All Stories

  1. Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions

    Article • Pflügers Archiv - European Journal of Physiology, November 2013, Springer Science + Business Media

    PhD Daniel Khananshvili

  2. The C2B Domain Is the Primary Ca2+ Sensor in DOC2B: A Structural and Functional Analysis

    Article • Journal of Molecular Biology, November 2013, Elsevier

    PhD Daniel Khananshvili

  3. Population Shift Underlies Ca2+-induced Regulatory Transitions in the Sodium-Calcium Exchanger (NCX)

    Article • Journal of Biological Chemistry, June 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Daniel Khananshvili

  4. NCLX: The mitochondrial sodium calcium exchanger

    Article • Journal of Molecular and Cellular Cardiology, June 2013, Elsevier

    PhD Daniel Khananshvili

  5. SK4 Ca 2+ activated K + channel is a critical player in cardiac pacemaker derived from human embryonic stem cells

    Article • Proceedings of the National Academy of Sciences, April 2013, Proceedings of the National Academy of Sciences

    PhD Daniel Khananshvili

  6. The SLC8 gene family of sodium–calcium exchangers (NCX) – Structure, function, and regulation in health and disease

    Article • Molecular Aspects of Medicine, April 2013, Elsevier

    PhD Daniel Khananshvili

  7. Molecular Determinants of Allosteric Regulation in NCX Proteins

    Article • October 2012, Springer Science + Business Media

    PhD Daniel Khananshvili

  8. The Mitochondrial Na+/Ca2+ Exchanger Upregulates Glucose Dependent Ca2+ Signalling Linked to Insulin Secretion

    Article • PLoS ONE, October 2012, PLOS

    PhD Daniel Khananshvili

  9. G503 Is Obligatory for Coupling of Regulatory Domains in NCX Proteins

    Article • Biochemistry, September 2012, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  10. A Common Ca2+-Driven Interdomain Module Governs Eukaryotic NCX Regulation

    Article • PLoS ONE, June 2012, PLOS

    PhD Daniel Khananshvili

  11. Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants

    Article • Cell Calcium, June 2012, Elsevier

    PhD Daniel Khananshvili

  12. A Previously Unrecognized Conductance is a Critical New Player in the Pacemaker of Cardiomyocytes Derived from Human Embryonic Stem Cells

    Article • Biophysical Journal, January 2012, Elsevier

    PhD Daniel Khananshvili

  13. Proton-sensing Ca2+ Binding Domains Regulate the Cardiac Na+/Ca2+ Exchanger

    Article • Journal of Biological Chemistry, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Daniel Khananshvili

  14. The pH Sensitivity of the Cardiac Na+/Ca2+ Exchanger Depend on Calcium Binding Domains (CBD) of NCX1

    Article • Biophysical Journal, February 2011, Elsevier

    PhD Daniel Khananshvili

  15. Essential Role of the CBD1-CBD2 Linker in Slow Dissociation of Ca2+ from the Regulatory Two-domain Tandem of NCX1

    Article • Journal of Biological Chemistry, June 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Daniel Khananshvili

  16. NCLX is an essential component of mitochondrial Na + /Ca 2+ exchange

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    PhD Daniel Khananshvili

  17. Kinetic and Equilibrium Properties of Regulatory Calcium Sensors of NCX1 Protein

    Article • Journal of Biological Chemistry, January 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Daniel Khananshvili

  18. Direct Loading of the Purified Endogenous Inhibitor into the Cytoplasm of Patched Cardiomyocytes Blocks the Ion Currents and Calcium Transport through the NCX1 Protein

    Article • Biochemistry, May 2008, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  19. Effects of purified endogenous inhibitor of the Na+/Ca2+ exchanger on ouabain-induced arrhythmias in the atria and ventricle strips of guinea pig

