All Stories

  1. Crystal structure of Qa-1a with bound Qa-1 determinant modifier peptide

    Article • PLoS ONE, August 2017, PLOS

    Dirk Zajonc

  2. Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

    Article • Scientific Reports, June 2017, Nature

    Dirk Zajonc

  3. Autoreactivity to Sulfatide by Human Invariant NKT Cells

    Article • The Journal of Immunology, May 2017, The American Association of Immunologists

    Dirk Zajonc

  4. N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death

    Article • Cell Death and Differentiation, February 2017, Nature

    Dirk Zajonc

  5. Unconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01

    Article • Journal of Biological Chemistry, February 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dirk Zajonc

  6. Antibody Recognition of Immunodominant Vaccinia Virus Envelope Proteins

    Article • January 2017, Springer Science + Business Media

    Dirk Zajonc

  7. Structure of HLA-A2:01 with peptide Y16R

    Article • December 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  8. Structure of HLA-A2:01 with peptide G11N

    Article • December 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  9. Structure of HLA-A2:01 with peptide Y9L

    Article • December 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  10. Structure of HLA-A2:01 with peptide Y10L

    Article • December 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  11. Structure of HLA-A2:01 with peptide G13E

    Article • December 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  12. Structure of HLA-A2:01 with peptide G9L

    Article • November 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  13. Structure of HLA-A2:01 with the 12-mer peptide F12K

    Article • July 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  14. The CD1 family: serving lipid antigens to T cells since the Mesozoic era

    Article • Immunogenetics, July 2016, Springer Science + Business Media

    Dirk Zajonc

  15. Crystal structure of mouse CD1d in complex with the p99p lipopeptide

    Article • March 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  16. Crystal structure of the mouse CD1d in complex with the p99 peptide

    Article • March 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  17. Structure of an α-Helical Peptide and Lipopeptide Bound to the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule CD1d

    Article • Journal of Biological Chemistry, March 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dirk Zajonc

  18. Structure of the murine Fab 1G6 bound to the vaccinia virus A27 peptide 31-40

    Article • March 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  19. Structure of the murine antibody Fab 8E3 bound to the vaccinia virus A27 peptide 101-110

    Article • March 2016, Protein Data Bank, Rutgers University

    Dirk Zajonc

  20. Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox

    Article • Journal of Virology, February 2016, ASM Journals

    Dirk Zajonc

  21. Toxoplasma gondiipeptide ligands open the gate of the HLA class I binding groove

    Article • eLife, January 2016, eLife

    Dirk Zajonc

  22. Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer

    Article • PLoS Pathogens, September 2015, PLOS

    Dirk Zajonc

  23. Recognition of Microbial Glycolipids by Natural Killer T Cells

    Article • Frontiers in Immunology, August 2015, Frontiers

    Dirk Zajonc

  24. Synthesis of C-5″ and C-6″-modified α-GalCer analogues as iNKT-cell agonists

    Article • Bioorganic & Medicinal Chemistry, July 2015, Elsevier

    Dirk Zajonc

  25. Crystal structure of the mCD1d/DB06-1/iNKTCR ternary complex

    Article • July 2015, Protein Data Bank, Rutgers University

    Dirk Zajonc

  26. A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production

    Article • The Journal of Immunology, June 2015, The American Association of Immunologists

    Dirk Zajonc

  27. Crystal structure of the mCD1d/NC-aGC/iNKTCR ternary complex

    Article • June 2015, Protein Data Bank, Rutgers University

    Dirk Zajonc

  28. Crystal structure of the mCD1d/GCK152/iNKTCR ternary complex

    Article • May 2015, Protein Data Bank, Rutgers University

    Dirk Zajonc

  29. Crystal structure of the mCD1d/7DW8-5/iNKTCR ternary complex

    Article • May 2015, Protein Data Bank, Rutgers University

    Dirk Zajonc

  30. Crystal structure of the mCD1d/EF77/iNKTCR ternary complex

    Article • May 2015, Protein Data Bank, Rutgers University

    Dirk Zajonc

  31. Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E

    Article • PLoS Pathogens, December 2014, PLOS

    Dirk Zajonc

  32. The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian α-Linked Glycosylceramides

    Article • Immunity, November 2014, Elsevier

    Dirk Zajonc

  33. Structure of mouse CD1d in complex with dioleoyl-phosphatidic acid

    Article • October 2014, Protein Data Bank, Rutgers University

    Dirk Zajonc

  34. The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian α-Linked Glycosylceramides

    Article • Immunity, October 2014, Elsevier

    Dirk Zajonc

  35. Recognition of Lysophosphatidylcholine by Type II NKT Cells and Protection from an Inflammatory Liver Disease

    Article • The Journal of Immunology, September 2014, The American Association of Immunologists

