All Stories

  1. Evolution of human, chicken, alligator, frog, and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity

    Article • Science Signaling, July 2018, American Association for the Advancement of Science

    Dr Michael E Baker

  2. The promiscuous estrogen receptor: Evolution of physiological estrogens and response to phytochemicals and endocrine disruptors

    Article • The Journal of Steroid Biochemistry and Molecular Biology, July 2018, Elsevier

    Dr Michael E Baker

  3. Progesterone activation of zebrafish mineralocorticoid receptor may influence growth of some transplanted tumors

    Article • Proceedings of the National Academy of Sciences, March 2018, Proceedings of the National Academy of Sciences

    Dr Michael E Baker

  4. Transcriptional Activation of a Cartilaginous Fish (Elephant Shark, Callorhinchus milii) Mineralocorticoid Receptor by Corticosteroids, Progestins and Spironolactone

    Article • February 2018, Cold Spring Harbor Laboratory Press

    Dr Michael E Baker

  5. The promiscuous estrogen receptor: evolution of physiological estrogens and response to phytochemicals and endocrine disruptors

    Article • December 2017, Cold Spring Harbor Laboratory Press

    Dr Michael E Baker

  6. Evolution of human, chicken, alligator, frog and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity

    Article • June 2017, Cold Spring Harbor Laboratory Press

    Dr Michael E Baker

  7. Evolution of the Mineralocorticoid Receptor

    Article • Journal of Endocrinology, May 2017, Bioscientifica

    Dr Michael E Baker

  8. Corticosteroid and progesterone transactivation of mineralocorticoid receptors from Amur sturgeon and tropical gar

    Article • May 2016, Cold Spring Harbor Laboratory Press

    Dr Michael E Baker

  9. Evolution of corticosteroid specificity for human, chicken, alligator and frog glucocorticoid receptors

    Article • January 2016, Cold Spring Harbor Laboratory Press

    Dr Michael E Baker

  10. Structural and evolutionary analysis of the co-activator binding domain in vertebrate progesterone receptors

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2014, Elsevier

    Dr Michael E Baker

  11. Transcriptional analysis of endocrine disruption using zebrafish and massively parallel sequencing

    Article • April 2014, Bioscientifica

    Dr Michael E Baker

  12. Understanding How Coumestrol, a Chemical in Plants, Interacts with the Estrogen Receptor

    Article • Steroids, February 2014, Elsevier

    Dr Michael E Baker

  13. Biological responses of marine flatfish exposed to municipal wastewater effluent

    Article • Environmental Toxicology and Chemistry, January 2014, Wiley

    Dr Doris E. Vidal-Dorsch, Dr Michael E Baker

  14. Corrigendum to “Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors” [J. Steroid Biochem. Mol. Biol. 137 (2013) 57–70]

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2014, Elsevier

    Dr Michael E Baker

  15. Expanding the structural footprint of xenoestrogens

    Article • Endocrine Disruptors, January 2014, Taylor & Francis

    Dr Michael E Baker

  16. The microbiome as a target for endocrine disruptors: Novel chemicals may disrupt androgen and microbiome-mediated autoimmunity

    Article • Endocrine Disruptors, January 2014, Taylor & Francis

    Dr Michael E Baker

  17. Molecular Analysis of Endocrine Disruption in Hornyhead Turbot at Wastewater Outfalls in Southern California Using a Second Generation Multi-Species Microarray

    Article • PLoS ONE, September 2013, PLOS

    Dr Doris E. Vidal-Dorsch, Dr Michael E Baker

  18. Genomic and phenotypic response of hornyhead turbot exposed to municipal wastewater effluents

    Article • Aquatic Toxicology, September 2013, Elsevier

    Dr Doris E. Vidal-Dorsch, Dr Michael E Baker

  19. Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors

    Article • The Journal of Steroid Biochemistry and Molecular Biology, September 2013, Elsevier

    Dr Michael E Baker

  20. Fluorescent Ligand for Human Progesterone Receptor Imaging in Live Cells

    Article • Bioconjugate Chemistry, May 2013, American Chemical Society (ACS)

    Dr Michael E Baker

  21. What are the physiological estrogens?

    Article • Steroids, March 2013, Elsevier

    Dr Michael E Baker

  22. Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals

    Article • International Journal of Cell Biology, January 2013, Hindawi Publishing Corporation

