All Stories

  1. Scaling up self-assembly: bottom-up approaches to macroscopic particle organization

    Article • Soft Matter, January 2015, Royal Society of Chemistry

    Dr Steven R Little

  2. Positive charge of “sticky” peptides and proteins impedes release from negatively charged PLGA matrices

    Article • Journal of Materials Chemistry B, January 2015, Royal Society of Chemistry

    Dr Steven R Little

  3. One-step synthesis of fluorescently labelled, single-walled carbon nanotubes

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Dr Steven R Little

  4. One administration of a brimonidine tartrate delivery system replaces 56 eye drops in a rabbit model

    Article • Experimental Eye Research, August 2014, Elsevier

    Dr Steven R Little

  5. Restoring Host-Microbe HomeostasisviaSelective Chemoattraction of Tregs

    Article • Journal of Dental Research, July 2014, SAGE Publications

    Dr Steven R Little

  6. Artificial Thermalization and Self Assembly of Large Particles

    Article • Langmuir, July 2014, American Chemical Society (ACS)

    Dr Steven R Little

  7. In silico programming of degradable microparticles to hide and then reveal immunogenic payloads in vivo

    Article • Journal of Materials Chemistry B, January 2014, Royal Society of Chemistry

    Dr Steven R Little

  8. In vitro characterization of a controlled-release ocular insert for delivery of brimonidine tartrate

    Article • Acta Biomaterialia, January 2014, Elsevier

    Dr Steven R Little

  9. In VitroCharacterization of a Sustained-Release Formulation for Enfuvirtide

    Article • Antimicrobial Agents and Chemotherapy, December 2013, ASM Journals

    Dr Steven R Little

  10. Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes

    Article • Proceedings of the National Academy of Sciences, October 2013, Proceedings of the National Academy of Sciences

    Dr Steven R Little

  11. “Zero-Dimensional” Single-Walled Carbon Nanotubes

    Article • Angewandte Chemie International Edition, September 2013, Wiley

    Dr Steven R Little

  12. All-trans retinoic acid and rapamycin synergize with transforming growth factor- 1 to induce regulatory T cells but confer different migratory capacities

    Article • Journal of Leukocyte Biology, July 2013, Society for Leukocyte Biology

    Dr Steven R Little

  13. A Retrospective Mathematical Analysis of Controlled Release Design and Experimentation

    Article • Molecular Pharmaceutics, October 2012, American Chemical Society (ACS)

    Dr Steven R Little

  14. The Effect of Monomer Order on the Hydrolysis of Biodegradable Poly(lactic-co-glycolic acid) Repeating Sequence Copolymers

    Article • Journal of the American Chemical Society, September 2012, American Chemical Society (ACS)

    Dr Steven R Little

  15. Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo

    Article • Advanced Materials, July 2012, Wiley

    Dr Steven R Little

  16. Biomimetic Delivery with Micro- and Nanoparticles

    Article • Advanced Materials, April 2012, Wiley

    Dr Steven R Little

  17. Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells

    Article • Journal of Controlled Release, April 2012, Elsevier

    Dr Steven R Little

  18. A mathematical model for release of biologics from porous hollow fibers

    Article • Journal of Biomedical Materials Research Part A, January 2012, Wiley

    Dr Steven R Little

  19. Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand T fh cells and promote germinal center induction

    Article • Proceedings of the National Academy of Sciences, January 2012, Proceedings of the National Academy of Sciences

    Dr Steven R Little

  20. Interactions of End-functionalized Nanotubes with Lipid Vesicles: Spontaneous Insertion and Nanotube Self-Organization

    Article • Current Nanoscience, October 2011, Bentham Science Publishers

    Dr Steven R Little, Dr Meenakshi Dutt

  21. Patchy, Anisotropic Microspheres with Soft Protein Islets

    Article • Angewandte Chemie International Edition, August 2011, Wiley

    Dr Steven R Little

  22. Microparticulate systems for targeted drug delivery to phagocytes

    Article • Cell Cycle, July 2011, Taylor & Francis

    Dr Steven R Little

  23. Modeling the Self-Assembly of Lipids and Nanotubes in Solution: Forming Vesicles and Bicelles with Transmembrane Nanotube Channels

    Article • ACS Nano, May 2011, American Chemical Society (ACS)

    Dr Steven R Little, Dr Meenakshi Dutt

  24. Sequential Delivery of Basic Fibroblast Growth Factor and Platelet-Derived Growth Factor for Angiogenesis

    Article • Tissue Engineering Part A, May 2011, Mary Ann Liebert Inc

    Dr Steven R Little

  25. Forming transmembrane channels using end-functionalized nanotubes

    Article • Nanoscale, January 2011, Royal Society of Chemistry

    Dr Steven R Little, Dr Meenakshi Dutt

  26. A “tool box” for rational design of degradable controlled release formulations

    Article • Journal of Materials Chemistry, January 2011, Royal Society of Chemistry

