All Stories

  1. The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity

    Article • PLoS Biology, September 2022, PLOS

    Professor Gideon J Davies

  2. Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi

    Article • Acta Crystallographica Section D Structural Biology, October 2020, International Union of Crystallography

    Professor Gideon J Davies

  3. A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis

    Article • Acta Crystallographica Section D Structural Biology, May 2020, International Union of Crystallography

    Professor Gideon J Davies

  4. Structural studies of a surface-entropy reduction mutant of O-GlcNAcase

    Article • Acta Crystallographica Section D Structural Biology, January 2019, International Union of Crystallography

    Professor Gideon J Davies

  5. Structure and function of a glycoside hydrolase family 8 endoxylanase fromTeredinibacter turnerae

    Article • Acta Crystallographica Section D Structural Biology, October 2018, International Union of Crystallography

    Professor Gideon J Davies

  6. Structural and Biochemical Insights into the Function and Evolution of Sulfoquinovosidases

    Article • ACS Central Science, September 2018, American Chemical Society (ACS)

    Professor Gideon J Davies

  7. Structural studies of the unusual metal-ion site of the GH124 endoglucanase from Ruminiclostridium thermocellum

    Article • Acta Crystallographica Section F Structural Biology Communications, August 2018, International Union of Crystallography

    Professor Gideon J Davies

  8. Structure of the GH9 glucosidase/glucosaminidase fromVibrio cholerae

    Article • Acta Crystallographica Section F Structural Biology Communications, August 2018, International Union of Crystallography

    Professor Gideon J Davies

  9. Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25 Å resolution

    Article • Acta Crystallographica Section F Structural Biology Communications, July 2018, International Union of Crystallography

    Professor Gideon J Davies

  10. Exploration of Strategies for Mechanism-Based Inhibitor Design for Family GH99 endo -α-1,2-Mannanases

    Article • Chemistry - A European Journal, April 2018, Wiley

    Professor Gideon J Davies

  11. Structural insight into industrially relevant glucoamylases: flexible positions of starch-binding domains

    Article • Acta Crystallographica Section D Structural Biology, April 2018, International Union of Crystallography

    Professor Gideon J Davies

  12. Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif

    Article • Acta Crystallographica Section D Structural Biology, April 2018, International Union of Crystallography

    Professor Gideon J Davies

  13. QM/MM Studies into the H2O2-Dependent Activity of Lytic Polysaccharide Monooxygenases: Evidence for the Formation of a Caged Hydroxyl Radical Intermediate

    Article • ACS Catalysis, January 2018, American Chemical Society (ACS)

    Professor Gideon J Davies

  14. A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

    Article • Journal of the American Chemical Society, September 2017, American Chemical Society (ACS)

    Professor Gideon J Davies

  15. Conformational Analysis of the Mannosidase Inhibitor Kifunensine: A Quantum Mechanical and Structural Approach

    Article • ChemBioChem, June 2017, Wiley

    Professor Gideon J Davies

  16. Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors

    Article • Journal of the American Chemical Society, May 2017, American Chemical Society (ACS)

    Professor Gideon J Davies

  17. Structural and functional insight into human O-GlcNAcase

    Article • Nature Methods, March 2017, Nature

    Professor Gideon J Davies

  18. An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-α-mannanase inhibitor

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Professor Gideon J Davies

  19. Increase of enzyme activity through specific covalent modification with fragments

    Article • Chemical Science, January 2017, Royal Society of Chemistry

    Professor Gideon J Davies

  20. A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism

    Article • ACS Central Science, December 2016, American Chemical Society (ACS)

    Professor Gideon J Davies

  21. Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2)

    Article • ACS Chemical Biology, July 2016, American Chemical Society (ACS)

    Professor Gideon J Davies, Professor James R Ketudat Cairns

  22. Structural dissection of a complexBacteroides ovatusgene locus conferring xyloglucan metabolism in the human gut

    Article • Open Biology, July 2016, Royal Society Publishing

    Professor Gideon J Davies

  23. Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

    Article • ACS Central Science, May 2016, American Chemical Society (ACS)

