All Stories

  1. Computer-aided Design of Coumarins for Neurodegenerative Diseases: Trends of the Last Decade

    Article • Current Topics in Medicinal Chemistry, October 2021, Bentham Science Publishers

    Professor Fernanda Borges, Dr Maria João Matos, Eugenio Uriarte

  2. Structure-Based Optimization of Coumarin hA3 Adenosine Receptor Antagonists

    Article • Journal of Medicinal Chemistry, December 2019, American Chemical Society (ACS)

    Dr Maria João Matos, Professor Fernanda Borges

  3. Artificial Intelligence Applied to Flavonoid Data in Food Matrices

    Article • Foods, November 2019, MDPI AG

    Dr Maria João Matos

  4. Antibacterial Activity and Molecular Docking Studies of a Selected Series of Hydroxy-3-arylcoumarins

    Article • Molecules, August 2019, MDPI AG

    Dr Maria João Matos

  5. Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

    Article • ACS Central Science, July 2019, American Chemical Society (ACS)

    Dr Maria João Matos

  6. Design, Synthesis and Docking Calculations of Prenylated Chalcones as Selective Monoamine Oxidase B Inhibitors with Antioxidant Activity

    Article • ChemistrySelect, July 2019, Wiley

    Dr Maria João Matos

  7. Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation

    Article • Angewandte Chemie, April 2019, Wiley

    Dr Maria João Matos

  8. Synthesis, molecular docking and cholinesterase inhibitory activity of hydroxylated 2-phenylbenzofuran derivatives

    Article • Bioorganic Chemistry, March 2019, Elsevier

    Dr Maria João Matos

  9. Targeting α -(1,4)-Glucosidase in Diabetes Mellitus Type 2: The Role of New Synthetic Coumarins as Potent Inhibitors

    Article • Current Topics in Medicinal Chemistry, January 2019, Bentham Science Publishers

    Dr Maria João Matos, Eugenio Uriarte, Catalina Figueroa, Rubén Veas

  10. Novel Coumarin-Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease

    Article • ChemistrySelect, January 2019, Wiley

    Dr Maria João Matos, Dr Jans H. Alzate-Morales

  11. Coumarin derivatives as promising xanthine oxidase inhibitors

    Article • International Journal of Biological Macromolecules, December 2018, Elsevier

    Dr Maria João Matos

  12. Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

    Article • Nature Protocols, November 2018, Springer Science + Business Media

    Dr Maria João Matos

  13. PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor

    Article • ACS Applied Materials & Interfaces, October 2018, American Chemical Society (ACS)

    Dr Maria João Matos, Professor Fernanda Borges

  14. Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates

    Article • Chemistry - A European Journal, May 2018, Wiley

    Dr Maria João Matos

  15. Unexpected one-step synthesis of 3-benzoyl-2-phenylbenzofurans under Wittig conditions

    Article • Tetrahedron Letters, May 2018, Elsevier

    Dr Maria João Matos

  16. A silicon-labelled amino acid suitable for late-stage fluorination and unexpected oxidative cleavage reactions in the preparation of a key intermediate in the Strecker synthesis

    Article • Peptide Science, April 2018, Wiley

    Dr Maria João Matos

  17. Evaluation of trypanocidal and antioxidant activities of a selected series of 3-amidocoumarins

    Article • Medicinal Chemistry, April 2018, Bentham Science Publishers

    Dr Maria João Matos, Eugenio Uriarte, Michel Lapier

  18. Learning from nature: the role of albumin in drug delivery

    Article • Future Medicinal Chemistry, April 2018, Future Science

    Dr Maria João Matos

  19. Trends in patented chromones for skin diseases

    Article • Pharmaceutical Patent Analyst, April 2018, Future Science

    Dr Maria João Matos

  20. Novel 2-pheynlbenzofuran derivatives as selective butyrylcholinesterase inhibitors for Alzheimer’s disease

    Article • Scientific Reports, March 2018, Springer Science + Business Media

    Dr Maria João Matos

  21. Chemo- and Regioselective Lysine Modification on Native Proteins

    Article • Journal of the American Chemical Society, February 2018, American Chemical Society (ACS)

    Dr Maria João Matos

  22. Coumarins as Promising Scaffold for the Treatment of Age-related Diseases – An Overview of the Last Five Years

    Article • Current Topics in Medicinal Chemistry, January 2018, Bentham Science Publishers

    Dr Maria João Matos

  23. A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging

    Article • Chemical Science, January 2018, Royal Society of Chemistry

    Dr Maria João Matos

  24. Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

    Article • Journal of the American Chemical Society, December 2017, American Chemical Society (ACS)

    Dr Maria João Matos

  25. Coumarins and adenosine receptors: New perceptions in structure-affinity relationships

    Article • Chemical Biology & Drug Design, September 2017, Wiley

    Dr Maria João Matos, Professor Fernanda Borges

  26. Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?

