All Stories

  1. Different TP53 mutations are associated with specific chromosomal rearrangements, telomere length changes, and remodeling of the nuclear architecture of telomeres

    Article • Genes Chromosomes and Cancer, July 2014, Wiley

    Dr Regen Drouin

  2. Evaluation of the impact of density gradient centrifugation on fetal cell loss during enrichment from maternal peripheral blood

    Article • Prenatal Diagnosis, June 2014, Wiley

    Dr Regen Drouin

  3. Validation of automatic scanning of microscope slides in recovering rare cellular events: application for detection of fetal cells in maternal blood

    Article • Prenatal Diagnosis, March 2014, Wiley

    Dr Regen Drouin

  4. Strengths and pitfalls of Canadian gamete and embryo donor registries: searching for beneficent solutions

    Article • Reproductive BioMedicine Online, March 2014, Elsevier

    Dr Regen Drouin

  5. Gender Eugenics Between Medicine, Culture, and Society

    Article • The American Journal of Bioethics, October 2013, Taylor & Francis

    Dr Regen Drouin

  6. A new der(1;7)(q10;p10) leading to a singular 1p loss in a case of glioblastoma with oligodendroglioma component

    Article • Neuropathology, September 2013, Wiley

    Dr Regen Drouin, Dr David Mathieu

  7. Cytosine containing dipyrimidine sites can be hotspots of cyclobutane pyrimidine dimer formation after UVB exposure

    Article • Photochemical & Photobiological Sciences, August 2013, Springer Science + Business Media

    Dr Regen Drouin

  8. Differences between selective termination of pregnancy and fetal reduction in multiple pregnancy: a narrative review

    Article • Reproductive BioMedicine Online, June 2013, Elsevier

    Dr Regen Drouin

  9. Update of PAX2 mutations in renal coloboma syndrome and establishment of a locus-specific database

    Article • Human Mutation, January 2012, Hindawi Publishing Corporation

    Dr Regen Drouin, Dr Francesco Benedicenti, Mike Eccles

  10. Efficiency of Manual Scanning in Recovering Rare Cellular Events Identified by FluorescenceIn SituHybridization: Simulation of the Detection of Fetal Cells in Maternal Blood

    Article • Journal of Biomedicine and Biotechnology, January 2012, Hindawi Publishing Corporation

    Dr Regen Drouin

  11. A survey of APC mutations in Quebec

    Article • Familial Cancer, July 2011, Springer Science + Business Media

    Dr Regen Drouin

  12. Neurofibromatosis Type 1 and the “Elephant Man's” Disease: The Confusion Persists: An Ethnographic Study

    Article • PLoS ONE, February 2011, PLOS

    Dr Regen Drouin

  13. Prenatal diagnosis and molecular characterization of two constitutional rings derived from one chromosome 22

    Article • American Journal of Medical Genetics Part A, January 2011, Wiley

    Dr Regen Drouin

  14. DNAc: A Clustering Method for Identifying Kinship Relations Between DNA Profiles Using a Novel Similarity Measure*

    Article • Journal of Forensic Sciences, November 2010, Wiley

    Dr Regen Drouin

  15. The Sunscreen Agent 2-Phenylbenzimidazole-5-Sulfonic Acid Photosensitizes the Formation of Oxidized Guanines In Cellulo after UV-A or UV-B Exposure

    Article • Journal of Investigative Dermatology, October 2010, Elsevier

    Dr Regen Drouin

  16. Sizing the ends: Normal length of human telomeres

    Article • Annals of Anatomy - Anatomischer Anzeiger, September 2010, Elsevier

    Dr Regen Drouin

  17. p53 functions and cell lines: Have we learned the lessons from the past?