    Professor Gideon J Davies

  24. On the catalytic mechanisms of lytic polysaccharide monooxygenases

    Article • Current Opinion in Chemical Biology, April 2016, Elsevier

    Professor Gideon J Davies

  25. Functional and structural characterization of a potent GH 74 endo ‐xyloglucanase from the soil saprophyte Cellvibrio japonicus unravels the first step of xyloglucan degradation

    Article • FEBS Journal, March 2016, Wiley

    Professor Gideon J Davies

  26. YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids

    Article • Nature Methods, February 2016, Nature

    Professor Gideon J Davies

  27. The Contribution of Non-catalytic Carbohydrate Binding Modules to the Activity of Lytic Polysaccharide Monooxygenases

    Article • Journal of Biological Chemistry, January 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  28. Activity, stability and 3-D structure of the Cu(ii) form of a chitin-active lytic polysaccharide monooxygenase from Bacillus amyloliquefaciens

    Article • Dalton Transactions, January 2016, Royal Society of Chemistry

    Professor Gideon J Davies

  29. Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase

    Article • Chemical Science, January 2016, Royal Society of Chemistry

    Professor Gideon J Davies

  30. Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation

    Article • Chemical Communications, January 2016, Royal Society of Chemistry

    Professor Gideon J Davies

  31. Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family

    Article • Nature Communications, December 2015, Nature

    Professor Gideon J Davies

  32. Structural and Functional Characterization of a Novel Family GH115 4-O-Methyl-α-Glucuronidase with Specificity for Decorated Arabinogalactans

    Article • Journal of Molecular Biology, December 2015, Elsevier

    Professor Gideon J Davies, Professor Lubbert Dijkhuizen

  33. Lytic Polysaccharide Monooxygenases in Biomass Conversion

    Article • Trends in Biotechnology, December 2015, Elsevier

    Professor Gideon J Davies

  34. Structural characterization of human heparanase reveals insights into substrate recognition

    Article • Nature Structural & Molecular Biology, November 2015, Nature

    Professor Gideon J Davies

  35. A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors

    Article • Angewandte Chemie International Edition, November 2015, Wiley

    Professor Gideon J Davies

  36. Privateer: software for the conformational validation of carbohydrate structures

    Article • Nature Structural & Molecular Biology, November 2015, Nature

    Professor Gideon J Davies

  37. The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan

    Article • Journal of Biological Chemistry, August 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  38. Carbohydrate anomalies in the PDB

    Article • Nature Methods, April 2015, Nature

    Professor Gideon J Davies

  39. Three-dimensional structure of a variant `Termamyl-like'Geobacillus stearothermophilusα-amylase at 1.9 Å resolution

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2015, International Union of Crystallography

    Professor Gideon J Davies

  40. Discovery of Selective Small‐Molecule Activators of a Bacterial Glycoside Hydrolase

    Article • Angewandte Chemie International Edition, October 2014, Wiley

    Professor Gideon J Davies

  41. Dissecting conformational contributions to glycosidase catalysis and inhibition

    Article • Current Opinion in Structural Biology, October 2014, Elsevier

    Professor Gideon J Davies

  42. A complex gene locus enables xyloglucan utilization in the model saprophyte Cellvibrio japonicus

    Article • Molecular Microbiology, September 2014, Wiley

    Professor Gideon J Davies

  43. Spectroscopic and computational insight into the activation of O 2 by the mononuclear Cu center in polysaccharide monooxygenases

    Article • Proceedings of the National Academy of Sciences, June 2014, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  44. A human gut symbiont degrades complex plant carbohydrates.

    Article • Nature, January 2014, Springer Science + Business Media

    Professor Gideon J Davies, Dr Lauren S McKee

  45. Discovery and characterization of a new family of lytic polysaccharide monooxygenases

    Article • Nature Chemical Biology, December 2013, Springer Science + Business Media

    Professor Gideon J Davies

  46. Combined Inhibitor Free‐Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate

    Article • Angewandte Chemie International Edition, December 2013, Wiley

    Professor Gideon J Davies

  47. Three dimensional structure of a bacterial α-l-fucosidase with a 5-membered iminocyclitol inhibitor

    Article • Bioorganic & Medicinal Chemistry, August 2013, Elsevier

    Professor Gideon J Davies

  48. α-L-Fucosidase Inhibition by Pyrrolidine-Ferrocene Hybrids: Rationalization of Ligand-Binding Properties by Structural Studies

