Professor Renger Witkamp
Current affiliation: Wageningen Universiteit
Subject: Medicine And Medical Sciences
Primary location: Netherlands
Palmitoylethanolamide (PEA)—‘Promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma
Published in:PharmaNutrition
Publication date:2014-01-01What's it about?Palmitoylethanolamide is a new kid on the block in autacoid medicine, and widely available as a food supplement. In this article we describe the gr...
Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold
Published in:International Journal of Inflammation
Publication date:2013-01-01What's it about?Palmitoylethanolamide is available as supplement and has a proven and relevant effficacy as well as a prophylactic value at least comparable to vac...
Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry†
Published in:The Analyst
Publication date:1998-01-01
The endocannabinoid system and appetite: relevance for food reward
Published in:Nutrition Research Reviews
Publication date:2014-06-01
Multi-laboratory study of the analysis and kinetics of stanozolol and its metabolites in treated calves†
Published in:The Analyst
Publication date:1998-01-01
The preparation, solubilisation and binding characteristics of a β2-adrenoceptor isolated from transfected Chinese hamster cells
Published in:The Analyst
Publication date:2001-01-01
Short-term oral exposure to white wine transiently lowers serum free fatty acids
Published in:Appetite
Publication date:2010-08-01
Comparison of conventional immunoassays and the oestrogen radioreceptor assay for screening for the presence of oestrogenic anabolic compounds in u...
Published in:The Analyst
Publication date:1998-01-01
In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle†
Published in:The Analyst
Publication date:1998-01-01
Congener specific PCB and polychlorinated camphene (toxaphene) levels in Svalbard ringed seals (Phoca hispida) in relation to sex, age, condition a...
Published in:The Science of The Total Environment
Publication date:1998-05-01
Moderate alcohol consumption stimulates food intake and food reward of savoury foods
Published in:Appetite
Publication date:2015-06-01
Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoidN-docosahexaenoylethan...
Published in:British Journal of Pharmacology
Publication date:2014-09-23DHEA modulates eicosanoid synthesis
Effects of Long- and Short-Chain Fatty Acids on the Release of Gastrointestinal Hormones using an ex Vivo Porcine Intestinal Tissue Model
Published in:Journal of Agricultural and Food Chemistry
Publication date:2012-08-30
Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract
Published in:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publication date:2011-10-01
Hypothalamic food intake regulation in a cancer-cachectic mouse model
Published in:Journal of Cachexia Sarcopenia and Muscle
Publication date:2013-11-13
Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice
Published in:Journal of Cachexia Sarcopenia and Muscle
Publication date:2015-04-27Reduction of sarcopenia in caloric-restricted ageing mice
Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase- Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids
Published in:Letters in Organic Chemistry
Publication date:2009-09-01
Measurement of Palmitoylethanolamide and Other N-Acylethanolamines During Physiological and Pathological Conditions
Published in:CNS & Neurological Disorders - Drug Targets
Publication date:2013-03-01
Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolis...
Published in:British Journal Of Nutrition
Publication date:2011-12-06
Alterations in total and high–molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women
Published in:Metabolism
Publication date:2011-08-01
Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting c...
Published in:Nutrition & Metabolism
Publication date:2010-01-01
Validation of web-based, multiple 24-h recalls combined with nutritional supplement intake questionnaires against nitrogen excretions to determine ...
Published in:British Journal Of Nutrition
Publication date:2015-10-05
Nutrient Intake by Ultramarathon Runners: Can They Meet Recommendations?
Published in:International Journal of Sport Nutrition and Exercise Metabolism
Publication date:2015-08-01
Hypothalamic inflammation and food intake regulation during chronic illness
Published in:Peptides
Publication date:2016-03-01
Fatty acids, endocannabinoids and inflammation
Published in:European Journal of Pharmacology
Publication date:2016-08-01What's it about?The endocannabinoid system (ECS) was discovered in the ‘90s of last century and derived its name from the observation that THC, the compound from C...