    Dr Steven R Little

  27. Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis

    Article • Biomaterials, October 2010, Elsevier

    Dr Steven R Little

  28. Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis

    Article • BioMedical Engineering OnLine, September 2010, Springer Science + Business Media

    Dr Steven R Little

  29. Augmentation of Therapeutic Efficacy in Drug-Resistant Tumor Models Using Ceramide Coadministration in Temporal-Controlled Polymer-Blend Nanoparticle Delivery Systems

    Article • The AAPS Journal, February 2010, American Association of Pharmaceutical Scientists (AAPS)

    Dr Steven R Little

  30. Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres

    Article • Journal of Controlled Release, January 2010, Elsevier

    Dr Steven R Little

  31. A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices

    Article • Biomaterials, March 2009, Elsevier

    Dr Steven R Little

  32. Delivery of rapamycin to dendritic cells using degradable microparticles

    Article • Journal of Controlled Release, February 2009, Elsevier

    Dr Steven R Little

  33. In vitro and In vivo studies of local arterial gene delivery and transfection using lipopolyplexes-embedded stents

    Article • Journal of Biomedical Materials Research Part A, January 2009, Wiley

    Dr Steven R Little

  34. Biodistribution and Pharmacokinetic Analysis of Paclitaxel and Ceramide Administered in Multifunctional Polymer-Blend Nanoparticles in Drug Resistant Breast Cancer Model

    Article • Molecular Pharmaceutics, July 2008, American Chemical Society (ACS)

    Dr Steven R Little

  35. Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells

    Article • Cancer Chemotherapy and Pharmacology, July 2008, Springer Science + Business Media

    Dr Steven R Little

  36. Poly(β-amino ester) and Cationic Phospholipid-Based Lipopolyplexes for Gene Delivery and Transfection in Human Aortic Endothelial and Smooth Muscle Cells

    Article • Biomacromolecules, February 2008, American Chemical Society (ACS)

    Dr Steven R Little

  37. Polymers for intracellular delivery of nucleic acids

    Article • Journal of Materials Chemistry, January 2008, Royal Society of Chemistry

    Dr Steven R Little

  38. A simple model framework for the prediction of controlled release from bulk eroding polymer matrices

    Article • Journal of Materials Chemistry, January 2008, Royal Society of Chemistry

    Dr Steven R Little

  39. Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice

    Article • Proceedings of the National Academy of Sciences, March 2007, Proceedings of the National Academy of Sciences

    Dr Steven R Little

  40. Synthesis of Poly(β-amino ester)s with Thiol-Reactive Side Chains for DNA Delivery

    Article • Journal of the American Chemical Society, September 2006, American Chemical Society (ACS)

    Dr Steven R Little

  41. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model

    Article • Cancer Chemotherapy and Pharmacology, July 2006, Springer Science + Business Media

    Dr Steven R Little

  42. Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies

    Article • Pharmaceutical Research, November 2005, Springer Science + Business Media

    Dr Steven R Little

  43. Poly(ester-anhydride):poly(β-amino ester) micro- and nanospheres: DNA encapsulation and cellular transfection

    Article • International Journal of Pharmaceutics, November 2005, Elsevier

    Dr Steven R Little

  44. A Family of Hierarchically Self-Assembling Linear-Dendritic Hybrid Polymers for Highly Efficient Targeted Gene Delivery

    Article • Angewandte Chemie International Edition, October 2005, Wiley

    Dr Steven R Little

  45. Formulation and characterization of poly (β amino ester) microparticles for genetic vaccine delivery

    Article • Journal of Controlled Release, October 2005, Elsevier

    Dr Steven R Little

  46. Poly(ethylene oxide)-Modified Poly(β-amino ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs. 1. In Vitro Evaluations

    Article • Molecular Pharmaceutics, August 2005, American Chemical Society (ACS)

    Dr Steven R Little

  47. Gene Therapy and Gene Delivery Systems

    Article • January 2005

    Dr Steven R Little

  48. pH-Triggered Microparticles for Peptide Vaccination

    Article • The Journal of Immunology, November 2004, The American Association of Immunologists

    Dr Steven R Little

  49. pH-Triggered Microparticles for Peptide Vaccination

    Article • The Journal of Immunology, August 2004, The American Association of Immunologists

    Dr Steven R Little

  50. Poly-β amino ester-containing microparticles enhance the activity of nonviral genetic vaccines

    Article • Proceedings of the National Academy of Sciences, June 2004, Proceedings of the National Academy of Sciences

    Dr Steven R Little