    Article • European Journal of Pharmacology, December 2006, Elsevier

    PhD Daniel Khananshvili

  20. Single α-Domain Constructs of the Na+/Ca2+Exchanger, NCLX, Oligomerize To Form a Functional Exchanger

    Article • Biochemistry, September 2006, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  21. Purified endogenous inhibitor of the Na/Ca exchanger can enhance the cardiomyocytes contractility and calcium transients

    Article • Biochemical and Biophysical Research Communications, August 2006, Elsevier

    PhD Daniel Khananshvili

  22. Advanced procedures for separation and analysis of low molecular weight inhibitor (NCXIF) of the cardiac sodium–calcium exchanger

    Article • Biochemical and Biophysical Research Communications, November 2005, Elsevier

    PhD Daniel Khananshvili

  23. The low molecular weight inhibitor of NCX1 interacts with a cytosolic domain that differs from the ion-transport site of the Na/Ca exchanger

    Article • Biochemical and Biophysical Research Communications, November 2004, Elsevier

    PhD Daniel Khananshvili

  24. Inotropic and Lusitropic Effects Induced by the Inhibitory Factor of the Na/Ca Exchanger Are Not Mediated by the β-Adrenergic Activation

    Article • Journal of Cardiovascular Pharmacology, October 2004, Wolters Kluwer Health

    PhD Daniel Khananshvili

  25. The endogenous inhibitor of NCX1 does not resemble the properties of digitalis compound

    Article • Biochemical and Biophysical Research Communications, August 2003, Elsevier

    PhD Daniel Khananshvili

  26. An Unknown Endogenous Inhibitor of Na/Ca Exchange Can Enhance the Cardiac Muscle Contractility

    Article • Biochemical and Biophysical Research Communications, October 2000, Elsevier

    PhD Daniel Khananshvili

  27. Time-Resolved Monitoring of Electrogenic Na+−Ca2+Exchange in the Isolated Cardiac Sarcolemma Vesicles by Using a Rapid-Response Fluorescent Probe

    Article • Biochemistry, January 1999, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  28. Actions of myristyl-FRCRCFa, a cell-permeant blocker of the cardiac sarcolemmal Na-Ca exchanger, tested in rabbit ventricular myocytes

    Article • Pflügers Archiv - European Journal of Physiology, July 1998, Springer Science + Business Media

    PhD Daniel Khananshvili

  29. Inhibition of the cardiac sarcolemma (cell membrane) Na+-Ca2+ exchanger (NCX1) by peptide based blockers

    Article • Emerging Therapeutic Targets, July 1998, Informa Healthcare

    PhD Daniel Khananshvili

  30. The peptide ?FRCRCFa", dialysed intracellularly, inhibits the Na/Ca exchange in rabbit ventricular myocytes with high affinity

    Article • Pflügers Archiv - European Journal of Physiology, January 1997, Springer Science + Business Media

    PhD Daniel Khananshvili

  31. Kinetics and Mechanism: Modulation of Ion Transport in the Cardiac Sarcolemma Sodium‐Calcium Exchanger by Protons, Monovalent Ions, and Temperatureac

    Article • Annals of the New York Academy of Sciences, April 1996, Wiley

    PhD Daniel Khananshvili

  32. Rapid Interaction of FRCRCFa with the Cytosolic Side of the Cardiac Sarcolemma Na+−Ca2+ Exchanger Blocks the Ion Transport without Preventing the Binding of either Sodium or Calcium

    Article • Biochemistry, January 1996, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  33. Rate-limiting mechanisms of exchange reactions in the cardiac sarcolemma Na+-Ca2+ exchanger

    Article • Biochemistry, August 1995, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  34. Positively Charged Cyclic Hexapeptides, Novel Blockers for the Cardiac Sarcolemma Na+-Ca2+ Exchanger

    Article • Journal of Biological Chemistry, July 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Daniel Khananshvili

  35. The cardiac sodium-calcium exchanger: Relative rates of calcium and sodium movements and their modulation by protonation-deprotonation of the carrier