Effects of Mood Inductions by Meal Ambiance and Moderate Alcohol Consumption on Endocannabinoids and N-Acylethanolamines in Humans: A Randomized Cr...
Published in:PLoS ONE
Publication date:2015-05-11
Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy
Published in:Physiology & Behavior
Publication date:2015-02-01
The endocannabinoid system
Published in:Current Opinion in Clinical Nutrition & Metabolic Care
Publication date:2014-03-01an emerging key player in inflammation
The Biphasic Effects of Moderate Alcohol Consumption with a Meal on Ambiance-Induced Mood and Autonomic Nervous System Balance: A Randomized Crosso...
Published in:PLoS ONE
Publication date:2014-01-21
The Association Between Drugs Frequently Used by the Elderly and Vitamin D Blood Levels: A Review of Observational and Experimental Studies
Published in:Drugs & Aging
Publication date:2014-01-03
Steviol Glycoside Rebaudioside A Induces Glucagon-like Peptide-1 and Peptide YY Release in a Porcine ex Vivo Intestinal Model
Published in:Journal of Agricultural and Food Chemistry
Publication date:2014-08-20
Omega-3 Polyunsaturated N-Acylethanolamines: A Link Between Diet and Cellular Biology
Published in:The Endocannabinoidome
Publication date:2015-01-01
Medication-Related Fall Incidents in an Older, Ambulant Population: The B-PROOF Study
Published in:Drugs & Aging
Publication date:2014-11-15
Associations Between Medication Use and Homocysteine Levels in an Older Population, and Potential Mediation by Vitamin B12 and Folate: Data from th...
Published in:Drugs & Aging
Publication date:2014-07-04
Comparative analyses of seeds of wild fruits of Rubus and Sambucus species from Southern Italy: Fatty acid composition of the oil, total phenolic c...
Published in:Food Chemistry
Publication date:2013-10-01
N-acyl amines of docosahexaenoic acid and othern-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads
Published in:British Journal of Pharmacology
Publication date:2013-05-27n-3 PUFAs and the endocannabinoid system
Liquid chromatography–tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells
Published in:Analytical Biochemistry
Publication date:2013-03-01
Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues
Published in:Metabolomics
Publication date:2012-04-11
Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice f...
Published in:International Immunopharmacology
Publication date:2012-06-01
Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice
Published in:PLoS ONE
Publication date:2012-01-23
A standardised approach towards PROving the efficacy of foods and food constituents for health CLAIMs (PROCLAIM): providing guidance
Published in:British Journal Of Nutrition
Publication date:2011-11-01
26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: Evidence-based nutrition
Published in:Nutrition
Publication date:2011-10-01
Current and Future Drug Targets in Weight Management
Published in:Pharmaceutical Research
Publication date:2010-12-23
The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evide...
Published in:British Journal Of Nutrition
Publication date:2011-02-04
Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties
Published in:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publication date:2010-10-01
Biologically Active Compounds in Food Products and Their Effects on Obesity and Diabetes
Published in:Comprehensive Natural Products II
Publication date:2010-01-01
Xanthohumol from Hop (Humulus lupulus L.) Is an Efficient Inhibitor of Monocyte Chemoattractant Protein-1 and Tumor Necrosis Factor-α Release in LP...
Published in:Journal of Agricultural and Food Chemistry
Publication date:2009-08-26
Development and validation of a quantitative method for the determination of 12 endocannabinoids and related compounds in human plasma using liquid...
Published in:Journal of Chromatography B
Publication date:2009-05-01
Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor ...
Published in:International Immunopharmacology
Publication date:2006-04-01
Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology
Published in:Phytotherapy Research
Publication date:2005-01-01
In Search of Secreted Protein Biomarkers for the Anti-inflammatory Effect of β 2 -Adrenergic Receptor Agonists: Application of DIGE Technology in...
Published in:Journal of Proteome Research
Publication date:2005-12-01
A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophag...