    Article • Chemistry - A European Journal, June 2013, Wiley

    Professor Gideon J Davies

  49. The Copper Active Site of CBM33 Polysaccharide Oxygenases

    Article • Journal of the American Chemical Society, April 2013, American Chemical Society (ACS)

    Professor Gideon J Davies

  50. How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity

    Article • Proceedings of the National Academy of Sciences, December 2012, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  51. Recent structural and mechanistic insights into post-translational enzymatic glycosylation

    Article • Current Opinion in Chemical Biology, December 2012, Elsevier

    Professor Gideon J Davies

  52. Structural Enzymology of Cellvibrio japonicus Agd31B Protein Reveals  -Transglucosylase Activity in Glycoside Hydrolase Family 31

    Article • Journal of Biological Chemistry, November 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  53. Glycobiology: The case of the missing base

    Article • Nature Methods, October 2012, Nature

    Professor Gideon J Davies

  54. The Reaction Coordinate of a Bacterial GH47 α-Mannosidase: A Combined Quantum Mechanical and Structural Approach

    Article • Angewandte Chemie International Edition, September 2012, Wiley

    Professor Gideon J Davies

  55. Structure of the catalytic core module of theChaetomium thermophilumfamily GH6 cellobiohydrolase Cel6A

    Article • Acta Crystallographica Section D Biological Crystallography, July 2012, International Union of Crystallography

    Professor Gideon J Davies

  56. Fleetamine (3-O-α-d-glucopyranosyl-swainsonine): the synthesis of a hypothetical inhibitor of endo-α-mannosidase

    Article • Tetrahedron Asymmetry, July 2012, Elsevier

    Professor Gideon J Davies

  57. Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR  -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF  -O-LINKED  -N-ACETYLGLUCOSAMINIDASE

    Article • Journal of Biological Chemistry, June 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  58. Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates

    Article • Nature Chemistry, May 2012, Nature

    Professor Gideon J Davies

  59. Conformational Analyses of the Reaction Coordinate of Glycosidases

    Article • Accounts of Chemical Research, February 2012, American Chemical Society (ACS)

    Professor Gideon J Davies

  60. Three-dimensional structure of a thermophilic family GH11 xylanase fromThermobifida fusca

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, January 2012, International Union of Crystallography

    Professor Gideon J Davies

  61. Genome analyses highlight the different biological roles of cellulases

    Article • Nature Reviews Microbiology, January 2012, Nature

    Professor Gideon J Davies

  62. Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

    Article • Proceedings of the National Academy of Sciences, January 2012, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  63. The Crystallization and Structural Analysis of Cellulases (and Other Glycoside Hydrolases)

    Article • January 2012, Elsevier

    Professor Gideon J Davies

  64. Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components

    Article • Proceedings of the National Academy of Sciences, August 2011, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  65. Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase

    Article • Nature Methods, August 2011, Nature

    Professor Gideon J Davies

  66. Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44

    Article • Journal of Biological Chemistry, July 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  67. Building Custom Polysaccharides in Vitro with an Efficient, Broad-Specificity Xyloglucan Glycosynthase and a Fucosyltransferase

    Article • Journal of the American Chemical Society, July 2011, American Chemical Society (ACS)

    Professor Gideon J Davies

  68. Structural and enzymatic characterization of a glycoside hydrolase family 31 α-xylosidase from Cellvibrio japonicus involved in xyloglucan saccharification

    Article • Biochemical Journal, June 2011, Portland Press Ltd.

    Professor Gideon J Davies

  69. Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  70. The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease

    Article • Biochemical Society Transactions, October 2010, Portland Press Ltd.

