All Stories

  1. Amyloidogenic mutations in human apolipoprotein A‐I are not necessarily destabilizing – a common mechanism of apolipoprotein A‐I misfolding in familial amyloidosis and atherosclerosis

    Article • FEBS Journal, April 2014, Wiley

    Dr Olga Gursky

  2. Hot spots in apolipoprotein A‐II misfolding and amyloidosis in mice and men

    Article • FEBS Letters, February 2014, Wiley

    Dr Olga Gursky

  3. Aggregation and fusion of low-density lipoproteins in vivo and in vitro

    Article • BioMolecular Concepts, October 2013, De Gruyter

    Dr Olga Gursky

  4. Crystal Structure of Δ(185–243)ApoA-I Suggests a Mechanistic Framework for the Protein Adaptation to the Changing Lipid Load in Good Cholesterol: From Flatland to Sphereland via Double Belt, Belt Buckle, Double Hairpin and Trefoil/Tetrafoil

    Article • Journal of Molecular Biology, January 2013, Elsevier

    Dr Olga Gursky

  5. Role of Apolipoprotein A-II in the Structure and Remodeling of Human High-Density Lipoprotein (HDL): Protein Conformational Ensemble on HDL

    Article • Biochemistry, June 2012, American Chemical Society (ACS)

    Dr Olga Gursky

  6. Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis

    Article • Biochemical Journal, March 2012, Portland Press Ltd.

    Dr Olga Gursky

  7. The Crystal Structure of the C-Terminal Truncated Apolipoprotein A-I Sheds New Light on Amyloid Formation by the N-Terminal Fragment

    Article • Biochemistry, December 2011, American Chemical Society (ACS)

    Dr Olga Gursky

  8. Pressure Perturbation Calorimetry of Lipoproteins Reveals an Endothermic Transition without Detectable Volume Changes. Implications for Adsorption of Apolipoprotein to a Phospholipid Surface

    Article • Biochemistry, April 2011, American Chemical Society (ACS)

    Dr Olga Gursky

  9. Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH

    Article • Journal of Lipids, January 2011, Hindawi Publishing Corporation

    Dr Olga Gursky

  10. The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain

    Article • Biochemistry, October 2010, American Chemical Society (ACS)

    Dr Olga Gursky

  11. Pressure perturbation calorimetry of apolipoproteins in solution and in model lipoproteins

    Article • Proteins Structure Function and Bioinformatics, October 2009, Wiley

    Dr Olga Gursky

  12. Differential Stability of High-density Lipoprotein Subclasses: Effects of Particle Size and Protein Composition

    Article • Journal of Molecular Biology, April 2009, Elsevier

    Dr Olga Gursky

  13. Correlation of Structural Stability with Functional Remodeling of High-Density Lipoproteins: The Importance of Being Disordered

    Article • Biochemistry, October 2008, American Chemical Society (ACS)

    Dr Olga Gursky

  14. Effects of Protein Oxidation on the Structure and Stability of Model Discoidal High-Density Lipoproteins

    Article • Biochemistry, February 2008, American Chemical Society (ACS)

    Dr Olga Gursky

  15. Mild Oxidation Promotes and Advanced Oxidation Impairs Remodeling of Human High-Density Lipoprotein In Vitro

    Article • Journal of Molecular Biology, February 2008, Elsevier

    Dr Olga Gursky

  16. Thermal Transitions in Human Very-Low-Density Lipoprotein:  Fusion, Rupture, and Dissociation of HDL-like Particles

    Article • Biochemistry, May 2007, American Chemical Society (ACS)

    Dr Olga Gursky

  17. Effects of Oxidation on the Structure and Stability of Human Low-Density Lipoprotein

    Article • Biochemistry, April 2007, American Chemical Society (ACS)

    Dr Olga Gursky

  18. Role of Secondary Structure in Protein−Phospholipid Surface Interactions:  Reconstitution and Denaturation of Apolipoprotein C-I:DMPC Complexes

