All Stories

  1. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)

    Article • British Journal of Pharmacology, January 2017, Wiley

    Dr Scott P Webster

  2. Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis

    Article • Scientific Reports, September 2016, Nature

    Dr Scott P Webster

  3. 11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

    Article • Endocrinology, July 2016, Endocrine Society

    Dr Scott P Webster

  4. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

    Article • Nature Medicine, June 2016, Nature

    Dr Scott P Webster, Jose Fernandez-Real

  5. Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

    Article • Journal of Medicinal Chemistry, May 2016, American Chemical Society (ACS)

    Dr Scott P Webster

  6. Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback

    Article • Cell Death and Disease, April 2016, Nature

    Dr Scott P Webster

  7. Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

    Article • Nature Medicine, January 2016, Nature

    Dr Scott P Webster

  8. Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11β-HSD1 inhibitors

    Article • Bioorganic & Medicinal Chemistry, December 2015, Elsevier

    Dr Scott P Webster

  9. Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

    Article • Endocrinology, December 2015, Endocrine Society

    Dr Scott P Webster

  10. Novel 11β-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold

    Article • Bioorganic & Medicinal Chemistry Letters, October 2015, Elsevier

    Dr Scott P Webster

  11. Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice

    Article • Neuropharmacology, April 2015, Elsevier

    Dr Scott P Webster

  12. UFSRAT: Ultra-Fast Shape Recognition with Atom Types –The Discovery of Novel Bioactive Small Molecular Scaffolds for FKBP12 and 11βHSD1

    Article • PLoS ONE, February 2015, PLOS

    Dr Scott P Webster

  13. A Magnetic Bead–Based Ligand Binding Assay to Facilitate Human Kynurenine 3-Monooxygenase Drug Discovery

    Article • SLAS DISCOVERY, February 2015, SAGE Publications

    Dr Scott P Webster

  14. Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

    Article • Neurobiology of Aging, January 2015, Elsevier

    Dr Scott P Webster

  15. β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction

    Article • Frontiers in Endocrinology, October 2014, Frontiers

    Dr Scott P Webster

  16. Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning

    Article • Neuropharmacology, June 2014, Elsevier

    Dr Scott P Webster

  17. Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities

    Article • European Journal of Medicinal Chemistry, March 2014, Elsevier

    Dr Scott P Webster

  18. Bacterial expression of human kynurenine 3-monooxygenase: Solubility, activity, purification

    Article • Protein Expression and Purification, March 2014, Elsevier

    Dr Scott P Webster

  19. Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

    Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

    Dr Scott P Webster

  20. Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry

    Article • SLAS DISCOVERY, December 2013, SAGE Publications

    Dr Scott P Webster

  21. Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

    Article • Analytical Chemistry, December 2013, American Chemical Society (ACS)

    Dr Scott P Webster

  22. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

    Article • Biochemical Pharmacology, July 2013, Elsevier

    Dr Scott P Webster

  23. Discovery, synthesis and in combo studies of a tetrazole analogue of clofibric acid as a potent hypoglycemic agent

    Article • Bioorganic & Medicinal Chemistry Letters, June 2013, Elsevier

    Master in Pharmacy Gabriela Avila Villarreal, Dr Scott P Webster

  24. Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD 1

    Article • Phytomedicine, May 2013, Elsevier

    Dr Yolanda Rios Gómez, Dr Scott P Webster

  25. Optimal Elevation of  -Cell 11 -Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet-Induced  -Cell Failure

    Article • Diabetes, February 2012, American Diabetes Association

    Dr Scott P Webster

  26. Partial Deficiency or Short-Term Inhibition of 11 -Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice

    Article • Journal of Neuroscience, October 2010, Society for Neuroscience

    Dr Scott P Webster

  27. Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

    Article • Bioorganic & Medicinal Chemistry Letters, June 2010, Elsevier

    Dr Scott P Webster

  28. A comparative study of flavonoid analogues on streptozotocin–nicotinamide induced diabetic rats: Quercetin as a potential antidiabetic agent acting via 11β-Hydroxysteroid dehydrogenase type 1 inhibition

    Article • European Journal of Medicinal Chemistry, June 2010, Elsevier

    Dr Scott P Webster

  29. Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides

    Article • Bioorganic & Medicinal Chemistry Letters, May 2008, Elsevier

    Dr Scott P Webster

  30. 11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 diabetes mellitus and obesity

    Article • Expert Opinion on Investigational Drugs, March 2008, Informa Healthcare

    Dr Scott P Webster

  31. Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, May 2007, Elsevier

    Dr Scott P Webster

  32. Suicide inhibition of α-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine

    Article • Organic & Biomolecular Chemistry, January 2006, Royal Society of Chemistry

    Dr Scott P Webster

  33. Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway

    Article • FEBS Letters, February 2002, Wiley

    Dr Scott P Webster

  34. Probing the NADPH-binding site of Escherichia coli flavodoxin oxidoreductase

    Article • Biochemical Journal, December 2000, Portland Press Ltd.

    Dr Scott P Webster

  35. Mechanistic Studies Of 8-Amino-7-Oxononanoate Synthase.

    Article • January 2000, Springer Science + Business Media

    Dr Scott P Webster

  36. Mechanism of 8-Amino-7-oxononanoate Synthase:  Spectroscopic, Kinetic, and Crystallographic Studies † , ‡

    Article • Biochemistry, January 2000, American Chemical Society (ACS)

    Dr Scott P Webster

  37. The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme 1 1Edited by R. Huber

    Article • Journal of Molecular Biology, November 1998, Elsevier

    Dr Scott P Webster

  38. Characterisation of 8-amino-7-oxononanoate synthase: A bacterial PLP-dependent, acyl CoA condensing enzyme

    Article • Biochemical Society Transactions, August 1998, Portland Press Ltd.

    Dr Scott P Webster