    Professor Gideon J Davies

  71. Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

    Article • Chemistry & Biology, September 2010, Elsevier

    Professor Gideon J Davies

  72. The structure of a family GH25 lysozyme fromAspergillus fumigatus

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, August 2010, International Union of Crystallography

    Professor Gideon J Davies

  73. Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses

    Article • Amino Acids, August 2010, Springer Science + Business Media

    Professor Gideon J Davies

  74. Structural and Thermodynamic Analyses of α-L-Fucosidase Inhibitors

    Article • ChemBioChem, July 2010, Wiley

    Professor Gideon J Davies

  75. Signature Active Site Architectures Illuminate the Molecular Basis for Ligand Specificity in Family 35 Carbohydrate Binding Module,

    Article • Biochemistry, July 2010, American Chemical Society (ACS)

    Professor Gideon J Davies

  76. Circular Permutation Provides an Evolutionary Link between Two Families of Calcium-dependent Carbohydrate Binding Modules

    Article • Journal of Biological Chemistry, July 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies, Didier Nurizzo

  77. Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines

    Article • Angewandte Chemie International Edition, March 2010, Wiley

    Professor Gideon J Davies

  78. Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase

    Article • Journal of the American Chemical Society, February 2010, American Chemical Society (ACS)

    Professor Gideon J Davies

  79. Analysis of the Reaction Coordinate of α- l -Fucosidases: A Combined Structural and Quantum Mechanical Approach

    Article • Journal of the American Chemical Society, February 2010, American Chemical Society (ACS)

    Professor Gideon J Davies

  80. Structural analyses of enzymes involved in the O-GlcNAc modification

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, February 2010, Elsevier

    Professor Gideon J Davies

  81. Mechanistic Insight into Enzymatic Glycosyl Transfer with Retention of Configuration through Analysis of Glycomimetic Inhibitors

    Article • Angewandte Chemie International Edition, January 2010, Wiley

    Professor Gideon J Davies

  82. Casuarine-6-O-α-d-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

    Article • Chemical Communications, January 2010, Royal Society of Chemistry

    Laura Cipolla, Professor Gideon J Davies

  83. Glycosidase inhibition: assessing mimicry of the transition state

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Professor Gideon J Davies

  84. Mechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiont

    Article • December 2009, Nature

    Professor Gideon J Davies

  85. The crystal structure of a family GH25 lysozyme from Bacillus anthracis implies a neighboring-group catalytic mechanism with retention of anomeric configuration

    Article • Carbohydrate Research, September 2009, Elsevier

    Professor Gideon J Davies

  86. Structure of a pullulanase fromBacillus acidopullulyticus

    Article • Proteins Structure Function and Bioinformatics, August 2009, Wiley

    Professor Gideon J Davies

  87. Understanding How Diverse β-Mannanases Recognize Heterogeneous Substrates

    Article • Biochemistry, July 2009, American Chemical Society (ACS)

    Professor Gideon J Davies

  88. Functional Characterization of Xyloglucan Glycosynthases from GH7, GH12, and GH16 Scaffolds

    Article • Biomacromolecules, July 2009, American Chemical Society (ACS)

    Professor Gideon J Davies

  89. The X-ray Crystal Structure of an Arthrobacter protophormiae Endo-β-N-Acetylglucosaminidase Reveals a (β/α)8 Catalytic Domain, Two Ancillary Domains and Active Site Residues Key for Transglycosylation Activity

    Article • Journal of Molecular Biology, May 2009, Elsevier

    Professor Gideon J Davies

  90. Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion

    Article • Journal of the American Chemical Society, April 2009, American Chemical Society (ACS)

    Professor Gideon J Davies

  91. Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

    Article • Protein Science, April 2009, Wiley

    Professor Gideon J Davies

  92. Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function

    Article • Proceedings of the National Academy of Sciences, March 2009, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  93. Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase

    Article • Carbohydrate Research, March 2009, Elsevier

    Professor Gideon J Davies

  94. Total Syntheses of Casuarine and Its 6-O-α-Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families

    Article • Chemistry - A European Journal, February 2009, Wiley

    Professor Gideon J Davies

  95. Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Professor Gideon J Davies

  96. Structure of the Michaelis complex of β-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Professor Gideon J Davies

  97. The Chitopentaose Complex of a Mutant Hen Egg-White Lysozyme Displays No Distortion of the –1 Sugar Away from a 4 C 1 Chair Conformation

    Article • Australian Journal of Chemistry, January 2009, CSIRO Publishing

    Professor Gideon J Davies

  98. Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues

    Article • ChemBioChem, November 2008, Wiley

    Professor Gideon J Davies

  99. Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

    Article • Journal of Biological Chemistry, October 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  100. Chemistry's prodigal child: enzyme mechanism