    Dr Atanas G. Atanasov, Dr Michael E Baker

  23. Evaluation of reproductive endocrine status in hornyhead turbot sampled from Southern California's urbanized coastal environments

    Article • Environmental Toxicology and Chemistry, October 2012, Wiley

    Dr Doris E. Vidal-Dorsch, Dr Michael E Baker

  24. 3D Models of MBP, a Biologically Active Metabolite of Bisphenol A, in Human Estrogen Receptor α and Estrogen Receptor β

    Article • PLoS ONE, October 2012, PLOS

    Dr Michael E Baker

  25. 3D models of human ERα and ERβ complexed with 5-androsten-3β,17β-diol

    Article • Steroids, October 2012, Elsevier

    Dr Michael E Baker

  26. Evolutionary analysis of the segment from helix 3 through helix 5 in vertebrate progesterone receptors

    Article • The Journal of Steroid Biochemistry and Molecular Biology, October 2012, Elsevier

    Dr Michael E Baker

  27. 3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone

    Article • Steroids, December 2011, Elsevier

    Dr Michael E Baker

  28. A novel steroidal antiandrogen targeting wild type and mutant androgen receptors

    Article • Biochemical Pharmacology, December 2011, Elsevier

    Dr Michael E Baker

  29. Biological effects of marine contaminated sediments on Sparus aurata juveniles

    Article • Aquatic Toxicology, August 2011, Elsevier

    Dr Michael E Baker

  30. Insights from the structure of estrogen receptor into the evolution of estrogens: Implications for endocrine disruption

    Article • Biochemical Pharmacology, July 2011, Elsevier

    Dr Michael E Baker

  31. Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1

    Article • Biochemical Journal, June 2011, Portland Press Ltd.

    Dr Michael E Baker

  32. Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors

    Article • Molecular and Cellular Endocrinology, March 2011, Elsevier

    Dr Michael E Baker

  33. 3D models of lamprey progesterone receptor complexed with progesterone, 7α-hydroxy-progesterone and 15α-hydroxy-progesterone

    Article • Steroids, January 2011, Elsevier

    Dr Michael E Baker

  34. Molecular staging of marine medaka: A model organism for marine ecotoxicity study

    Article • Marine Pollution Bulletin, January 2011, Elsevier

    Dr Michael E Baker

  35. 11β-Hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17β-Hydroxysteroid dehydrogenase-type 2

    Article • Biochemical and Biophysical Research Communications, August 2010, Elsevier

    Dr Michael E Baker

  36. Evolution of 11β-hydroxysteroid dehydrogenase-type 1 and 11β-hydroxysteroid dehydrogenase-type 3

    Article • FEBS Letters, March 2010, Wiley

    Dr Michael E Baker

  37. 3D model of amphioxus steroid receptor complexed with estradiol

    Article • Biochemical and Biophysical Research Communications, August 2009, Elsevier

    Dr Michael E Baker

  38. Independent elaboration of steroid hormone signaling pathways in metazoans

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    Dr Michael E Baker

  39. 3D Model of Lamprey Estrogen Receptor with Estradiol and 15α-Hydroxy-Estradiol

    Article • PLoS ONE, June 2009, PLOS

    Dr Michael E Baker

  40. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members

    Article • Physiological Genomics, May 2009, American Physiological Society

    Dr Michael E Baker

  41. Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1

    Article • Molecular and Cellular Endocrinology, March 2009, Elsevier

    Dr Michael E Baker

  42. Dibutyltin Disrupts Glucocorticoid Receptor Function and Impairs Glucocorticoid-Induced Suppression of Cytokine Production

    Article • PLoS ONE, October 2008, PLOS

    Dr Michael E Baker

  43. Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution

    Article • Biochemical and Biophysical Research Communications, October 2008, Elsevier

    Dr Michael E Baker

  44. Analysis of Endocrine Disruption in Southern California Coastal Fish Using an Aquatic Multispecies Microarray

    Article • Environmental Health Perspectives, August 2008, Environmental Health Perspectives

    Dr Doris E. Vidal-Dorsch, Dr Michael E Baker

  45. Variation of the genetic expression pattern after exposure to estradiol-17β and 4-nonylphenol in male zebrafish (Danio rerio)