    Dirk Zajonc

  36. Vaccinia L1/M12B9-Fab complex

    Article • August 2014, Protein Data Bank, Rutgers University

    Dirk Zajonc

  37. Structure of murine IgG2b A2C7-Fab in complex with vaccinia antigen A33R at the resolution of 2.3 Angstroms

    Article • August 2014, Protein Data Bank, Rutgers University

    Dirk Zajonc

  38. Structure of murine IgG2a A27D7-Fab in complex with vaccinia antigen A33R at the resolution of 1.6 Angstroms

    Article • August 2014, Protein Data Bank, Rutgers University

    Dirk Zajonc

  39. Structure of murine IgG2a A20G2-Fab in complex with vaccinia antigen A33R at the resolution of 2.9 Angstroms

    Article • July 2014, Protein Data Bank, Rutgers University

    Dirk Zajonc

  40. Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

    Article • The Journal of Experimental Medicine, June 2014, Rockefeller University Press

    Dirk Zajonc

  41. Using a Combined Computational-Experimental Approach to Predict Antibody-Specific B Cell Epitopes

    Article • Structure, April 2014, Elsevier

    Dirk Zajonc

  42. Structure of Human Cytomegalovirus Immune Modulator UL141

    Article • February 2014, Protein Data Bank, Rutgers University

    Dirk Zajonc

  43. The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding

    Article • Acta Crystallographica Section D Biological Crystallography, February 2014, International Union of Crystallography

    Dirk Zajonc

  44. Helicobacter pylori Cholesteryl α-Glucosides Contribute to Its Pathogenicity and Immune Response by Natural Killer T Cells

    Article • PLoS ONE, December 2013, PLOS

    Dirk Zajonc

  45. A γδ T‐cell glimpse of glycolipids

    Article • Immunology and Cell Biology, November 2013, Wiley

    Dirk Zajonc

  46. Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex

    Article • September 2013, Protein Data Bank, Rutgers University

    Dirk Zajonc

  47. Structure of the mouse CD1d-4ClPhC-alpha-GalCer-iNKT TCR complex

    Article • August 2013, Protein Data Bank, Rutgers University

    Dirk Zajonc

  48. A 'GEM' of a cell

    Article • Nature Immunology, June 2013, Springer Science + Business Media

    Dirk Zajonc

  49. Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2

    Article • April 2013, Protein Data Bank, Rutgers University

    Dirk Zajonc

  50. Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral Defenses

    Article • Cell Host & Microbe, March 2013, Elsevier

    Dirk Zajonc

  51. Crystal structure of bovine CD1d with bound C12-di-sulfatide

    Article • November 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  52. Crystal structure of bovine CD1d with bound C16:0-alpha-galactosyl ceramide

    Article • November 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  53. Crystal Structures of Bovine CD1d Reveal Altered αGalCer Presentation and a Restricted A’ Pocket Unable to Bind Long-Chain Glycolipids

    Article • PLoS ONE, October 2012, PLOS

    Dirk Zajonc

  54. Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells

    Article • Immunological Reviews, October 2012, Wiley

    Dirk Zajonc

  55. Phage display generation of a novel human anti-CD1A monoclonal antibody with potent cytolytic activity

    Article • British Journal of Haematology, August 2012, Wiley

    Dirk Zajonc

  56. Crystal structure of the Hy19.3 type II NKT TCR

    Article • July 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  57. Crystal structure of the mouse CD1d-lysosulfatide-Hy19.3 TCR complex

    Article • July 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  58. Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens

    Article • Nature Immunology, July 2012, Nature

    Dirk Zajonc

  59. Vaccinia D8L ectodomain structure

    Article • June 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  60. Fab structure of anti-Vaccinia virus D8L antigen mouse IgG2a LA5

    Article • June 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  61. Vaccinia virus D8L IMV envelope protein in complex with Fab of murine IgG2a LA5