    Article • BioEssays, April 2010, Wiley

    Dr Regen Drouin

  18. Comprendre la mutagenèse somatique grâce à la cartographie des dommages à l’ADN

    Article • médecine/sciences, February 2010, EDP Sciences

    Dr Regen Drouin

  19. 11. Marked variability in urinary Gb3/creatinine excretion in healthy infants

    Article • Molecular Genetics and Metabolism, February 2010, Elsevier

    Dr Regen Drouin

  20. EGF receptor inhibitors in the treatment of glioblastoma multiform: Old clinical allies and newly emerging therapeutic concepts

    Article • European Journal of Pharmacology, December 2009, Elsevier

    Dr Regen Drouin

  21. Fetal–maternal exchange of multipotent stem/progenitor cells: microchimerism in diagnosis and disease

    Article • Trends in Molecular Medicine, November 2009, Elsevier

    Dr Regen Drouin

  22. Is the 1p/19q deletion a diagnostic marker of oligodendrogliomas?

    Article • Cancer Genetics and Cytogenetics, October 2009, Elsevier

    Dr Regen Drouin

  23. Fabry disease urinary globotriaosylceramide/creatinine biomarker evaluation by liquid chromatography–tandem mass spectrometry in healthy infants from birth to 6months

    Article • Molecular Genetics and Metabolism, August 2009, Elsevier

    Dr Regen Drouin

  24. Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, June 2009, Elsevier

    Dr Regen Drouin

  25. P53 transcriptional activities: A general overview and some thoughts

    Article • Mutation Research/Reviews in Mutation Research, March 2009, Elsevier

    Dr Regen Drouin

  26. In Cellulo DNA Analysis (LMPCR Footprinting)

    Article • January 2009, Springer Science + Business Media

    Dr Regen Drouin

  27. Postprandial free fatty acids metabolism early in the natural history of type 2 diabetes mellitus

    Article • Canadian Journal of Diabetes, January 2009, Elsevier

    Dr Regen Drouin

  28. Disruption of AP1S1, Causing a Novel Neurocutaneous Syndrome, Perturbs Development of the Skin and Spinal Cord

    Article • PLoS Genetics, December 2008, PLOS

    Dr Regen Drouin

  29. Urinary globotriaosylceramide excretion correlates with the genotype in children and adults with Fabry disease

    Article • Molecular Genetics and Metabolism, March 2008, Elsevier

    Dr Regen Drouin, M.D. DANIEL G BICHET

  30. High-resolution R-banding at the 1250-band level

    Article • Hereditas, February 2008, Springer Science + Business Media

    Dr Regen Drouin

  31. Application of Multi-PRINS to Simultaneously Identify Chromosomes 18, X, and Y in Prenatal Diagnosis

    Article • January 2008, Springer Science + Business Media

    Dr Regen Drouin

  32. Postprandial Free Fatty Acids (FFA) Metabolism Early in the Natural History of Type 2 Diabetes Mellitus (DM2)

    Article • Canadian Journal of Diabetes, January 2008, Elsevier

    Dr Regen Drouin

  33. 74 Development of a filter paper method applicable to a mass urinary screening for Fabry disease

    Article • Molecular Genetics and Metabolism, December 2007, Elsevier

    Dr Regen Drouin

  34. Repair kinetics of specific types of nitroso-induced DNA damage using the comet assay in human cells

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, November 2007, Elsevier

    Dr Regen Drouin

  35. In vivo footprinting analysis of the Glypican 3 (GPC3) promoter region in neuroblastoma cells

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, March 2007, Elsevier

    Dr Regen Drouin

  36. Pyrimidine (6–4) Pyrimidone Photoproduct Mapping After Sublethal UVC Doses: Nucleotide Resolution Using Terminal Transferase‐dependent PCR

    Article • Photochemistry and Photobiology, September 2006, Wiley

    Dr Regen Drouin

  37. Formamidopyrimidine adducts are detected using the comet assay in human cells treated with reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, August 2006, Elsevier

    Dr Regen Drouin

  38. Activité dominante négative des protéines p53 mutées

    Article • médecine/sciences, March 2006, EDP Sciences

    Dr Regen Drouin

  39. A GC/MS validated method for the nanomolar range determination of succinylacetone in amniotic fluid and plasma: An analytical tool for tyrosinemia type I

    Article • Journal of Chromatography B, February 2006, Elsevier

    Dr Regen Drouin

  40. From DNA Photolesions to Mutations, Skin Cancer and Cell Death

    Article • November 2005, Royal Society of Chemistry

    Dr Regen Drouin

  41. SW480, a p53 Double-mutant Cell Line Retains Proficiency for Some p53 Functions

    Article • Journal of Molecular Biology, September 2005, Elsevier

    Dr Regen Drouin

  42. In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor ( BDKRB1 ) gene promoter: evidence for cell-specific regulation

    Article • Biochemical Journal, July 2005, Portland Press Ltd.

