signaling Cascade in a Rat Model of Alzheimer’s Disease

    Article • Molecular Neurobiology, October 2017, Springer Science + Business Media

    Professor Karim A Alkadhi

  5. Meet Our Editorial Board Member:

    Article • Current Neuropharmacology, March 2016, Bentham Science Publishers

    Professor Karim A Alkadhi

  6. Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1

    Article • Molecular and Cellular Neuroscience, March 2016, Elsevier

    Professor Karim A Alkadhi

  7. Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer’s Disease Model

    Article • Molecular Neurobiology, December 2015, Springer Science + Business Media

    Professor Karim A Alkadhi

  8. Caffeine treatment prevents rapid eye movement sleep deprivation-induced impairment of late-phase long-term potentiation in the dentate gyrus

    Article • European Journal of Neuroscience, November 2015, Wiley

    Professor Karim A Alkadhi

  9. Prevention by Regular Exercise of Acute Sleep Deprivation-Induced Impairment of Late Phase LTP and Related Signaling Molecules in the Dentate Gyrus

    Article • Molecular Neurobiology, April 2015, Springer Science + Business Media

    Professor Karim A Alkadhi

  10. Abnormal Brain Activity Triggers Long-Term Potentiation in Sympathetic Ganglia: Implication for Sudden Death

    Article • March 2015, Taylor & Francis

    Professor Karim A Alkadhi

  11. Chronic psychosocial stress impairs early LTP but not late LTP in the dentate gyrus of at-risk rat model of Alzheimer׳s disease

    Article • Brain Research, November 2014, Elsevier

    Professor Karim A Alkadhi

  12. Moderate Treadmill Exercise Protects Synaptic Plasticity of the Dentate Gyrus and Related Signaling Cascade in a Rat Model of Alzheimer’s Disease

    Article • Molecular Neurobiology, October 2014, Springer Science + Business Media

    Professor Karim A Alkadhi

  13. Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer’s Disease

    Article • Molecular Neurobiology, August 2014, Springer Science + Business Media

    Professor Karim A Alkadhi

  14. Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder

    Article • Physiology & Behavior, May 2014, Elsevier

    Professor Karim A Alkadhi

  15. Editorial: Neurobiological Consequences of Oxidative Stress.

    Article • Current Neuropharmacology, March 2014, Bentham Science Publishers

    Professor Karim A Alkadhi

  16. Levothyroxin replacement therapy restores hypothyroidism induced impairment of L-LTP induction: Critical role of CREB

    Article • Brain Research Bulletin, January 2014, Elsevier

    Professor Karim A Alkadhi

  17. Chronic Nicotine Treatment Reverses Hypothyroidism-Induced Impairment of L-LTP Induction Phase: Critical Role of CREB

    Article • Molecular Neurobiology, November 2013, Springer Science + Business Media

    Professor Karim A Alkadhi

  18. Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer's disease

    Article • The International Journal of Neuropsychopharmacology, November 2013, Oxford University Press (OUP)

    Professor Karim A Alkadhi

  19. Grape Powder Intake Prevents Ovariectomy-Induced Anxiety-Like Behavior, Memory Impairment and High Blood Pressure in Female Wistar Rats

    Article • PLoS ONE, September 2013, PLOS

    Professor Karim A Alkadhi

  20. Regular treadmill exercise prevents sleep deprivation-induced disruption of synaptic plasticity and associated signaling cascade in the dentate gyrus

    Article • Molecular and Cellular Neuroscience, September 2013, Elsevier

    Professor Karim A Alkadhi

  21. Regular Exercise Prevents Sleep Deprivation Associated Impairment of Long-Term Memory and Synaptic Plasticity in The CA1 Area of the Hippocampus

    Article • SLEEP, May 2013, Associated Professional Sleep Societies (APSS)

    Professor Karim A Alkadhi

  22. Treadmill Exercise Prevents Learning and Memory Impairment in Alzheimer’s Disease-Like Pathology

    Article • Current Alzheimer Research, May 2013, Bentham Science Publishers

    Professor Karim A Alkadhi

  23. Neurobiological Consequences of Sleep Deprivation

    Article • Current Neuropharmacology, April 2013, Bentham Science Publishers

    Professor Karim A Alkadhi

  24. Brain Physiology and Pathophysiology in Mental Stress

    Article • ISRN Physiology, January 2013, Hindawi Publishing Corporation

    Professor Karim A Alkadhi

  25. Prevention of Brain Disorders by Nicotine

    Article • January 2013, Springer Science + Business Media

    Professor Karim A Alkadhi

  26. Role of α7- and α4β2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory

    Article • The International Journal of Neuropsychopharmacology, October 2012, Oxford University Press (OUP)