Published in:PROTEOMICS
Publication date:2004-04-01
TRANSFER OF POLYCHLORINATED BIPHENYLS AND CHLORINATED PESTICIDES FROM MOTHER TO PUP IN RELATION TO CYTOCHROME P450 ENZYME ACTIVITIES IN HARP SEALS ...
Published in:Environmental Toxicology and Chemistry
Publication date:2002-01-01
Transfer of polychlorinated biphenyls and chlorinated pesticides from mother to pup in relation to cytochrome P450 enzyme activities in harp seals ...
Published in:Environmental Toxicology and Chemistry
Publication date:2002-01-01
Use of Animal Models of Disease in the Preclinical Safety Evaluation of Biopharmaceuticals
Published in:Pharmaceutical Sciences Encyclopedia
Publication date:2010-03-15
Use of Animal Models of Disease in the Preclinical Safety Evaluation of Biopharmaceuticals
Published in:Preclinical Safety Evaluation of Biopharmaceuticals
Publication date:Not available
Tiamulin inhibits human CYP3A4 activity in an NIH/3T3 cell line stably expressing CYP3A4 cDNA
Published in:Biochemical Pharmacology
Publication date:1995-09-01
Pharma–nutrition interface: The gap is narrowing
Published in:European Journal of Pharmacology
Publication date:2011-01-01
The effects of a meal with moderate alcohol consumption on mood and autonomic nervous system balance
Published in:Psychoneuroendocrinology
Publication date:2015-11-01
Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome p450
Published in:Biochemical Pharmacology
Publication date:1996-10-01
The Endocannabinoid System: A Dynamic Signalling System at the Crossroads Between Metabolism and Disease
Published in:Pharma-Nutrition
Publication date:2014-01-01
ChemInform Abstract: Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase-Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty ...
Published in:ChemInform
Publication date:2010-02-16
Analysis of Omega-3 Fatty Acid Derived N-Acylethanolamines in Biological Matrices
Published in:Methods in Molecular Biology
Publication date:2016-01-01
Intraileal casein infusion increases plasma concentrations of amino acids in humans: A randomized cross over trial
Published in:Clinical Nutrition
Publication date:2016-01-01
Self-Reported Use and Reasons among the General Population for Using Sports Nutrition Products and Dietary Supplements
Published in:Sports
Publication date:2016-06-07
Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis
Published in:International Immunopharmacology
Publication date:2004-11-01
Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor fro...
Published in:International Immunopharmacology
Publication date:2006-01-01
Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells
Published in:Environmental Toxicology and Pharmacology
Publication date:1997-02-01
Suppression of Cytochrome P450- and UDP Glucuronosyl Transferase-Dependent Enzyme Activities by Proinflammatory Cytokines and Possible Role of Nitr...
Published in:Toxicology and Applied Pharmacology
Publication date:1996-04-01
Contributors
Published in:The Endocannabinoidome
Publication date:2015-01-01
Chlorinated pesticide concentrations, with an emphasis on polychlorinated camphenes (toxaphenes), in relation to cytochrome P450 enzyme activities ...
Published in:Environmental Toxicology and Chemistry
Publication date:2000-06-01
Differential effects of pentoxifylline on the hepatic inflammatory response in porcine liver cell cultures
Published in:Biochemical Pharmacology
Publication date:2001-05-01
Nutrient-induced glucagon like peptide-1 release is modulated by serotonin
Published in:The Journal of Nutritional Biochemistry
Publication date:2016-06-01
Bovine Colostrum Supplementation’s Lack of Effect on Immune Variables during Short-Term Intense Exercise in Well-Trained Athletes
Published in:International Journal of Sport Nutrition and Exercise Metabolism
Publication date:2011-04-01
High-performance liquid chromatographic method for the routine determination of sulphadimidine, its hydroxy metabolites and N4-acetylsulphadimidine...
Published in:Journal of Chromatography B Biomedical Sciences and Applications
Publication date:1991-12-01
The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the c...