    Article • Journal of Medicinal Chemistry, August 2017, American Chemical Society (ACS)

    Dr Maria João Matos, Professor Fernanda Borges

  27. New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies

    Article • Bioorganic & Medicinal Chemistry, March 2017, Elsevier

    Dr Maria João Matos, Professor Fernanda Borges

  28. Heterocyclic Antioxidants in Nature: Coumarins

    Article • Current Organic Chemistry, January 2017, Bentham Science Publishers

    Dr Maria João Matos, Professor Fernanda Borges

  29. Synthesis, antioxidant and antichagasic properties of a selected series of hydroxy-3-arylcoumarins

    Article • Bioorganic & Medicinal Chemistry, January 2017, Elsevier

    Dr Maria João Matos

  30. In silico genotoxicity of coumarins: application of the Phenol-Explorer food database to functional food science

    Article • Food & Function, January 2017, Royal Society of Chemistry

    Dr Maria João Matos

  31. MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, in vitro study, and docking calculations

    Article • MedChemComm, January 2017, Royal Society of Chemistry

    Dr Maria João Matos, Professor Fernanda Borges

  32. Trends in therapeutic drug conjugates for bacterial diseases: a patent review

    Article • Expert Opinion on Therapeutic Patents, November 2016, Taylor & Francis

    Dr Maria João Matos

  33. Structural elucidation of a series of 6-methyl-3-carboxamidocoumarins

    Article • Magnetic Resonance in Chemistry, November 2016, Wiley

    Dr Maria João Matos, Professor Fernanda Borges

  34. In silico study of new structural alerts of agents clastogenic

    Article • November 2016, MDPI AG

    Dr Maria João Matos

  35. Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

    Article • Nature Communications, October 2016, Springer Science + Business Media

    Dr Maria João Matos

  36. Evaluation of Antioxidant and Antitrypanosomal Properties of a Selected Series of Synthetic 3-Carboxamidocoumarins

    Article • ChemistrySelect, September 2016, Wiley

    Dr Maria João Matos, Professor Fernanda Borges

  37. Facing Chagas' Disease: Trypanocidal Properties of New Coumarinchalcone Scaffolds

    Article • Medicinal Chemistry, July 2016, Bentham Science Publishers

    Dr Maria João Matos

  38. 6-Methyl-2-oxo-N-(quinolin-6-yl)-2H-chromene-3-carboxamide: crystal structure and Hirshfeld surface analysis

    Article • Acta Crystallographica Section E Crystallographic Communications, July 2016, International Union of Crystallography

    Dr John N Low, Dr Maria João Matos, Professor Fernanda Borges

  39. Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives

    Article • Acta Crystallographica Section E Crystallographic Communications, June 2016, International Union of Crystallography

    Dr John N Low, Dr Maria João Matos, Professor Fernanda Borges

  40. 2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling

    Article • Bioorganic & Medicinal Chemistry Letters, May 2016, Elsevier

    Dr Maria João Matos

  41. Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold

    Article • RSC Advances, January 2016, Royal Society of Chemistry

    Dr Maria João Matos, Professor Fernanda Borges

  42. Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Dr Maria João Matos, Professor Fernanda Borges

  43. Prediction of the total antioxidant capacity of food based on artificial intelligence algorithms

    Article • December 2015, MDPI AG

    Dr Maria João Matos

  44. Design, synthesis and antibacterial study of new potent and selective coumarin–chalcone derivatives for the treatment of tenacibaculosis

    Article • Bioorganic & Medicinal Chemistry, November 2015, Elsevier

    Dr Maria João Matos, Professor Fernanda Borges

  45. 3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

    Article • ChemMedChem, October 2015, Wiley

    Dr. María Isabel Rodríguez-Franco, Dr Maria João Matos, Dr Martin Estrada Valencia, Professor Fernanda Borges

