All Stories

  1. Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel syndrome

    Article • Human Mutation, September 2018, Wiley

    Professor Noel F. Lowndes

  2. The Transcription Factor Hif-1 Enhances the Radio-Resistance of Mouse MSCs

    Article • Frontiers in Physiology, April 2018, Frontiers

    Professor Noel F. Lowndes

  3. Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression

    Article • Immunology and Cell Biology, March 2018, Wiley

    Professor Noel F. Lowndes

  4. Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability

    Article • Oncotarget, March 2018, Impact Journals, LLC

    Professor Noel F. Lowndes

  5. Correction for Travesa et al., “Repression of G1/S Transcription Is Mediated via Interaction of the GTB Motifs of Nrm1 and Whi5 with Swi6”

    Article • Molecular and Cellular Biology, July 2017, ASM Journals

    Professor Noel F. Lowndes

  6. Analysis of Biphenyl-Type Inhibitors Targeting the Eg5 α4/α6 Allosteric Pocket

    Article • ACS Omega, May 2017, American Chemical Society (ACS)

    Professor Noel F. Lowndes

  7. Differential Response of Mouse Thymic Epithelial Cell Types to Ionizing Radiation-Induced DNA Damage

    Article • Frontiers in Immunology, April 2017, Frontiers

    Professor Noel F. Lowndes

  8. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining

    Article • Open Biology, September 2016, Royal Society Publishing

    Professor Noel F. Lowndes

  9. BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells

    Article • Molecular and Cellular Biology, August 2015, ASM Journals

    Professor Kevin Hiom, Professor Noel F. Lowndes

  10. Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells

    Article • Stem Cells, July 2014, Oxford University Press (OUP)

    Professor Noel F. Lowndes

  11. Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

    Article • eLife, July 2014, eLife

    Professor Noel F. Lowndes

  12. Rational design and validation of a Tip60 histone acetyltransferase inhibitor

    Article • Scientific Reports, June 2014, Springer Science + Business Media

    Professor Noel F. Lowndes, Dr James A.L. Brown

  13. The RSF1 Histone-Remodelling Factor Facilitates DNA Double-Strand Break Repair by Recruiting Centromeric and Fanconi Anaemia Proteins

    Article • PLoS Biology, May 2014, PLOS

    Professor Noel F. Lowndes

  14. ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset

    Article • Cell Reports, November 2013, Elsevier

    Professor Noel F. Lowndes

  15. Hypoxia enhances the radio-resistance of mouse mesenchymal stromal cells

    Article • Experimental Hematology, August 2013, Elsevier

    Rhodri Ceredig, Professor Noel F. Lowndes

  16. Binding Specificity of the G1/S Transcriptional Regulators in Budding Yeast

    Article • PLoS ONE, April 2013, PLOS

    Professor Noel F. Lowndes, Dr Robertus Antonius Maria de Bruin

  17. Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1

    Article • PLoS Genetics, April 2013, PLOS

    Professor Noel F. Lowndes

  18. Repression of G1/S Transcription Is Mediated via Interaction of the GTB Motifs of Nrm1 and Whi5 with Swi6

    Article • Molecular and Cellular Biology, February 2013, ASM Journals

    Professor Noel F. Lowndes

  19. Multiple Facets of the DNA Damage Response Contribute to the Radioresistance of Mouse Mesenchymal Stromal Cell Lines

    Article • Stem Cells, December 2012, Oxford University Press (OUP)

    Rhodri Ceredig, Professor Noel F. Lowndes, Dr James A.L. Brown

  20. Mesenchymal stromal cells: radio‐resistant members of the bone marrow

    Article • Immunology and Cell Biology, November 2012, Wiley

    Rhodri Ceredig, Professor Noel F. Lowndes

  21. ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway

    Article • Cancer Research, January 2012, American Association for Cancer Research (AACR)

    Professor Noel F. Lowndes

  22. Co‐mutation of histone H2AX S139A with Y142A rescues Y142A‐induced ionising radiation sensitivity

    Article • FEBS Open Bio, January 2012, Wiley

    Professor Noel F. Lowndes, Dr James A.L. Brown

  23. Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

    Article • Cellular and Molecular Life Sciences, November 2011, Springer Science + Business Media

    Professor Noel F. Lowndes

  24. Modification of Histones by Sugar β- N -Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated

    Article • Journal of Biological Chemistry, September 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Noel F. Lowndes

  25. Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor

    Article • PLoS ONE, February 2011, PLOS

    Professor Noel F. Lowndes

  26. The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer

    Article • DNA Repair, October 2010, Elsevier

    Professor Noel F. Lowndes

  27. Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

    Article • PLoS Genetics, August 2010, PLOS

    Professor Noel F. Lowndes

  28. Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56

    Article • December 2009, Springer Science + Business Media

    Professor Noel F. Lowndes

  29. MRN and the race to the break

    Article • Chromosoma, October 2009, Springer Science + Business Media

    Professor Noel F. Lowndes

  30. 53BP1: function and mechanisms of focal recruitment

    Article • Biochemical Society Transactions, August 2009, Portland Press Ltd.

