All Stories

  1. Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons

    Article • Frontiers in Cellular Neuroscience, September 2014, Frontiers

    Dr Robert F Margolskee

  2. Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells

    Article • Neuroscience Letters, June 2014, Elsevier

    Dr Robert F Margolskee

  3. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency

    Article • Molecular Metabolism, April 2014, Elsevier

    Dr Robert F Margolskee

  4. The Bamboo-Eating Giant Panda (Ailuropoda melanoleuca) Has a Sweet Tooth: Behavioral and Molecular Responses to Compounds That Taste Sweet to Humans

    Article • PLoS ONE, March 2014, PLOS

    Dr Robert F Margolskee

  5. Bitter and sweet taste receptors regulate human upper respiratory innate immunity

    Article • Journal of Clinical Investigation, February 2014, American Society for Clinical Investigation

    Dr Robert F Margolskee, Robert Lee

  6. Endocrine taste cells

    Article • British Journal Of Nutrition, January 2014, Cambridge University Press

    Dr Robert F Margolskee

  7. Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components

    Article • Innate Immunity, September 2013, SAGE Publications

    Dr Robert F Margolskee, Robert Lee

  8. Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  9. Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue

    Article • Stem Cells, April 2013, Oxford University Press (OUP)

    Dr Robert F Margolskee

  10. Angiotensin II Modulates Salty and Sweet Taste Sensitivities

    Article • Journal of Neuroscience, April 2013, Society for Neuroscience

    Dr Robert F Margolskee

  11. Impact of T1r3 and Trpm5 on Carbohydrate Preference and Acceptance in C57BL/6 Mice

    Article • Chemical Senses, April 2013, Oxford University Press (OUP)

    Dr Robert F Margolskee

  12. Gustducin couples fatty acid receptors to GLP-1 release in colon

    Article • AJP Endocrinology and Metabolism, January 2013, American Physiological Society

    Dr Robert F Margolskee

  13. Mo2078 α-Gustducin Is Involved in GLP-1 Release Mediated by Fatty Acid Receptors in the Colon

    Article • Gastroenterology, September 2012, Elsevier

    Dr Robert F Margolskee

  14. The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice

    Article • Physiology & Behavior, August 2012, Elsevier

    Dr Robert F Margolskee

  15. Reply to Zhao and Zhang: Loss of taste receptor function in mammals is directly related to feeding specializations

    Article • Proceedings of the National Academy of Sciences, May 2012, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  16. Targeted Taste Cell-specific Overexpression of Brain-derived Neurotrophic Factor in Adult Taste Buds Elevates Phosphorylated TrkB Protein Levels in Taste Cells, Increases Taste Bud Size, and Promotes Gustatory Innervation

    Article • Journal of Biological Chemistry, March 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee

  17. Major taste loss in carnivorous mammals

    Article • Proceedings of the National Academy of Sciences, March 2012, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  18. Umami taste in mice uses multiple receptors and transduction pathways

    Article • The Journal of Physiology, January 2012, Wiley

    Dr Robert F Margolskee

  19. A Conditioned Aversion Study of Sucrose and SC45647 Taste in TRPM5 Knockout Mice

    Article • Chemical Senses, October 2011, Oxford University Press (OUP)

    Dr Robert F Margolskee

  20. Expression of Gα subunits in sweet and umami taste cells in mice

    Article • Neuroscience Research, September 2011, Elsevier

    Dr Robert F Margolskee

  21. Glucose transporters and ATP-gated K + (K ATP ) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells

    Article • Proceedings of the National Academy of Sciences, March 2011, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  22. REEP2 Enhances Sweet Receptor Function by Recruitment to Lipid Rafts

    Article • Journal of Neuroscience, October 2010, Society for Neuroscience

    Dr Robert F Margolskee

  23. Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice

    Article • AJP Regulatory Integrative and Comparative Physiology, October 2010, American Physiological Society

    Dr Robert F Margolskee

  24. Gustation Genetics: Sweet Gustducin!

    Article • Chemical Senses, July 2010, Oxford University Press (OUP)