    Article • Current Opinion in Chemical Biology, October 2008, Elsevier

    Professor James Henderson Naismith, Professor Gideon J Davies

  101. Mechanistic insights into glycosidase chemistry

    Article • Current Opinion in Chemical Biology, October 2008, Elsevier

    Professor Gideon J Davies

  102. Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut Flora

    Article • Chemistry & Biology, October 2008, Elsevier

    Professor Gideon J Davies

  103. The Cellvibrio japonicus Mannanase CjMan26C Displays a Unique exo-Mode of Action That Is Conferred by Subtle Changes to the Distal Region of the Active Site

    Article • Journal of Biological Chemistry, September 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  104. Crystal structure of a family GT4 glycosyltransferase from Bacillus anthracis ORF BA1558

    Article • Proteins Structure Function and Bioinformatics, August 2008, Wiley

    Professor Gideon J Davies

  105. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

    Article • Nature Methods, June 2008, Nature

    Professor Gideon J Davies

  106. Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation

    Article • Nature Structural & Molecular Biology, June 2008, Nature

    Professor Gideon J Davies

  107. Glycosyltransferases: Structures, Functions, and Mechanisms

    Article • Annual Review of Biochemistry, June 2008, Annual Reviews

    Professor Gideon J Davies

  108. The Clostridium cellulolyticum Dockerin Displays a Dual Binding Mode for Its Cohesin Partner

    Article • Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies, Henri Fierobe

  109. Structural and biochemical evidence for a boat-like transition state in β-mannosidases

    Article • Nature Methods, April 2008, Nature

    Professor Gideon J Davies

  110. Probing the β-1,3:1,4 glucanase, CtLic26A, with a thio-oligosaccharide and enzyme variants

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Gideon J Davies

  111. Characterization and engineering of the bifunctional N - and O -glucosyltransferase involved in xenobiotic metabolism in plants

    Article • Proceedings of the National Academy of Sciences, December 2007, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  112. Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors

    Article • Angewandte Chemie International Edition, May 2007, Wiley

    Professor Gideon J Davies, Dr Jose Luis Chiara

  113. A Glycosynthase Catalyst for the Synthesis of Flavonoid Glycosides

    Article • Angewandte Chemie International Edition, May 2007, Wiley

    Professor Gideon J Davies

  114. The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

    Article • Proceedings of the National Academy of Sciences, March 2007, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  115. Characterization and Three-dimensional Structures of Two Distinct Bacterial Xyloglucanases from Families GH5 and GH12

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  116. Evidence for a dual binding mode of dockerin modules to cohesins

    Article • Proceedings of the National Academy of Sciences, February 2007, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  117. Mannose Foraging by Bacteroides thetaiotaomicron: STRUCTURE AND SPECIFICITY OF THE beta-MANNOSIDASE, BtMan2A

    Article • Journal of Biological Chemistry, February 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  118. Glycosidase Inhibition:  An Assessment of the Binding of 18 Putative Transition-State Mimics

    Article • Journal of the American Chemical Society, February 2007, American Chemical Society (ACS)

    Professor Gideon J Davies

  119. A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Professor Gideon J Davies

  120. Structural basis for cyclophellitol inhibition of a β-glucosidase

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Professor Gideon J Davies

  121. D-Glucosylated Derivatives of Isofagomine and Noeuromycin and Their Potential as Inhibitors of β-Glycoside Hydrolases

    Article • Australian Journal of Chemistry, January 2007, CSIRO Publishing

    Professor Gideon J Davies

  122. Analysis of PUGNAc and NAG-thiazoline as Transition State Analogues for Human O -GlcNAcase:  Mechanistic and Structural Insights into Inhibitor Selectivity and Transition State Poise

    Article • Journal of the American Chemical Society, January 2007, American Chemical Society (ACS)

    Professor Gideon J Davies

  123. Insights into the Synthesis of Lipopolysaccharide and Antibiotics through the Structures of Two Retaining Glycosyltransferases from Family GT4

    Article • Chemistry & Biology, November 2006, Elsevier

    Professor Gideon J Davies

  124. Structure of a carbohydrate esterase from Bacillus anthracis

    Article • Proteins Structure Function and Bioinformatics, October 2006, Wiley

    Professor Gideon J Davies

  125. Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a β- N -acetylglucosaminidase and not a hyaluronidase

    Article • Biochemical Journal, October 2006, Portland Press Ltd.