    Professor Noel F. Lowndes

  31. Enhanced Protein Detection Using a Trapping Mode on a Hybrid Quadrupole Linear Ion Trap (Q-Trap)

    Article • Analytical Chemistry, June 2009, American Chemical Society (ACS)

    Professor Noel F. Lowndes

  32. Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes

    Article • PLoS Genetics, January 2009, PLOS

    Professor Noel F. Lowndes

  33. The MRN complex

    Article • Current Biology, June 2008, Elsevier

    Professor Noel F. Lowndes

  34. Transcriptional Response of Candida parapsilosis following Exposure to Farnesol

    Article • Antimicrobial Agents and Chemotherapy, June 2008, ASM Journals

    Professor Noel F. Lowndes

  35. Autofluorescent Proteins

    Article • January 2008, Elsevier

    Professor Noel F. Lowndes

  36. Comparisons Between DT40 Wild Type and DT40-Cre1 Cells as Suitable Model Systems for Studying the DNA Damage Response

    Article • Cell Cycle, September 2007, Taylor & Francis

    Professor Noel F. Lowndes

  37. Chaperoning the Cln3 Cyclin Prevents Promiscuous Activation of Start

    Article • Molecular Cell, July 2007, Elsevier

    Professor Noel F. Lowndes

  38. Transcriptional Response of Candida parapsilosis following Exposure to Farnesol

    Article • Antimicrobial Agents and Chemotherapy, April 2007, ASM Journals

    Professor Noel F. Lowndes

  39. An early experimental study indicating anomalous subdiffusive behavior in live cells

    Article • Experimental and Molecular Pathology, April 2007, Elsevier

    Professor Noel F. Lowndes, PRESERVE FROM BEING FORGOTTEN: Professor Zeno Földes-Papp [Biochemist, Gerontologist (Biochemiker, Geriater)]: Laying the Foundation of Single-Molecule Biophysics & Biochemistry Based On the Stochastic Nature of Diffusion: The Individual Molecule, from the Mathematical Core to the Physical Theory. -- I hope that my humble scientific work will be well received by the communities of single-molecule imaging and spectroscopy and by all users of these technologies as well as biotechnologies in the various and different disciplines:, Professor Alan G. Ryder

  40. Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain

    Article • Yeast, January 2007, Wiley

    Professor Noel F. Lowndes

  41. Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation

    Article • FEMS Yeast Research, August 2006, Oxford University Press (OUP)

    Professor Noel F. Lowndes

  42. Chromatin modulation and the DNA damage response

    Article • Experimental Cell Research, August 2006, Elsevier

    Professor Noel F. Lowndes

  43. DNA repair: From molecular mechanism to human disease

    Article • DNA Repair, August 2006, Elsevier

    Professor Noel F. Lowndes

  44. Genetic dissection of vertebrate 53BP1: A major role in non-homologous end joining of DNA double strand breaks

    Article • DNA Repair, June 2006, Elsevier

    Professor Noel F. Lowndes

  45. Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation

    Article • DNA Repair, June 2006, Elsevier

    Professor Noel F. Lowndes

  46. Multiple Approaches to Study S. cerevisiae Rad9, a Prototypical Checkpoint Protein

    Article • January 2006, Elsevier

    Professor Noel F. Lowndes

  47. DNA Repair: The Importance of Phosphorylating Histone H2AX

    Article • Current Biology, February 2005, Elsevier

    Professor Noel F. Lowndes

  48. The switch from survival responses to apoptosis after chromosomal breaks

    Article • DNA Repair, August 2004, Elsevier

    Professor Noel F. Lowndes

  49. Remodelling the Rad9 Checkpoint Complex: Preparing Rad53 for Action

    Article • Cell Cycle, February 2004, Taylor & Francis

    Professor Noel F. Lowndes

  50. The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function

    Article • EMBO Reports, September 2003, EMBO

    Professor Noel F. Lowndes

  51. The MRN complex: coordinating and mediating the response to broken chromosomes

    Article • EMBO Reports, September 2003, EMBO

    Professor Noel F. Lowndes

  52. Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage

    Article • EMBO Reports, June 2003, EMBO

    Professor Noel F. Lowndes

  53. Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint

    Article • Molecular and Cellular Biology, November 2001, ASM Journals

    Professor Noel F. Lowndes

  54. Transducing the DNA damage signal in yeast

    Article • Biochemical Society Transactions, October 2001, Portland Press Ltd.

