All Stories

  1. Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, September 2019, Elsevier

    Dr. Andreas Weigert

  2. PGE2 in fibrosis and cancer: Insights into fibroblast activation

    Article • Prostaglandins & Other Lipid Mediators, August 2019, Elsevier

    Dr. Andreas Weigert

  3. Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation

    Article • Cells, July 2019, MDPI AG

    Dr. Andreas Weigert

  4. Nitric oxide maintains endothelial redox homeostasis through PKM 2 inhibition

    Article • The EMBO Journal, July 2019, EMBO

    Dr. Andreas Weigert

  5. Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater

    Article • Frontiers in Immunology, July 2019, Frontiers

    Dr. Andreas Weigert

  6. Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis

    Article • International Journal of Molecular Sciences, June 2019, MDPI AG

    Dr. Andreas Weigert

  7. HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT

    Article • Cellular and Molecular Immunology, June 2019, Springer Science + Business Media

    Dr. Andreas Weigert, DVM, PhD Maria-Luisa del Rio-Gonzalez

  8. The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFκB-Dependent Manner

    Article • Oxidative Medicine and Cellular Longevity, April 2019, Hindawi Publishing Corporation

    Dr. Andreas Weigert

  9. IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells

    Article • Cell Reports, April 2019, Elsevier

    Dr. Andreas Weigert

  10. Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

    Article • Nature Communications, March 2019, Springer Science + Business Media

    Dr. Andreas Weigert

  11. Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase

    Article • Oncogene, February 2019, Springer Science + Business Media

    Dr. Andreas Weigert

  12. The histone demethylase PHF 8 facilitates alternative splicing of the histocompatibility antigen HLA ‐G

    Article • FEBS Letters, February 2019, Wiley

    Dr. Andreas Weigert

  13. Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation

    Article • PLoS ONE, January 2019, PLOS

    Dr. Andreas Weigert

  14. Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

    Article • Theranostics, January 2019, Ivyspring International Publisher

    Dr. Andreas Weigert

  15. Redox-signals and macrophage biology

    Article • Molecular Aspects of Medicine, October 2018, Elsevier

    Dr. Andreas Weigert

  16. The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue

    Article • Frontiers in Immunology, October 2018, Frontiers

    Dr. Andreas Weigert

  17. The portal vein as a distinct immunological compartment – A comprehensive immune phenotyping study

    Article • Human Immunology, October 2018, Elsevier

    Dr. Andreas Weigert

  18. An in vitro test system for compounds that modulate human inflammatory macrophage polarization

    Article • European Journal of Pharmacology, August 2018, Elsevier

    Dr. Andreas Weigert

  19. IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

    Article • OncoImmunology, July 2018, Taylor & Francis

    Dr. Andreas Weigert

  20. mPGES-1 and ALOX5/-15 in tumor-associated macrophages

    Article • Cancer and Metastasis Reviews, May 2018, Springer Science + Business Media

    Dr. Andreas Weigert

  21. The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage

    Article • Journal of Biological Chemistry, May 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Andreas Weigert

  22. NoxO1 Controls Proliferation of Colon Epithelial Cells

    Article • Frontiers in Immunology, May 2018, Frontiers

    Dr. Andreas Weigert

  23. The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice

    Article • Redox Biology, May 2018, Elsevier

    Dr. Andreas Weigert

  24. Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma

    Article • International Journal of Molecular Sciences, March 2018, MDPI AG

    Dr. Andreas Weigert, DVM, PhD Maria-Luisa del Rio-Gonzalez

  25. VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia

    Article • The Journal of Cell Biology, March 2018, Rockefeller University Press

    Dr. Andreas Weigert

  26. Selective targeting of tumor associated macrophages in different tumor models

    Article • PLoS ONE, February 2018, PLOS

    Dr. Andreas Weigert

  27. Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages

    Article • The Journal of Immunology, December 2017, The American Association of Immunologists

    Dr. Andreas Weigert

  28. Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment

    Article • OncoImmunology, November 2017, Taylor & Francis

    Dr. Andreas Weigert

  29. Lung cancer–associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell–immune cell cross-talk

    Article • Science Translational Medicine, November 2017, American Association for the Advancement of Science

    Dr. Andreas Weigert

  30. Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis

    Article • Molecular Immunology, October 2017, Elsevier

    Dr. Andreas Weigert

  31. Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2?