Published in:The Journal of Nutritional Biochemistry
Publication date:2010-08-01
Cross-Species Comparison of Genes Related to Nutrient Sensing Mechanisms Expressed along the Intestine
Published in:PLoS ONE
Publication date:2014-09-12
Contributor contact details
Published in:Food for the Ageing Population
Publication date:2009-01-01
Voeding en geneesmiddelen
Published in:Het Voeding Formularium
Publication date:2011-01-01
Molecule formed in gut from n-3 fatty acid DHA and serotonin may be beneficial in attenuating IBD
Published in:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publication date:2016-12-01What's it about?DHA is a n-3 (also called omega-3) fatty acid, which we should normally get through our diet, in particular by eating fatty fish. In a previous stu...
17α-Ethyl-5β-estrane-3α,17β-diol, a biological marker for the abuse of norethandrolone and ethylestrenol in slaughter cattle
Published in:Journal of Chromatography B Biomedical Sciences and Applications
Publication date:1999-05-01
Optimal nutrition and the ever-changing dietary landscape: a conference report
Published in:European Journal of Nutrition
Publication date:2017-05-05
Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient grou...
Published in:Clinical Nutrition
Publication date:2017-03-01
N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharid...
Published in:ACS Chemical Neuroscience
Publication date:2016-12-06
Micronutrient Intakes in 553 Dutch Elite and Sub-Elite Athletes: Prevalence of Low and High Intakes in Users and Non-Users of Nutritional Supplements
Published in:Nutrients
Publication date:2017-02-15
Macronutrient Intakes in 553 Dutch Elite and Sub-Elite Endurance, Team, and Strength Athletes: Does Intake Differ between Sport Disciplines?
Published in:Nutrients
Publication date:2017-02-10
Nutritional Supplement Use by Dutch Elite and Sub-Elite Athletes: Does Receiving Dietary Counseling Make a Difference?
Published in:International Journal of Sport Nutrition and Exercise Metabolism
Publication date:2017-02-01
Adaptation of exercise-induced stress in well-trained healthy young men
Published in:Experimental Physiology
Publication date:2016-12-11Adaptation of exercise-induced stress
CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis
Published in:Journal of the American Medical Directors Association
Publication date:2017-01-01
Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins
Published in:Journal of Immunological Methods
Publication date:2017-01-01
Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans
Published in:Nutrients
Publication date:2017-01-21
Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours—Potential Conse...
Published in:International Journal of Sport Nutrition and Exercise Metabolism
Publication date:2017-06-01
Moderate alcohol consumption after a mental stressor attenuates the endocrine stress response
Published in:Alcohol
Publication date:2016-12-01
The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mous...
Published in:Journal of Nutrition
Publication date:2016-10-26
Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients
Published in:European Journal of Clinical Pharmacology
Publication date:2016-02-12
Increased hypothalamic serotonin turnover in inflammation-induced anorexia
Published in:BMC Neuroscience
Publication date:2016-05-20
Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies
Published in:Cancer Epidemiology Biomarkers & Prevention
Publication date:2015-09-22
Review article: the role of gastrointestinal hormones in the treatment of delayed gastric emptying in critically ill patients
Published in:Alimentary Pharmacology & Therapeutics (Suppl)
Publication date:2013-07-23
Vitamin D: do we get enough?
Published in:Osteoporosis International
Publication date:2012-12-11A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe
Absorption, Distribution, and Biliary Excretion of Cafestol, a Potent Cholesterol-Elevating Compound in Unfiltered Coffees, in Mice
Published in:Drug Metabolism and Disposition
Publication date:2010-01-04
Commentary: “A systems view on the future of medicine: Inspiration from Chinese medicine?”
Published in:Journal of Ethnopharmacology
Publication date:2009-01-01
Herbal products: Marketing strategies and legislation
Published in:International Journal of Green Pharmacy
Publication date:2009-01-01
Genomics and systems biology - how relevant are the developments to veterinary pharmacology, toxicology and therapeutics?