    Article • Biochemistry, January 1994, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  36. Opiates and ?cardioexcitatory? tetrapeptides inhibit sodium-calcium exchange in cardiac sarcolemma vesicles Daniel Khananshvili, Department of Biochemistry, Weizmann Institute of Science, Rehovot 76100, P.O.B. 26, Israel

    Article • Journal of Molecular and Cellular Cardiology, July 1992, Elsevier

    PhD Daniel Khananshvili

  37. The effect of opiate agonists and antagonists on Na+-Ca2+ exchange in cardiac sarcolemma vesicles

    Article • Life Sciences, January 1992, Elsevier

    PhD Daniel Khananshvili

  38. Mechanism of Partial Reactions in the Cardiac Na+ ‐Ca2+ Exchange Systemaa

    Article • Annals of the New York Academy of Sciences, December 1991, Wiley

    PhD Daniel Khananshvili

  39. Cation antiportes

    Article • Current Opinion in Cell Biology, August 1990, Elsevier

    PhD Daniel Khananshvili

  40. Distinction between the two basic mechanisms of cation transport in the cardiac sodium-calcium exchange system

    Article • Biochemistry, March 1990, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  41. The calcium ATPase of sarcoplasmic reticulum is inhibited by one Ca2+ ion

    Article • FEBS Letters, January 1990, Wiley

    PhD Daniel Khananshvili

  42. Empirical estimation of interaction energies for ligands binding in the isolated .beta.-subunit of F0F1 ATP synthase from Rhodospirillum rubrum

    Article • Biochemistry, October 1988, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  43. [53] Selective extraction and reconstitution of F1 subunits from Rhodospirillum rubrum chromatophores

    Article • January 1986, Elsevier

    PhD Daniel Khananshvili

  44. Characterization of an inorganic phosphate binding site on the isolated, reconstitutively active .beta. subunit of F0.cntdot.F1 ATP synthase

    Article • Biochemistry, May 1985, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  45. Evidence that the Mg-dependent low-affinity binding site for ATP and Pi demonstrated on the isolated beta subunit of the F0.F1 ATP synthase is a catalytic site.

    Article • Proceedings of the National Academy of Sciences, April 1985, Proceedings of the National Academy of Sciences

    PhD Daniel Khananshvili

  46. Khananshvili, D. and Z. Gromet‐Elhanan, Demonstration of two binding sites for ADP on the isolated β‐subunit of the Rhodospirillum rubrum RrF0F1‐ATP synthase (1984) FEBS Letters 178, 10‐14

    Article • FEBS Letters, March 1985, Wiley

    PhD Daniel Khananshvili

  47. Demonstration of two binding sites for ADP on the isolated β‐subunit of the Rhodospirillum rubrum R1F0F1‐ATP synthase

    Article • FEBS Letters, December 1984, Wiley

    PhD Daniel Khananshvili

  48. Characterization of two nucleotide binding sites on the isolated, reconstitutively active .beta. subunit of the F0.cntdot.F1 ATP synthase

    Article • Biochemistry, February 1984, American Chemical Society (ACS)

    PhD Daniel Khananshvili

  49. Chemical Modification of Essential Amino-Acid Residues in the Chromatophore F1-ATPase and Its Isolated β-Subunit

    Article • January 1984, Springer Science + Business Media

    PhD Daniel Khananshvili

  50. Modification of histidine residues by diethyl pyrocarbonate leads to inactivation of the Rhodospirillum rubrum RrF1‐ATPase

    Article • FEBS Letters, August 1983, Wiley

    PhD Daniel Khananshvili

  51. Chemical modification of the >β-subunit isolated from a membrane-bound Fo·F1-ATP synthase

    Article • Biochemical and Biophysical Research Communications, September 1982, Elsevier

    PhD Daniel Khananshvili

  52. Sequential removal and reconstitution of subunits β and γ from a membrane-bound Fo·Fl-ATP synthase

    Article • Biochemical and Biophysical Research Communications, July 1981, Elsevier

    PhD Daniel Khananshvili