All Stories

  1. Towards the development of chromone-based MEK1/2 modulators

    Article • European Journal of Medicinal Chemistry, October 2014, Elsevier

    Professor Morten Grötli

  2. 8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide

    Article • Tetrahedron Letters, April 2014, Elsevier

    Professor Morten Grötli

  3. Application of a peptide-based assay to characterize inhibitors targeting protein kinases from yeast

    Article • Current Genetics, March 2014, Springer Science + Business Media

    Professor Morten Grötli, Professor Markus J Tamas

  4. A Single-Cell Study of a Highly Effective Hog1 Inhibitor for in Situ Yeast Cell Manipulation

    Article • Micromachines, February 2014, MDPI AG

    Professor Morten Grötli

  5. Synthesis and photophysical characterisation of new fluorescent triazole adenine analogues

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Morten Grötli

  6. Inhibition of MAPK Hog1 Results in Increased Hsp104 Aggregate Formation Probably through Elevated Arsenite Influx into the Cells, an Approach with Numerous Potential Applications

    Article • American Journal of Molecular Biology, January 2014, Scientific Research Publishing, Inc,

    Professor Morten Grötli

  7. Synthesis and photophysical characterization of 1- and 4-(purinyl)triazoles

    Article • Tetrahedron, October 2013, Elsevier

    Professor Morten Grötli

  8. Effect of MAPK Inhibitor on the Arsenite uptake by Aquaglyceroporin in Single Yeast Cells

    Article • January 2013, Optical Society of America (OSA)

    Professor Morten Grötli

  9. Design and evaluation of a microfluidic system for inhibition studies of yeast cell signaling

    Article • October 2012, SPIE

    Professor Morten Grötli

  10. Validation of regulated protein phosphorylation events in yeast by quantitative mass spectrometry analysis of purified proteins

    Article • PROTEOMICS, September 2012, Wiley

    Professor Morten Grötli

  11. Proline-mediated formation of novel chroman-4-one tetrahydropyrimidines

    Article • Tetrahedron, September 2012, Elsevier

    Professor Morten Grötli

  12. Determination of primary sequence specificity of Arabidopsis MAPKs MPK3 and MPK6 leads to identification of new substrates

    Article • Biochemical Journal, September 2012, Portland Press Ltd.

    Professor Morten Grötli, Professor Markus J Tamas

  13. Method for Activation and Recycling of Trityl Resins

    Article • The Journal of Organic Chemistry, August 2012, American Chemical Society (ACS)

    Professor Morten Grötli

  14. Solid‐Phase Synthesis of 5′‐O‐[N‐(Acyl)sulfamoyl]adenosine Derivatives

    Article • European Journal of Organic Chemistry, May 2012, Wiley

    Professor Morten Grötli

  15. Preparation of 3-Substituted-1-Isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET Kinase Inhibitors

    Article • Journal of Medicinal Chemistry, May 2012, American Chemical Society (ACS)

    Professor Morten Grötli

  16. Investigation, optimization and synthesis of sulfamoyloxy-linked aminoacyl-AMP analogues

    Article • Tetrahedron, February 2012, Elsevier

    Professor Morten Grötli

  17. Design, Synthesis, and Biological Evaluation of Chromone-Based p38 MAP Kinase Inhibitors

    Article • Journal of Medicinal Chemistry, September 2011, American Chemical Society (ACS)

    Fredrik Wallner, Professor Morten Grötli

  18. NMR-Based Substrate Analog Docking to Escherichia coli Peptidyl-tRNA Hydrolase

    Article • Journal of Molecular Biology, September 2011, Elsevier

    Professor Morten Grötli

  19. Design, Synthesis and Characterization of a Highly Effective Inhibitor for Analog-Sensitive (as) Kinases

    Article • PLoS ONE, June 2011, PLOS

    Professor Morten Grötli, Professor Corey Nislow

  20. Design, Synthesis, and Characterization of a Highly Effective Hog1 Inhibitor: A Powerful Tool for Analyzing MAP Kinase Signaling in Yeast

