All Stories

  1. Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile

    Article • The Journal of Antibiotics, April 2018, Springer Science + Business Media

    Dr. John P Hegarty

  2. Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures

    Article • mSphere, January 2018, ASM Journals

    Dr. John P Hegarty

  3. Advances in therapeutic bacterial antisense biotechnology

    Article • Applied Microbiology and Biotechnology, December 2017, Springer Science + Business Media

    Dr. John P Hegarty

  4. The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients

    Article • Scientific Reports, August 2017, Nature

    Kathleen M Schieffer, Dr. John P Hegarty

  5. Association of the haem oxygenase-1 gene with inflammatory bowel disease

    Article • Swiss Medical Weekly, August 2017, EMH Swiss Medical Publishers, Ltd.

    Dr. John P Hegarty

  6. Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

    Article • World Journal of Gastroenterology, January 2017, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Dr. John P Hegarty

  7. Antisense nanocomplex treatment of Clostridium difficile

    Article • International Journal of Nanomedicine, August 2016, Dove Medical Press

    Professor Volkmar Weissig, Dr. John P Hegarty

  8. Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study

    Article • Frontiers in Microbiology, May 2016, Frontiers

    Dr. John P Hegarty, Kathleen M Schieffer

  9. Induction and Purification of C. difficile Phage Tail-Like Particles

    Article • January 2016, Springer Science + Business Media

    Dr. John P Hegarty

  10. Phage tail-like particles kill Clostridium difficile and represent an alternative to conventional antibiotics

    Article • Surgery, January 2015, Elsevier

    Dr. John P Hegarty

  11. Characterization of Clostridium difficile Isolates from Human Fecal Samples and Retail Meat from Pennsylvania

    Article • Foodborne Pathogens and Disease, October 2014, Mary Ann Liebert Inc

    Dr Kumar Venkitanarayanan, Dr. John P Hegarty

  12. Proton pump inhibitors induce changes in colonocyte gene expression that may affect Clostridium difficile infection

    Article • Surgery, October 2014, Elsevier

    Dr. John P Hegarty

  13. An interleukin-4 polymorphism is associated with susceptibility to Clostridium difficile infection in patients with inflammatory bowel disease: Results of a retrospective cohort study

    Article • Surgery, October 2014, Elsevier

    Dr. John P Hegarty

  14. Phage therapy for Clostridium difficile infection: An alternative to antibiotics?

    Article • Seminars in Colon and Rectal Surgery, September 2014, Elsevier

    Dr. John P Hegarty

  15. Single Nucleotide Polymorphisms of the tcdC Gene and Presence of the Binary Toxin Gene Predict Recurrent Episodes of Clostridium difficile Infection

    Article • Annals of Surgery, August 2014, Wolters Kluwer Health

    Dr. John P Hegarty

  16. T-cell activation Rho GTPase–activating protein expression varies with inflammation location and severity in Crohn's disease

    Article • Journal of Surgical Research, August 2014, Elsevier

    Dr. John P Hegarty

  17. Ulcerative colitis neoplasia is not associated with common inflammatory bowel disease single-nucleotide polymorphisms

    Article • Surgery, August 2014, Elsevier

    Dr. John P Hegarty

  18. The TNFSF15 Gene Single Nucleotide Polymorphism rs7848647 Is Associated With Surgical Diverticulitis

    Article • Annals of Surgery, June 2014, Wolters Kluwer Health

    Dr. John P Hegarty

  19. Correlation between virulence gene expression and proton pump inhibitors and ambient pH in Clostridium difficile: results of an in vitro study

    Article • Journal of Medical Microbiology, October 2013, Society for General Microbiology

    Dr. John P Hegarty

  20. A Single Nucleotide Polymorphism in the STAT5 Gene Favors Colonic as Opposed to Small-Bowel Inflammation in Crohn’s Disease

    Article • Diseases of the Colon & Rectum, September 2013, Wolters Kluwer Health

    Dr. John P Hegarty

  21. A model for family-based case-control studies of genetic imprinting and epistasis

    Article • Briefings in Bioinformatics, July 2013, Oxford University Press (OUP)