  46. Coumarins — An Important Class of Phytochemicals

    Article • September 2015, IntechOpen

    Dr Maria João Matos

  47. Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold

    Article • Bioorganic Chemistry, August 2015, Elsevier

    Dr Maria João Matos, Professor Fernanda Borges

  48. Bioactive Coumarins from Marine Sources: Origin, Structural Features and Pharmacological Properties

    Article • Current Topics in Medicinal Chemistry, June 2015, Bentham Science Publishers

    Dr Maria João Matos, Professor Fernanda Borges

  49. In silico clastogenic activity of dietary phenolic acids

    Article • LWT, April 2015, Elsevier

    Dr Maria João Matos

  50. Interest of Antioxidant Agents in Parasitic Diseases. The Case Study of Coumarins

    Article • Current Topics in Medicinal Chemistry, March 2015, Bentham Science Publishers

    Professor Fernanda Borges, Dr Maria João Matos

  51. Oxidative Stress and Neurodegenerative Diseases: Looking for a Therapeutic Solution Inspired on Benzopyran Chemistry

    Article • Current Topics in Medicinal Chemistry, February 2015, Bentham Science Publishers

    Professor Fernanda Borges, Dr Maria João Matos

  52. Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds

    Article • Molecules, February 2015, MDPI AG

    Professor Fernanda Borges, Dr Maria João Matos

  53. Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, February 2015, Elsevier

    Dr. María Isabel Rodríguez-Franco, Dr Maria João Matos, Dr Martin Estrada Valencia

  54. Potential pharmacological uses of chalcones: a patent review (from June 2011 – 2014)

    Article • Expert Opinion on Therapeutic Patents, January 2015, Informa Healthcare

    Dr Maria João Matos

  55. Design and discovery of tyrosinase inhibitors based on a coumarin scaffold

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Dr Maria João Matos, Professor Fernanda Borges

  56. Back Cover: Insight into the Interactions between Novel Coumarin Derivatives and Human A3 Adenosine Receptors (ChemMedChem 10/2014)

    Article • ChemMedChem, September 2014, Wiley

    Dr Maria João Matos, Professor Fernanda Borges

  57. Insight into the Interactions between Novel Coumarin Derivatives and Human A3 Adenosine Receptors

    Article • ChemMedChem, July 2014, Wiley

    Dr Maria João Matos, Professor Fernanda Borges

  58. Synthesis and electrochemical study of new 3-(hydroxyphenyl)benzo[f]coumarins

    Article • Journal of Electroanalytical Chemistry, July 2014, Elsevier

    Dr Maria João Matos

  59. Insight into the Functional and Structural Properties of 3‐Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition

    Article • ChemMedChem, April 2014, Wiley

    Dr Maria João Matos

  60. Synthesis, pharmacological study and docking calculations of new benzo[f]coumarin derivatives as dual inhibitors of enzymatic systems involved in neurodegenerative diseases

    Article • Future Medicinal Chemistry, March 2014, Future Science

    Dr Maria João Matos, Professor Fernanda Borges

  61. Chromone: A Valid Scaffold in Medicinal Chemistry

    Article • Chemical Reviews, February 2014, American Chemical Society (ACS)

    Dr Maria João Matos, Professor Fernanda Borges

  62. Synthesis and evaluation of antioxidant and trypanocidal properties of a selected series of coumarin derivatives

    Article • Future Medicinal Chemistry, October 2013, Future Science

    Dr Maria João Matos

  63. Comparative study of the 3-phenylcoumarin scaffold: Synthesis, X-ray structural analysis and semiempirical calculations of a selected series of compounds

    Article • Journal of Molecular Structure, October 2013, Elsevier

    Dr Maria João Matos

  64. Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins

    Article • Journal of Pharmacy and Pharmacology, August 2013, Oxford University Press (OUP)

    Dr Maria João Matos, Professor Fernanda Borges

  65. QSAR and Complex Network Recognition of miRNAs in Stem Cells

    Article • Current Bioinformatics, August 2013, Bentham Science Publishers

    Professor Fernanda Borges, Dr Maria João Matos

  66. Synthesis and Electrochemical and Biological Studies of Novel Coumarin–Chalcone Hybrid Compounds

    Article • Journal of Medicinal Chemistry, July 2013, American Chemical Society (ACS)

