Dr Douglas S. Johnson
Current affiliation: Pfizer Worldwide Research and Development
Subject: Chemistry
Primary location: United States
Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probes
Published in:MedChemComm
Publication date:2014-01-01
Development of CBAP-BPyne, a probe for γ-secretase and presenilinase
Published in:MedChemComm
Publication date:2014-01-01
Discovery of selective 2,4-diaminopyrimidine-based photoaffinity probes for glyoxalase I
Published in:MedChemComm
Publication date:2014-01-01
Molecular medicine and neurodegenerative diseases
Published in:Chemical Society Reviews
Publication date:2014-08-08
Development and Mechanism of γ-Secretase Modulators for Alzheimer’s Disease
Published in:Biochemistry
Publication date:2013-05-14
Target of γ-secretase modulators, presenilin marks the spot
Published in:The EMBO Journal
Publication date:2011-11-30Target of GSMs, presenilin marks the spot
Gamma-secretase inhibitors and gamma-secretase modulators differentially regulate amyloid-beta 42 peptide generation in native brain membrane prepa...
Published in:Alzheimer s & Dementia
Publication date:2010-07-01
Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012
Published in:Expert Opinion on Therapeutic Patents
Publication date:2013-07-23
Novel γ-secretase modulators: a review of patents from 2008 to 2010
Published in:Expert Opinion on Therapeutic Patents
Publication date:2011-01-14
Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1
Published in:ACS Chemical Neuroscience
Publication date:2011-12-21
Understanding the target and evaluating the consequences of gamma-secretase modulation from in vitro models to higher-order species
Published in:Alzheimer s & Dementia
Publication date:2013-07-01
Development of clickable active site-directed photoaffinity probes for γ-secretase
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:2012-04-01
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:2012-04-01
Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ-Secretase Modulators
Published in:Journal of Medicinal Chemistry
Publication date:2014-02-13
O -Hydroxyacetamide Carbamates as a Highly Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors
Published in:ACS Chemical Neuroscience
Publication date:2012-05-16
Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders
Published in:Expert Opinion on Drug Discovery
Publication date:2009-06-09
Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity †
Published in:Biochemistry
Publication date:2007-11-01
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:2009-05-01
The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)
Published in:Nuclear Medicine and Biology
Publication date:2012-10-01
An Isotopically Tagged Azobenzene-Based Cleavable Linker for Quantitative Proteomics
Published in:ChemBioChem
Publication date:2013-07-16
Contemporary Drug Synthesis
Published in:Not available
Publication date:2004-06-18Li/Drug Synthesis
The Art of Drug Synthesis
Published in:Not available
Publication date:2007-06-20
Modern Drug Synthesis
Published in:Not available
Publication date:2010-07-16Li/Modern
Neuraminidase Inhibitors for Influenza: Oseltamivir Phosphate (Tamiflu®) and Zanamivir (Relenza®)
Published in:The Art of Drug Synthesis
Publication date:Not available
Chemical Proteomic Technologies for Drug Target Identification
Published in:Annual Reports in Medicinal Chemistry
Publication date:2010-01-01
Alkyne insertion reactions of metal-carbenes derived from enynyl-.alpha.-diazoketones [R'CN2COCR2CH2C.tplbond.C(CH2)n-2CH:CH2]
Published in:The Journal of Organic Chemistry
Publication date:1990-07-01
Recent advances in medicinal chemistry
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:2011-05-01
CC-1065 CBI analogs: an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions
Published in:Bioorganic & Medicinal Chemistry
Publication date:1995-06-01
pH Dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:1997-01-01
Induction of endonucleolytic DNA fragmentation and apoptosis by the duocarmycins
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:1994-02-01
Evaluation of functional Analogs of CC-1065 and the Duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]be...
Published in:Bioorganic & Medicinal Chemistry
Publication date:1993-07-01
Molecular basis for sequence selective DNA alkylation by (+)- and ent-(−)-CC-1065 and related agents: Alkylation site models that accommodate the o...
Published in:Bioorganic & Medicinal Chemistry
Publication date:1994-02-01
Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:1996-09-01
Discovery of PF-00217830: Aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:2011-05-01
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
Published in:ACS Medicinal Chemistry Letters
Publication date:2011-02-10
Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces In...
Published in:Journal of Pharmacology and Experimental Therapeutics
Publication date:2011-04-19
Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain
Published in:Chemistry & Biology
Publication date:2009-04-01
Structure-guided inhibitor design for human FAAH by interspecies active site conversion
Published in:Proceedings of the National Academy of Sciences
Publication date:2008-08-27
Synthesis of chromanyl and dihydrobenzofuranyl piperazines
Published in:Tetrahedron Letters
Publication date:2007-04-01
Synthesis of fluorinated 1,8-naphthyridinone derivatives
Published in:Tetrahedron Letters
Publication date:2007-11-01
Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines
Published in:Not available
Publication date:2007-07-01
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
Published in:Future Medicinal Chemistry
Publication date:2010-06-01
Duocarmycin SA Shortened, Simplified, and Extended Agents: A Systematic Examination of the Role of the DNA Binding Subunit
Published in:Journal of the American Chemical Society
Publication date:1997-05-01
Second Definitive Test of Proposed Models for the Origin of the CC-1065 and Duocarmycin DNA Alkylation Selectivity
Published in:Journal of the American Chemical Society
Publication date:1995-02-01
(+)- and ent-(-)-Duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA Alkylation Properties.Alkylation Site Models That Accommodate the Offset AT-Rich...
Published in:Journal of the American Chemical Society
Publication date:1994-03-01
Reversed and Sandwiched Analogs of Duocarmycin SA: Establishment of the Origin of the Sequence-Selective Alkylation of DNA and New Insights into t...
Published in:Journal of the American Chemical Society
Publication date:1997-05-01
CC-1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies
Published in:Angewandte Chemie International Edition
Publication date:1996-07-01
CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
Published in:Proceedings of the National Academy of Sciences
Publication date:1995-04-25
Catalytic Enantioselective Amination of Enolsilanes Using C 2 -Symmetric Copper(II) Complexes as Chiral Lewis Acids
Published in:Organic Letters
Publication date:1999-08-01