All Stories

  1. RT-DOb, a switch gene for the gene pair {Csf1r, Milr1}, can influence the onset of Alzheimer’s disease by regulating communication between mast cell and microglia
  2. Structural systems pharmacology: A framework for integrating metabolic network and structure-based virtual screening for drug discovery against bacteria
  3. Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases
  4. In silico prediction of enzymatic reactions catalyzed by acid phosphatases
  5. A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer’s disease
  6. A reconciliation of genome-scale metabolic network model of Zymomonas mobilis ZM4
  7. Systematically gap-filling the genome-scale model of CHO cells
  8. Manually curated genome-scale reconstruction of the metabolic network of Bacillus megaterium DSM319
  9. A metabolic network-based approach for developing feeding strategies for CHO cells to increase monoclonal antibody production
  10. The metabolic network model of primed/naive human embryonic stem cells underlines the importance of oxidation-reduction potential and tryptophan metabolism in primed pluripotency
  11. SAFEPPP: a Simple And Fast method to Find and analyze Extreme Points of a metabolic Phenotypic Phase Plane
  12. A genome-scale metabolic network reconstruction of extremely halophilic bacterium Salinibacter ruber
  13. Accounting for robustness in modeling signal transduction responses
  14. Three-way interaction model with switching mechanism as an effective strategy for tracing functionally-related genes
  15. Genome-Scale Metabolic Network Models of Bacillus Species Suggest that Model Improvement is Necessary for Biotechnological Applications
  16. A graph-based approach to analyze flux-balanced pathways in metabolic networks
  17. Applications of a metabolic network model of mesenchymal stem cells for controlling cell proliferation and differentiation
  18. Three-way interaction model to trace the mechanisms involved in Alzheimer’s disease transgenic mice
  19. Biomedical applications of cell- and tissue-specific metabolic network models
  20. Discovering missing reactions of metabolic networks by using gene co-expression data
  21. A sperm-specific proteome-scale metabolic network model identifies non-glycolytic genes for energy deficiency in asthenozoospermia
  22. A multiscale agent-based framework integrated with a constraint-based metabolic network model of cancer for simulating avascular tumor growth
  23. In silico prediction of specific pathways that regulate mesangial cell proliferation in IgA nephropathy
  24. A network biology approach to understanding the importance of chameleon proteins in human physiology and pathology
  25. A kidney-specific genome-scale metabolic network model for analyzing focal segmental glomerulosclerosis
  26. CAMWI: Detecting protein complexes using weighted clustering coefficient and weighted density
  27. PCD-GED: Protein complex detection considering PPI dynamics based on time series gene expression data
  28. On correlated reaction sets and coupled reaction sets in metabolic networks
  29. Evidence for the relationship between the regulatory effects of microRNAs and attack robustness of biological networks
  30. Reconstruction and validation of a constraint-based metabolic network model for bone marrow-derived mesenchymal stem cells
  31. Hierarchical organization of fluxes in Escherichia coli metabolic network: Using flux coupling analysis for understanding the physiological properties of metabolic genes
  32. Can scientific journals be classified based on their ‘citation profiles’?
  33. Genome-scale reconstruction of the metabolic network in Pseudomonas stutzeri A1501
  34. Reconstruction of phylogenetic trees of prokaryotes using maximal common intervals
  35. FCDECOMP: Decomposition of metabolic networks based on flux coupling relations
  36. A mathematical approach to emergent properties of metabolic networks: Partial coupling relations, hyperarcs and flux ratios
  37. Reconstruction of a generic metabolic network model of cancer cells
  38. Modeling the Differences in Biochemical Capabilities ofPseudomonasSpecies by Flux Balance Analysis: How Good Are Genome-Scale Metabolic Networks at Predicting the Differences?
  39. Evolutionarily conserved motifs and modules in mitochondrial protein–protein interaction networks
  40. Finding elementary flux modes in metabolic networks based on flux balance analysis and flux coupling analysis: application to the analysis of Escherichia coli metabolism
  41. Exploring biological processes involved in embryonic stem cell differentiation by analyzing proteomic data
  42. Studying the Relationship between Robustness against Mutations in Metabolic Networks and Lifestyle of Organisms
  43. On flux coupling analysis of metabolic subsystems
  44. Analysis of Metabolic Subnetworks by Flux Cone Projection
  45. Flux coupling analysis of metabolic networks is sensitive to missing reactions
  46. FFCA: a feasibility-based method for flux coupling analysis of metabolic networks
  47. Binding of Tris to Bacillus licheniformis α-Amylase Can Affect Its Starch Hydrolysis Activity
  48. Impact of residue accessible surface area on the prediction of protein secondary structures
  49. β-Sheet capping: Signals that initiate and terminate β-sheet formation
  50. A tale of two symmetrical tails: Structural and functional characteristics of palindromes in proteins
  51. Evolution of ‘Ligand-Diffusion Chreodes’ on Protein-Surface Models: A Genetic-Algorithm Study
  52. Adaptation of proteins to different environments: A comparison of proteome structural properties in Bacillus subtilis and Escherichia coli
  53. On the mechanism of apoptosis-inducing activity of human calprotectin: Zinc sequestration, induction of a signaling pathway, or something else?
  54. Conformational Study of Human Serum Albumin in Pre-denaturation Temperatures by Differential Scanning Calorimetry, Circular Dichroism and UV Spectroscopy
  55. Importance of RNA secondary structure information for yeast donor and acceptor splice site predictions by neural networks
  56. Application of β-lactamase-dependent prodrugs in clostridial-directed enzyme therapy (CDEPT): A proposal
  57. Modeling directed ligand passage toward enzyme active site by a ‘double cellular automata’ model
  58. On the identity of “citers”: Are papers promptly recognized by other investigators?
  59. Nanotechnology helps medicine: Nanoscale swimmers and their future applications
  60. Why major nonenzymatic glycation sites of human serum albumin are preferred to other residues?
  61. Correlations between genomic GC levels and optimal growth temperatures are not ‘robust’
  62. How reliable re-adjustment is: correspondence regarding A. Fuglsang, “The ‘effective number of codons’ revisited”