    Article • PLoS ONE, May 2011, PLOS

    Professor Morten Grötli, Professor Corey Nislow, Professor Markus J Tamas

  21. Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents

    Article • Bioorganic & Medicinal Chemistry, April 2011, Elsevier

    Professor Morten Grötli

  22. Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA

    Article • Nucleic Acids Research, January 2011, Oxford University Press (OUP)

    Professor Morten Grötli

  23. Positional Scanning Peptide Libraries for Kinase Substrate Specificity Determinations: Straightforward and Reproducible Synthesis Using Pentafluorophenyl Esters

    Article • Journal of Combinatorial Chemistry, July 2010, American Chemical Society (ACS)

    Fredrik Wallner, Professor Morten Grötli

  24. KHMDS Enhanced SmI2-Mediated Reformatsky Type α-Cyanation

    Article • Organic Letters, April 2010, American Chemical Society (ACS)

    Professor Morten Grötli

  25. Structural Influence on Radical Formation and Sensitizing Capacity of Alkylic Limonene Hydroperoxide Analogues in Allergic Contact Dermatitis

    Article • Chemical Research in Toxicology, February 2010, American Chemical Society (ACS)

    Professor Morten Grötli

  26. Synthesis of Chiral 1,4-Disubstituted-1,2,3-Triazole Derivatives from Amino Acids

    Article • Molecules, December 2009, MDPI AG

    Professor Morten Grötli

  27. Solid-Phase Peptide Synthesis in Water Using Microwave-Assisted Heating

    Article • Organic Letters, September 2009, American Chemical Society (ACS)

    Professor Morten Grötli

  28. Synthesis and Photophysical Characterisation of Fluorescent 8‐(1H‐1,2,3‐Triazol‐4‐yl)adenosine Derivatives

    Article • European Journal of Organic Chemistry, March 2009, Wiley

    Professor Morten Grötli

  29. Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation

    Article • The Journal of Organic Chemistry, March 2009, American Chemical Society (ACS)

    Professor Morten Grötli

  30. Synthesis of 3-(1,2,3-triazol-1-yl)- and 3-(1,2,3-triazol-4-yl)-substituted pyrazolo[3,4-d]pyrimidin-4-amines via click chemistry: potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Professor Morten Grötli

  31. Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitorsvia [3+2]-cycloaddition chemistry

    Article • New Journal of Chemistry, January 2009, Royal Society of Chemistry

    Professor Morten Grötli

  32. Enhanced microwave‐assisted method for on‐bead disulfide bond formation: Synthesis of α‐conotoxin MII

    Article • Biopolymers, November 2008, Wiley

    Professor Morten Grötli

  33. Carbon- and Oxygen-Centered Radicals Are Equally Important Haptens of Allylic Hydroperoxides in Allergic Contact Dermatitis

    Article • Chemical Research in Toxicology, July 2008, American Chemical Society (ACS)

    Professor Morten Grötli

  34. Synthesis and photophysical properties of novel cyclonucleosides—substituent effects on fluorescence emission

    Article • Tetrahedron, July 2008, Elsevier

    Professor Morten Grötli

  35. Microwave assisted synthesis of spiro-2,5-diketopiperazines

    Article • Tetrahedron, September 2007, Elsevier

    Professor Morten Grötli

  36. A practical synthesis of 2′-aminoacylamino-2′-deoxyadenosines

    Article • Tetrahedron, July 2007, Elsevier

    Professor Morten Grötli

  37. Synthesis of 3-Aminomethyl-2-aryl- 8-bromo-6-chlorochromones

    Article • Organic Letters, January 2007, American Chemical Society (ACS)

    Professor Morten Grötli

  38. Synthesis of Functionalized, Unsymmetrical 1,3,4,6-Tetrasubstituted 2,5-Diketopiperazines

    Article • The Journal of Organic Chemistry, December 2006, American Chemical Society (ACS)