    Article • General and Comparative Endocrinology, August 2008, Elsevier

    Dr Michael E Baker

  46. Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors: Toward a better understanding of estrogen receptor evolution

    Article • Biochemical and Biophysical Research Communications, July 2008, Elsevier

    Dr Michael E Baker

  47. Activity versus Peroxisomal Targeting of PerCR

    Article • Structure, March 2008, Elsevier

    Dr Michael E Baker

  48. Analysis of 3D models of octopus estrogen receptor with estradiol: Evidence for steric clashes that prevent estrogen binding

    Article • Biochemical and Biophysical Research Communications, September 2007, Elsevier

    Dr Michael E Baker

  49. Evolution of the Estrogen Receptor

    Article • Endocrinology, August 2007, Endocrine Society

    Dr Michael E Baker

  50. Hexose-6-phosphate Dehydrogenase Modulates 11β-Hydroxysteroid Dehydrogenase Type 1-Dependent Metabolism of 7-keto- and 7β-hydroxy-neurosteroids

    Article • PLoS ONE, June 2007, PLOS

    Dr Atanas G. Atanasov, Dr Michael E Baker

  51. Article • BMC Evolutionary Biology, January 2007, Springer Science + Business Media

    Dr Michael E Baker

  52. Evolution of metamorphosis: role of environment on expression of mutant nuclear receptors and other signal-transduction proteins

    Article • Integrative and Comparative Biology, October 2006, Oxford University Press (OUP)

    Dr Michael E Baker

  53. Evolution of the thyroid hormone, retinoic acid, ecdysone and liver X receptors

    Article • Integrative and Comparative Biology, October 2006, Oxford University Press (OUP)

    Dr Michael E Baker

  54. Rat 3α-Hydroxysteroid Dehydrogenase: To Oxidize or Reduce, that Is the Question

    Article • Endocrinology, April 2006, Endocrine Society

    Dr Michael E Baker

  55. The genetic response to Snowball Earth: role of HSP90 in the Cambrian explosion

    Article • Geobiology, March 2006, Wiley

    Dr Michael E Baker

  56. Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids

    Article • FEBS Letters, December 2005, Wiley

    Dr Michael E Baker

  57. Tetrahydrogestrinone Is an Androgenic Steroid that Stimulates Androgen Receptor-Mediated, Myogenic Differentiation in C3H10T1/2 Multipotent Mesenchymal Cells and Promotes Muscle Accretion in Orchidectomized Male Rats

    Article • Endocrinology, October 2005, Endocrine Society

    Dr Michael E Baker

  58. Organotins Disrupt the 11β-Hydroxysteroid Dehydrogenase Type 2–Dependent Local Inactivation of Glucocorticoids

    Article • Environmental Health Perspectives, July 2005, Environmental Health Perspectives

    Dr Atanas G. Atanasov, Dr Michael E Baker

  59. Dissecting the Axoneme Interactome: The Mammalian Orthologue of Chlamydomonas PF6 Interacts with Sperm-Associated Antigen 6, The Mammalian Orthologue of Chlamydomonas PF16

    Article • Molecular & Cellular Proteomics, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Michael E Baker

  60. Evolutionary analysis of 11β-hydroxysteroid dehydrogenase-type 1, -type 2, -type 3 and 17β-hydroxysteroid dehydrogenase-type 2 in fish

    Article • FEBS Letters, August 2004, Wiley

    Dr Michael E Baker

  61. Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors

    Article • Molecular and Cellular Endocrinology, February 2004, Elsevier

    Dr Michael E Baker

  62. The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist

    Article • Molecular and Cellular Endocrinology, February 2004, Elsevier

    Dr Michael E Baker

  63. Steroid Receptors, Evolution of

    Article • January 2004, Elsevier

    Dr Michael E Baker

  64. Evolution of Glucocorticoid and Mineralocorticoid Responses: Go Fish

    Article • Endocrinology, October 2003, Endocrine Society

    Dr Michael E Baker

  65. Inhibition of 11β-hydroxysteroid dehydrogenase type 2 by dithiocarbamates

    Article • Biochemical and Biophysical Research Communications, August 2003, Elsevier