    Article • June 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  62. Crystal structure of the LDL receptor tail in complex with autosomal recessive hypercholesterolemia PTB domain

    Article • April 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  63. Structure of the mouse CD1d-HS44-iNKT TCR complex

    Article • February 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  64. Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells

    Article • Annals of the New York Academy of Sciences, February 2012, Wiley

    Dirk Zajonc

  65. Structure of the mouse CD1d-SMC124-iNKT TCR complex

    Article • February 2012, Protein Data Bank, Rutgers University

    Dirk Zajonc

  66. Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy

    Article • Journal of Clinical Investigation, January 2012, American Society for Clinical Investigation

    Dirk Zajonc

  67. Glycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T Cells

    Article • Chemistry & Biology, December 2011, Elsevier

    Dirk Zajonc

  68. Structure of the mouse CD1d-Glc-DAG-s2-iNKT TCR complex

    Article • November 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  69. Structural Basis for the Recognition of C20:2-αGalCer by the Invariant Natural Killer T Cell Receptor-like Antibody L363

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dirk Zajonc

  70. Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex

    Article • November 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  71. Unique Interplay between Sugar and Lipid in Determining the Antigenic Potency of Bacterial Antigens for NKT Cells

    Article • PLoS Biology, November 2011, PLOS

    Dirk Zajonc

  72. Crystal structure of the mouse CD1d-Glc-DAG-s2 complex

    Article • September 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  73. Structure of the self-antigen iGb3 bound to mouse CD1d and in complex with the iNKT TCR

    Article • August 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  74. Structure of the mouse CD1d-NU-alpha-GalCer-iNKT TCR complex

    Article • June 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  75. Structure of the mouse CD1d-alpha-C-GalCer-iNKT TCR complex

    Article • June 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  76. Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex

    Article • June 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  77. Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

    Article • The EMBO Journal, May 2011, Wiley

    Dirk Zajonc

  78. Crystal structure of Cardiolipin bound to mouse CD1D

    Article • March 2011, Protein Data Bank, Rutgers University

    Dirk Zajonc

  79. Divergent synthetic approach to 6′′-modified α-GalCer analogues

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Dirk Zajonc

  80. IEDB-3D: structural data within the immune epitope database

    Article • Nucleic Acids Research, October 2010, Oxford University Press (OUP)

    Dirk Zajonc

  81. The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode

    Article • The Journal of Experimental Medicine, October 2010, Rockefeller University Press

    Dirk Zajonc

  82. Recognition of Glycolipid Antigen by iNKT Cell TCR

    Article • September 2010, Protein Data Bank, Rutgers University

    Dirk Zajonc

  83. Recognition of a Glycolipid Antigen by the iNKT Cell TCR

    Article • September 2010, Protein Data Bank, Rutgers University

    Dirk Zajonc

  84. Synthesis and Evaluation of Amino-Modified α-GalCer Analogues

    Article • Organic Letters, July 2010, American Chemical Society (ACS)

    Dirk Zajonc

  85. Crystal structure of bovine CD1b3 with endogenously bound ligands

    Article • June 2010, Protein Data Bank, Rutgers University

    Dirk Zajonc

  86. Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor

    Article • Journal of Biological Chemistry, March 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dirk Zajonc

  87. Crystal Structure of chicken CD1-1

    Article • February 2010, Protein Data Bank, Rutgers University

    Dirk Zajonc

  88. Conservation of CD1 protein expression patterns in the chicken

    Article • Developmental & Comparative Immunology, February 2010, Elsevier

    Dirk Zajonc

  89. Structure of mCD1d with bound glycolipid BbGL-2c from Borrelia burgdorferi

    Article • January 2010, Protein Data Bank, Rutgers University

    Dirk Zajonc

  90. Structure of mCD1d with bound glycolipid BbGL-2f from Borrelia burgdorferi

    Article • January 2010, Protein Data Bank, Rutgers University

    Dirk Zajonc

  91. Structural Basis for Lipid-Antigen Recognition in Avian Immunity

    Article • The Journal of Immunology, January 2010, The American Association of Immunologists