    Dr. John P Hegarty

  22. NOD2 Mutations Affect Muramyl Dipeptide Stimulation of Human B Lymphocytes and Interact with Other IBD-Associated Genes

    Article • Digestive Diseases and Sciences, May 2013, Springer Science + Business Media

    Dr. John P Hegarty

  23. Mutation in TAGAP Is Protective of Anal Sepsis in Ileocolic Crohn’s Disease

    Article • Diseases of the Colon & Rectum, November 2012, Wolters Kluwer Health

    Dr. John P Hegarty

  24. Predicting Recurrence of C. difficile Colitis Using Bacterial Virulence Factors: Binary Toxin Is the Key

    Article • Journal of Gastrointestinal Surgery, October 2012, Springer Science + Business Media

    Dr. John P Hegarty

  25. Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients

    Article • Digestive Diseases and Sciences, July 2012, Springer Science + Business Media

    Dr. John P Hegarty

  26. Genetic Risk Profiling and Gene Signature Modeling to Predict Risk of Complications After IPAA

    Article • Diseases of the Colon & Rectum, March 2012, Wolters Kluwer Health

    Dr. John P Hegarty

  27. Mutations in IRGM Are Associated With More Frequent Need for Surgery in Patients With Ileocolonic Crohnʼs Disease

    Article • Diseases of the Colon & Rectum, February 2012, Wolters Kluwer Health

    Dr. John P Hegarty

  28. DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility

    Article • Swiss Medical Weekly, November 2011, EMH Swiss Medical Publishers, Ltd.

    Dr. John P Hegarty

  29. Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1

    Article • Inflammation, October 2011, Springer Science + Business Media

    Dr. John P Hegarty

  30. NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT

    Article • Molecular Genetics and Metabolism, September 2011, Elsevier

    Dr. John P Hegarty

  31. Genetic Variants and Monoallelic Expression of Surfactant Protein-D in Inflammatory Bowel Disease

    Article • Annals of Human Genetics, July 2011, Wiley

    Dr. John P Hegarty

  32. Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene

    Article • Inflammatory Bowel Diseases, June 2011, Wolters Kluwer Health

    Dr. John P Hegarty

  33. NKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells

    Article • PLoS ONE, May 2011, PLOS

    Dr. John P Hegarty

  34. NOD2/CARD15 Mutations Correlate With Severe Pouchitis After Ileal Pouch-Anal Anastomosis

    Article • Diseases of the Colon & Rectum, November 2010, Wolters Kluwer Health

    Dr. John P Hegarty

  35. Identification of disease-associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease

    Article • Clinical Genetics, October 2010, Wiley

    Dr. John P Hegarty

  36. A General Model for Multilocus Epistatic Interactions in Case-Control Studies

    Article • PLoS ONE, August 2010, PLOS

    Dr. John P Hegarty

  37. Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: Implication of endothelin-1 in inflammatory bowel disease

    Article • Molecular Genetics and Metabolism, May 2010, Elsevier

    Dr. John P Hegarty

  38. Genes Regulated by Nkx2-3 in Sporadic and Inflammatory Bowel Disease-Associated Colorectal Cancer Cell Lines

    Article • Digestive Diseases and Sciences, February 2010, Springer Science + Business Media

    Dr. John P Hegarty

  39. Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease

    Article • Journal of Crohn s and Colitis, September 2009, Oxford University Press (OUP)

    Dr. John P Hegarty

  40. Effect of Oxidizing Disinfectants (Chlorine, Monochloramine, and Ozone) on Helicobacter pylori

    Article • Applied and Environmental Microbiology, February 2002, ASM Journals

    Dr. John P Hegarty

  41. Presence of Helicobacter pylori in Drinking Water is Associated with Clinical Infection

    Article • Scandinavian Journal of Infectious Diseases, January 2001, Taylor & Francis

    Dr. John P Hegarty

  42. Occurrence of Helicobacter pylori in surface water in the United States

    Article • Journal of Applied Microbiology, October 1999, Wiley

    Dr. John P Hegarty

  43. Detection and occurrence of indicator organisms and pathogens

    Article • Water Environment Research, June 1997, Wiley

    Dr. John P Hegarty