    Dr Robert F Margolskee

  25. Action Potential-Enhanced ATP Release From Taste Cells Through Hemichannels

    Article • Journal of Neurophysiology, June 2010, American Physiological Society

    Dr Robert F Margolskee

  26. Taste cells of the gut and endocrine cells of the tongue

    Article • Appetite, June 2010, Elsevier

    Dr Robert F Margolskee

  27. Inhibition of the sweet taste receptor with lactisole attenuates post-prandial glucose levels and increases glucagon-like peptide levels in normal weight men

    Article • Appetite, June 2010, Elsevier

    Dr Robert F Margolskee

  28. Loss of high-frequency glucose-induced Ca 2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5 −/− ...

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  29. G Proteins in Gustatory Transduction

    Article • January 2010, Elsevier

    Dr Robert F Margolskee

  30. GABA influence on taste cell responses in mice

    Article • Neuroscience Research, January 2010, Elsevier

    Dr Robert F Margolskee

  31. Endocannabinoids enhance sweet taste sensitivities in mice

    Article • Neuroscience Research, January 2010, Elsevier

    Dr Robert F Margolskee

  32. A Reduction of Glucose-Induced Bursting Frequency in Pancreatic Islets Correlates with Decreased Insulin Release and Impaired Glucose Tolerance in TRPM5-/- Mice

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Robert F Margolskee

  33. Endocannabinoids selectively enhance sweet taste

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  34. Phenoxy Herbicides and Fibrates Potently Inhibit the Human Chemosensory Receptor Subunit T1R3

    Article • Journal of Medicinal Chemistry, October 2009, American Chemical Society (ACS)

    Dr Robert F Margolskee

  35. Discrimination of taste qualities among mouse fungiform taste bud cells

    Article • The Journal of Physiology, September 2009, Wiley

    Dr Robert F Margolskee

  36. Role of Olfaction in the Conditioned Sucrose Preference of Sweet-Ageusic T1R3 Knockout Mice

    Article • Chemical Senses, September 2009, Oxford University Press (OUP)

    Dr Robert F Margolskee

  37. Release of Endogenous Opioids From Duodenal Enteroendocrine Cells Requires Trpm5

    Article • Gastroenterology, August 2009, Elsevier

    Dr Robert F Margolskee

  38. S11.2 Role of gustducin, taste receptors and transient receptor potential channel M5 in gastrointestinal chemosensation

    Article • Autonomic Neuroscience, August 2009, Elsevier

    Dr Robert F Margolskee

  39. T1r3 and α‐Gustducin in Gut Regulate Secretion of Glucagon‐like Peptide‐1

    Article • Annals of the New York Academy of Sciences, July 2009, Wiley

    Dr Robert F Margolskee

  40. Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones

    Article • American Journal of Clinical Nutrition, July 2009, Oxford University Press (OUP)

    Dr Robert F Margolskee

  41. Glucose-conditioned preferences in taste-impaired TRPM5 knockout mice

    Article • Appetite, June 2009, Elsevier

    Dr Robert F Margolskee

  42. Olfaction is critical for conditioned sucrose preference in sweet-taste impaired T1R3 knockout mice

    Article • Appetite, June 2009, Elsevier

    Dr Robert F Margolskee

  43. T1R3 taste receptor is critical for sucrose but not Polycose taste

    Article • AJP Regulatory Integrative and Comparative Physiology, February 2009, American Physiological Society

    Dr Robert F Margolskee

  44. Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity

    Article • AJP Regulatory Integrative and Comparative Physiology, February 2009, American Physiological Society

    Dr Robert F Margolskee

  45. Enhancement of sweet taste responses by the addition of salt compounds in the mouse chorda tympani nerve

    Article • Neuroscience Research, January 2009, Elsevier

    Dr Robert F Margolskee

  46. Responses of mouse fungiform taste cells to multiple bitter or sour taste compounds

    Article • Neuroscience Research, January 2009, Elsevier

    Dr Robert F Margolskee

  47. Contribution of the T1r3 Taste Receptor to the Response Properties of Central Gustatory Neurons

    Article • Journal of Neurophysiology, December 2008, American Physiological Society