    Article • Frontiers in Immunology, September 2017, Frontiers

    Dr. Andreas Weigert

  32. GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency

    Article • PLoS ONE, August 2017, PLOS

    Dr. Andreas Weigert

  33. Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis

    Article • Shock, August 2017, Wolters Kluwer Health

    Dr. Andreas Weigert

  34. Cancer cell and macrophage cross-talk in the tumor microenvironment

    Article • Current Opinion in Pharmacology, August 2017, Elsevier

    Dr. Andreas Weigert

  35. THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

    Article • Molecular Immunology, August 2017, Elsevier

    Dr. Andreas Weigert

  36. The RNA-binding protein HuR inhibits expression of CCL5 and limits recruitment of macrophages into tumors

    Article • Molecular Carcinogenesis, July 2017, Wiley

    Dr. Andreas Weigert

  37. S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

    Article • The Journal of Experimental Medicine, July 2017, Rockefeller University Press

    Dr. Andreas Weigert

  38. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity

    Article • Cellular and Molecular Life Sciences, April 2017, Springer Science + Business Media

    Dr. Andreas Weigert

  39. Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

    Article • Oncotarget, April 2017, Impact Journals, LLC

    Dr. Andreas Weigert

  40. Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

    Article • Clinical Cancer Research, February 2017, American Association for Cancer Research (AACR)

    Dr. Andreas Weigert

  41. Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

    Article • Mediators of Inflammation, January 2017, Hindawi Publishing Corporation

    Dr. Andreas Weigert

  42. S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2

    Article • Mediators of Inflammation, January 2017, Hindawi Publishing Corporation

    Dr. Andreas Weigert

  43. Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice

    Article • Acta Dermato Venereologica, January 2017, Acta Dermato-Venereologica

    Dr. Andreas Weigert

  44. Macrophage NOS2 in Tumor Leukocytes

    Article • Antioxidants & Redox Signaling, August 2016, Mary Ann Liebert Inc

    Dr. Andreas Weigert

  45. Lipocalin 2 from macrophages stimulated by tumor cell–derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

    Article • Science Signaling, June 2016, American Association for the Advancement of Science

    Dr. Andreas Weigert

  46. Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis

    Article • The Journal of Pathology, April 2016, Wiley

    Dr. Andreas Weigert

  47. Cellular analysis of the histamine H4 receptor in human myeloid cells

    Article • Biochemical Pharmacology, March 2016, Elsevier

    Dr. Andreas Weigert

  48. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses

    Article • Journal of Molecular Cell Biology, February 2016, Oxford University Press (OUP)

    Dr. Andreas Weigert

  49. S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells

    Article • The Journal of Immunology, January 2016, The American Association of Immunologists

    Dr. Andreas Weigert

  50. IL-1 family cytokines in cancer immunity – a matter of life and death

    Article • Biological Chemistry, January 2016, De Gruyter

    Dr. Andreas Weigert

  51. Killing Is Not Enough: How Apoptosis Hijacks Tumor-Associated Macrophages to Promote Cancer Progression

    Article • January 2016, Springer Science + Business Media

    Dr. Andreas Weigert

  52. Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Andreas Weigert

  53. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling

    Article • Journal of Biological Chemistry, October 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Andreas Weigert

  54. Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma

    Article • PLoS ONE, September 2015, PLOS

    Dr. Andreas Weigert

  55. Macrophage Polarization In The Tumor Microenvironment

    Article • Redox Biology, August 2015, Elsevier

    Dr. Andreas Weigert

  56. Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner

    Article • Neoplasia, June 2015, Elsevier

    Dr. Andreas Weigert

  57. Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability

    Article • Free Radical Biology and Medicine, June 2015, Elsevier

    Dr. Andreas Weigert

  58. MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

    Article • Oncotarget, May 2015, Impact Journals, LLC

    Dr. Andreas Weigert

  59. Mo1823 Dietary Wheat Alpha-Amylase-Trypsin Inhibitors (ATIS) Worsen Intestinal Inflammation in Mice

    Article • Gastroenterology, April 2015, Elsevier

    Dr. Andreas Weigert

  60. Macrophage and Cancer Cell Cross-talk via CCR2 and CX3CR1 Is a Fundamental Mechanism Driving Lung Cancer

    Article • American Review of Respiratory Disease, February 2015, American Thoracic Society

