All Stories

  1. Histamine H1 Receptor-Mediated JNK Phosphorylation Is Regulated by Gq Protein-Dependent but Arrestin-Independent Pathways

    Article • International Journal of Molecular Sciences, March 2024, MDPI AG

    Dr Shigeru Hishinuma

  2. Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins

    Article • Biochemical Pharmacology, July 2023, Elsevier

    Dr Shigeru Hishinuma

  3. Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury

    Article • Cells, February 2023, MDPI AG

    Dr Shigeru Hishinuma

  4. Molecular Determinants of the Kinetic Binding Properties of Antihistamines at the Histamine H1 Receptors

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Dr Shigeru Hishinuma

  5. Differential Regulation of Bilastine Affinity for Human Histamine H1 Receptors by Lys 179 and Lys 191 via Its Binding Enthalpy and Entropy

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Dr Shigeru Hishinuma

  6. Roles of Lys191 and Lys179 in regulating thermodynamic binding forces of ligands to determine their binding affinity for human histamine H1 receptors

    Article • Biochemical Pharmacology, October 2020, Elsevier

    Dr Shigeru Hishinuma

  7. Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H1 Receptors

    Article • International Journal of Molecular Sciences, December 2018, MDPI AG

    Dr Shigeru Hishinuma

  8. Ca2+ -dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells

    Article • Journal of Neurochemistry, November 2017, Wiley

    Dr Shigeru Hishinuma

  9. Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165

    Article • Frontiers in Endocrinology, April 2017, Frontiers

    Dr Shigeru Hishinuma

  10. Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na+

    Article • Biochemical Pharmacology, December 2016, Elsevier

    Dr Shigeru Hishinuma

  11. C-terminal of human histamine H1receptors regulates their agonist-induced clathrin-mediated internalization and G-protein signaling

    Article • Journal of Neurochemistry, September 2016, Wiley

    Dr Shigeru Hishinuma

  12. Differential Regulation of Plasma Copeptin Levels in Patients with Heart Failure: A Single-Center Prospective Study

    Article • The Tohoku Journal of Experimental Medicine, January 2016, Tohoku University Medical Press

    Dr Shigeru Hishinuma

  13. Erratum to “Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors” [Biochem. Pharmacol. 91 (2014) 231–241]

    Article • Biochemical Pharmacology, November 2014, Elsevier

    Dr Shigeru Hishinuma

  14. Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors

    Article • Biochemical Pharmacology, September 2014, Elsevier

    Dr Shigeru Hishinuma

  15. Molecular Determinants Responsible for Sedative and Non-sedative Properties of Histamine H1–Receptor Antagonists

    Article • Journal of Pharmacological Sciences, January 2014, Japanese Pharmacological Society

    Dr Shigeru Hishinuma

  16. Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation

    Article • Journal of Smooth Muscle Research, January 2013, Japan Society of Smooth Muscle Research

    Dr Shigeru Hishinuma

  17. The Affinity of Histamine for Gq Protein-Coupled Histamine H1-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells

    Article • Journal of Pharmacological Sciences, January 2012, Japanese Pharmacological Society

    Dr Shigeru Hishinuma

  18. Desensitization of depolarization-mediated contractile pathways does not necessarily regulate receptor-mediated excitation-contraction coupling in longitudinal smooth muscle of guinea pig ileum

    Article • Clinical and Experimental Pharmacology and Physiology, March 2011, Wiley

    Dr Shigeru Hishinuma

  19. Ubiquitin/proteasome-dependent down-regulation following clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells

    Article • Journal of Neurochemistry, May 2010, Wiley

    Dr Shigeru Hishinuma

  20. Impairment of α1-adrenoceptor-mediated contractile activity in caudal arterial smooth muscle from Type 2 diabetic Goto-Kakizaki rats

    Article • Clinical and Experimental Pharmacology and Physiology, March 2010, Wiley

    Dr Shigeru Hishinuma

  21. Histamine Develops Homologous Desensitization under Ca2+-free Conditions with Increase in Basal Tone in Smooth Muscle of Guinea Pig Taenia Caeci

    Article • YAKUGAKU ZASSHI, January 2010, Pharmaceutical Society of Japan

    Dr Shigeru Hishinuma

  22. A Systematic Review on the Short-term Efficacy and Safety of Nicorandil for Stable Angina Pectoris in Comparison with Those of β-Blockers, Nitrates and Calcium Antagonists

    Article • YAKUGAKU ZASSHI, January 2010, Pharmaceutical Society of Japan

    Dr Shigeru Hishinuma

  23. Effects of Antacids on Clinical Efficacy of Gefitinib in Patients with Non-Small Cell Lung Cancer

    Article • Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), January 2010, Japanese Society of Pharmaceutical Health Care and Sciences

    Dr Shigeru Hishinuma

  24. HISTAMINE-INDUCED PROGRESSION FROM HETEROLOGOUS TO HOMOLOGOUS DESENSITIZATION OF CONTRACTION IN SMOOTH MUSCLE OF GUINEA-PIG TAENIA CAECI

    Article • Clinical and Experimental Pharmacology and Physiology, November 2008, Wiley

    Dr Shigeru Hishinuma

  25. Intact Cell Binding for In Vitro Prediction of Sedative and Non-sedative Histamine H1–Receptor Antagonists Based on Receptor Internalization

