All Stories

  1. How to evaluate agreement between quantitative measurements
  2. Power gains by using external information in clinical trials are typically not possible when requiring strict type I error control
  3. Monitoring futility and efficacy in phase II trials with Bayesian posterior distributions-A calibration approach
  4. Multiple-rater kappas for binary data: Models and interpretation
  5. Parametric modeling and optimal experimental designs for estimating isobolograms for drug interactions in toxicology
  6. Testing R Code R. Cotton  Boca Raton, FL: Chapman & Hall/CRC Press. 178 pages, ISBN 978-1-4987-6365-3
  7. Addressing small sample size bias in multiple-biomarker trials: Inclusion of biomarker-negative patients and Firth correction
  8. Functional analysis of high-content high-throughput imaging data
  9. Cell type-specific expression and localization of cytochrome P450 isoforms in tridimensional aggregating rat brain cell cultures
  10. Quantitative in vitro to in vivo extrapolation of tissues toxicity
  11. Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period
  12. Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing
  13. Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation
  14. Richly Parametrized Linear Models: Additive, Time Series, and Spatial Models Using Random Effects. J. S. Hodges (2014). Boca Raton: Chapman & Hall/CRC Texts in Statistical Science. 431 pages, ISBN: 978-1-4398-6683-2.
  15. Statistical strategies for averaging EC50 from multiple dose–response experiments
  16. A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy
  17. Quantitative Emphysema Distribution in Anatomic and Non-anatomic Lung Regions
  18. Optimal experimental designs for dose–response studies with continuous endpoints
  19. Reproducible Research with R and RStudio. C. Gandrud (2013). Chapman & Hall/CRC: The R Series. 294 pages, ISBN-13: 978-1466572843.
  20. Genomic Clinical Trials and Predictive Medicine. R. M. Simon (2013). New York: Cambridge University Press. 144 pages, ISBN: 978-1-107-40135-8.
  21. Magnetic Resonance Imaging Detects Changes in Structure and Perfusion, and Response to Therapy in Early Cystic Fibrosis Lung Disease
  22. Summarizing EC50 estimates from multiple dose-response experiments: A comparison of a meta-analysis strategy to a mixed-effects model approach
  23. GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3
  24. Efficacy and toxicity of chemoradiation in patients with anal cancer - a retrospective analysis
  25. Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience
  26. Validation of Fourier decomposition MRI with dynamic contrast-enhanced MRI using visual and automated scoring of pulmonary perfusion in young cystic fibrosis patients
  27. Evaluation of the ESUR PI-RADS scoring system for multiparametric MRI of the prostate with targeted MR/TRUS fusion-guided biopsy at 3.0 Tesla
  28. Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich Cultures
  29. Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project
  30. Data management in large-scale collaborative toxicity studies: How to file experimental data for automated statistical analysis
  31. Design of a testing strategy using non-animal based test methods: Lessons learnt from the ACuteTox project
  32. Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity
  33. Selection of test methods to be included in a testing strategy to predict acute oral toxicity: An approach based on statistical analysis of data collected in phase 1 of the ACuteTox project
  34. The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox
  35. MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
  36. Biological and Tumor-Promoting Effects of Dioxin-like and Non-Dioxin-like Polychlorinated Biphenyls in Mouse Liver After Single or Combined Treatment
  37. Accuracy and Variability of Semiautomatic Centerline Analysis versus Manual Aortic Measurement Techniques for TEVAR
  38. Diffusion-weighted imaging in rectal carcinoma patients without and after chemoradiotherapy: A comparative study with histology
  39. Stochastic time‐concentration activity models for cytotoxicity in 3D brain cell cultures
  40. The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging
  41. Natural variants in the major neutralizing epitope of human papillomavirus minor capsid protein L2
  42. The impact of data transformations on concentration–response modeling