    Professor Morten Grötli

  39. Microwave-Assisted Solid-Phase Synthesis of 2,5-Diketopiperazines:  Solvent and Resin Dependence

    Article • Journal of Combinatorial Chemistry, October 2006, American Chemical Society (ACS)

    Professor Morten Grötli

  40. Synthesis of 2,3,6,8-Tetrasubstituted Chromone Scaffolds

    Article • The Journal of Organic Chemistry, August 2006, American Chemical Society (ACS)

    Professor Morten Grötli

  41. Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating

    Article • Tetrahedron, July 2006, Elsevier

    Professor Morten Grötli

  42. Microwave-assisted synthesis of the Schöllkopf chiral auxiliaries: (3S)- and (3R)-3,6-dihydro-2,5-diethoxy-3-isopropyl-pyrazine

    Article • Tetrahedron Letters, July 2006, Elsevier

    Professor Morten Grötli

  43. A Scaffold Approach to 3,6,8-Trisubstituted Flavones

    Article • Synlett, April 2006, Thieme Publishing Group

    Professor Morten Grötli

  44. Discovering New Classes of Brugia malayi Asparaginyl-tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change

    Article • Journal of Computer-Aided Molecular Design, March 2006, Springer Science + Business Media

    Professor Morten Grötli

  45. Synthesis of adenosine-based fluorosides containing a novel heterocyclic ring system

    Article • Tetrahedron Letters, September 2005, Elsevier

    Professor Morten Grötli

  46. The Biotin Repressor: Modulation of Allostery by Corepressor Analogs

    Article • Journal of Molecular Biology, April 2004, Elsevier

    Professor Morten Grötli

  47. Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase

    Article • Molecular Cell, April 2003, Elsevier

    Professor Morten Grötli

  48. ChemInform Abstract: Physical Properties of Polyethylene Glycol (PEG)‐Based Resins for Solid‐Phase Organic Chemistry: A Comparison of PEG Crosslinked and PEG Grafted Resins.

    Article • ChemInform, September 2002, Wiley

    Professor Morten Grötli, Prof. Morten Meldal

  49. SPOCC-194, a New High Functional Group Density PEG-Based Resin for Solid-Phase Organic Synthesis

    Article • Journal of Combinatorial Chemistry, August 2002, American Chemical Society (ACS)

    Professor Morten Grötli, Prof. Morten Meldal

  50. Palladium on Carbon Encapsulated in POEPOP1500:  A Resin-Supported Catalyst for Hydrogenation Reactions

    Article • Organic Letters, December 2001, American Chemical Society (ACS)

    Professor Morten Grötli, Prof. Morten Meldal

  51. Solid-Phase Glycosylation of Peptide Templates and On-Bead MAS-NMR Analysis: Perspectives for Glycopeptide Libraries

    Article • Chemistry - A European Journal, August 2001, Wiley

    Professor Morten Grötli, Prof. Morten Meldal

  52. Diffusion of Reagents in Macrobeads

    Article • Journal of Combinatorial Chemistry, August 2001, American Chemical Society (ACS)

    Professor Morten Grötli, Prof. Morten Meldal

  53. A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase

    Article • Journal of Molecular Biology, June 2001, Elsevier

    Professor Morten Grötli

  54. ChemInform Abstract: Identification of Protease Inhibitors Using Biocompatible Resins and Library Synthesis

    Article • ChemInform, December 2000, Wiley

    Professor Morten Grötli, Prof. Morten Meldal

  55. Surfactant Mediated Cationic and Anionic Suspension Polymerization of PEG-Based Resins in Silicon Oil:  Beaded SPOCC 1500 and POEPOP 1500

    Article • Journal of Combinatorial Chemistry, November 2000, American Chemical Society (ACS)

    Professor Morten Grötli, Prof. Morten Meldal

  56. Crystallization and preliminary crystallographic analysis ofThermus thermophilusleucyl-tRNA synthetase and its complexes with leucine and a non-hydrolysable leucyl-adenylate analogue