    Professor Karim A Alkadhi

  27. The beneficial effects of regular exercise on cognition in REM sleep deprivation: Behavioral, electrophysiological and molecular evidence

    Article • Neurobiology of Disease, March 2012, Elsevier

    Professor Karim A Alkadhi

  28. Excercised Muscles and the Brain

    Article • Clinical and Experimental Pharmacology, January 2012, OMICS Publishing Group

    Professor Karim A Alkadhi

  29. Chronic psychosocial stress exposes Alzheimer s disease phenotype in a novel at-risk model

    Article • Frontiers in Bioscience, January 2012, Frontiers in Bioscience

    Professor Karim A Alkadhi

  30. Chronic psychosocial stress exposes Alzheimer's disease phenotype in a novel at-risk model

    Article • Frontiers in Bioscience, January 2012, Frontiers in Bioscience

    Professor Karim A Alkadhi

  31. Chapter 16. Neuroprotective Effects of Caffeine in Sleep Deprivation

    Article • January 2012, Royal Society of Chemistry

    Professor Karim A Alkadhi

  32. Editorial [Hot Topic: The Complex and Multifactorial Nature of Alzheimers Disease (Guest Editors: Karim Alkadhi and Jason Eriksen)]

    Article • Current Neuropharmacology, December 2011, Bentham Science Publishers

    Professor Karim A Alkadhi

  33. Chronic Stress and Alzheimers Disease-Like Pathogenesis in a Rat Model: Prevention by Nicotine

    Article • Current Neuropharmacology, December 2011, Bentham Science Publishers

    Professor Karim A Alkadhi

  34. Chronic Psychosocial Stress Exacerbates Impairment of Synaptic Plasticity in β-Amyloid Rat Model of Alzheimers Disease: Prevention by Nicotine

    Article • Current Alzheimer Research, November 2011, Bentham Science Publishers

    Professor Karim A Alkadhi

  35. Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms

    Article • Behavioural Brain Research, October 2011, Elsevier

    Professor Karim A Alkadhi

  36. Chronic psychosocial stress enhances long-term depression in a subthreshold amyloid-beta rat model of Alzheimer’s disease

    Article • Journal of Neurochemistry, September 2011, Wiley

    Professor Karim A Alkadhi

  37. Post-learning REM sleep deprivation impairs long-term memory: Reversal by acute nicotine treatment

    Article • Neuroscience Letters, July 2011, Elsevier

    Professor Karim A Alkadhi

  38. Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia

    Article • Hippocampus, May 2011, Wiley

    Professor Karim A Alkadhi

  39. Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease

    Article • Neurobiology of Aging, May 2011, Elsevier

    Professor Karim A Alkadhi

  40. Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: Protection by caffeine

    Article • Molecular and Cellular Neuroscience, April 2011, Elsevier

    Professor Karim A Alkadhi

  41. Elevation of BACE in an Aβ rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine

    Article • The International Journal of Neuropsychopharmacology, February 2011, Oxford University Press (OUP)

    Professor Karim A Alkadhi

  42. Synaptic Plasticity of Autonomic Ganglia

    Article • November 2010, Taylor & Francis

    Professor Karim A Alkadhi

  43. Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease

    Article • Molecular and Cellular Neuroscience, November 2010, Elsevier

    Professor Karim A Alkadhi

  44. In vivo expression of ganglionic long-term potentiation in superior cervical ganglia from hypertensive aged rats

    Article • Neurobiology of Aging, May 2010, Elsevier

    Professor Karim A Alkadhi

  45. Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer's disease

    Article • Hippocampus, April 2010, Wiley

    Professor Karim A Alkadhi

  46. Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus

    Article • European Journal of Neuroscience, April 2010, Wiley

    Professor Karim A Alkadhi

  47. Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease

    Article • Neurobiology of Disease, March 2010, Elsevier

    Professor Karim A Alkadhi

  48. Chronic Stress Accelerates and Intensifies Aß-induced Alzheimer’s-disease-like Pathogenesis in Rat Models

    Article • touchREVIEWS in Neurology, January 2010, Touch Digital Media, Ltd.