    Professor Noel F. Lowndes

  55. Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex

    Article • Nature Cell Biology, August 2001, Springer Science + Business Media

    Professor Noel F. Lowndes

  56. Budding Yeast Rad9 Is an ATP-Dependent Rad53 Activating Machine

    Article • Molecular Cell, July 2001, Elsevier

    Professor Noel F. Lowndes

  57. RAD9, RAD24, RAD16 and RAD26 are required for the inducible nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers from the transcribed and non-transcribed regions of the Saccharomyces cerevisiae MFA2 gene

    Article • Mutation Research/DNA Repair, April 2001, Elsevier

    Professor Noel F. Lowndes

  58. A role for Saccharomyces cerevisiae histone H2A in DNA repair

    Article • Nature, December 2000, Springer Science + Business Media

    Professor Noel F. Lowndes

  59. DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae

    Article • FEBS Letters, November 2000, Wiley

    Professor Noel F. Lowndes

  60. The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non‐homologous end joining

    Article • FEBS Letters, February 2000, Wiley

    Professor Noel F. Lowndes

  61. Sensing and responding to DNA damage

    Article • Current Opinion in Genetics & Development, February 2000, Elsevier

    Professor Noel F. Lowndes

  62. A novel Rad24 checkpoint protein complex closely related to replication factor C

    Article • Current Biology, February 2000, Elsevier

    Professor Noel F. Lowndes

  63. A novel Rad24 checkpoint protein complex closely related to replication factor C

    Article • Current Biology, January 2000, Elsevier

    Professor Noel F. Lowndes

  64. DNA damage-dependent checkpoints in yeasts and human cells

    Article • European Journal of Cancer, September 1999, Elsevier

    Professor Noel F. Lowndes

  65. The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9–Rad9 interaction after DNA damage

    Article • Current Biology, May 1999, Elsevier

    Professor Noel F. Lowndes

  66. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage

    Article • The EMBO Journal, October 1998, Wiley

    Professor Noel F. Lowndes

  67. Human and mouse homologs of Schizosaccharomyces pombe rad1+ and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis

    Article • Genes & Development, August 1998, Cold Spring Harbor Laboratory Press

    Professor Noel F. Lowndes

  68. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation

    Article • The EMBO Journal, May 1998, Wiley

    Professor Noel F. Lowndes

  69. DNA synthesis control in yeast: An evolutionarily conserved mechanism for regulating DNA synthesis genes?

    Article • BioEssays, December 1992, Wiley

    Professor Noel F. Lowndes

  70. SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast

    Article • Nature, June 1992, Springer Science + Business Media

    Professor Noel F. Lowndes

  71. Parallel pathways of cell cycle-regulated gene expression

    Article • Trends in Genetics, March 1992, Elsevier

    Professor Noel F. Lowndes

  72. Cell cycle control of DNA synthesis in budding yeast

    Article • Nucleic Acids Research, January 1992, Oxford University Press (OUP)

    Professor Noel F. Lowndes

  73. Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdclO+

    Article • Nature, January 1992, Springer Science + Business Media

    Professor Noel F. Lowndes

  74. Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated trans factor

    Article • Nature, March 1991, Springer Science + Business Media

    Professor Noel F. Lowndes

  75. The yeast DNA ligase gene C DC9 is controlled by six orientation specific upstream activating sequences that respond to cellular proliferation but which alone cannot mediate cell cycle regulation

    Article • Nucleic Acids Research, January 1991, Oxford University Press (OUP)

    Professor Noel F. Lowndes

  76. A Cell-cycle-regulated trans-Factor, DSC1, Controls Expression of DNA Synthesis Genes in Yeast

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 1991, Cold Spring Harbor Laboratory Press

    Professor Noel F. Lowndes

  77. An Investigation into 53BP1 Complex Formation

    Article • Springer Science + Business Media

    Professor Noel F. Lowndes

  78. Purification and Analysis of Checkpoint Protein Complexes From <I>Saccharomyces cerevisiae</I>

    Article • Springer Science + Business Media

    Professor Noel F. Lowndes

  79. Abstract

    Article • eLife

    Professor Noel F. Lowndes