All Stories

  1. Is rapamycin a rapalog?

    Article • Nutrition and Healthy Aging, April 2019, IOS Press

    Dudley Lamming

  2. Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms

    Article • The FASEB Journal, June 2018, Federation of American Societies For Experimental Biology (FASEB)

    Dudley Lamming

  3. Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice

    Article • Nutrition and Healthy Aging, December 2017, IOS Press

    Dudley Lamming

  4. Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

    Article • The FASEB Journal, June 2017, Federation of American Societies For Experimental Biology (FASEB)

    Dudley Lamming

  5. mTORC2 Puts Its Shoulder to Krebs’ Wheel

    Article • Molecular Cell, September 2016, Elsevier

    Dudley Lamming

  6. Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

    Article • Cell Reports, July 2016, Elsevier

    Dudley Lamming

  7. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

    Article • Aging Cell, June 2016, Wiley

    Dudley Lamming

  8. Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced K ATP Channel Activity

    Article • Diabetes, June 2016, American Diabetes Association

    Dudley Lamming

  9. The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

    Article • Cell Metabolism, June 2016, Elsevier

    Dudley Lamming

  10. Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

    Article • The Journals of Gerontology Series A, May 2016, Oxford University Press (OUP)

    Dudley Lamming

  11. Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

    Article • The Journals of Gerontology Series A, April 2016, Oxford University Press (OUP)

    Dudley Lamming

  12. Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond

    Article • Cold Spring Harbor Perspectives in Medicine, April 2016, Cold Spring Harbor Laboratory Press

    Dudley Lamming

  13. ID: 21: ALTERNATIVE RAPAMYCIN TREATMENT REGIMENS MITIGATE THE IMPACT OF RAPAMYCIN ON GLUCOSE HOMEOSTASIS AND THE IMMUNE SYSTEM, AND EXTENDS LIFESPAN

    Article • Journal of Investigative Medicine, March 2016, BMJ

    Dudley Lamming

  14. ID: 78: IMPROVING GLYCEMIC CONTROL THROUGH REDUCTION OF SPECIFIC DIETARY AMINO ACIDS

    Article • Journal of Investigative Medicine, March 2016, BMJ

    Dudley Lamming

  15. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

    Article • Nature, March 2016, Nature

    Dudley Lamming

  16. Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

    Article • Diabetes, February 2016, American Diabetes Association

    Dudley Lamming

  17. Regulation of Hepatic Metabolism by the Mechanistic Target of Rapamycin

    Article • December 2015, Springer Science + Business Media

    Dudley Lamming

  18. Sex‐ and tissue‐specific changes in mTOR signaling with age in C57 BL /6J mice

    Article • Aging Cell, November 2015, Wiley

    Dudley Lamming

  19. Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

    Article • Aging Cell, October 2015, Wiley

    Dudley Lamming

  20. Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

    Article • Oncotarget, October 2015, Impact Journals, LLC

    Dudley Lamming

  21. Hot topics at the intersection of aging and energetics: Diabetes/insulin resistance, Sirtuins, and the Microbiome

    Article • F1000Research, October 2014, Faculty of 1000, Ltd.

    Dudley Lamming

  22. Metabolic Effects of Caloric Restriction

    Article • October 2014, Wiley

    Dudley Lamming

  23. mTORC2 takes the longevity stAGE

    Article • Oncotarget, September 2014, Impact Journals, LLC

    Dudley Lamming

  24. Rapamycin-induced metabolic defects are reversible in both lean and obese mice

    Article • Aging, September 2014, Impact Journals, LLC

    Dudley Lamming

  25. Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan

    Article • Aging Cell, July 2014, Wiley

    Dudley Lamming

  26. RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

    Article • Developmental Cell, May 2014, Elsevier

    Dudley Lamming

  27. The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

    Article • Science Signaling, February 2014, American Association for the Advancement of Science

    Dudley Lamming

  28. Diminished mTOR signaling: a common mode of action for endocrine longevity factors

    Article • SpringerPlus, January 2014, Springer Science + Business Media

    Dudley Lamming

  29. Aging

    Article • January 2014, Elsevier

    Dudley Lamming

  30. The TSC-mTOR pathway regulates macrophage polarization

    Article • Nature Communications, November 2013, Nature

    Dudley Lamming

  31. A Central Role for mTOR in Lipid Homeostasis

    Article • Cell Metabolism, October 2013, Elsevier

    Dudley Lamming

  32. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

    Article • The FASEB Journal, September 2013, Federation of American Societies For Experimental Biology (FASEB)

    Dudley Lamming

  33. Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

    Article • Aging, July 2013, Impact Journals, LLC

    Dudley Lamming

  34. Young and old genetically heterogeneous HET 3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

    Article • Aging Cell, June 2013, Wiley

    Dudley Lamming

  35. Calorie restriction in humans inhibits the PI 3 K / AKT pathway and induces a younger transcription profile

    Article • Aging Cell, June 2013, Wiley

    Dudley Lamming

  36. Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

    Article • Science, March 2013, American Association for the Advancement of Science

    Dudley Lamming

  37. Rapalogs and mTOR inhibitors as anti-aging therapeutics

    Article • Journal of Clinical Investigation, March 2013, American Society for Clinical Investigation

    Dudley Lamming

  38. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

    Article • Nature, May 2012, Nature

    Dudley Lamming

  39. TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

    Article • Cell Metabolism, May 2012, Elsevier

    Dudley Lamming

  40. Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

    Article • Science, March 2012, American Association for the Advancement of Science

    Dudley Lamming

  41. Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

    Article • Frontiers in Genetics, January 2012, Frontiers

    Dudley Lamming

  42. Pharmacologic Means of Extending Lifespan

    Article • Journal of Clinical & Experimental Pathology, January 2012, OMICS Publishing Group

    Dudley Lamming

  43. A Radical Role for TOR in Longevity

    Article • Cell Metabolism, June 2011, Elsevier

    Dudley Lamming

  44. Regulation of TOR Signaling in Mammals

    Article • January 2010, Elsevier

    Dudley Lamming

  45. MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

    Article • PLoS Biology, October 2007, PLOS

    Dudley Lamming

  46. Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

    Article • Cell, September 2007, Elsevier

    Dudley Lamming

  47. HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction

    Article • Science, September 2005, American Association for the Advancement of Science

    Dudley Lamming

  48. Small molecules that regulate lifespan: evidence for xenohormesis

    Article • Molecular Microbiology, July 2004, Wiley

    Dudley Lamming

  49. CHAPTER 14. Extending Lifespan by Inhibiting the Mechanistic Target of Rapamycin (mTOR)

    Article • Royal Society of Chemistry

    Dudley Lamming