    Dr Robert F Margolskee

  48. Expression of the voltage‐gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null‐mutation on taste preferences

    Article • The Journal of Comparative Neurology, November 2008, Wiley

    Dr Robert F Margolskee

  49. Tonic activity of Gα‐gustducin regulates taste cell responsivity

    Article • FEBS Letters, October 2008, Wiley

    Dr Robert F Margolskee

  50. Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice

    Article • BMC Neuroscience, October 2008, Springer Science + Business Media

    Dr Robert F Margolskee

  51. Involvement of T1R3 in calcium-magnesium taste

    Article • Physiological Genomics, June 2008, American Physiological Society

    Dr Robert F Margolskee

  52. Taste Cells of the Gut and Gastrointestinal Chemosensation

    Article • Molecular Interventions, April 2008, CLOCKSS Archive

    Dr Robert F Margolskee

  53. Making Sense of the Sweet Taste Receptor

    Article • March 2008, American Chemical Society (ACS)

    Dr Robert F Margolskee

  54. Molecular Models of Sweet Taste Receptors Provide Insights into Function

    Article • March 2008, American Chemical Society (ACS)

    Dr Robert F Margolskee

  55. TRPM5-Expressing Solitary Chemosensory Cells Respond to Odorous Irritants

    Article • Journal of Neurophysiology, January 2008, American Physiological Society

    Dr Robert F Margolskee, Professor Thomas E. Finger

  56. The taste transduction channel TRPM5 is a locus for bitter‐sweet taste interactions

    Article • The FASEB Journal, December 2007, Wiley

    Dr Robert F Margolskee

  57. Intestinal glucose sensing and regulation of intestinal glucose absorption

    Article • Biochemical Society Transactions, November 2007, Portland Press Ltd.

    Dr Robert F Margolskee

  58. Gustducin and Transducin: A Tale of two G Proteins

    Article • September 2007, Wiley

    Dr Robert F Margolskee

  59. T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1

    Article • Proceedings of the National Academy of Sciences, September 2007, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  60. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

    Article • Proceedings of the National Academy of Sciences, September 2007, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  61. Immuno-localization of vesicular acetylcholine transporter in mouse taste cells and adjacent nerve fibers: indication of acetylcholine release

    Article • Cell and Tissue Research, August 2007, Springer Science + Business Media

    Dr Robert F Margolskee

  62. Fat and carbohydrate preferences in mice: the contribution of  -gustducin and Trpm5 taste-signaling proteins

    Article • AJP Regulatory Integrative and Comparative Physiology, August 2007, American Physiological Society

    Dr Robert F Margolskee

  63. The Transduction Channel TRPM5 Is Gated by Intracellular Calcium in Taste Cells

    Article • Journal of Neuroscience, May 2007, Society for Neuroscience

    Dr Robert F Margolskee

  64. Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals

    Article • Proceedings of the National Academy of Sciences, February 2007, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  65. Wnt signaling interacts with Shh to regulate taste papilla development

    Article • Proceedings of the National Academy of Sciences, February 2007, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  66. Perception of sweet taste is important for voluntary alcohol consumption in mice

    Article • Genes Brain & Behavior, February 2007, Wiley

    Dr Robert F Margolskee

  67. Afferent neurotransmission mediated by hemichannels in mammalian taste cells

    Article • The EMBO Journal, January 2007, Springer Science + Business Media

    Dr Robert F Margolskee

  68. Modulations of sweet taste responses by salts, acids and bitter compounds in the mouse chorda tympani nerve

    Article • Neuroscience Research, January 2007, Elsevier

    Dr Robert F Margolskee

  69. The Heterodimeric Sweet Taste Receptor has Multiple Potential Ligand Binding Sites

    Article • Current Pharmaceutical Design, December 2006, Bentham Science Publishers

    Dr Robert F Margolskee

  70. Making Sense of Taste

    Article • Scientific American, September 2006, Springer Science + Business Media

    Dr Robert F Margolskee

  71. G 13 Interacts with PDZ Domain-containing Proteins

    Article • Journal of Biological Chemistry, February 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee

  72. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste

    Article • December 2005

    Dr Robert F Margolskee

  73. Identification of the Cyclamate Interaction Site within the Transmembrane Domain of the Human Sweet Taste Receptor Subunit T1R3

