All Stories

  1. Arabinonucleic Acids: 2′-Stereoisomeric Modulators of siRNA Activity
  2. Rigid 2′,4′-Difluororibonucleosides: Synthesis, Conformational Analysis, and Incorporation into Nascent RNA by HCV Polymerase
  3. An evaluation of selective deprotection conditions for the synthesis of RNA on a light labile solid support
  4. Regiospecific Solid-Phase Synthesis of Branched Oligoribonucleotides That Mimic Intronic Lariat RNA Intermediates
  5. Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography
  6. An orthogonal photolabile linker for the complete “on-support” synthesis/fast deprotection/hybridization of RNA
  7. 2'F-ANA/2'F-RNA alternated sequences
  8. Structure of 2'F-RNA/2'F-ANA chimeric duplex
  9. Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery
  10. Backbone FCH⋅⋅⋅O Hydrogen Bonds in 2′F‐Substituted Nucleic Acids
  11. Backbone FCH⋅⋅⋅O Hydrogen Bonds in 2′F‐Substituted Nucleic Acids
  12. Parallel human telomeric quadruplex containing 2'F-ANA substitutions
  13. Dramatic Effect of Furanose C2′ Substitution on Structure and Stability: Directing the Folding of the Human Telomeric Quadruplex with a Single Fluorine Atom
  14. The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity
  15. Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing
  16. Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids
  17. Phenylpyrrolocytosine as an Unobtrusive Base Modification for Monitoring Activity and Cellular Trafficking of siRNA
  18. New light labile linker for solid phase synthesis of 2′-O-acetalester oligonucleotides and applications to siRNA prodrug development
  19. siRNA nanocarriers based on methacrylic acid copolymers
  20. RNA synthesis via dimer and trimer phosphoramidite block coupling
  21. Energetically Important C−H···F−C Pseudohydrogen Bonding in Water: Evidence and Application to Rational Design of Oligonucleotides with High Binding Affinity
  22. Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat
  23. ChemInform Abstract: In situ Chemical Synthesis of RU‐DNA Chimeras on Chips and Enzymic Recognition
  24. Delivery of Nucleic Acids through the Controlled Disassembly of Multifunctional Nanocomplexes
  25. Delivery of Nucleic Acids through the Controlled Disassembly of Multifunctional Nanocomplexes
  26. Chemical Modification of siRNA
  27. Acetal Levulinyl Ester (ALE) Groups for 2′-Hydroxyl Protection of Ribonucleosides in the Synthesis of Oligoribonucleotides on Glass and Microarrays
  28. Studies on the hydrolytic stability of 2′-fluoroarabinonucleic acid (2′F-ANA)
  29. ChemInform Abstract: 2′F‐Arabinonucleic Acids (2′F‐ANA) — History, Properties, and New Frontiers
  30. Chemically modified siRNA: tools and applications
  31. Probing DNA polymerase activity with stereoisomeric 2′-fluoro-β-D-arabinose (2′F-araNTPs) and 2′-fluoro-β-D-ribose (2′F-rNTPs) nucleoside 5′-triphosphates
  32. 2′F-Arabinonucleic acids (2′F-ANA) — History, properties, and new frontiers
  33. Synthesis and Biophysical Characterization of Oligonucleotides Containing a 4′-Selenonucleotide
  34. Synthesis and Properties of Oligonucleotides Containing A 7-Membered (Oxepane) Sugar Ring
  35. DNA Polymerase Recognition of 2′-Deoxy-2′-Fluoroarabinonucleoside 5′-Triphosphates (2′F-Arantps)
  36. Oligonucleotide Synthesis Using Ionic Liquids as Soluble Supports
  37. A Novel Approach to the Synthesis of DNA and RNA Lariats
  38. Oxepane Nucleic Acids:  Synthesis, Characterization, and Properties of Oligonucleotides Bearing a Seven-Membered Carbohydrate Ring
  39. Polymerase-Directed Synthesis of 2‘-Deoxy-2‘-fluoro-β-D-arabinonucleic Acids
  40. Ion-tagged synthesis of an oligoribonucleotide pentamer — The continuing versatility of TBDMS chemistry
  41. Solid-Phase Synthesis and On-Column Deprotection of RNA from 2‘- (and 3‘-) O-Levulinated (Lv) Ribonucleoside Monomers
  42. Induction of RNase H Activity by Arabinose−Peptide Nucleic Acid Chimeras
  43. A Novel Approach to Oligonucleotide Synthesis Using an Imidazolium Ion Tag as a Soluble Support.
  44. A Novel Approach to Oligonucleotide Synthesis Using an Imidazolium Ion Tag as a Soluble Support
  45. Synthesis, characterization, and biological properties of small branched RNA fragments containing chiral (Rpand Sp) 2′,5′-phosphorothioate linkages
  46. Preference for Ribose Over Deoxyribose in Loop-Closing Base Pairs of Extra Stable Nucleic Acid Hairpins
  47. Selective Inhibition of HIV‐1 Reverse Transcriptase (HIV‐1 RT) RNase H by Small RNA Hairpins and Dumbbells
  48. Molecular Requirements for Duplex Recognition and Cleavage by Eukaryotic RNase III: Discovery of an RNA-dependent DNA Cleavage Activity of Yeast Rnt1p