    Article • Journal of Pharmacological Sciences, January 2008, Japanese Pharmacological Society

    Dr Shigeru Hishinuma

  26. DESENSITIZATION OF GUINEA-PIG TAENIA CAECI SMOOTH MUSCLE INDUCED BY A LOW CONCENTRATION OF CARBACHOL

    Article • Clinical and Experimental Pharmacology and Physiology, July 2007, Wiley

    Dr Shigeru Hishinuma

  27. DIFFERENTIAL DEVELOPMENT OF CARBACHOL-INDUCED DESENSITIZATION IN RECEPTOR-MEDIATED Ca2+INFLUX AND Ca2+RELEASE PATHWAYS IN SMOOTH MUSCLE OF GUINEA-PIG TAENIA CAECI

    Article • Clinical and Experimental Pharmacology and Physiology, March 2007, Wiley

    Dr Shigeru Hishinuma

  28. Transient Resensitization Interrupting the Development of Carbachol-induced Desensitization in Smooth Muscle of Guinea-pig Taenia Caeci: Ca2+-dependent Termination of Resensitization

    Article • YAKUGAKU ZASSHI, January 2007, Pharmaceutical Society of Japan

    Dr Shigeru Hishinuma

  29. Ca2+-DEPENDENT DIFFERENTIAL DEVELOPMENT OF CARBACHOL-INDUCED DESENSITIZATION TO RECEPTOR AGONISTS AND HIGH K+IN GUINEA-PIG TAENIA CAECI

    Article • Clinical and Experimental Pharmacology and Physiology, January 2007, Wiley

    Dr Shigeru Hishinuma

  30. DIFFERENTIAL ROLES OF RYANODINE- AND THAPSIGARGIN-SENSITIVE INTRACELLULAR Ca2+STORES IN EXCITATION?CONTRACTION COUPLING IN SMOOTH MUSCLE OF GUINEA-PIG TAENIA CAECI

    Article • Clinical and Experimental Pharmacology and Physiology, December 2006, Wiley

    Dr Shigeru Hishinuma

  31. Ca2+/Calmodulin-Mediated Regulation of Agonist-Induced Sequestration of Gq Protein-Coupled Histamine H1 Receptors in Human U373 MG Astrocytoma Cells

    Article • Journal of Neurochemistry, November 2002, Wiley

    Dr Shigeru Hishinuma

  32. Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase

    Article • Biochemical Journal, June 2002, Portland Press Ltd.

    Dr Shigeru Hishinuma

  33. Cloning and characterization of novel snake venom proteins that block smooth muscle contraction

    Article • European Journal of Biochemistry, May 2002, Wiley

    Dr Shigeru Hishinuma

  34. Ca2+/Calmodulin-Mediated Regulation of the Desensitizing Process in Gq Protein-Coupled Histamine H1 Receptor-Mediated Ca2+ Responses in Human U373 MG Astrocytoma Cells

    Article • Journal of Neurochemistry, January 2002, Wiley

    Dr Shigeru Hishinuma

  35. Contrasting effects of carbachol, McN-A-343 and AHR-602 on Ca2+-mobilization and Ca2+-influx pathways in taenia caeci

    Article • British Journal of Pharmacology, November 1997, Wiley

    Dr Shigeru Hishinuma

  36. Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation

    Article • British Journal of Pharmacology, November 1995, Wiley

    Dr Shigeru Hishinuma

  37. Novel regulation of muscarinic receptors and their coupling with G proteins in smooth muscle: transient resensitization during desensitizing process

    Article • British Journal of Pharmacology, June 1993, Wiley

    Dr Shigeru Hishinuma

  38. Haloperidol differentiates smooth muscle contractions induced by release of intracellularly stored Ca and by influx of extracellular Ca

    Article • General Pharmacology The Vascular System, March 1992, Elsevier

    Dr Shigeru Hishinuma

  39. Blockade by the local anaesthetic, tetracaine, of desensitization of Ca-induced Ca release after muscarinic stimulation in smooth muscle

    Article • British Journal of Pharmacology, June 1991, Wiley

    Dr Shigeru Hishinuma

  40. Short-term desensitization of phosphatidylinositol turnover via muscarinic acetylcholine receptors and histamine H1-receptors in smooth muscle

    Article • Biochemical and Biophysical Research Communications, July 1989, Elsevier

    Dr Shigeru Hishinuma

  41. Short-term desensitization of guinea-pig taenia caecum induced by carbachol occurs at intracellular Ca stores and that by histamine at H1-receptors

    Article • British Journal of Pharmacology, July 1988, Wiley

    Dr Shigeru Hishinuma

  42. Effects of local anaesthetics on short-term desensitization of guinea-pig taenia caecum to histamine

    Article • British Journal of Pharmacology, December 1987, Wiley

    Dr Shigeru Hishinuma

  43. Dual Processes of Desensitization and Resensitization Regulate Cellular Responsiveness in Smooth Muscle of Guinea-pig Taenia Caeci

    Article • Karger Publishers

    Dr Shigeru Hishinuma

  44. Desensitization of Cellular Responses Mediated by Histamine H1-receptors in Central Nervous System Tissues

    Article • Karger Publishers

    Dr Shigeru Hishinuma