All Stories

  1. Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, February 2018, ASM Journals

    Robert Jansen, Professor Thomas Dick, Veronique Dartois

  2. Emerging Approaches to Tuberculosis Drug Development: At Home in the Metabolome

    Article • Trends in Pharmacological Sciences, April 2017, Elsevier

    Robert Jansen

  3. Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis

    Article • Cell Chemical Biology, March 2017, Elsevier

    Robert Jansen

  4. Metabolic Perspectives on Persistence

    Article • Microbiology Spectrum, February 2017, ASM Journals

    Robert Jansen

  5. Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison

    Article • Investigational New Drugs, March 2016, Springer Science + Business Media

    Robert Jansen

  6. MRP1 mediates folate transport and antifolate sensitivity inPlasmodium falciparum

    Article • FEBS Letters, February 2016, Wiley

    Robert Jansen

  7. ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs

    Article • Journal of Biological Chemistry, October 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Robert Jansen

  8. N -lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids

    Article • Proceedings of the National Academy of Sciences, May 2015, Proceedings of the National Academy of Sciences

    Robert Jansen

  9. Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

    Article • Pharmacology Research & Perspectives, March 2015, Wiley

    Robert Jansen

  10. ABCC6-Mediated ATP Secretion by the Liver Is the Main Source of the Mineralization Inhibitor Inorganic Pyrophosphate in the Systemic Circulation--Brief Report

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2014, Wolters Kluwer Health

    Robert Jansen, Flora Szeri

  11. ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release

    Article • Proceedings of the National Academy of Sciences, November 2013, Proceedings of the National Academy of Sciences

    Robert Jansen

  12. Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [14C]Bendamustine

    Article • Drug Metabolism and Disposition, April 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Robert Jansen

  13. Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study

    Article • Cancer Chemotherapy and Pharmacology, March 2012, Springer Science + Business Media

    Robert Jansen

  14. Mass Balance Study of [14C]Eribulin in Patients with Advanced Solid Tumors

    Article • Drug Metabolism and Disposition, October 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Robert Jansen

  15. Phase I Study of Oral Gemcitabine Prodrug (LY2334737) Alone and in Combination with Erlotinib in Patients with Advanced Solid Tumors

    Article • Clinical Cancer Research, July 2011, American Association for Cancer Research (AACR)

    Robert Jansen

  16. Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine

    Article • Cancer Chemotherapy and Pharmacology, May 2011, Springer Science + Business Media

    Robert Jansen

  17. Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

    Article • Fundamental and Clinical Pharmacology, March 2011, Wiley

    Robert Jansen

  18. Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs

    Article • Mass Spectrometry Reviews, July 2010, Wiley

    Robert Jansen

  19. Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

    Article • Journal of Chromatography B, March 2010, Elsevier

    Robert Jansen

  20. Facile Small Scale Synthesis of Nucleoside 5′-Phosphate Mixtures

    Article • Nucleosides Nucleotides & Nucleic Acids, January 2010, Taylor & Francis

    Robert Jansen

  21. Simultaneous quantification of 2′,2′-difluorodeoxycytidine and 2′,2′-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, October 2009, Wiley

    Robert Jansen

  22. Pharmacokinetics of Gemcitabine and Metabolites in a Patient with Double-Sided Nephrectomy: A Case Report and Review of the Literature

    Article • The Oncologist, September 2009, Alphamed Press

    Robert Jansen

  23. Protein versus DNA as a marker for peripheral blood mononuclear cell counting

    Article • Analytical and Bioanalytical Chemistry, August 2009, Springer Science + Business Media

    Robert Jansen

  24. Coadministration of Ritonavir Strongly Enhances the Apparent Oral Bioavailability of Docetaxel in Patients with Solid Tumors

    Article • Clinical Cancer Research, June 2009, American Association for Cancer Research (AACR)

    Robert Jansen

  25. Retention studies of 2′-2′-difluorodeoxycytidine and 2′-2′-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: Development of a liquid chromatography–tandem mass spectrometry method

    Article • Journal of Chromatography A, April 2009, Elsevier

    Robert Jansen

  26. Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides

    Article • Molecular Cancer Therapeutics, September 2008, American Association for Cancer Research (AACR)

    Robert Jansen

  27. Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study

    Article • Clinical Cancer Research, June 2008, American Association for Cancer Research (AACR)

    Robert Jansen

  28. Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

    Article • Rapid Communications in Mass Spectrometry, January 2007, Wiley

    Robert Jansen

  29. Multidrug Resistance Protein 2 Is an Important Determinant of Paclitaxel Pharmacokinetics

    Article • Clinical Cancer Research, October 2006, American Association for Cancer Research (AACR)

    Robert Jansen

  30. Pharmacogenetic Screening of CYP3A and ABCB1 in Relation to Population Pharmacokinetics of Docetaxel

    Article • Clinical Cancer Research, October 2006, American Association for Cancer Research (AACR)

    Robert Jansen

  31. Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

    Article • Journal of Mass Spectrometry, January 2006, Wiley

    Robert Jansen

  32. LC-MS/MS systematic toxicological analysis: Comparison of MS/MS spectra obtained with different instruments and settings

    Article • Clinical Biochemistry, April 2005, Elsevier

    Robert Jansen