    Professor Gideon J Davies

  126. Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors†,‡

    Article • Biochemistry, October 2006, American Chemical Society (ACS)

    Professor Gideon J Davies

  127. Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases

    Article • Angewandte Chemie International Edition, August 2006, Wiley

    Professor Gideon J Davies

  128. Crystal Structures of Clostridium thermocellum Xyloglucanase, XGH74A, Reveal the Structural Basis for Xyloglucan Recognition and Degradation

    Article • Journal of Biological Chemistry, June 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  129. Dissection of Conformationally Restricted Inhibitors Binding to a β-Glucosidase

    Article • ChemBioChem, April 2006, Wiley

    Professor Gideon J Davies

  130. Family 6 Carbohydrate Binding Modules in beta-Agarases Display Exquisite Selectivity for the Non-reducing Termini of Agarose Chains

    Article • Journal of Biological Chemistry, April 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  131. Structural insight into the ligand specificity of a thermostable family 51 arabinofuranosidase, Ara f 51, from Clostridium thermocellum

    Article • Biochemical Journal, April 2006, Portland Press Ltd.

    Professor Gideon J Davies

  132. Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity

    Article • Nature Structural & Molecular Biology, March 2006, Nature

    Professor Gideon J Davies

  133. Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

    Article • The EMBO Journal, February 2006, Wiley

    Professor Gideon J Davies

  134. Structure and Activity of Two Metal Ion-dependent Acetylxylan Esterases Involved in Plant Cell Wall Degradation Reveals a Close Similarity to Peptidoglycan Deacetylases

    Article • Journal of Biological Chemistry, January 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  135. Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor

    Article • Chemical Communications, January 2006, Royal Society of Chemistry

    Professor Gideon J Davies

  136. Recent structural insights into the expanding world of carbohydrate-active enzymes

    Article • Current Opinion in Structural Biology, December 2005, Elsevier

    Professor Gideon J Davies

  137. Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded β-helix

    Article • Proceedings of the National Academy of Sciences, November 2005, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  138. Crystal structure of levansucrase from the Gram-negative bacterium Gluconacetobacter diazotrophicus

    Article • Biochemical Journal, August 2005, Portland Press Ltd.

    Professor Gideon J Davies

  139. Structural dissection and high-throughput screening of mannosylglycerate synthase

    Article • Nature Structural & Molecular Biology, June 2005, Nature

    Professor Gideon J Davies

  140. Insights into the Structural Determinants of Cohesin—Dockerin Specificity Revealed by the Crystal Structure of the Type II Cohesin from Clostridium thermocellum SdbA

    Article • Journal of Molecular Biology, June 2005, Elsevier

    Professor Gideon J Davies

  141. Probing the Mechanism of Ligand Recognition in Family 29 Carbohydrate-binding Modules

    Article • Journal of Biological Chemistry, March 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies, Didier Nurizzo

  142. Structure and Kinetics of a Monomeric Glucosamine 6-Phosphate Deaminase: MISSING LINK OF THE NagB SUPERFAMILY?

    Article • Journal of Biological Chemistry, March 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  143. Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A

    Article • Proceedings of the National Academy of Sciences, February 2005, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  144. NAD+ and Metal-ion Dependent Hydrolysis by Family 4 Glycosidases: Structural Insight into Specificity for Phospho-β-d-glucosides

    Article • Journal of Molecular Biology, February 2005, Elsevier

    Professor Gideon J Davies

  145. Structure of aBacillus halmapalusfamily 13 α-amylase, BHA, in complex with an acarbose-derived nonasaccharide at 2.1 Å resolution

    Article • Acta Crystallographica Section D Biological Crystallography, January 2005, International Union of Crystallography

    Professor Gideon J Davies

  146. Molecular determinants of substrate specificity in the feruloyl esterase module of xylanase 10B fromClostridium thermocellum