    Professor Karim A Alkadhi

  49. Acute nicotine treatment prevents REM sleep deprivation-induced learning and memory impairment in rat

    Article • Hippocampus, January 2010, Wiley

    Professor Karim A Alkadhi

  50. Chronic Psychosocial Stress Exacerbates Impairment of Cognition and Long-Term Potentiation in β-Amyloid Rat Model of Alzheimer's Disease

    Article • Biological Psychiatry, June 2009, Elsevier

    Professor Karim A Alkadhi

  51. Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats

    Article • Neuroscience Research, February 2009, Elsevier

    Professor Karim A Alkadhi

  52. Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies

    Article • Hippocampus, January 2009, Wiley

    Professor Karim A Alkadhi

  53. Long-term depression in the superior cervical ganglion of the rat

    Article • Brain Research, October 2008, Elsevier

    Professor Karim A Alkadhi

  54. Effect of chronic stress or nicotine on hypothyroidism–induced enhancement of LTD: Electrophysiological and molecular studies

    Article • Neurobiology of Disease, October 2008, Elsevier

    Professor Karim A Alkadhi

  55. Expression of gLTP in Sympathetic Ganglia of Obese Zucker Rats In Vivo: Molecular Evidence

    Article • Journal of Molecular Neuroscience, June 2008, Springer Science + Business Media

    Professor Karim A Alkadhi

  56. Expression of gLTP in Sympathetic Ganglia from Stress-hypertensive Rats: Molecular Evidence

    Article • Journal of Molecular Neuroscience, April 2008, Springer Science + Business Media

    Professor Karim A Alkadhi

  57. Rhythmic Discharge Induced by Temperature Variation and Drugs in Isolated Sympathetic Ganglia

    Article • Clinical and Experimental Hypertension, January 2008, Taylor & Francis

    Professor Karim A Alkadhi

  58. The sliding threshold of modification hypothesis: Application to the effect of hypothyroidism or chronic psychosocial stress and nicotine on synaptic plasticity

    Article • Neuroscience Letters, January 2008, Elsevier

    Professor Karim A Alkadhi

  59. Adult-onset hypothyroidism facilitates and enhances LTD: Reversal by chronic nicotine treatment

    Article • Neurobiology of Disease, April 2007, Elsevier

    Professor Karim A Alkadhi

  60. Role of Long-Term Potentiation of Sympathetic Ganglia (gLTP) in Hypertension

    Article • Clinical and Experimental Hypertension, January 2007, Taylor & Francis

    Professor Karim A Alkadhi

  61. Nicotine prevents disruption of the late phase LTP-related molecular cascade in adult-onset hypothyroidism

    Article • Hippocampus, January 2007, Wiley

    Professor Karim A Alkadhi

  62. A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism

    Article • Experimental Neurology, January 2007, Elsevier

    Professor Karim A Alkadhi

  63. Chronic but not acute nicotine treatment reverses stress-induced impairment of LTP in anesthetized rats

    Article • Brain Research, June 2006, Elsevier

    Professor Karim A Alkadhi

  64. Chronic psychosocial stress-induced impairment of hippocampal LTP: Possible role of BDNF

    Article • Neurobiology of Disease, June 2006, Elsevier

    Professor Karim A Alkadhi

  65. Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies

    Article • Journal of Neuroscience Research, January 2006, Wiley

    Professor Karim A Alkadhi

  66. Psychosocial stress-induced hypertension results from in vivo expression of long-term potentiation in rat sympathetic ganglia

    Article • Neurobiology of Disease, December 2005, Elsevier

    Professor Karim A Alkadhi

  67. Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: Electrophysiological and molecular studies

    Article • Experimental Neurology, October 2005, Elsevier

    Professor Karim A Alkadhi

  68. Nicotine blocks stress-induced impairment of spatial memory and long-term potentiation of the hippocampal CA1 region

    Article • The International Journal of Neuropsychopharmacology, September 2005, Oxford University Press (OUP)

    Professor Karim A Alkadhi

  69. Plasticity of synaptic transmission in autonomic ganglia

    Article • Progress in Neurobiology, February 2005, Elsevier

    Professor Karim A Alkadhi

  70. Impairment of Long-Term Potentiation in the CA1, But Not Dentate Gyrus, of the Hippocampus in Obese Zucker Rats: Role of Calcineurin and Phosphorylated CaMKII

    Article • Journal of Molecular Neuroscience, January 2005, Springer Science + Business Media