  43. Accuracy of MRI with an endorectal coil for staging endometrial cancer
  44. Morphologic and functional scoring of cystic fibrosis lung disease using MRI
  45. Proposal for a New Prognostic Score for Linac-Based Radiosurgery in Cerebral Arteriovenous Malformations
  46. Clinical phase I/II trial to investigate neoadjuvant intensity-modulated short term radiation therapy (5 × 5 gy) and intraoperative radiation therapy (15 gy) in patients with primarily resectable pancreatic cancer - NEOPANC
  47. Epstein-Barr Virus Stimulates Torque Teno Virus Replication: A Possible Relationship to Multiple Sclerosis
  48. An Adaptive Group Sequential Phase II Design to Compare Treatments for Survival Endpoints in Rare Patient Entities
  49. Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer: the HIL trial
  50. The Feasibility of Low Mechanical Index Contrast Enhanced Ultrasound (CEUS) in Distinguishing Malignant from Benign Thoracic Lesions
  51. High-resolution phase-contrast MRI of aortic and pulmonary blood flow during rest and physical exercise using a MRI compatible bicycle ergometer
  52. Repeatability and Reproducibility of Quantitative Whole-lung Perfusion Magnetic Resonance Imaging
  53. Concordance Analysis
  54. E6 and E7 from Beta Hpv38 Cooperate with Ultraviolet Light in the Development of Actinic Keratosis-Like Lesions and Squamous Cell Carcinoma in Mice
  55. Robust biclustering by sparse singular value decomposition incorporating stability selection
  56. Fine Tuning of the Threshold of T Cell Selection by the Nck Adapters
  57. Glossopharyngeal Insufflation and Pulmonary Hemodynamics in Elite Breath Hold Divers
  58. Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire
  59. Optimization and prevalidation of the in vitro ERα CALUX method to test estrogenic and antiestrogenic activity of compounds
  60. Time- and Dose-Dependency of Radiographic Normal Tissue Changes of the Lung After Stereotactic Radiotherapy
  61. HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth
  62. Application of a two-phenotype color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment
  63. Modelling the genesis and treatment of cancer: The potential role of physiologically based pharmacodynamics
  64. 4D-CT-based target volume definition in stereotactic radiotherapy of lung tumours: Comparison with a conventional technique using individual margins
  65. Toxicogenomic analysis of N-nitrosomorpholine induced changes in rat liver: Comparison of genomic and proteomic responses and anchoring to histopathological parameters
  66. Simulation-based comparison of two approaches frequently used for dynamic contrast-enhanced MRI
  67. “ToxRTool”, a new tool to assess the reliability of toxicological data
  68. Respiratory Displacement of the Thoracic Aorta: Physiological Phenomenon With Potential Implications for Thoracic Endovascular Repair
  69. Changes of prostate gland volume with and without androgen deprivation after intensity modulated radiotherapy – A follow-up study
  70. Histone Deacetylase 8 in Neuroblastoma Tumorigenesis
  71. Morphology, metabolism, microcirculation, and strength of skeletal muscles in cancer-related cachexia
  72. Intrinsic Gating for Small-Animal Computed Tomography: A Robust ECG-Less Paradigm for Deriving Cardiac Phase Information and Functional Imaging
  73. Assessment of thoracic aortic conformational changes by four-dimensional computed tomography angiography in patients with chronic aortic dissection type b
  74. Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro
  75. Semi-automated volumetric analysis of lymph node metastases in patients with malignant melanoma stage III/IV-A feasibility study
  76. Magnetic resonance-compatible-spirometry: principle, technical evaluation and application
  77. C4.4A as a candidate marker in the diagnosis of colorectal cancer
  78. Assessment of Morphological MRI for Pulmonary Changes in Cystic Fibrosis (CF) Patients
  79. Comparison of Mode of Action of Four Hepatocarcinogens: A Model-Based Approach
  80. TTV infection in colorectal cancer tissues and normal mucosa
  81. E6/E7 Expression of Human Papillomavirus Type 20 (HPV-20) and HPV-27 Influences Proliferation and Differentiation of the Skin in UV-Irradiated SKH-hr1 Transgenic Mice
  82. Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment
  83. Investigating the Formation and Growth of α-Particle Radiation-Induced Foci of Altered Hepatocytes: A Model-Based Approach
  84. Comparison of Software Tools to Improve the Detection of Carcinogen Induced Changes in the Rat Liver Proteome by Analyzing SELDI-TOF−MS Spectra
  85. Serological analysis of human renal cell carcinoma
  86. Reduced Expression of Interleukin-2 Decreases the Frequency of Alopecia Areata Onset in C3H/HeJ Mice
  87. Origins of the mutational origin of cancer
  88. Adjuvant Therapy with Edrecolomab versus Observation in Stage II Colon Cancer: A Multicenter Randomized Phase III Study*
  89. Molecular approaches to the identification of biomarkers of exposure and effect—report of an expert meeting organized by COST Action B15
  90. Differential signatures of protein expression in marmoset liver and thymus induced by single-dose TCDD treatment
  91. Increased Incidence of Squamous Cell Carcinomas in Mastomys natalensis Papillomavirus E6 Transgenic Mice during Two-Stage Skin Carcinogenesis
  92. Randomized Clinical Trial: Myths around Elementary Statistical Principles
  93. Biostatistical Evaluation of Focal Hepatic Preneoplasia
  94. Prevalidation of a Rat Liver Foci Bioassay (RLFB) Based on Results from 1600 Rats: A Study Report
  95. Deviation from Additivity in Mixture Toxicity: Relevance of Nonlinear Dose-Response Relationships and Cell Line Differences in Genotoxicity Assays with Combinations of Chemical Mutagens and -Radiation
  96. Adjuvant Chemotherapy in Stage III Colon Cancer with 5-Fluorouracil and Levamisole versus 5-Fluorouracil and Leucovorin
  97. Woodchuck hepatitis virus replication and antigen expression gradually decrease in preneoplastic hepatocellular lineages
  98. Incorporating phenotype-dependent growth rates into the color-shift model for preneoplastic hepatocellular lesions
  99. Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization
  100. Modeling cancer detection: tumor size as a source of information on unobservable stages of carcinogenesis
  101. Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma
  102. A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells
  103. Hepadnaviral hepatocarcinogenesis: in situ visualization of viral antigens, cytoplasmic compartmentation, enzymic patterns, and cellular proliferation in preneoplastic hepatocellular lineages in woodchucks
  104. Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism
  105. Threshold dose response for tumor induction by genotoxic carcinogens modeled via cell-cycle delay
  106. Xenomorphic hepatocellular precursors and neoplastic progression of tigroid cell foci induced in rats with low doses of N-nitrosomorpholine
  107. Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: Suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2
  108. Statistical models for low dose exposure
  109. A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
  110. Carcinogenesis models for risk assessment
  111. Calculating tumor incidence rates in stochastic models of carcinogenesis
  112. Modeling the Number and Size of Hepatic Focal Lesions Following Exposure to 2,3,7,8-TCDD
  113. Effects of low doses of N -nitrosomorpholine on the development of early stages of hepatocarcinogenesis
  114. Carcinoma formation in NMRI mouse skin painting studies is a process suggesting greater than two stages
  115. Malignant progression of papillomas induced by the initiation-promotion protocol in NMRI mouse skin
  116. Multistage Models of Carcinogenesis: An Approximation for the Size and Number Distribution of Late-Stage Clones
  117. The Exact Formula for Tumor Incidence in the Two-Stage Model
  118. Porphyrin studies in TCDD-exposed workers
  119. A stem cell model for carcinogenesis
  120. Cell proliferation and cell death (apoptosis) in hepatic preneoplasia and neoplasia are closely related to phenotypic cellular diversity and instability
  121. The use of cell proliferation data in modeling of skin carcinogenesis
  122. Using cell replication data in mathematical modeling in carcinogenesis
  123. Birth and death/differentiation rates of papillomas in mouse skin
  124. Distinguishing between models of carcinogenesis: The role of clonal expansion
  125. A Multistage Model of Carcinogenesis Incorporating DNA Damage and Repair
  126. The application of a multistage model that incorporates DNA damage and repair to the analysis of initiation/promotion experiments