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  1. Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead

    Article • Proceedings of the National Academy of Sciences, February 2021, Proceedings of the National Academy of Sciences

    Dr Lachlan D Rash

  2. Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

    Article • British Journal of Pharmacology, January 2018, Wiley

    Dr Lachlan D Rash

  3. Systemically delivered PcTx1 is neuroprotective in traumatic spinal cord injury in rats.

    Article • F1000Research, July 2016, Faculty of 1000, Ltd.

    Prof Norman R Saunders, Dr Lachlan D Rash

  4. PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

    Article • Neuropharmacology, December 2015, Elsevier

    Dr Lachlan D Rash

  5. Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels

    Article • Scientific Reports, October 2015, Nature

    Dr Lachlan D Rash

  6. Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a

    Article • British Journal of Pharmacology, September 2015, Wiley

    Dr Lachlan D Rash

  7. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

    Article • Toxins, June 2015, MDPI AG

    Dr Lachlan D Rash

  8. Chapter 8. Therapeutic Applications of Spider-Venom Peptides

    Article • January 2015, Royal Society of Chemistry

    Dr Lachlan D Rash

  9. Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

    Article • Nature Genetics, November 2014, Nature

    Dr Lachlan D Rash

  10. Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

    Article • Journal of Medicinal Chemistry, November 2014, American Chemical Society (ACS)

    Dr Lachlan D Rash

  11. Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels

    Article • Biochemical Pharmacology, May 2014, Elsevier

    Dr Lachlan D Rash, Distinguished Professor David J. Adams

  12. Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2

    Article • Angewandte Chemie, December 2013, Wiley

    Dr Lachlan D Rash

  13. Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2

    Article • Angewandte Chemie International Edition, December 2013, Wiley

    Dr Lachlan D Rash

  14. ASIC3: First the Heartache, Now a Migraine!

    Article • Headache The Journal of Head and Face Pain, September 2013, Wiley

    Dr Lachlan D Rash

  15. Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli

    Article • PLoS ONE, May 2013, PLOS

    Dr Lachlan D Rash

  16. Functional Expression in Escherichia coli of the Disulfide-Rich Sea Anemone Peptide APETx2, a Potent Blocker of Acid-Sensing Ion Channel 3

    Article • Marine Drugs, July 2012, MDPI AG

    Dr Lachlan D Rash

  17. Cyclisation Increases the Stability of the Sea Anemone Peptide APETx2 but Decreases Its Activity at Acid-Sensing Ion Channel 3

    Article • Marine Drugs, July 2012, MDPI AG

    Dr Lachlan D Rash

  18. Inhibition of voltage-gated Na+ currents in sensory neurones by the sea anemone toxin APETx2

    Article • British Journal of Pharmacology, March 2012, Wiley

    Dr Lachlan D Rash

  19. Inhibition of Voltage-Gated Na+ Currents in Sensory Neurons by the Sea Anemone Toxin APETx2

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Lachlan D Rash

  20. De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina)

    Article • Toxicon, February 2011, Elsevier

    Dr Lachlan D Rash

  21. Spider-Venom Peptides as Therapeutics

    Article • Toxins, December 2010, MDPI AG

    Dr Lachlan D Rash

  22. Venomics: a new paradigm for natural products-based drug discovery

    Article • Amino Acids, February 2010, Springer Science + Business Media

    Dr Lachlan D Rash

  23. Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3

    Article • Toxicon, July 2009, Elsevier

    Dr Lachlan D Rash, Distinguished Professor David J. Adams

  24. Neurotoxicity and Other Pharmacological Activities of the Snake Venom Phospholipase A 2 OS 2 :  The N-Terminal Region Is More Important Than Enzymatic Activity †

    Article • Biochemistry, May 2006, American Chemical Society (ACS)

    Dr Lachlan D Rash

  25. The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

    Article • The Journal of Physiology, January 2006, Wiley

    Dr Lachlan D Rash

  26. Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes

    Article • Molecular Pharmacology, November 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Lachlan D Rash

  27. Tarantulas: eight-legged pharmacists and combinatorial chemists

    Article • Toxicon, April 2004, Elsevier

    Dr Lachlan D Rash

  28. A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons

    Article • The EMBO Journal, March 2004, Wiley

    Dr Lachlan D Rash

  29. Pharmacology and biochemistry of spider venoms

    Article • Toxicon, March 2002, Elsevier

    Dr Lachlan D Rash

  30. Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata)

    Article • Toxicon, August 2000, Elsevier

    Dr Lachlan D Rash

  31. Neurotoxic activity of venom from the Australian Eastern mouse spider (Missulena bradleyi ) involves modulation of sodium channel gating

    Article • British Journal of Pharmacology, August 2000, Wiley

    Dr Lachlan D Rash

  32. Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi)

    Article • Toxicon, March 1998, Elsevier

    Dr Lachlan D Rash