All Stories

  1. Digital Technology: The Future Is Bright

    Article • Clinical Pharmacology & Therapeutics, June 2018, Wiley

    Brian P Smith

  2. Innovation in the Design of Clinical Trials: Necessary for Innovation in Medicine

    Article • Clinical Pharmacology & Therapeutics, November 2017, Wiley

    Brian P Smith

  3. Phase I, Randomized, Double-blind, Placebo-controlled, Single-dose, and Multiple-dose Studies of Erenumab in Healthy Subjects and Patients With Migraine

    Article • Clinical Pharmacology & Therapeutics, October 2017, Wiley

    Brian P Smith, Gabriel Vargas

  4. Reducing Costs and Improving Fit for Clinical Trials that Have Positive-Valued Data

    Article • Statistics in Biopharmaceutical Research, October 2016, Taylor & Francis

    Brian P Smith

  5. Challenges and Opportunities in Rare Disease Drug Development

    Article • Clinical Pharmacology & Therapeutics, September 2016, Wiley

    Brian P Smith

  6. Relative bioavailability, food effect, and safety of the single-dose pharmacokinetics of omecamtiv mecarbil following administration of different modified-release formulations in healthy subjects

    Article • International Journal of Clinical Pharmacology and Therapeutics, March 2016, Dustri-Verlgag Dr. Karl Feistle

    Brian P Smith

  7. Movember Is Mustache Month

    Article • Clinical Pharmacology & Therapeutics, November 2015, Wiley

    Brian P Smith

  8. Novel approaches to address challenges in global drug development

    Article • Clinical Pharmacology & Therapeutics, January 2015, Wiley

    Brian P Smith

  9. Whither Pharmacometrics?: Present State and Future Choices

    Article • Clinical Pharmacology & Therapeutics, June 2014, Nature

    Brian P Smith

  10. Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels

    Article • Journal of the American College of Cardiology, November 2012, Elsevier

    Brian P Smith

  11. Quantitative Model of the Relationship Between Dipeptidyl Peptidase-4 (DPP-4) Inhibition and Response: Meta-Analysis of Alogliptin, Saxagliptin, Sitagliptin, and Vildagliptin Efficacy Results

    Article • The Journal of Clinical Pharmacology, October 2012, Wiley

    Brian P Smith

  12. Models of Physiology and Physiologically Based Models in Clinical Pharmacology

    Article • Clinical Pharmacology & Therapeutics, July 2012, Nature

    Brian P Smith

  13. Population Pharmacokinetic/Pharmacodynamic Model of Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Activity After Oral Administration of AMG 221, a Selective 11β-HSD1 Inhibitor

    Article • The Journal of Clinical Pharmacology, June 2011, Wiley

    Brian P Smith

  14. Pharmacokinetic and Pharmacodynamic Perspectives on the Clinical Drug Development of Panitumumab

    Article • Clinical Pharmacokinetics, November 2010, Springer Science + Business Media

    Juan Jose Perez Ruixo, Brian P Smith

  15. Biostatistics and Pharmacometrics: Quantitative Sciences to Propel Drug Development Forward

    Article • Clinical Pharmacology & Therapeutics, August 2010, Nature

    Brian P Smith

  16. Statistical Analysis Methods For QT/QTc Prolongation

    Article • Journal of Biopharmaceutical Statistics, May 2008, Taylor & Francis

    Brian P Smith

  17. It’s time

    Article • The AAPS Journal, September 2005, American Association of Pharmaceutical Scientists (AAPS)

    Brian P Smith

  18. Hemodynamic Effects of Acute Administration of Atomoxetine and Methylphenidate

    Article • The Journal of Clinical Pharmacology, July 2005, Wiley

    Brian P Smith

  19. Atomoxetine Hydrochloride: Clinical Drug-Drug Interaction Prediction and Outcome

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Brian P Smith

  20. Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites

    Article • Clinical Pharmacology & Therapeutics, March 2003, Nature

    Brian P Smith

  21. Atomoxetine Pharmacokinetics in Children and Adolescents with Attention Deficit Hyperactivity Disorder

    Article • Journal of Child and Adolescent Psychopharmacology, March 2003, Mary Ann Liebert Inc

    Brian P Smith

  22. Repeated-measures models in the analysis of QT interval

    Article • Pharmaceutical Statistics, January 2003, Wiley

    Brian P Smith

  23. Effect of Potent CYP2D6 Inhibition by Paroxetine on Atomoxetine Pharmacokinetics

    Article • The Journal of Clinical Pharmacology, November 2002, Wiley

    Brian P Smith

  24. Conditional Generalized Liouville Distributions on the Simplex

    Article • Statistics, January 2002, Taylor & Francis

    Brian P Smith

  25. PhRMA Perspective on Population and Individual Bioequivalence

    Article • The Journal of Clinical Pharmacology, June 2000, Wiley

    Brian P Smith

  26. Update to the PhRMA Perspective on Population and Individual Bioequivalence

    Article • The Journal of Clinical Pharmacology, June 2000, Wiley

    Brian P Smith

  27. Article • Pharmaceutical Research, January 2000, Springer Science + Business Media

    Brian P Smith

  28. Maintaining blood compartment volume in dialyzers reprocessed with peracetic acid maintains Kt/V but not β2-microglobulin removal

    Article • American Journal of Kidney Diseases, October 1997, Elsevier

    Brian P Smith

  29. Statistical Approach to Neural Network Model Building for Gentamicin Peak Predictions

    Article • Journal of Pharmaceutical Sciences, January 1996, Elsevier

    Brian P Smith

  30. Skeletal growth patterns of Thoroughbred horses

    Article • Journal of Equine Veterinary Science, January 1994, Elsevier

    Brian P Smith