All Stories

  1. Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family
  2. Structural insights into the mechanisms and pharmacology of K2P potassium channels
  3. K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions
  4. Polynuclear Ruthenium Amines Inhibit K2P Channels via a “Finger in the Dam” Mechanism
  5. Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins
  6. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent
  7. A Calmodulin C-Lobe Ca 2+ -Dependent Switch Governs Kv7 Channel Function
  8. Global versus local mechanisms of temperature sensing in ion channels
  9. Cryo-EM structures of the TMEM16A calcium-activated chloride channel
  10. K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site
  11. Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation
  12. Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart
  13. Insights into the molecular foundations of electrical excitation
  14. Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels
  15. Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels
  16. Apo States of Calmodulin and CaBP1 Control CaV1 Voltage-Gated Calcium Channel Function through Direct Competition for the IQ Domain
  17. Structure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-Helix Complex Provides Insight into M Current Modulation