    Dr Regen Drouin

  43. Optimal conditions and specific characteristics ofVentexo– DNA polymerase in ligation-mediated polymerase chain reaction protocols

    Article • Biochemistry and Cell Biology, April 2005, Canadian Science Publishing

    Dr Regen Drouin

  44. Characterization of the survival motor neuron (SMN) promoter provides evidence for complex combinatorial regulation in undifferentiated and differentiated P19 cells

    Article • Biochemical Journal, January 2005, Portland Press Ltd.

    Dr Regen Drouin

  45. Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1

    Article • Cancer Genetics and Cytogenetics, January 2005, Elsevier

    Dr Regen Drouin

  46. Quantification of fetal nucleated cells in maternal blood of pregnant women with a male trisomy 21 fetus using molecular cytogenetic techniques

    Article • Prenatal Diagnosis, January 2005, Wiley

    Dr Regen Drouin

  47. An atypical form of erythrokeratodermia variabilis maps to chromosome 7q22

    Article • Human Genetics, November 2004, Springer Science + Business Media

    Dr Regen Drouin

  48. De la conception du PRINS à son couronnement

    Article • médecine/sciences, April 2004, EDP Sciences

    Dr Regen Drouin

  49. Genetic Cooperation between the Werner Syndrome Protein and Poly(ADP-Ribose) Polymerase-1 in Preventing Chromatid Breaks, Complex Chromosomal Rearrangements, and Cancer in Mice

    Article • American Journal Of Pathology, May 2003, Elsevier

    Dr Regen Drouin

  50. Mouse telomere analysis using an optimized primed in situ (PRINS) labeling technique

    Article • Chromosoma, April 2003, Springer Science + Business Media

    Dr Regen Drouin

  51. A unique clone involving multiple structural chromosome rearrangements in a myelodysplastic syndrome case

    Article • Cancer Genetics and Cytogenetics, January 2003, Elsevier

    Dr Regen Drouin

  52. Evidence that extrachromosomal double-strand break repair can be coupled to the repair of chromosomal double-strand breaks in mammalian cells

    Article • Chromosoma, December 2002, Springer Science + Business Media

    Dr Regen Drouin

  53. Human cells bearing homozygous mutations in the DNA mismatch repair genes hMLH1 or hMSH2 are fully proficient in transcription-coupled nucleotide excision repair

    Article • Oncogene, August 2002, Springer Science + Business Media

    Dr Regen Drouin

  54. A physical sunscreen protects engineered human skin against artificial solar ultraviolet radiation-induced tissue and DNA damage

    Article • Photochemical & Photobiological Sciences, June 2002, Springer Science + Business Media

    Dr Regen Drouin

  55. Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in human genomic DNA

    Article • Journal of Molecular Biology, October 2001, Elsevier

    Dr Regen Drouin

  56. Repeated exposures of human skin equivalent to low doses of ultraviolet-B radiation lead to changes in cellular functions and accumulation of cyclobutane pyrimidine dimers

    Article • Biochemistry and Cell Biology, August 2001, Canadian Science Publishing

    Dr Regen Drouin

  57. Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines11Edited by I. Tinoco

    Article • Journal of Molecular Biology, February 2001, Elsevier

    Dr Regen Drouin

  58. Tetrasomy 8 is associated with a major cellular proliferative advantage and a poor prognosis

    Article • Cancer Genetics and Cytogenetics, February 2001, Elsevier

    Dr Regen Drouin

  59. Creating a new color by omission of 3′ end blocking step for simultaneous detection of different chromosomes in multi-PRINS technique

    Article • Chromosoma, February 2001, Springer Science + Business Media

    Dr Regen Drouin

  60. Trisomy 8 and monosomy 7 detected in bone marrow using primed in situ labeling, fluorescence in situ hybridization, and conventional cytogenetic analyses.