    Dirk Zajonc

  92. Optimizing the iNKT Cell Dependent Antitumor Effect Using an Altered Glycolipid

    Article • Clinical Immunology, January 2010, Elsevier

    Dirk Zajonc

  93. Crystal structure of the alpha-galactosylceramide analog OCH in complex with mouse CD1d

    Article • December 2009, Protein Data Bank, Rutgers University

    Dirk Zajonc

  94. Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells

    Article • The Journal of Immunology, November 2009, The American Association of Immunologists

    Dirk Zajonc

  95. Synthesis of Dideoxymycobactin Antigens Presented by CD1a Reveals T Cell Fine Specificity for Natural Lipopeptide Structures

    Article • Journal of Biological Chemistry, July 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dirk Zajonc

  96. Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells

    Article • Immunological Reviews, July 2009, Wiley

    Dirk Zajonc

  97. Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants

    Article • Molecular Immunology, April 2009, Elsevier

    Dirk Zajonc

  98. Polyclonal IgE Induces Mast Cell Survival and Cytokine Production

    Article • Allergology International, January 2009, Japanese Society of Allergology

    Dirk Zajonc

  99. Structure of chicken CD1-2 with bound fatty acid

    Article • November 2008, Protein Data Bank, Rutgers University

    Dirk Zajonc

  100. pH-Dependent Interdomain Tethers of CD1b Regulate Its Antigen Capture

    Article • Immunity, June 2008, Elsevier

    Dirk Zajonc

  101. Two canine CD1a proteins are differentially expressed in skin

    Article • Immunogenetics, May 2008, Springer Science + Business Media

    Dirk Zajonc

  102. Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids

    Article • Journal of Molecular Biology, April 2008, Elsevier

    Dirk Zajonc

  103. Structure of the mouse invariant NKT cell receptor Valpha14

    Article • April 2008, Protein Data Bank, Rutgers University

    Dirk Zajonc

  104. Structure of the endogenous iNKT cell ligand iGb3 bound to mCD1d

    Article • April 2008, Protein Data Bank, Rutgers University

    Dirk Zajonc

  105. Mycobacterial lipoglycan presentation by CD1d

    Article • September 2006, Protein Data Bank, Rutgers University

    Dirk Zajonc

  106. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria

    Article • Nature Immunology, August 2006, Nature

    Dirk Zajonc

  107. Role of lipid trimming and CD1 groove size in cellular antigen presentation

    Article • The EMBO Journal, June 2006, Wiley

    Dirk Zajonc

  108. Structure of a microbial glycosphingolipid bound to mouse CD1d

    Article • March 2006, Protein Data Bank, Rutgers University

    Dirk Zajonc

  109. Structural basis of sulfatide presentation by mouse CD1d

    Article • December 2005, Protein Data Bank, Rutgers University

    Dirk Zajonc

  110. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity

    Article • The Journal of Experimental Medicine, November 2005, Rockefeller University Press

    Dirk Zajonc

  111. Structure of a highly potent short-chain galactosyl ceramide agonist bound to CD1D

    Article • July 2005, Protein Data Bank, Rutgers University

    Dirk Zajonc

  112. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor

    Article • Nature Immunology, July 2005, Nature

    Dirk Zajonc

  113. T-cell activation by lipopeptide antigens

    Article • Current Opinion in Immunology, June 2005, Elsevier

    Dirk Zajonc

  114. Anatomy of CD1–lipid antigen complexes

    Article • Nature Reviews Immunology, May 2005, Springer Science + Business Media

    Dirk Zajonc

  115. Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide

    Article • March 2005, Protein Data Bank, Rutgers University

    Dirk Zajonc

  116. CD1 assembly and the formation of CD1–antigen complexes

    Article • Current Opinion in Immunology, February 2005, Elsevier

    Dirk Zajonc

  117. Molecular Mechanism of Lipopeptide Presentation by CD1a

    Article • Immunity, February 2005, Elsevier

    Dirk Zajonc

  118. Crystal Structure of CD1a in Complex with a Sulfatide

    Article • August 2003, Protein Data Bank, Rutgers University

    Dirk Zajonc

  119. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å

    Article • Nature Immunology, June 2003, Nature

    Dirk Zajonc

  120. ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae

    Article • FEBS Journal, August 2002, Wiley

    Dirk Zajonc

  121. Fatty acid elongation in yeast. Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants

    Article • FEBS Journal, March 1998, Wiley

    Dirk Zajonc

  122. Architecture of CD1 Proteins

    Article • Springer Science + Business Media

    Dirk Zajonc