    Dr. Andreas Weigert

  61. S1PR4 is required for plasmacytoid dendritic cell differentiation

    Article • Biological Chemistry, January 2015, De Gruyter

    Dr. Andreas Weigert

  62. Macrophage Heterogeneity During Inflammation

    Article • January 2015, Springer Science + Business Media

    Dr. Andreas Weigert

  63. Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response

    Article • Cell Death and Disease, December 2014, Springer Science + Business Media

    Dr. Andreas Weigert

  64. Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity

    Article • Pain, October 2014, Wolters Kluwer Health

    Dr. Andreas Weigert

  65. Vitamin D Promotes Vascular Regeneration

    Article • Circulation, September 2014, Wolters Kluwer Health

    Dr. Andreas Weigert

  66. Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors

    Article • Mucosal Immunology, July 2014, Springer Science + Business Media

    Dr. Andreas Weigert

  67. Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly

    Article • Blood, May 2014, American Society of Hematology

    Dr Halvard B Bonig, Dr. Andreas Weigert

  68. Resveratrol-induced potentiation of the antitumor effects of oxaliplatin is accompanied by an altered cytokine profile of human monocyte-derived macrophages

    Article • APOPTOSIS, April 2014, Springer Science + Business Media

    Dr. Andreas Weigert

  69. Sphingosine-1 phosphate promotes thymic atrophy during sepsis progression

    Article • Critical Care, April 2014, Springer Science + Business Media

    Dr. Andreas Weigert

  70. Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages

    Article • Pain, March 2014, Wolters Kluwer Health

    Dr. Andreas Weigert

  71. Response to Sympathoinhibitory Effect of Diltiazem and Prevention of Aneurysm Formation

    Article • Hypertension, March 2014, Wolters Kluwer Health

    Dr. Andreas Weigert

  72. PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis

    Article • Biochemical Pharmacology, February 2014, Elsevier

    Dr. Andreas Weigert

  73. Endo-PDI is required for TNFα-induced angiogenesis

    Article • Free Radical Biology and Medicine, December 2013, Elsevier

    Dr. Andreas Weigert

  74. l -Type Calcium Channel Inhibitor Diltiazem Prevents Aneurysm Formation by Blood Pressure–Independent Anti-Inflammatory Effects

    Article • Hypertension, December 2013, Wolters Kluwer Health

    Dr. Andreas Weigert

  75. Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration

    Article • European Journal of Immunology, August 2013, Wiley

    Dr. Andreas Weigert

  76. Redox Control of Inflammation in Macrophages

    Article • Antioxidants & Redox Signaling, August 2013, Mary Ann Liebert Inc

    Dr. Andreas Weigert

  77. Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2to promote tumor growth and to inhibit T cell activation

    Article • International Journal of Cancer, April 2013, Wiley

    Dr. Andreas Weigert

  78. RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6/IL-10 expression

    Article • Immunobiology, January 2013, Elsevier

    Dr. Andreas Weigert

  79. Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages

    Article • Carcinogenesis, December 2012, Oxford University Press (OUP)

    Dr. Andreas Weigert

  80. The multi-faceted roles of prostaglandin E2 in cancer-infiltrating mononuclear phagocyte biology

    Article • Immunobiology, December 2012, Elsevier

    Dr. Andreas Weigert

  81. HIF-1  is a negative regulator of plasmacytoid DC development in vitro and in vivo

    Article • Blood, August 2012, American Society of Hematology

    Dr. Andreas Weigert

  82. IRES-dependent translation of egr2 is induced under inflammatory conditions

    Article • RNA, August 2012, Cold Spring Harbor Laboratory Press

    Dr. Andreas Weigert

  83. Interleukin-10-Induced Neutrophil Gelatinase-Associated Lipocalin Production in Macrophages with Consequences for Tumor Growth

    Article • Molecular and Cellular Biology, July 2012, ASM Journals

    Dr. Andreas Weigert

  84. Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages

    Article • International Journal of Cancer, July 2012, Wiley

    Dr. Andreas Weigert

  85. Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine

    Article • Journal of Molecular Medicine, June 2012, Springer Science + Business Media

    Dr. Andreas Weigert

  86. Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

    Article • European Journal of Immunology, June 2012, Wiley

    Dr. Andreas Weigert

  87. The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages

    Article • Oncogene, March 2012, Springer Science + Business Media

    Dr. Andreas Weigert

  88. S1P Regulation of Macrophage Functions in the Context of Cancer

    Article • Anti-Cancer Agents in Medicinal Chemistry, November 2011, Bentham Science Publishers

