All Stories

  1. CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule

    Article • Integrative Biology, January 2015, Oxford University Press (OUP)

    Professor Fatih Uckun

  2. CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells

    Article • Integrative Biology, January 2014, Oxford University Press (OUP)

    Professor Fatih Uckun

  3. Incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia

    Article • Haematologica, December 2013, Ferrata Storti Foundation (Haematologica)

    Professor Fatih Uckun

  4. Constitutive Function of the Ikaros Transcription Factor in Primary Leukemia Cells from Pediatric Newly Diagnosed High-Risk and Relapsed B-precursor ALL Patients

    Article • PLoS ONE, November 2013, PLOS

    Professor Fatih Uckun

  5. Regulatory Phosphorylation of Ikaros by Bruton's Tyrosine Kinase

    Article • PLoS ONE, August 2013, PLOS

    Professor Fatih Uckun

  6. Supramolecular Self‐Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF‐α siRNA against Systemic Inflammation

    Article • Angewandte Chemie, April 2013, Wiley

    Professor Fatih Uckun, Professor Haoyu Tang

  7. Monoclonal Antibodies in Oncology

    Article • April 2013, Future Medicine

    Professor Fatih Uckun

  8. Protein kinase inhibitors against malignant lymphoma

    Article • Expert Opinion on Pharmacotherapy, March 2013, Informa Healthcare

    Professor Fatih Uckun

  9. Novel Bruton's tyrosine kinase inhibitors currently in development

    Article • OncoTargets and Therapy, March 2013, Taylor & Francis

    Professor Fatih Uckun

  10. Biotargeted nanomedicines for cancer: six tenets before you begin

    Article • Nanomedicine, February 2013, Future Medicine

    Professor Fatih Uckun

  11. Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A–PBX1 fusion gene expression in human Pre-B leukemia

    Article • Integrative Biology, September 2012, Oxford University Press (OUP)

    Professor Fatih Uckun

  12. Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS

    Article • Expert Opinion on Investigational Drugs, February 2012, Informa Healthcare

    Professor Fatih Uckun

  13. Stat3-Syk Molecular Complex as A Target for Anti-Cancer Nanomedicines

    Article • Journal of Nanomedicine & Nanotechnology, January 2012, OMICS Publishing Group

    Professor Fatih Uckun

  14. Stampidine as a Potent Epigenetic Silencer of Host HIV Dependency Factor Genes in HIV-Infected Cells

    Article • Journal of AIDS & Clinical Research, January 2012, OMICS Publishing Group

    Professor Fatih Uckun

  15. Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles

    Article • Journal of Analytical Oncology, January 2012, Lifescience Global

    Professor Fatih Uckun

  16. CD22 Exon 12 deletion is a characteristic genetic defect of therapy‐refractory clones in paediatric acute lymphoblastic leukaemia

    Article • British Journal of Haematology, October 2011, Wiley

    Professor Fatih Uckun

  17. Inducing apoptosis in chemotherapy‐resistant B‐lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti‐apoptotic unfolded protein response signalling network

    Article • British Journal of Haematology, April 2011, Wiley

    Professor Fatih Uckun

  18. Recombinant human CD19‐ligand protein as a potent anti‐leukaemic agent

    Article • British Journal of Haematology, February 2011, Wiley

    Professor Fatih Uckun

  19. Lipid Spheres as Attractive Nanoscale Drug Delivery Platforms for Cancer Therapy

    Article • Journal of Nanomedicine & Nanotechnology, January 2011, OMICS Publishing Group

    Professor Fatih Uckun

  20. JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia

    Article • Expert Review of Anticancer Therapy, January 2011, Taylor & Francis

    Professor Fatih Uckun

  21. Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity

    Article • Expert Opinion on Therapeutic Patents, September 2010, Informa Healthcare

    Professor Fatih Uckun

  22. Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas

    Article • Expert Review of Anticancer Therapy, September 2010, Taylor & Francis

    Professor Fatih Uckun

  23. Polo‐like‐kinase 1 (PLK1) as a molecular target to overcome SYK‐mediated resistance of B‐lineage acute lymphoblastic leukaemia cells to oxidative stress

    Article • British Journal of Haematology, February 2010, Wiley

    Professor Fatih Uckun

  24. Meta Analysis of Advanced Cancer Survival Data Using Lognormal Parametric Fitting: A Statistical Method to Identify Effective Treatment Protocols

    Article • Current Pharmaceutical Design, May 2007, Bentham Science Publishers

    Professor Fatih Uckun

  25. Bruton's tyrosine kinase prevents activation of the anti‐apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B‐cells and B‐cell precursors exposed to oxidative stress

    Article • British Journal of Haematology, January 2007, Wiley

    Professor Fatih Uckun

  26. Vinorelbine‐based salvage chemotherapy for therapy‐refractory aggressive leukaemias

    Article • British Journal of Haematology, October 2006, Wiley

    Professor Fatih Uckun

  27. Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft‐versus‐host disease (GVHD) in a murine allogeneic bone marrow transplantation model

    Article • British Journal of Haematology, August 2004, Wiley

    Professor Fatih Uckun

  28. Organic Phenyl Arsonic Acid Compounds with Potent Antileukemic Activity

    Article • ChemInform, May 2003, Wiley

    Professor Fatih Uckun

  29. Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia

    Article • Oncogene, April 2003, Springer Science + Business Media

    Professor Fatih Uckun

  30. Organic phenyl arsonic acid compounds with potent antileukemic activity

    Article • Bioorganic & Medicinal Chemistry Letters, February 2003, Elsevier

    Professor Fatih Uckun

  31. Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity

    Article • Expert Opinion on Investigational Drugs, December 2002, Informa Healthcare