    Article • Biochemistry, March 2007, American Chemical Society (ACS)

    Dr Olga Gursky

  19. Does Alpha-Helix Folding Necessarily Provide an Energy Source for the Protein-Lipid Binding?

    Article • Protein and Peptide Letters, February 2007, Bentham Science Publishers

    Dr Olga Gursky

  20. Effects of Salt on the Thermal Stability of Human Plasma High-Density Lipoprotein

    Article • Biochemistry, March 2006, American Chemical Society (ACS)

    Dr Olga Gursky

  21. Electrostatic Effects on the Stability of Discoidal High-Density Lipoproteins

    Article • Biochemistry, June 2005, American Chemical Society (ACS)

    Dr Olga Gursky

  22. Apolipoprotein structure and dynamics

    Article • Current Opinion in Lipidology, June 2005, Wolters Kluwer Health

    Dr Olga Gursky

  23. Thermodynamic Stability of a κI Immunoglobulin Light Chain: Relevance to Multiple Myeloma

    Article • Biophysical Journal, June 2005, Elsevier

    Dr Olga Gursky

  24. Kinetic Stabilization and Fusion of Apolipoprotein A-2:DMPC Disks: Comparison with apoA-1 and apoC-1

    Article • Biophysical Journal, April 2005, Elsevier

    Dr Olga Gursky

  25. Structural Basis for Thermal Stability of Human Low-Density Lipoprotein

    Article • Biochemistry, February 2005, American Chemical Society (ACS)

    Dr Olga Gursky

  26. Poly(ethylene glycol)-Induced Fusion and Destabilization of Human Plasma High-Density Lipoproteins

    Article • Biochemistry, April 2004, American Chemical Society (ACS)

    Dr Olga Gursky

  27. Lipid-Binding Studies of Human Apolipoprotein A-I and Its Terminally Truncated Mutants

    Article • Biochemistry, October 2003, American Chemical Society (ACS)

    Dr Olga Gursky

  28. Structural Studies of N- and C-Terminally Truncated Human Apolipoprotein A-I

    Article • Biochemistry, May 2003, American Chemical Society (ACS)

    Dr Olga Gursky

  29. Effects of Mutations in Apolipoprotein C-1 on the Reconstitution and Kinetic Stability of Discoidal Lipoproteins

    Article • Biochemistry, April 2003, American Chemical Society (ACS)

    Dr Olga Gursky

  30. Human Plasma High-density Lipoproteins are Stabilized by Kinetic Factors

    Article • Journal of Molecular Biology, April 2003, Elsevier

    Dr Olga Gursky

  31. Complex of Human Apolipoprotein C-1 with Phospholipid:  Thermodynamic or Kinetic Stability?

    Article • Biochemistry, May 2002, American Chemical Society (ACS)

    Dr Olga Gursky

  32. Solution Conformation of Human Apolipoprotein C-1 Inferred from Proline Mutagenesis:  Far- and Near-UV CD Study

    Article • Biochemistry, September 2001, American Chemical Society (ACS)

    Dr Olga Gursky

  33. Probing the Lipid-Free Structure and Stability of Apolipoprotein A-I by Mutation

    Article • Biochemistry, November 2000, American Chemical Society (ACS)

    Dr Olga Gursky

  34. Temperature-dependent β-sheet formation in β-amyloid Aβ1–40 peptide in water: uncoupling β-structure folding from aggregation

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, January 2000, Elsevier

    Dr Olga Gursky

  35. Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide

    Article • Protein Science, January 1999, Wiley

    Dr Olga Gursky

  36. Thermodynamic Analysis of Human Plasma Apolipoprotein C-1:  High-Temperature Unfolding and Low-Temperature Oligomer Dissociation

    Article • Biochemistry, January 1998, American Chemical Society (ACS)

    Dr Olga Gursky

  37. High‐ and low‐temperature unfolding of human high‐density apolipoprotein A‐2

    Article • Protein Science, September 1996, Wiley

    Dr Olga Gursky