    Dr. Andreas Weigert

  89. Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration

    Article • The Journal of Pathology, October 2011, Wiley

    Dr. Andreas Weigert

  90. Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

    Article • Carcinogenesis, July 2011, Oxford University Press (OUP)

    Dr. Andreas Weigert

  91. Peroxisome Proliferator–activated Receptor γ–induced T Cell Apoptosis Reduces Survival during Polymicrobial Sepsis

    Article • American Review of Respiratory Disease, July 2011, American Thoracic Society

    Dr. Andreas Weigert

  92. Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2

    Article • The FASEB Journal, March 2011, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Andreas Weigert

  93. Anti-inflammatory Role of Microsomal Prostaglandin E Synthase-1 in a Model of Neuroinflammation

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Andreas Weigert

  94. Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB

    Article • Cellular and Molecular Life Sciences, October 2010, Springer Science + Business Media

    Dr. Andreas Weigert

  95. Neuromediators in inflammation—a macrophage/nerve connection

    Article • Immunobiology, September 2010, Elsevier

    Dr. Andreas Weigert

  96. Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death

    Article • Cancer Chemotherapy and Pharmacology, August 2010, Springer Science + Business Media

    Dr. Andreas Weigert

  97. Technical Advance: Generation of human pDC equivalents from primary monocytes using Flt3-L and their functional validation under hypoxia

    Article • Journal of Leukocyte Biology, May 2010, Wiley

    Dr. Andreas Weigert

  98. Knockout of HIF-1  in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

    Article • Carcinogenesis, April 2010, Oxford University Press (OUP)

    Dr. Andreas Weigert

  99. Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells

    Article • Blood, March 2010, American Society of Hematology

    Dr. Andreas Weigert

  100. Regulation of macrophage function by sphingosine-1-phosphate

    Article • Immunobiology, September 2009, Elsevier

    Dr. Andreas Weigert

  101. Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti‐inflammatory phenotype

    Article • International Journal of Cancer, July 2009, Wiley

    Dr. Andreas Weigert

  102. The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1  in macrophages via sphingosine-1-phosphate and transforming growth factor- 

    Article • Blood, June 2009, American Society of Hematology

    Dr. Andreas Weigert

  103. Hypoxia Enhances Sphingosine Kinase 2 Activity and Provokes Sphingosine-1-Phosphate-Mediated Chemoresistance in A549 Lung Cancer Cells

    Article • Molecular Cancer Research, March 2009, American Association for Cancer Research (AACR)

    Dr. Andreas Weigert

  104. Heme Oxygenase-1 Contributes to an Alternative Macrophage Activation Profile Induced by Apoptotic Cell Supernatants

    Article • Molecular Biology of the Cell, March 2009, American Society for Cell Biology (ASCB)

    Dr. Andreas Weigert

  105. The liaison between apoptotic cells and macrophages – the end programs the beginning

    Article • Biological Chemistry, January 2009, De Gruyter

    Dr. Andreas Weigert

  106. Tumor-associated macrophages as targets for tumor immunotherapy

    Article • Immunotherapy, January 2009, Future Medicine

    Dr. Andreas Weigert

  107. Nitric oxide, apoptosis and macrophage polarization during tumor progression

    Article • Nitric Oxide, September 2008, Elsevier

    Dr. Andreas Weigert

  108. Hypoxia stimulus: An adaptive immune response during dendritic cell maturation

    Article • Kidney International, April 2008, Elsevier

    Dr. Andreas Weigert

  109. Tumor Cell Apoptosis Polarizes Macrophages—Role of Sphingosine-1-Phosphate

    Article • Molecular Biology of the Cell, October 2007, American Society for Cell Biology (ASCB)

    Dr. Andreas Weigert

  110. Apoptotic cells induce arginase II in macrophages, thereby attenuating NO production

    Article • The FASEB Journal, April 2007, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Andreas Weigert

  111. PPARγ1 attenuates cytosol to membrane translocation of PKCα to desensitize monocytes/macrophages

    Article • The Journal of Experimental Medicine, March 2007, Rockefeller University Press

    Dr. Andreas Weigert

  112. PPARγ1 attenuates cytosol to membrane translocation of PKCα to desensitize monocytes/macrophages

    Article • The Journal of Cell Biology, February 2007, Rockefeller University Press

    Dr. Andreas Weigert

  113. Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate

    Article • Blood, May 2006, American Society of Hematology

    Dr. Andreas Weigert