    Dr Atanas G. Atanasov, Dr Michael E Baker

  66. Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity

    Article • BioEssays, March 2003, Wiley

    Dr Michael E Baker

  67. Glutamate-115 renders specificity of human 11β-hydroxysteroid dehydrogenase type 2 for the cofactor NAD+

    Article • Molecular and Cellular Endocrinology, March 2003, Elsevier

    Dr Michael E Baker

  68. Albumin, steroid hormones and the origin of vertebrates

    Article • Journal of Endocrinology, October 2002, Bioscientifica

    Dr Michael E Baker

  69. Recent insights into the origins of adrenal and sex steroid receptors

    Article • Journal of Molecular Endocrinology, June 2002, Bioscientifica

    Dr Michael E Baker

  70. Deletion of 12 carboxyl-terminal residues from pig 3α/β,20β-hydroxysteroid dehydrogenase affects steroid metabolism

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, December 2001, Elsevier

    Dr Michael E Baker

  71. Adrenal and sex steroid receptor evolution: environmental implications

    Article • Journal of Molecular Endocrinology, April 2001, Bioscientifica

    Dr Michael E Baker

  72. Hydroxysteroid dehydrogenases: ancient and modern regulators of adrenal and sex steroid action

    Article • Molecular and Cellular Endocrinology, April 2001, Elsevier

    Dr Michael E Baker

  73. Evolution of 17β-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action

    Article • Molecular and Cellular Endocrinology, January 2001, Elsevier

    Dr Michael E Baker

  74. Mutation of threonine-241 to proline eliminates autocatalytic modification of human carbonyl reductase

    Article • Biochemical Journal, August 2000, Portland Press Ltd.

    Dr Michael E Baker

  75. Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression

    Article • Cellular and Molecular Life Sciences, May 2000, Springer Science + Business Media

    Dr Michael E Baker

  76. TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases

    Article • Current Biology, July 1999, Elsevier

    Dr Michael E Baker

  77. A common ancestor for a subunit in the mitochondrial proton-translocating NADH:ubiquinone oxidoreductase (complex I) and short-chain dehydrogenases/reductases

    Article • Cellular and Molecular Life Sciences, March 1999, Springer Science + Business Media

    Dr Michael E Baker

  78. Albumin's role in steroid hormone action and the origins of vertebrates: is albumin an essential protein?

    Article • FEBS Letters, November 1998, Wiley

    Dr Michael E Baker

  79. Evolution of mammalian 11β- and 17β-hydroxysteroid dehydrogenases-type 2 and retinol dehydrogenases from ancestors in Caenorhabditis elegans and evidence for horizontal transfer of a eukaryote dehydrogenase to E. coli

    Article • The Journal of Steroid Biochemistry and Molecular Biology, September 1998, Elsevier

    Dr Michael E Baker

  80. Characterization of Ke 6, a New 17 -Hydroxysteroid Dehydrogenase, and Its Expression in Gonadal Tissues

    Article • Journal of Biological Chemistry, August 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Michael E Baker

  81. Spinach CSP41, an mRNA-Binding Protein and Ribonuclease, Is Homologous to Nucleotide-Sugar Epimerases and Hydroxysteroid Dehydrogenases

    Article • Biochemical and Biophysical Research Communications, July 1998, Elsevier

    Dr Michael E Baker

  82. Steroid receptor phylogeny and vertebrate origins

    Article • Molecular and Cellular Endocrinology, December 1997, Elsevier

    Dr Michael E Baker

  83. MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis

    Article • Proceedings of the National Academy of Sciences, August 1997, Proceedings of the National Academy of Sciences

    Dr Michael E Baker

  84. An artificial intelligence approach to motif discovery in protein sequences: Application to steroid dehydrogenases

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 1997, Elsevier

    Dr Michael E Baker

  85. Hidden Markov Model Analysis of Motifs in Steroid Dehydrogenases and Their Homologs

    Article • Biochemical and Biophysical Research Communications, February 1997, Elsevier

    Dr Michael E Baker

  86. Bacterial 3α-hydroxysteroid dehydrogenase is homologous to a fusion of bacterial ribosomal L10 and genes

    Article • The Journal of Steroid Biochemistry and Molecular Biology, December 1996, Elsevier

    Dr Michael E Baker

  87. Structures Important in NAD(P)(H) Specificity for Mammalian Retinol and 11-Cis-Retinol Dehydrogenases

    Article • Biochemical and Biophysical Research Communications, September 1996, Elsevier