    Dr Maria João Matos

  67. Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins

    Article • Bioorganic & Medicinal Chemistry, July 2013, Elsevier

    Dr Maria João Matos, Professor Fernanda Borges

  68. Synthesis, NMR characterization, X-ray structural analysis and theoretical calculations of amide and ester derivatives of the coumarin scaffold

    Article • Journal of Molecular Structure, June 2013, Elsevier

    Dr Maria João Matos

  69. Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study

    Article • European Journal of Medicinal Chemistry, May 2013, Elsevier

    Dr Maria João Matos

  70. (1S,2S,5S)-2-Methyl-3-oxo-5-(prop-1-en-2-yl)cyclohexane-1-carbonitrile

    Article • Acta Crystallographica Section E Structure Reports Online, April 2013, International Union of Crystallography

    Dr Maria João Matos

  71. [(2S,3aR,6aR)-5-Oxohexahydrofuro[3,2-b]furan-2-yl]methyl acetate

    Article • Acta Crystallographica Section E Structure Reports Online, April 2013, International Union of Crystallography

    Dr Maria João Matos

  72. MAO Inhibitory Activity of 2‐Arylbenzofurans versus 3‐Arylcoumarins: Synthesis, in vitro Study, and Docking Calculations

    Article • ChemMedChem, April 2013, Wiley

    Dr Maria João Matos

  73. ChemInform Abstract: Improved Synthesis of 3‐(Aminoaryl)coumarins.

    Article • ChemInform, March 2013, Wiley

    Dr Maria João Matos, Professor Fernanda Borges

  74. Editorial (Hot Topic: Monoamine Oxidase as a Target in Medicinal Chemistry and Drug Discovery)

    Article • Current Topics in Medicinal Chemistry, February 2013, Bentham Science Publishers

    Dr Maria João Matos

  75. Focusing on New Monoamine Oxidase Inhibitors: Differently Substituted Coumarins As An Interesting Scaffold

    Article • Current Topics in Medicinal Chemistry, February 2013, Bentham Science Publishers

    Dr Maria João Matos

  76. Chalcone-based derivatives as new scaffolds for h A3 adenosine receptor antagonists

    Article • Journal of Pharmacy and Pharmacology, January 2013, Oxford University Press (OUP)

    Dr Maria João Matos, Professor Fernanda Borges

  77. Synthesis and Structure-Activity Relationships of Novel Amino/Nitro Substituted 3-Arylcoumarins as Antibacterial Agents

    Article • Molecules, January 2013, MDPI AG

    Dr Maria João Matos

  78. Synthesis of coumarin–chalcone hybrids and evaluation of their antioxidant and trypanocidal properties

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Dr Maria João Matos

  79. New hydroxylated 3-arylcoumarins, synthesis and electrochemical study

    Article • Journal of Electroanalytical Chemistry, January 2013, Elsevier

    Dr Maria João Matos

  80. Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives

    Article • Journal of Pharmacy and Pharmacology, December 2012, Oxford University Press (OUP)

    Dr Maria João Matos, Professor Fernanda Borges

  81. N-(2-Oxo-2H-chromen-3-yl)cyclohexanecarboxamide

    Article • Acta Crystallographica Section E Structure Reports Online, November 2012, International Union of Crystallography

    Dr Maria João Matos

  82. Looking for New Targets: Simple Coumarins as Antibacterial Agents

    Article • Medicinal Chemistry, November 2012, Bentham Science Publishers

    Dr Maria João Matos

  83. Editorial (Hot Topic: Monoamine Oxidase as a Target in Medicinal Chemistry and Drug Discovery)

    Article • Current Topics in Medicinal Chemistry, October 2012, Bentham Science Publishers

    Dr Maria João Matos

  84. Focusing on New Monoamine Oxidase Inhibitors: Differently Substituted Coumarins As An Interesting Scaffold

    Article • Current Topics in Medicinal Chemistry, October 2012, Bentham Science Publishers

    Dr Maria João Matos

  85. Monoamine Oxidase Inhibitors: Ten Years of Docking Studies

    Article • Current Topics in Medicinal Chemistry, October 2012, Bentham Science Publishers

