All Stories

  1. Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions
  2. Recent advances in understanding hepatic drug transport
  3. Alterations in Enterohepatic Fgf15 Signaling and Changes in Bile Acid Composition Depend on Localization of Murine Intestinal Inflammation
  4. Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate
  5. Proteomic Analysis of the Rat Canalicular Membrane Reveals Expression of a Complex System of P4-ATPases in Liver
  6. Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis
  7. Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake
  8. Intestinal and Hepatocellular Transporters: Therapeutic Effects and Drug Interactions of Herbal Supplements
  9. Flagging Drugs That Inhibit the Bile Salt Export Pump
  10. Influence of 24-Nor-Ursodeoxycholic Acid on Hepatic Disposition of [18F]Ciprofloxacin, a Positron Emission Tomography Study in Mice
  11. Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate
  12. Protein kinase C-dependent regulation of human hepatic drug transporter expression
  13. Expression and function of placental uric acid transporter GLUT9
  14. Polarized location of SLC and ABC drug transporters in monolayer-cultured human hepatocytes
  15. Transporters in the Liver
  16. Impaired uptake of conjugated bile acids and hepatitis b virus pres1‐binding in na + ‐taurocholate cotransporting polypeptide knockout mice
  17. Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes
  18. Efflux and uptake transporters involved in the disposition of bazedoxifene
  19. 292: Placental urate transport is GLUT9-mediated and unidirectional
  20. The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells
  21. Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney
  22. Bile Salt Transporters
  23. Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS
  24. Rivaroxaban postmarketing risk of liver injury
  25. Resveratrol and its major sulfated conjugates are substrates of organic anion transporting polypeptides (OATPs): Impact on growth of ZR-75-1 breast cancer cells
  26. Bile acid disposition by confocal microscopy
  27. Chronic cholestatic liver diseases: Clues from histopathology for pathogenesis
  28. Molecular pathogenesis of chronic cholestatic liver disease: Impact on novel therapeutic approaches
  29. Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems
  30. Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
  31. Organic Anion-Transporting Polypeptides
  32. Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes
  33. Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters
  34. ATP-binding cassette transporters in liver
  35. Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells
  36. Role of skeletal muscle transport systems in statin-induced myotoxicity
  37. The SLCO (former SLC21) superfamily of transporters
  38. Functional expression and regulation of drug transporters in monolayer- and sandwich-cultured mouse hepatocytes
  39. BSEP (ABCB11)
  40. Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes
  41. Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis
  42. Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1
  43. Physiological and Biochemical Basis of Clinical Liver Function Tests
  44. Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment
  45. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation
  46. Drug interactions with hepatocellular transport systems and acquired forms of liver disease
  47. Diverse Functional Properties of Wilson Disease ATP7B Variants
  48. Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice
  49. The emerging role of transport systems in liver function tests
  50. Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene
  51. Combined effect of 25-OH vitamin D plasma levels and genetic Vitamin DReceptor (NR 1I1) variants on fibrosis progression rate in HCV patients
  52. Interaction of bile salts with rat canalicular membrane vesicles: Evidence for bile salt resistant microdomains
  53. Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3
  54. Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport
  55. Regulation of drug transporter expression by oncostatin M in human hepatocytes
  56. The Canalicular Bile Salt Export Pump BSEP (ABCB11) as a Potential Therapeutic Target
  57. Pharmacogenetics of drug transporters in the enterohepatic circulation
  58. Transporters involved in the hepatic uptake of 99mTc-mebrofenin and indocyanine green
  59. A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease
  60. Regulation of the expression of the hepatocellular sulfate–oxalate exchanger SAT-1 (SLC26A1) by glyoxylate: A metabolic link between liver and kidney?