    Article • Acta Crystallographica Section D Biological Crystallography, January 2005, International Union of Crystallography

    Professor Gideon J Davies

  147. Common Inhibition of Both β-Glucosidases and β-Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis

    Article • ChemBioChem, October 2004, Wiley

    Professor Gideon J Davies

  148. The Use of Forced Protein Evolution to Investigate and Improve Stability of Family 10 Xylanases: THE PRODUCTION OF Ca2+-INDEPENDENT STABLE XYLANASES

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  149. Structural, Thermodynamic, and Kinetic Analyses of Tetrahydrooxazine-derived Inhibitors Bound to  -Glucosidases

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  150. Novel Catalytic Mechanism of Glycoside Hydrolysis Based on the Structure of an NAD+/Mn2+-Dependent Phospho-α-Glucosidase from Bacillus subtilis

    Article • Structure, September 2004, Elsevier

    Professor Gideon J Davies

  151. A master of its sulfate

    Article • Nature Structural & Molecular Biology, August 2004, Nature

    Professor Gideon J Davies

  152. X-ray Crystal Structure of a Non-crystalline Cellulose-specific Carbohydrate-binding Module: CBM28

    Article • Journal of Molecular Biology, May 2004, Elsevier

    Professor Gideon J Davies, Didier Nurizzo

  153. Structural Studies of the β-Glycosidase from Sulfolobus solfataricus in Complex with Covalently and Noncovalently Bound Inhibitors †

    Article • Biochemistry, May 2004, American Chemical Society (ACS)

    Professor Gideon J Davies

  154. Insights into the Molecular Determinants of Substrate Specificity in Glycoside Hydrolase Family 5 Revealed by the Crystal Structure and Kinetics of Cellvibrio mixtus Mannosidase 5A

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  155. Ligand-mediated Dimerization of a Carbohydrate-binding Module Reveals a Novel Mechanism for Protein–Carbohydrate Recognition

    Article • Journal of Molecular Biology, March 2004, Elsevier

    Professor Gideon J Davies, Didier Nurizzo

  156. Structural and Biochemical Analysis of Cellvibrio japonicus Xylanase 10C: HOW VARIATION IN SUBSTRATE-BINDING CLEFT INFLUENCES THE CATALYTIC PROFILE OF FAMILY GH-10 XYLANASES

    Article • Journal of Biological Chemistry, January 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  157. Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10AElectronic supplementary information (ESI) available: kinetics and structural methods. See http://www.rsc.org/suppdata/cc/b4/b405152a/

    Article • Chemical Communications, January 2004, Royal Society of Chemistry

    Professor Gideon J Davies

  158. Crystallization and preliminary X-ray diffraction analysis of levansucrase (LsdA) fromGluconacetobacter diazotrophicusSRT4

    Article • Acta Crystallographica Section D Biological Crystallography, December 2003, International Union of Crystallography

    Professor Gideon J Davies

  159. The Mechanisms by Which Family 10 Glycoside Hydrolases Bind Decorated Substrates

    Article • Journal of Biological Chemistry, December 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  160. Cellulosome assembly revealed by the crystal structure of the cohesin–dockerin complex

    Article • Proceedings of the National Academy of Sciences, November 2003, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  161. Iminosugar Glycosidase Inhibitors:  Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to β-Glucosidases

    Article • Journal of the American Chemical Society, November 2003, American Chemical Society (ACS)

    Professor Gideon J Davies

  162. The Donor Subsite of Trehalose-6-phosphate Synthase: BINARY COMPLEXES WITH UDP-GLUCOSE AND UDP-2-DEOXY-2-FLUORO-GLUCOSE AT 2 A RESOLUTION

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  163. The Three-dimensional Structure of the N -Acetylglucosamine-6-phosphate Deacetylase, NagA, from Bacillus subtilis

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  164. Multifunctional Xylooligosaccharide/Cephalosporin C Deacetylase Revealed by the Hexameric Structure of the Bacillus subtilis Enzyme at 1.9Å Resolution