Published in:Journal of Veterinary Pharmacology and Therapeutics
Publication date:2005-06-01
Inhibitory effects of the beta2-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-alpha in vitro and in vivo
Published in:Journal of Veterinary Pharmacology and Therapeutics
Publication date:2005-12-01
Endotoxin-induced liver damage in rats is minimized by � 2 -adrenoceptor stimulation
Published in:Inflammation Research
Publication date:2004-02-01
Multi-detector computed tomography and 3-dimensional imaging in a multi-vendor picture archiving and communications systems (PACS) environment1
Published in:Academic Radiology
Publication date:2004-06-01
Development of an Androgen Reporter Gene Assay (AR-LUX) Utilizing a Human Cell Line with an Endogenously Regulated Androgen Receptor
Published in:Analytical Biochemistry
Publication date:2001-11-01
Stereoselectivity at the β 2 -adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of β 2 -agonists
Published in:Naunyn-Schmiedeberg s Archives of Pharmacology
Publication date:2000-07-18
Cytochrome P450-mediated enzyme activities and polychlorinated biphenyl accumulation in harp seal (Phoca groenlandica)
Published in:Marine Environmental Research
Publication date:1999-07-01
In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle
Published in:Research in Veterinary Science
Publication date:1999-01-01
The β-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-α and IL-6 in vitro and in vivo
Published in:Inflammation Research
Publication date:1999-09-01
Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes
Published in:Toxicology in Vitro
Publication date:1998-12-01
Dose and time dependency of cytochrome P4501A induction in liver and kidney of B(a)P exposed Arctic charr (Salvelinus alpinus)
Published in:Marine Environmental Research
Publication date:1998-07-01
Phase I and phase II enzyme activities in Ringed seals (Phoca hispida): characterization of hepatic cytochrome P450 by activity patterns, inhibitio...
Published in:Aquatic Toxicology
Publication date:1998-12-01
Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activityin vit...
Published in:Xenobiotica
Publication date:1997-01-01
The effect of sulfaphenazole and sulfadoxine on tolbutamide disposition in dwarf goats (Caprus hircus aegagrus)
Published in:Research in Veterinary Science
Publication date:1997-11-01
Time-dependent induction of two distinct hepatic cytochrome P4501A catalytic activities at low temperatures in Arctic charr (Salvelinus alpinus) af...
Published in:Aquatic Toxicology
Publication date:1996-06-01
Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats
Published in:Research in Veterinary Science
Publication date:1995-05-01
Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and in...
Published in:Xenobiotica
Publication date:1995-01-01
Dose-dependent pharmacokinetic interaction between antipyrine and paracetamolin vivoandin vitrowhen administered as a cocktail in pig
Published in:Xenobiotica
Publication date:1994-01-01
The Pig as a Model for Studying AH Receptor and Other PAH-Binding Proteins In Man
Published in:Biochemical and Biophysical Research Communications
Publication date:1994-04-01
Regioselective O-demethylation of scoparone (6,7-dimethoxycoumarin) to assess cytochrome P450 activities in vitro in rat. Effects of gonadal steroi...
Published in:Xenobiotica
Publication date:1993-01-01
Selective changes in oxidative xenobiotic metabolism in vivo and in vitro after parenteral administration of recombinant bovine somatotrophin to rats
Published in:Research in Veterinary Science
Publication date:1993-07-01
Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin
Published in:Xenobiotica
Publication date:1992-01-01
Species- and sex-related differences in the plasma clearance and metabolite formation of antipyrine. A comparative study in four animal species: Ca...
Published in:Xenobiotica
Publication date:1991-01-01
The influence of gender and gonadal hormones on the plasma clearance and metabolite formation of antipyrine in ruminants
Published in:European Journal of Pharmacology
Publication date:1990-07-01
Food–Drug Interactions in Older People
Published in:Food for the Ageing Population
Publication date:2009-01-01
Calcium Imaging of GPCR Activation Using Arrays of Reverse Transfected HEK293 Cells in a Microfluidic System
Published in:Sensors
Publication date:2018-02-16
The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite
Published in:Molecular Aspects of Medicine
Publication date:2018-01-01