    Article • Cancer Genetics and Cytogenetics, February 2001, Elsevier

    Dr Regen Drouin

  61. Establishment and Characterization of a New Cell Line Derived from a Human Primary Breast Carcinoma

    Article • Cancer Genetics and Cytogenetics, July 2000, Elsevier

    Dr Regen Drouin

  62. Treatment of Human Cells with N-Nitroso(acetoxymethyl)methylamine:  Distribution Patterns of Piperidine-Sensitive DNA Damage at the Nucleotide Level of Resolution Are Related to the Sequence Context

    Article • Chemical Research in Toxicology, August 1999, American Chemical Society (ACS)

    Dr Regen Drouin

  63. Physiological and Cytogenetic Characterization of Immortalized Human Endometriotic Cells Containing Episomal Simian Virus 40 DNA

    Article • American Journal Of Pathology, April 1999, Elsevier

    Dr Regen Drouin

  64. Mapping Reactive Oxygen-Induced DNA Damage at Nucleotide Resolution

    Article • January 1999, Springer Science + Business Media

    Dr Regen Drouin

  65. ABC50, a Novel Human ATP-Binding Cassette Protein Found in Tumor Necrosis Factor-α-Stimulated Synoviocytes

    Article • Genomics, October 1998, Elsevier

    Dr Regen Drouin

  66. Chemical inactivators as sterilization agents for bovine collagen materials

    Article • Journal of Biomedical Materials Research, November 1997, Wiley

    Dr Regen Drouin

  67. UVB‐induced Cyclobutane Pyrimidine Dimer Frequency Correlates with Skin Cancer Mutational Hotspots in p53

    Article • Photochemistry and Photobiology, November 1997, Wiley

    Dr Regen Drouin

  68. A Hot Spot for Hydrogen Peroxide-Induced Damage in the Human Hypoxia-Inducible Factor 1 Binding Site of thePGK 1Gene

    Article • Archives of Biochemistry and Biophysics, February 1997, Elsevier

    Dr Regen Drouin

  69. Agarose Gel Electrophoresis for DNA Damage Analysis

    Article • January 1996, Springer Science + Business Media

    Dr Regen Drouin

  70. Ligation-Mediated PCR for Analysis of Oxidative DNA Damage

    Article • January 1996, Springer Science + Business Media

    Dr Regen Drouin

  71. Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications

    Article • Free Radical Biology and Medicine, January 1996, Elsevier

    Dr Regen Drouin

  72. High-Resolution Replication Bands Compared with Morphologic G- and R-bands

    Article • January 1994, Springer Science + Business Media

    Dr Regen Drouin

  73. Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR

    Article • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, July 1993, Elsevier

    Dr Regen Drouin

  74. Detection by electron microscopy of a small subband 13q14.11 deletion in an hereditary retinoblastoma

    Article • Cancer Genetics and Cytogenetics, September 1990, Elsevier

    Dr Regen Drouin

  75. Analysis of DNA replication during S-phase by means of dynamic chromosome banding at high resolution

    Article • Chromosoma, August 1990, Springer Science + Business Media

    Dr Regen Drouin

  76. High-resolution R-banding at the 1250-band level. II. Schematic representation and nomenclature of human RBG-banded chromosomes

    Article • Genome, June 1989, Canadian Science Publishing

    Dr Regen Drouin

  77. Idiograms of horse chromosomes at prometaphase, early metaphase, and midmetaphase after R-banding by BrdU incorporation followed by the fluorochrome–photolysis–Giemsa technique

    Article • Genome, August 1987, Canadian Science Publishing

    Dr Regen Drouin

  78. In Vivo DNA Analysis

    Article • Springer Science + Business Media

    Dr Regen Drouin

  79. New Rapid Multicolor PRINS Protocol

    Article • Springer Science + Business Media

    Dr Regen Drouin

  80. Dual-Color PRINS for <i>In Situ</i> Detection of Fetal Cells in Maternal Blood

    Article • Springer Science + Business Media

    Dr Regen Drouin