    Article • Acta Crystallographica Section D Biological Crystallography, May 2000, International Union of Crystallography

    Professor Morten Grötli

  57. Physical Properties of Poly(ethylene glycol) (PEG)-Based Resins for Combinatorial Solid Phase Organic Chemistry:  A Comparison of PEG-Cross-Linked and PEG-Grafted Resins

    Article • Journal of Combinatorial Chemistry, January 2000, American Chemical Society (ACS)

    Professor Morten Grötli, Prof. Morten Meldal

  58. Towards peptide isostere libraries: aqueous aldol reactions on hydrophilic solid supports

    Article • Journal of the Chemical Society Perkin Transactions 1, January 2000, Royal Society of Chemistry

    Professor Morten Grötli, Prof. Morten Meldal

  59. HYDRA: A novel hydroxy and amine functionalised resin synthesised by reductive amination of PEG aldehyde and a polyamine

    Article • Journal of the Chemical Society Perkin Transactions 1, January 2000, Royal Society of Chemistry

    Professor Morten Grötli, Prof. Morten Meldal

  60. Single-bead structure elucidation. Requirements for analysis of combinatorial solid-phase libraries by Nanoprobe MAS-NMR spectroscopy

    Article • Journal of the Chemical Society Perkin Transactions 1, January 2000, Royal Society of Chemistry

    Professor Morten Grötli, Prof. Morten Meldal

  61. SPOCC:  A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase

    Article • Journal of the American Chemical Society, May 1999, American Chemical Society (ACS)

    Professor Morten Grötli, Prof. Morten Meldal

  62. 2′-O-(carbamoylmethyl)oligoribonucleotides

    Article • Tetrahedron, April 1999, Elsevier

    Professor Morten Grötli

  63. Identification of Protease Inhibitors Using Biocompatible Resins and Library Synthesis

    Article • January 1999, Springer Science + Business Media

    Professor Morten Grötli, Prof. Morten Meldal

  64. 2′-O-Propargyl oligoribonucleotides: Synthesis and hybridisation

    Article • Tetrahedron, May 1998, Elsevier

    Professor Morten Grötli, Ramon Eritja

  65. Solid-phase synthesis of branched RNA and branched DNA/RNA chimeras

    Article • Tetrahedron, August 1997, Elsevier

    Professor Morten Grötli, Ramon Eritja

  66. A simple method for the synthesis of 2′-O-alkylguanosine derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, February 1997, Elsevier

    Professor Morten Grötli, Ramon Eritja

  67. Protection of the guanine residue during synthesis of 2′-O-alkylguanosine derivatives

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1997, Royal Society of Chemistry

    Professor Morten Grötli

  68. Ether, Carbonate and Urethane Deoxynucleoside Derivatives as Prodrugs.

    Article • Acta Chemica Scandinavica, January 1996, Danish Chemical Society

    Professor Morten Grötli

  69. Lithofibrin. A New Remarkably Stable Substance Found in Renal Stones.

    Article • Acta Chemica Scandinavica, January 1996, Danish Chemical Society

    Professor Morten Grötli

  70. Synthesis of 2'-Allyl-2'-Deoxyribonucleosides by Radical Reactions.

    Article • Acta Chemica Scandinavica, January 1995, Danish Chemical Society

    Professor Morten Grötli

  71. Design and Synthesis of Novel Chromone Based Peptidomimetics

    Article • Springer Science + Business Media

    Professor Morten Grötli

  72. SPOCC resins: Polar and chemically inert resins for organic synthesis and library enzyme assays

    Article • Springer Science + Business Media

    Professor Morten Grötli, Prof. Morten Meldal

  73. Investigation of enzyme activity and inhibition in the interior of novel solid supports

    Article • Springer Science + Business Media

    Professor Morten Grötli, Prof. Morten Meldal