  61. Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis
  62. The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients
  63. Efficient Generation of Multipotent Mesenchymal Stem Cells from Umbilical Cord Blood in Stroma-Free Liquid Culture
  64. Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans
  65. Relapsing features of bile salt export pump deficiency after liver transplantation in two patients with progressive familial intrahepatic cholestasis type 2
  66. The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats
  67. Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy
  68. ATP8B1 and ABCB11 analysis in 62 children with normal gamma-glutamyl transferase progressive familial intrahepatic cholestasis (PFIC): Phenotypic differences between PFIC1 and PFIC2 and natural history
  69. Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1
  70. Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice
  71. Role of the bile salt export pump, BSEP, in acquired forms of cholestasis
  72. Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers
  73. Recent insights into the function and regulation of the bile salt export pump (ABCB11)
  74. W1592 Vitamin D3 and Its Nuclear Receptor VDR Regulate the Expression and Activity of the Human Intestinal Proton-Coupled Folate Transporter PCFT
  75. ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes
  76. Taurocholate induces preferential release of phosphatidylcholine from rat liver canalicular vesicles
  77. Turning over or turning around: hepatic phosphatidylcholine in the mouse model for progressive familial intrahepatic cholestasis type 3
  78. Pharmacogenetics of OATP ( SLC21 / SLCO ), OAT and OCT ( SLC22 ) and PEPT ( SLC15 ) transporters in the intestine, liver and kidney
  79. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3
  80. Severe Bile Salt Export Pump Deficiency: 82 Different ABCB11 Mutations in 109 Families
  81. Isolation of renal proximal tubular brush-border membranes
  82. Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury
  83. Twenty years of ATP-binding cassette (ABC) transporters
  84. The bile salt export pump
  85. Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
  86. Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis
  87. Quantitative microscopy reveals 3D organization and kinetics of endocytosis in rat hepatocytes
  88. Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation inMdr2+/− mice
  89. Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency
  90. Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver
  91. Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
  92. Enterohepatic transport of bile salts and genetics of cholestasis
  93. Magnetic Resonance Imaging With Hepatospecific Contrast Agents in Cirrhotic Rat Livers
  94. Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex
  95. Differential expression of bile salt and organic anion transporters in developing rat liver
  96. Gd-BOPTA Transport Into Rat Hepatocytes: Pharmacokinetic Analysis of Dynamic Magnetic Resonance Images Using a Hollow-Fiber Bioreactor
  97. Enterohepatic bile salt transporters in normal physiology and liver disease
  98. Biliary cholesterol secretion: more lessons from plants?
  99. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat
  100. 827 Polarized transport differentiation of small heptocytes in culture
  101. Functional expression of the canalicular bile salt export pump of human liver
  102. Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice
  103. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
  104. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy
  105. Bile Salt Transporters
  106. Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17β-d-glucuronide in rats
  107. Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver
  108. FIC1: another bile salt carrier within the enterohepatic circulation?
  109. Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3
  110. Effects of Ursodeoxycholic and Cholic Acid Feeding on Hepatocellular Transporter Expression in Mouse Liver
  111. Tight Junctions in Liver Disease
  112. Metabolism of amiodarone
  113. Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver
  114. Microvesicular liver steatosis in rats with carnitine deficiency
  115. Expression of hepatocellular transporters in long-term cultured small hepatocytes
  116. Development and characterization of an animal model of carnitine deficiency
  117. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney
  118. Development and characterization of an animal model of carnitine deficiency
  119. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
  120. Apical endocytosis in rat hepatocytes in situ involves clathrin, traverses a subapical compartment, and leads to lysosomes
  121. Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2
  122. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver
  123. Characterization of L-carnitine transport into rat skeletal muscle plasma membrane vesicles
  124. Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
  125. Hepatic Transport of Bile Salts
  126. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
  127. Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver
  128. Localization and function of the organic anion–transporting polypeptide Oatp2 in rat liver
  129. Regulation of Bile Salt Export Pump mRNA Levels by Dexamethasone and Osmolarity in Cultured Rat Hepatocytes
  130. Decreased Na+-dependent taurocholate uptake and low expression of the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in livers of mdr2 P-glycoprotein-deficient mice
  131. Identification of Thyroid Hormone Transporters
  132. Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate
  133. Bile acid and xenobiotic transporters in liver
  134. Characterization of a sodium-dependent transport system for butyrobetaine into rat liver plasma membrane vesicles
  135. Expression of the liver Na+-independent organic anion transporting polypeptide (oatp-1) in rats with bile duct ligation
  136. Hepatic bile salt flux does not modulate level and activity of the sinusoidal Na+-taurocholate cotransporter (ntcp) in rats
  137. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein
  138. Differential Interaction of Bile Acids from Patients with Inborn Errors of Bile Acid Synthesis with Hepatocellular Bile Acid Transporters
  139. Interaction Between Amiodarone and Lidocaine
  140. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
  141. In situ localization of the hepatocytic na+/taurocholate cotransporting polypeptide in rat liver
  142. Functional characterization of the basolateral rat liver organic anion transporting polypeptide
  143. Effect of obstructive cholestasis on membrane traffic and domain-specific expression of plasma membrane proteins in rat liver parenchmal cells
  144. Parallel decrease of Na+ -taurocholate cotransport and its encoding mRNA in primary cultures of rat hepatocytes
  145. Molecular properties of the Na+-dependent taurocholate cotransporting polypeptide (Ntcp) of rat liver
  146. [20] Transport studies with renal proximal tubular and small intestinal brush border and basolateral membrane vesicles: Vesicle heterogeneity, coexistence of transport systems
  147. Na/H- and Cl/OH-exchange in rat jejunal and rat proximal tubular brush border membrane vesicles
  148. A high yield preparation for rat kidney brush border membranes Different behaviour of lysosomal markers
  149. Chapter 2. Drug Transporters in the Liver: Their Involvement in the Uptake and Export of Endo- and Xeno-biotics
  150. Chapter 1. Membrane Transporters: Fundamentals, Function and Their Role in ADME
  151. 1 Physiology of bile formation: Hepatocellular bile salt transporters
  152. 15 Drug-induced cholestatic liver injury
  153. Functions of the Liver