    Professor Karim A Alkadhi

  71. Role of phosphorylated CaMKII and calcineurin in the differential effect of hypothyroidism on LTP of CA1 and dentate gyrus

    Article • Hippocampus, January 2005, Wiley

    Professor Karim A Alkadhi

  72. Adverse effect of the combination of hypothyroidism and chronic psychosocial stress on hippocampus-dependent memory in rats

    Article • Behavioural Brain Research, November 2004, Elsevier

    Professor Karim A Alkadhi

  73. Hypothyroidism impairs long-term potentiation in sympathetic ganglia: Electrophysiologic and molecular studies

    Article • Journal of Neuroscience Research, November 2004, Wiley

    Professor Karim A Alkadhi

  74. Hypothyroidism impairs late LTP in CA1 region but not in dentate gyrus of the intact rat hippocampus: MAPK involvement

    Article • Hippocampus, January 2004, Wiley

    Professor Karim A Alkadhi

  75. Reduced basal CAMKII levels in hippocampal CA1 region: Possible cause of stress-induced impairment of LTP in chronically stressed rats

    Article • Hippocampus, January 2004, Wiley

    Professor Karim A Alkadhi

  76. Impaired long-term potentiation in obese zucker rats: possible involvement of presynaptic mechanism

    Article • Neuroscience, August 2003, Elsevier

    Professor Karim A Alkadhi

  77. Reduction of elevated arterial blood pressure in obese Zucker rats by inhibition of ganglionic long-term poteniation

    Article • Neuropharmacology, December 2002, Elsevier

    Professor Karim A Alkadhi

  78. Combination of hypothyroidism and stress abolishes early LTP in the CA1 but not dentate gyrus of hippocampus of adult rats

    Article • Brain Research, December 2001, Elsevier

    Professor Karim A Alkadhi

  79. Action of carbamazepine on epileptiform activity of the verartidine model in CA1 neurons

    Article • Brain Research, December 2000, Elsevier

    Professor Karim A Alkadhi

  80. Epileptiform activity of veratridine model in rat brain slices: effects of antiepileptic drugs

    Article • Epilepsy Research, February 2000, Elsevier

    Professor Karim A Alkadhi

  81. Valproic acid intensifies epileptiform activity in the hippocampal pyramidal neurons

    Article • Neuroscience Research, December 1999, Elsevier

    Professor Karim A Alkadhi

  82. Nitric oxide is required for the maintenance but not initiation of ganglionic long-term potentiation

    Article • Neuroscience, October 1999, Elsevier

    Professor Karim A Alkadhi

  83. Adenosine A1 receptor activation inhibits LTP in sympathetic ganglia

    Article • Brain Research, October 1998, Elsevier

    Professor Karim A Alkadhi

  84. Veratridine-treated brain slices: a cellular model for epileptiform activity

    Article • Brain Research, April 1998, Elsevier

    Professor Karim A Alkadhi

  85. Cyclic AMP antagonizes adenosine-induced inhibition of ganglionic transmission

    Article • Brain Research, March 1998, Elsevier

    Professor Karim A Alkadhi

  86. Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons

    Article • Neuropharmacology, November 1997, Elsevier

    Professor Karim A Alkadhi

  87. Nitric oxide mediates long-term potentiation in rat superior cervical ganglion

    Article • Brain Research, April 1997, Elsevier

    Professor Karim A Alkadhi

  88. Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats

    Article • Brain Research, December 1996, Elsevier

    Professor Karim A Alkadhi

  89. Induction and maintenance of ganglionic long-term potentiation require activation of 5-hydroxytryptamine (5-HT3) receptors.