    Article • Journal of Biological Chemistry, August 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee

  74. Sensory Systems: Taste Perception

    Article • Science Signaling, June 2005, American Association for the Advancement of Science

    Dr Robert F Margolskee

  75. Lactisole Interacts with the Transmembrane Domains of Human T1R3 to Inhibit Sweet Taste

    Article • Journal of Biological Chemistry, January 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee

  76. The Cysteine-rich Region of T1R3 Determines Responses to Intensely Sweet Proteins

    Article • Journal of Biological Chemistry, August 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee

  77. REDUCTION OF SWEET TASTE PERCEPTION IS ACCOMPANIED WITH DECREASED ETHANOL PREFRENCE AND CONSUMPTION IN ALPHA-GUSTDUCIN KNOCKOUT MICE.

    Article • Alcoholism Clinical and Experimental Research, August 2004, Wiley

    Dr Robert F Margolskee

  78. Insights into Taste Transduction and Coding from Molecular, Biochemical, and Transgenic Studies

    Article • November 2003, American Chemical Society (ACS)

    Dr Robert F Margolskee

  79. Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells

    Article • Cell Calcium, May 2003, Elsevier

    Dr Robert F Margolskee

  80. Molecular Physiology of Gustatory Transduction

    Article • March 2003, Taylor & Francis

    Dr Robert F Margolskee

  81. G Proteins Mediating Taste Transduction

    Article • January 2003, Elsevier

    Dr Robert F Margolskee

  82. G protein subunit Gγ13 is coexpressed with Gαo, Gβ3, and Gβ4 in retinal ON bipolar cells

    Article • The Journal of Comparative Neurology, November 2002, Wiley

    Dr Robert F Margolskee

  83. A transient receptor potential channel expressed in taste receptor cells

    Article • Nature Neuroscience, October 2002, Springer Science + Business Media

    Dr Robert F Margolskee

  84. Molecular mechanisms of taste transduction

    Article • Pure and Applied Chemistry, January 2002, De Gruyter

    Dr Robert F Margolskee

  85. Assaying G Protein–Phosphodiesterase Interactions in Sensory Systems

    Article • January 2002, Elsevier

    Dr Robert F Margolskee

  86. Molecular Mechanisms of Bitter and Sweet Taste Transduction

    Article • Journal of Biological Chemistry, November 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee

  87. Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in α-gustducin

    Article • Proceedings of the National Academy of Sciences, July 2001, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  88. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac

    Article • Nature Genetics, May 2001, Springer Science + Business Media

    Dr Robert F Margolskee

  89. Making Sense of Taste

    Article • Scientific American, March 2001, Springer Science + Business Media

    Dr Robert F Margolskee

  90. Phototransduction in transgenic mice after targeted deletion of the rod transducin α-subunit

    Article • Proceedings of the National Academy of Sciences, November 2000, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  91. The molecular physiology of taste transduction

    Article • Current Opinion in Neurobiology, August 2000, Elsevier

    Dr Robert F Margolskee

  92. Extracellular Matrix-Associated Protein Sc1 Is Not Essential for Mouse Development

    Article • Molecular and Cellular Biology, January 2000, ASM Journals

    Dr Robert F Margolskee

  93. Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds

    Article • Proceedings of the National Academy of Sciences, August 1999, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  94. Light-dependent Activation of Rod Transducin by Pineal Opsin

    Article • Journal of Biological Chemistry, October 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert F Margolskee, Dr Joseph S Takahashi

  95. Characterization and solubilization of bitter-responsive receptors that couple to gustducin

    Article • Proceedings of the National Academy of Sciences, July 1998, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  96. Extracellular K+ activates a K+‐ and H+‐permeable conductance in frog taste receptor cells