  49. Template‐Mediated Synthesis of Lariat RNA and DNA.
  50. Structure of 2′,5′‐Linked Tetraribonucleotide Loops: A Novel RNA Motif
  51. Branchpoint Sugar Stereochemistry Determines the Hydrolytic Susceptibility of Branched RNA Fragments by the Yeast Debranching Enzyme (YDBR)
  52. Synthesis and Binding Properties of a Homopyrimidine 2′,5′‐Linked Xylose Nucleic Acid (2′,5′‐XNA)
  53. Synthesis and Properties of Oligonucleotide Chimeras Containing 5′‐Amino‐2′‐deoxy‐2′‐fluoroarabinonucleosides
  54. A New Synthesis of 9‐(2‐Deoxy‐2‐fluoro‐β‐D‐arabinofuranosyl)guanine (araF‐G)
  55. Synthesis of 2′‐3′‐Dideoxy‐2′‐fluoro‐3′‐thioarabinothymidine and Its 3′‐Phosphoramidite Derivative
  56. Synthesis and Physicochemical Properties of 2′‐Deoxy‐2′,2′′‐difluoro‐β‐D‐ribofuranosyl and 2′‐Deoxy‐2′,2′′‐difluoro‐α‐D‐ribofuranosyl Oligonucleotides
  57. Template-Mediated Synthesis of Lariat RNA and DNA
  58. Synthesis and Physicochemical Properties of 2′-Deoxy- 2′,2″-difluoro-β-D-ribofuranosyl and 2′-Deoxy-2′,2″- difluoro-α-D-ribofuranosyl Oligonucleotides
  59. Synthesis and Binding Properties of a Homopyrimidine 2′,5′-Linked Xylose Nucleic Acid (2′,5′-XNA)
  60. Synthesis and Properties of Oligonucleotide Chimeras Containing 5′-Amino-2′-deoxy-2′-fluoroarabinonucleosides
  61. A New Synthesis of 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)guanine (araF-G)
  62. Synthesis of 2′,3′-Dideoxy-2′-fluoro-3′-thioarabinothymidine and Its 3′-Phosphoramidite Derivative
  63. Branchpoint Sugar Stereochemistry Determines the Hydrolytic Susceptibility of Branched RNA Fragments by the Yeast Debranching Enzyme (YDBR)
  64. Structure of 2′,5′-Linked Tetraribonucleotide Loops: A Novel RNA Motif
  65. A Novel RNA Motif Based on the Structure of Unusually Stable 2‘,5‘-Linked r(UUCG) Loops
  66. Synthesis of Lariat-DNA via the Chemical Ligation of a Dumbbell Complex
  67. Efficient RNase H-Directed Cleavage of RNA Promoted by Antisense DNA or 2‘F-ANA Constructs Containing Acyclic Nucleotide Inserts
  68. Flexible and Frozen Sugar-Modified Nucleic Acids - Modulation of Biological Activity Through Furanose Ring Dynamics in the Antisense Strand
  69. Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-β-D-arabino- and 2'-deoxy-nucleosides
  70. Synthesis of Protected 2′‐Deoxy‐2′‐fluoro‐β‐D‐arabinonucleosides
  71. Solid‐Phase Synthesis of 2′‐Deoxy‐2′‐fluoro‐ β‐D‐Oligoarabinonucleotides (2′F‐ANA) and Their Phosphorothioate Derivatives
  72. Oligonucleotides comprised of alternating 2′-Deoxy-2′-fluoro-β-d-arabinonucleosides and d-2′-deoxyribonucleosides (2′F-ANA/DNA ‘Altimers’) induce efficient RNA cleavage mediated by RNase H
  73. Solid‐Phase Synthesis of Branched Oligonucleotides
  74. Potent Gene-Specific Inhibitory Properties of Mixed-Backbone Antisense Oligonucleotides Comprised of 2‘-Deoxy-2‘-fluoro-d-arabinose and 2‘-Deoxyribose Nucleotides,
  75. Remarkable Stability of Hairpins Containing 2‘,5‘-Linked RNA Loops
  76. NMR Solution Structure of an Oligonucleotide Hairpin with a 2‘F-ANA/RNA Stem:  Implications for RNase H Specificity toward DNA/RNA Hybrid Duplexes
  77. EXTRA STABLE 2′,5′-LINKED RNA LOOPS
  78. EFFECT OF SUBSTITUTING ARABINONUCLEOSIDES FOR DEOXYNUCLEOTIDES IN THE DNA PRIMING STRAND ON THE POLYMERASE ACTION OF HIV-1 RT
  79. RNA Lariat Debranching Enzyme
  80. Synthesis and Biophysical Properties of Arabinonucleic Acids (ANA):  Circular Dichroic Spectra, Melting Temperatures, and Ribonuclease H Susceptibility of ANA·RNA Hybrid Duplexes
  81. Duplex Recognition by Oligonucleotides Containing 2‘-Deoxy-2‘-fluoro-d-arabinose and 2‘-Deoxy-2‘-fluoro-d-ribose. Intermolecular 2‘-OH−Phosphate Contacts versus Sugar Puckering in the Stabilization of Triple-Helical Complexes
  82. Recognition of nucleic acid double helices by homopyrimidine 2',5'-linked RNA
  83. Synthesis of a branched DNA/RNA chimera similar to the msDNA molecule of Myxococcus xanthus