    Article • The Journal of Physiology, October 1996, Wiley

    Professor Karim A Alkadhi

  90. Veratridine-enhanced persistent sodium current induces bursting in CA1 pyramidal neurons

    Article • Neuroscience, April 1996, Elsevier

    Professor Karim A Alkadhi

  91. Endogenous bursting due to altered sodium channel function in rat hippocampal CA1 neurons

    Article • Brain Research, May 1995, Elsevier

    Professor Karim A Alkadhi

  92. Inhibition of epileptiform activity by serotonin in rat CA1 neurons

    Article • Brain Research, January 1995, Elsevier

    Professor Karim A Alkadhi

  93. Valproic acid inhibits the depolarizing rectification in neurons of rat amygdala

    Article • Neuropharmacology, October 1994, Elsevier

    Professor Karim A Alkadhi

  94. Effects of ATP-sensitive K+-channel activators on transmitter release parameters at the frog neuromuscular junction

    Article • Brain Research, April 1993, Elsevier

    Professor Karim A Alkadhi

  95. Effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydroxypyridine (MPTP) on ganglionic transmission

    Article • Journal of Autonomic Pharmacology, February 1992, Wiley

    Professor Karim A Alkadhi

  96. Effects of inorganic potassium channel blockers on calcium requirement of transmission in a sympathetic ganglion

    Article • Journal of the Autonomic Nervous System, June 1991, Elsevier

    Professor Karim A Alkadhi

  97. A comparative study of the actions of histamine h2 receptor antagonists on transmission in the isolated superior cervical ganglion of the rat

    Article • Neuropharmacology, March 1990, Elsevier

    Professor Karim A Alkadhi

  98. Giant miniature end-plate potentials at the untreated and emetine-treated frog neuromuscular junction.

    Article • The Journal of Physiology, May 1989, Wiley

    Professor Karim A Alkadhi

  99. Effect of calcium on synaptic facilitation by potassium channel blockers in superior cervical ganglion of rat

    Article • Neuropharmacology, January 1989, Elsevier

    Professor Karim A Alkadhi

  100. Emetine increases giant miniature endplate potential population at the frog neuromuscular junction

    Article • Brain Research, May 1988, Elsevier

    Professor Karim A Alkadhi

  101. Effects of emetine and dehydroemetine at the frog neuromuscular junction

    Article • European Journal of Pharmacology, June 1987, Elsevier

    Professor Karim A Alkadhi

  102. 2,2′-Phthaloyl-, 2,2′-Isophthaloyl-, and 2,2′-Terephthaloylbis[1, 1, 1-trimethylhydrazinium] Dihydroxide, Bis(Inner Salts): Synthesis, Partition Coefficients, Toxicity and Effect on Ganglionic Transmission

    Article • Journal of Pharmaceutical Sciences, April 1986, Elsevier

    Professor Karim A Alkadhi

  103. Endplate channel actions of a hemicholinium-3 analog, DMAE

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, March 1986, Springer Science + Business Media

    Professor Karim A Alkadhi

  104. Phosphorus-Nitrogen Compounds. 26. Phosphaminimides. 2. 2,2'-Phosphinylidenebis(1,1,1-trimethylhydrazinium) Iodide Inner Salts as Agents Affecting Ganglionic Transmission

    Article • Journal of Medicinal Chemistry, May 1985, American Chemical Society (ACS)

    Professor Karim A Alkadhi

  105. P-N compounds.25. Phosphaminimides.1. Synthesis and bioevaluation of a derivative of tetrahydro-2H-1,3,4,2-oxadiazaphosphorinium inner salt

    Article • Journal of Heterocyclic Chemistry, January 1985, Wiley

    Professor Karim A Alkadhi

  106. Inhibitory effect of adenosine on transmission in sympathetic ganglia

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, November 1984, Springer Science + Business Media

    Professor Karim A Alkadhi

  107. Pre- and postsynaptic actions of valproic acid at the frog neuromuscular junction

    Article • Brain Research, July 1984, Elsevier

    Professor Karim A Alkadhi

  108. Antagonism by calcium of the inhibitory effect of methylmercury on sympathetic ganglia

    Article • Archives of Toxicology, November 1982, Springer Science + Business Media

    Professor Karim A Alkadhi

  109. Effects of methylmercuric chloride on sympathetic preganglionic nerves

    Article • Archives of Toxicology, July 1982, Springer Science + Business Media

    Professor Karim A Alkadhi

  110. Differential blockade of ganglionic transmission by extract from venom gland of black widow spider (Latrodectus mactans)

    Article • Toxicon, December 1974, Elsevier

    Professor Karim A Alkadhi

  111. EFFECT OF PREGANGLIONIC NERVE STIMULATION ON SENSITIVITY OF THE SUPERIOR CERVICAL GANGLION TO NICOTINIC BLOCKING AGENTS

    Article • British Journal of Pharmacology, August 1974, Wiley

    Professor Karim A Alkadhi

  112. Non-nicotinic transmission during ganglionic block with chlorisondamine and nicotine

    Article • European Journal of Pharmacology, October 1973, Elsevier

    Professor Karim A Alkadhi