    Article • The Journal of Physiology, March 1998, Wiley

    Dr Robert F Margolskee

  97. An mRNA Encoding a Putative GABA‐Gated Chloride Channel Is Expressed in the Human Cardiac Conduction System

    Article • Journal of Neurochemistry, April 1997, Wiley

    Dr Robert F Margolskee

  98. The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene.

    Article • Genome Research, November 1996, Cold Spring Harbor Laboratory Press

    Dr Robert F Margolskee

  99. Mechanisms of taste transduction

    Article • Current Opinion in Neurobiology, August 1996, Elsevier

    Dr Robert F Margolskee

  100. Transduction of bitter and sweet taste by gustducin

    Article • Nature, June 1996, Springer Science + Business Media

    Dr Robert F Margolskee

  101. SC1: a marker for astrocytes in the adult rodent brain is upregulated during reactive astrocytosis

    Article • Brain Research, February 1996, Elsevier

    Dr Robert F Margolskee

  102. A cyclic–nucleotide–suppressible conductance activated by transducin in taste cells

    Article • Nature, July 1995, Springer Science + Business Media

    Dr Robert F Margolskee

  103. Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells

    Article • Nature, July 1995, Springer Science + Business Media

    Dr Robert F Margolskee

  104. Pineal opsin: a nonvisual opsin expressed in chick pineal

    Article • Science, March 1995, American Association for the Advancement of Science

    Dr Robert F Margolskee, Dr Joseph S Takahashi

  105. Molecular cloning of G proteins and phosphodiesterases from rat taste cells

    Article • Physiology & Behavior, December 1994, Elsevier

    Dr Robert F Margolskee

  106. Biochemical analysis of the transducin-phosphodiesterase interaction

    Article • Nature Structural Biology, November 1994, Springer Science + Business Media

    Dr Robert F Margolskee

  107. Human taste cells express the G protein α-gustducin and neuron-specific enolase

    Article • Molecular Brain Research, March 1994, Elsevier

    Dr Robert F Margolskee

  108. Gustducin and Transducin Are Present in Taste Cells

    Article • January 1994, Springer Science + Business Media

    Dr Robert F Margolskee

  109. The molecular biology of taste transduction

    Article • BioEssays, October 1993, Wiley

    Dr Robert F Margolskee

  110. The biochemistry and molecular biology of taste transduction

    Article • Current Opinion in Neurobiology, August 1993, Elsevier

    Dr Robert F Margolskee

  111. Gustducin is a taste-cell-specific G protein closely related to the transducins

    Article • Nature, June 1992, Springer Science + Business Media

    Dr Robert F Margolskee

  112. Cloning muscle isoforms of neural cell adhesion molecule using an episomal shuttle vector

    Article • March 1992

    Dr Robert F Margolskee

  113. Isolation of a clone which induced expression of the gene encoding the human tumor necrosis factor receptor

    Article • Gene, February 1992, Elsevier

    Dr Robert F Margolskee

  114. α Gustducin: A Taste Cell Specific G Protein Subunit Closely Related to the α Transducins

    Article • January 1992, Springer Science + Business Media

    Dr Robert F Margolskee

  115. Epstein-Barr Virus Based Expression Vectors

    Article • January 1992, Springer Science + Business Media

    Dr Robert F Margolskee

  116. HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.

    Article • Proceedings of the National Academy of Sciences, December 1991, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  117. A highly efficient directional cDNA cloning method utilizing an asymmetrically tailed linker-primer plasmid

    Article • Nucleic Acids Research, January 1991, Oxford University Press (OUP)

    Dr Robert F Margolskee

  118. An RFLP associated with pcDLen2–14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12

    Article • Nucleic Acids Research, January 1986, Oxford University Press (OUP)

    Dr Robert F Margolskee

  119. Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin.

    Article • Proceedings of the National Academy of Sciences, December 1979, Proceedings of the National Academy of Sciences

    Dr Robert F Margolskee

  120. Alignment of the restriction map of mouse adenovirus FL with that of human adenovirus 2

    Article • Virology, September 1979, Elsevier

    Dr Robert F Margolskee

  121. THE NITROGEN FIXATION (nif) OPERON OF Klebsiella pneumoniae: CLONING nif GENES AND THE ISOLATION OF nif CONTROL MUTANTS

    Article • January 1977, Elsevier

    Dr Robert F Margolskee

  122. Cloning Nitrogen Fixing Genes from Klebsiella Pneumoniae In Vitro and the Isolation of NIF Promoter Mutants Affecting Glutamine Synthetase Regulation

    Article • January 1977, Springer Science + Business Media

    Dr Robert F Margolskee