    Dr Maria João Matos

  86. Looking for New Targets: Simple Coumarins as Antibacterial Agents

    Article • Medicinal Chemistry, September 2012, Bentham Science Publishers

    Dr Maria João Matos

  87. Monoamino Oxidase A: An Interesting Pharmacological Target for the Development of Multi-Target QSAR

    Article • Mini-Reviews in Medicinal Chemistry, September 2012, Bentham Science Publishers

    Dr Maria João Matos

  88. Lipodystrophy defined by Fat Mass Ratio in HIV-infected patients is associated with a high prevalence of glucose disturbances and insulin resistance

    Article • BMC Infectious Diseases, August 2012, Springer Science + Business Media

    Dr Maria João Matos, DAVIDE CARVALHO

  89. 3-Phenylcoumarin

    Article • Acta Crystallographica Section E Structure Reports Online, August 2012, International Union of Crystallography

    Dr Maria João Matos

  90. In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton

    Article • European Journal of Medicinal Chemistry, August 2012, Elsevier

    Dr Maria João Matos, Professor Fernanda Borges

  91. Tyrosine-like condensed derivatives as tyrosinase inhibitors

    Article • Journal of Pharmacy and Pharmacology, February 2012, Oxford University Press (OUP)

    Dr Maria João Matos

  92. Structural Alerts for Predicting Clastogenic Activity of Pro-oxidant Flavonoid Compounds

    Article • SLAS DISCOVERY, February 2012, SAGE Publications

    Dr Maria João Matos

  93. Thyroid carcinoma in children and adolescents: A retrospective review

    Article • Endocrinología y Nutrición, February 2012, Elsevier

    Dr Maria João Matos

  94. 8-Substituted 3-Arylcoumarins as Potent and Selective MAO-B Inhibitors: Synthesis, Pharmacological Evaluation, and Docking Studies

    Article • ChemMedChem, January 2012, Wiley

    Professor Fernanda Borges, Dr Maria João Matos

  95. 3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Maria João Matos

  96. Improved Synthesis of 3-(Aminoaryl)coumarins

    Article • Organic Preparations and Procedures International, January 2012, Taylor & Francis

    Dr Maria João Matos, Professor Fernanda Borges

  97. Hydroxycoumarins as selective MAO-B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, January 2012, Elsevier

    Dr Maria João Matos

  98. Synthesis and Study of a Series of 3-Arylcoumarins as Potent and Selective Monoamine Oxidase B Inhibitors

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Dr Maria João Matos

  99. ChemInform Abstract: New Halogenated Phenylcoumarins as Tyrosinase Inhibitors.

    Article • ChemInform, October 2011, Wiley

    Dr Maria João Matos

  100. MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins

    Article • Bioorganic & Medicinal Chemistry Letters, July 2011, Elsevier

    Dr Maria João Matos

  101. New halogenated phenylcoumarins as tyrosinase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, June 2011, Elsevier

    Dr Maria João Matos

  102. ChemInform Abstract: Synthesis of 3‐Arylcoumarins via Suzuki Cross‐Coupling Reactions of 3‐Chlorocoumarin.

    Article • ChemInform, May 2011, Wiley

    Dr Maria João Matos, Professor Fernanda Borges

  103. Synthesis of 3-arylcoumarins via Suzuki-cross-coupling reactions of 3-chlorocoumarin

    Article • Tetrahedron Letters, March 2011, Elsevier

    Dr Maria João Matos, Professor Fernanda Borges

  104. New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, September 2010, Elsevier

    Dr Maria João Matos, Professor Fernanda Borges

  105. Regioselective Synthesis of Bromo-Substituted 3-Arylcoumarins

    Article • Synthesis, June 2010, Thieme Publishing Group

    Dr Maria João Matos

  106. ChemInform Abstract: A New Series of 3‐Phenylcoumarins as Potent and Selective MAO‐B Inhibitors.

    Article • ChemInform, October 2009, Wiley

    Dr Maria João Matos

  107. Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, September 2009, Elsevier

    Dr Maria João Matos

  108. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids

    Article • Molecules, July 2009, MDPI AG

    Dr Maria João Matos

  109. Synthesis of Regioisomeric Functionalized Benzodifurans and Angelicins

    Article • Helvetica Chimica Acta, July 2009, Wiley

    Dr Maria João Matos

  110. A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, June 2009, Elsevier

    Dr Maria João Matos