All Stories

  1. The Road to Becoming Green

    Article • August 2013, Taylor & Francis

    Dr Hans-Jurgen Federsel

  2. En route to full implementation: driving the green chemistry agenda in the pharmaceutical industry

    Article • Green Chemistry, January 2013, Royal Society of Chemistry

    Dr Hans-Jurgen Federsel

  3. Regioisomerism in the Synthesis of a Chiral Aminotetralin Drug Compound: Unraveling Mechanistic Details and Diastereomer-Specific In-Depth NMR Investigations

    Article • The Journal of Organic Chemistry, June 2012, American Chemical Society (ACS)

    Dr Hans-Jurgen Federsel

  4. Key Amino Acid Residues for Reversed or Improved Enantiospecificity of an ω‐Transaminase

    Article • ChemCatChem, April 2012, Wiley

    Dr Hans-Jurgen Federsel

  5. Crystal structures of the Chromobacterium violaceumω‐transaminase reveal major structural rearrangements upon binding of coenzyme PLP

    Article • FEBS Journal, January 2012, Wiley

    Dr Hans-Jurgen Federsel

  6. Process R&D under the magnifying glass: Organization, business model, challenges, and scientific context

    Article • Bioorganic & Medicinal Chemistry, August 2010, Elsevier

    Dr Hans-Jurgen Federsel

  7. How to conduct research in the pharmaceutical industry? Facing the dilemma: small, autonomous teams versus large, integrated centers

    Article • Expert Opinion on Drug Discovery, July 2010, Informa Healthcare

    Dr Hans-Jurgen Federsel

  8. Asymmetric Catalysis on Industrial Scale

    Article • May 2010, Wiley

    Dr Hans-Jurgen Federsel

  9. Mechanism of the Asymmetric Sulfoxidation in the Esomeprazole Process: Effects of the Imidazole Backbone for the Enantioselection

    Article • Advanced Synthesis & Catalysis, April 2009, Wiley

    Dr Hans-Jurgen Federsel

  10. Optimization and Scale-up of a Pd-Catalyzed Aromatic C−N Bond Formation: A Key Step in the Synthesis of a Novel 5-HT1B Receptor Antagonist

    Article • Organic Process Research & Development, April 2008, American Chemical Society (ACS)

    Dr Hans-Jurgen Federsel

  11. ChemInform Abstract: Stereoselective Synthesis of Drugs — An Industrial Perspective

    Article • ChemInform, January 2008, Wiley

    Dr Hans-Jurgen Federsel

  12. To Overcome the Hurdles

    Article • December 2007, Taylor & Francis

    Dr Hans-Jurgen Federsel

  13. Construction of a Chiral Central Nervous System (CNS)-Active Aminotetralin Drug Compound Based on a Synthesis Strategy Using Multitasking Properties of ( S)-1-Phenylethylamine

    Article • Accounts of Chemical Research, August 2007, American Chemical Society (ACS)

    Dr Hans-Jurgen Federsel

  14. Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations

    Article • Chemical Communications, January 2007, Royal Society of Chemistry

    Dr Hans-Jurgen Federsel

  15. In search of sustainability: process R&D in light of current pharmaceutical industry challenges

    Article • Drug Discovery Today, November 2006, Elsevier

    Dr Hans-Jurgen Federsel

  16. The Integration of Process R&D in Drug Discovery - Challenges and Opportunities

    Article • Combinatorial Chemistry & High Throughput Screening, February 2006, Bentham Science Publishers

    Dr Hans-Jurgen Federsel

  17. Asymmetry on large scale: the roadmap to stereoselective processes

    Article • Nature Reviews Drug Discovery, July 2005, Springer Science + Business Media

    Dr Hans-Jurgen Federsel

  18. C–N Coupling Chemistry as a Means to Achieve a Complicated Molecular Architecture: the AR‐A2 Case Story

    Article • September 2003, Wiley

    Dr Hans-Jurgen Federsel

  19. Logistics of process R&D: transforming laboratory methods to manufacturing scale

    Article • Nature Reviews Drug Discovery, August 2003, Springer Science + Business Media

    Dr Hans-Jurgen Federsel

  20. Start small, think big — the art of process R&D

    Article • Nature Reviews Drug Discovery, December 2002, Springer Science + Business Media

    Dr Hans-Jurgen Federsel

  21. Drug discoverers –you need us!

    Article • Drug Discovery Today, April 2001, Elsevier

    Dr Hans-Jurgen Federsel

  22. Development of a Process for a Chiral Aminochroman Antidepressant:  A Case Story

    Article • Organic Process Research & Development, August 2000, American Chemical Society (ACS)

    Dr Hans-Jurgen Federsel

  23. Building bridges from process R&D: from a customer–supplier relationship to full partnership

    Article • Pharmaceutical Science & Technology Today, August 2000, Elsevier

    Dr Hans-Jurgen Federsel

  24. Dichloromethane as reactant in synthesis: an expedient transformation of prolinamide to a novel pyrrolo[1,2-c]imidazolone

    Article • The Journal of Organic Chemistry, March 1990, American Chemical Society (ACS)

    Dr Hans-Jurgen Federsel

  25. An Efficient Synthesis of a New, Chiral 2',6'-Pipecoloxylidide Local Anaesthetic Agent.

    Article • Acta Chemica Scandinavica, January 1987, Danish Chemical Society

    Dr Hans-Jurgen Federsel

  26. A novel base-induced ring expansion of quaternized heterocycles

    Article • Tetrahedron Letters, January 1980, Elsevier

    Dr Hans-Jurgen Federsel

  27. Rapid Rearrangement of Quaternized Oxazoles and Thiazoles through Base Treatment

    Article • Heterocycles, January 1980, Japan Institute of Heterocyclic Chemistry

    Dr Hans-Jurgen Federsel

  28. Rapid Base Induced Rearrangement of Some Quaterinized Thiazoles to Thietanes

    Article • Heterocycles, January 1979, Japan Institute of Heterocyclic Chemistry

    Dr Hans-Jurgen Federsel

  29. An Innovative Asymmetric Sulfide Oxidation: The Process Development History behind the New Antiulcer Agent Esomeprazole

    Article • Wiley

    Dr Hans-Jurgen Federsel