  84. Physicochemical and Biochemical Properties of 2‘,5‘-Linked RNA and 2‘,5‘-RNA:3‘,5‘-RNA “Hybrid” Duplexes,
  85. Divergent solid-phase synthesis of nucleic acid dendrimers
  86. Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase
  87. Regiospecific Solid-Phase Synthesis of Branched Oligonucleotides. Effect of Vicinal 2‘,5‘- (or 2‘,3‘-) and 3‘,5‘-Phosphodiester Linkages on the Formation of Hairpin DNA
  88. ChemInform Abstract: Synthesis of 2′‐Substituted Sulfide‐Linked Dinucleotides
  89. A novel N 3-functionalized thymidine linker for the stabilization of triple helical DNA
  90. Association of branched nucleic acids: structural and physicochemical analysis of antiparallel T.cntdot.AT triple-helical DNA
  91. Synthesis of 2′-Substituted Sulfide-Linked Dinucleotides
  92. Tricyclic “oxadiazaphosphorine oxide” guanosines A new strategy to functionalize guanosine at the exocyclic amino group
  93. Fiber-Optic DNA Sensor for Fluorometric Nucleic Acid Determination
  94. Structural basis for the RNA binding selectivity of oligonucleotide analogues containing alkylsulfide internucleoside linkages and 2′-substituted 3′-deoxyribonucleosides
  95. ChemInform Abstract: Hybridization Properties of Oligoarabinonucleotides.
  96. Antisense L/D-Oligodeoxynucleotide Chimeras: Nuclease Stability, Base-Pairing Properties, and Activity at Directing Ribonuclease H
  97. Fiber optic biosensor for fluorimetric detection of DNA hybridization
  98. ChemInform Abstract: Oligoribonucleotide Synthesis. The Silyl‐Phosphoramidite Method
  99. Hybridization properties of oligoarabinonucleotides
  100. Ein Sulfidbindungen enthaltendes Oligonucleotid‐Analogon mit selektiven Hybridisierungseigenschaften
  101. A Sulfide‐Linked Oligonucleotide Analogue with Selective Hybridization Properties
  102. Nucleic acid dendrimers: novel biopolymer structures
  103. Solid-phase synthesis and hybridization properties of DNA containing sulfide-linked dinucleosides
  104. Oligoribonucleotides containing 2′,5′-phosphodiester linkages exhibit binding selectivity for 3′,5′-RNA over 3′,5′-ssDNA
  105. Synthesis and hybridization properties of amide-linked thymidine dimers incorporated into oligodeoxynucleotides
  106. Tricyclic “oxadiazaphosphorine oxide” guanosines: A new strategy to the protection of guanine bases during RNA synthesis
  107. Solid-phase synthesis of branched oligoribonucleotides related to messenger RNA splicing intermediates
  108. Oligodeoxynucleotides containing unnatural L-2′-deoxyribose
  109. Time-of-flight Secondary Ion Mass Spectrometry of Branched RNA Fragrants: Messenger RNA Splicing Intermedistes
  110. An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis
  111. Solution and solid phase chemical synthesis of arabinonucleotides
  112. Automated solid-phase synthesis of branched oligonucleotides
  113. Conformational properties of branched RNA fragments in aqueous solution
  114. Synthesis and spectroscopic analysis of branched RNA fragments: messenger RNA splicing intermediates
  115. Differentiation between protected diastereomeric trinucleotides by time‐of‐flight secondary ion mass spectrometry
  116. The rapid chemical synthesis of arabinonucleotides
  117. Modification of guanine bases: reaction of N2-acylated guanine nucleosides with dichloro-(N,N-diisopropylamino)phosphine
  118. Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives
  119. Modification of guanine bases by nucleoside phosphoramidite reagents during the solid phase synthesis of oligonucleotides
  120. Chemical synthesis of branched RNA: novel trinucleoside diphosphates containing vicinal 2′–5′ and 3′–5′ phosphodiester linkages
  121. Necessary protection of the O6-position of guanine during the solid phase synthesis of oligonucleotides by the phosphoramidite approach
  122. Oligoribonucleotide Synthesis: The Silyl-Phosphoramidite Method
  123. Assay for Evaluating Ribonuclease H-Mediated Degradation of RNA–Antisense Oligonucleotide Duplexes