    Professor Fatih Uckun

  32. Abnormalities of chromosome bands 15q13‐15 in childhood acute lymphoblastic leukemia

    Article • Cancer, February 2002, Wiley

    Professor Fatih Uckun

  33. Genomic Studies of the Spleen Protein Tyrosine Kinase Locus Reveal a Complex Promoter Structure and Several Genetic Variants

    Article • Leukemia & Lymphoma, January 2002, Taylor & Francis

    Professor Fatih Uckun

  34. CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4′-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: Structural Basis for Inactivation by Regioselective O-Demethylation

    Article • Drug Metabolism and Disposition, January 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Fatih Uckun

  35. Role of STAT6 in IgE Receptor/Fc RI-Mediated Late Phase Allergic Responses of Mast Cells

    Article • The Journal of Immunology, January 2002, The American Association of Immunologists

    Professor Fatih Uckun

  36. Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

    Article • Oncogene, July 2001, Springer Science + Business Media

    Professor Fatih Uckun

  37. Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL

    Article • Oncogene, May 2001, Springer Science + Business Media

    Professor Fatih Uckun

  38. Anticancer activity of synthetic analogues of the phorboxazoles

    Article • Bioorganic & Medicinal Chemistry Letters, May 2001, Elsevier

    Professor Fatih Uckun

  39. Prognostic significance of cytogenetic abnormalities of chromosome arm 12p in childhood acute lymphoblastic leukemia

    Article • Cancer, April 2000, Wiley

    Professor Fatih Uckun

  40. Prognostic significance of cytogenetic abnormalities of chromosome arm 12p in childhood acute lymphoblastic leukemia

    Article • Cancer, April 2000, Wiley

    Professor Fatih Uckun

  41. Stereocontrolled synthesis of a novel pharmacophore of the tubulin-depolymerizing marine natural product spongistatin

    Article • Tetrahedron Letters, March 2000, Elsevier

    Professor Fatih Uckun

  42. Clinical Pharmacokinetics of the CD19 Receptor‐Directed Tyrosine Kinase Inhibitor B43‐Genistein in Patients with B‐Lineage Lymphoid Malignancies

    Article • The Journal of Clinical Pharmacology, December 1999, Wiley

    Professor Fatih Uckun

  43. Targeting Janus Kinase 3 in Mast Cells Prevents Immediate Hypersensitivity Reactions and Anaphylaxis

    Article • Journal of Biological Chemistry, September 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Fatih Uckun

  44. Bruton's Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex

    Article • Journal of Biological Chemistry, January 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Fatih Uckun

  45. Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies

    Article • Cancer, November 1998, Wiley

    Professor Fatih Uckun

  46. Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies

    Article • Cancer, November 1998, Wiley

    Professor Fatih Uckun

  47. Role of Tyrosine Kinases in Induction of the c-junProto-oncogene in Irradiated B-lineage Lymphoid Cells

    Article • Journal of Biological Chemistry, July 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Fatih Uckun

  48. Production of Recombinant DTctGMCSF Fusion Toxin in a Baculovirus Expression Vector System for Biotherapy of GMCSF-Receptor Positive Hematologic Malignancies

    Article • Protein Expression and Purification, July 1998, Elsevier

    Professor Fatih Uckun

  49. Augmented Post-Induction Therapy for Children with High-Risk Acute Lymphoblastic Leukemia and a Slow Response to Initial Therapy

    Article • New England Journal of Medicine, June 1998, New England Journal of Medicine (NEJM/MMS)

    Professor Fatih Uckun

  50. Early response to therapy and outcome in childhood acute lymphoblastic leukemia

    Article • Cancer, November 1997, Wiley

    Professor Fatih Uckun

  51. Plant resistance to fungal infection induced by nontoxic pokeweed antiviral protein mutants

    Article • Nature Biotechnology, October 1997, Springer Science + Business Media

    Professor Fatih Uckun

  52. BTK as a Mediator of Radiation-Induced Apoptosis in DT-40 Lymphoma B Cells

    Article • Science, August 1996, American Association for the Advancement of Science

    Professor Fatih Uckun

  53. Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

    Article • Science, February 1995, American Association for the Advancement of Science

    Professor Fatih Uckun

  54. Allogeneic bone marrow transplantation for acute lymphoblastic leukaemia: risk factors and clinical outcome

    Article • British Journal of Haematology, January 1994, Wiley

    Professor Fatih Uckun

  55. IMMUNOTOXINS FOR THE TREATMENT OF LEUKAEMIA

    Article • British Journal of Haematology, November 1993, Wiley

    Professor Fatih Uckun

  56. Pretransplantation Burden of Leukemic Progenitor Cells as a Predictor of Relapse after Bone Marrow Transplantation for Acute Lymphoblastic Leukemia

    Article • New England Journal of Medicine, October 1993, New England Journal of Medicine (NEJM/MMS)

    Professor Fatih Uckun

  57. Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies

    Article • Nature, September 1990, Springer Science + Business Media

    Professor Fatih Uckun

  58. Regulation of Human B Cell Growth

    Article • January 1989, Springer Science + Business Media

    Professor Fatih Uckun

  59. Immunobiologic differences between normal and leukemic human B-cell precursors.

    Article • Proceedings of the National Academy of Sciences, November 1988, Proceedings of the National Academy of Sciences

    Professor Fatih Uckun