    Dr Michael E Baker

  88. Structures important in mammalian 11β- and 17β-hydroxysteroid dehydrogenases

    Article • The Journal of Steroid Biochemistry and Molecular Biology, December 1995, Elsevier

    Dr Michael E Baker

  89. Structures Stabilizing the Dimer Interface on Human 11β-Hydroxysteroid Dehydrogenase Types 1 and 2 and Human 15-Hydroxyprostaglandin Dehydrogenase and Their Homologs

    Article • Biochemical and Biophysical Research Communications, December 1995, Elsevier

    Dr Michael E Baker

  90. Licorice-derived compounds inhibit linoleic acid (C:18:2ω6) desaturation in soybean chloroplasts

    Article • FEBS Letters, July 1995, Wiley

    Dr Michael E Baker

  91. Sequence analysis of steroid- and prostaglandin-metabolizing enzymes: Application to understanding catalysis

    Article • Steroids, April 1994, Elsevier

    Dr Michael E Baker

  92. Licorice and enzymes other than 11β-hydroxysteroid dehydrogenase: An evolutionary perspective

    Article • Steroids, February 1994, Elsevier

    Dr Michael E Baker

  93. Chicken Sterol Carrier Protein m2/Sterol Carrier Protein x: cDNA Cloning Reveals Evolutionary Conservation of Structure and Regulated Expression

    Article • Archives of Biochemistry and Biophysics, July 1993, Elsevier

    Dr Michael E Baker

  94. Inhibition of 3,5,3'-triiodothyronine binding to its receptor in rat liver by protease inhibitors and substrates

    Article • Molecular and Cellular Endocrinology, May 1993, Elsevier

    Dr Michael E Baker

  95. Physiological and molecular effects of brassinosteroids on Arabidopsis thaliana

    Article • Journal of Plant Growth Regulation, April 1993, Springer Science + Business Media

    Dr Michael E Baker

  96. Expansion of the mammalian 3β-hydroxysteroid dehydrogenase/plant dihydroflavonol reductase superfamily to include a bacterial cholesterol dehydrogenase, a bacterial UDP-galactose-4-epimerase, and open reading frames in vaccinia virus and fish lymphocystis

    Article • FEBS Letters, April 1992, Wiley

    Dr Michael E Baker

  97. Evolution of Enzymatic regulation of prostaglandin action: Novel connections to regulation of human sex and adrenal function, antibiotic synthesis and nitrogen fixation

    Article • Prostaglandins, November 1991, Elsevier

    Dr Michael E Baker

  98. Mammalian peripheral-type benzodiazepine receptor is homologous to CrtK protein of rhodobacter capsulatus, a photosynthetic bacterium

    Article • Cell, May 1991, Elsevier

    Dr Michael E Baker

  99. A common ancestor for bovine lens fiber major intrinsic protein, soybean nodulin-26 protein, and E. coli glycerol facilitator

    Article • Cell, January 1990, Elsevier

    Dr Michael E Baker

  100. Location of enzymatic and DNA-binding domains on E. coli protease La

    Article • FEBS Letters, February 1989, Wiley

    Dr Michael E Baker

  101. Evidence that progesterone binding uteroglobin is similar to myosin alkali light chain

    Article • FEBS Letters, September 1985, Wiley

    Dr Michael E Baker

  102. Human tissue-type plasminogen activator is related to albumin and alpha-fetoprotein

    Article • FEBS Letters, March 1985, Wiley

    Dr Michael E Baker

  103. Gossypol inhibits estrogen binding to rat /-fetoprotein

    Article • FEBS Letters, September 1984, Wiley

    Dr Michael E Baker

  104. Inhibition of estrogen binding to rat alpha-fetoprotein by tryptophan p-nitrophenyl esters

    Article • Journal of Steroid Biochemistry, April 1982, Elsevier

    Dr Michael E Baker

  105. Competitive inhibition of dexamethasone binding to the glucocorticoid receptor in HTC cells by tryptophan methyl ester

    Article • Journal of Steroid Biochemistry, August 1980, Elsevier

    Dr Michael E Baker

  106. Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors

    Article • SciVee, Inc

    Dr Michael E Baker