    Article • Journal of Molecular Biology, July 2003, Elsevier

    Professor Gideon J Davies

  165. Structural Basis for Ligand Binding and Processivity in Cellobiohydrolase Cel6A from Humicola insolens

    Article • Structure, July 2003, Elsevier

    Professor Gideon J Davies

  166. Structural and Thermodynamic Dissection of Specific Mannan Recognition by a Carbohydrate Binding Module, TmCBM27

    Article • Structure, June 2003, Elsevier

    Professor Gideon J Davies, Didier Nurizzo

  167. Direct Observation of the Protonation State of an Imino Sugar Glycosidase Inhibitor upon Binding

    Article • Journal of the American Chemical Society, June 2003, American Chemical Society (ACS)

    Professor Gideon J Davies

  168. The α-Glucuronidase, GlcA67A, ofCellvibrio japonicusUtilizes the Carboxylate and Methyl Groups of Aldobiouronic Acid as Important Substrate Recognition Determinants

    Article • Journal of Biological Chemistry, March 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies, Didier Nurizzo

  169. Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidasesElectronic supplementary information (ESI) available: details of data and structure quality for complex of cel6A with 1. See http:...

    Article • Chemical Communications, March 2003, Royal Society of Chemistry

    Professor Gideon J Davies

  170. A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomerElectronic supplementary information (ESI) available: details of data and structure quality for complex of 1 with Xyn10A. See http://www.rsc.org/suppdata/cc/b3/b301...

    Article • Chemical Communications, March 2003, Royal Society of Chemistry

    Professor Gideon J Davies

  171. Structure and Ligand Binding of Carbohydrate-binding Module CsCBM6-3 Reveals Similarities with Fucose-specific Lectins and “Galactose-binding” Domains

    Article • Journal of Molecular Biology, March 2003, Elsevier

    Professor Gideon J Davies

  172. Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides

    Article • Chemical Communications, January 2003, Royal Society of Chemistry

    Professor Gideon J Davies

  173. Structure of theHumicola insolenscellobiohydrolase Cel6A D416A mutant in complex with a non-hydrolysable substrate analogue, methyl cellobiosyl-4-thio-β-cellobioside, at 1.9 Å

    Article • Acta Crystallographica Section D Biological Crystallography, November 2002, International Union of Crystallography

    Professor Gideon J Davies

  174. Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose

    Article • Proceedings of the National Academy of Sciences, October 2002, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  175. Convergent evolution sheds light on the anti-β-elimination mechanism common to family 1 and 10 polysaccharide lyases

    Article • Proceedings of the National Academy of Sciences, September 2002, Proceedings of the National Academy of Sciences

    Professor Gideon J Davies

  176. Cellvibrio japonicus α-L-arabinanase 43A has a novel five-blade β-propeller fold

    Article • Nature Structural Biology, August 2002, Springer Science + Business Media

    Professor Gideon J Davies, Didier Nurizzo

  177. Differential Oligosaccharide Recognition by Evolutionarily-related β-1,4 and β-1,3 Glucan-binding Modules

    Article • Journal of Molecular Biology, June 2002, Elsevier

    Professor Gideon J Davies, Didier Nurizzo

  178. Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases 1 1Edited by R. Huber

    Article • Journal of Molecular Biology, December 2001, Elsevier

    Professor Gideon J Davies

  179. Structure of a Family 15 Carbohydrate-binding Module in Complex with Xylopentaose: EVIDENCE THAT XYLAN BINDS IN AN APPROXIMATE 3-FOLD HELICAL CONFORMATION

    Article • Journal of Biological Chemistry, October 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Gideon J Davies

  180. Clostridium thermocellum Xyn10B Carbohydrate-Binding Module 22-2:  The Role of Conserved Amino Acids in Ligand Binding † , ‡

    Article • Biochemistry, August 2001, American Chemical Society (ACS)

    Professor Gideon J Davies

  181. Structural Analysis of a Chimeric Bacterial α-Amylase. High-Resolution Analysis of Native and Ligand Complexes † , ‡

    Article • Biochemistry, August 2000, American Chemical Society (ACS)

    Professor Gideon J Davies

  182. Highly Efficient Synthesis of β(1 → 4)-Oligo- and -Polysaccharides Using a Mutant Cellulase

    Article • Journal of the American Chemical Society, June 2000, American Chemical Society (ACS)

    Professor Gideon J Davies