All Stories

  1. Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus

    Article • Antimicrobial Agents and Chemotherapy, October 2018, ASM Journals

    Dr Laurent Kremer

  2. Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages

    Article • Infection and Immunity, July 2018, ASM Journals

    Dr Laurent Kremer

  3. Alkylated/aminated nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates: Synthesis and anti-mycobacterial evaluation

    Article • Bioorganic & Medicinal Chemistry Letters, May 2018, Elsevier

    Dr Laurent Kremer

  4. B cells response directed against Cut4 and CFP21 lipolytic enzymes in active and latent tuberculosis infections

    Article • PLoS ONE, April 2018, PLOS

    Dr Laurent Kremer

  5. Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis β-ketoacyl-acyl carrier protein reductase MabA

    Article • Acta Crystallographica Section D Structural Biology, April 2018, International Union of Crystallography

    Dr Laurent Kremer

  6. Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms

    Article • PLoS ONE, April 2018, PLOS

    Dr Laurent Kremer

  7. Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus

    Article • Frontiers in Microbiology, April 2018, Frontiers

    Dr Laurent Kremer

  8. Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases

    Article • International Journal of Antimicrobial Agents, April 2018, Elsevier

    Dr Laurent Kremer

  9. A Simple and Rapid Gene Disruption Strategy in Mycobacterium abscessus: On the Design and Application of Glycopeptidolipid Mutants

    Article • Frontiers in Cellular and Infection Microbiology, March 2018, Frontiers

    Dr Laurent Kremer

  10. Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

    Article • Proceedings of the National Academy of Sciences, January 2018, Proceedings of the National Academy of Sciences

    Dr Laurent Kremer

  11. Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis

    Article • Scientific Reports, September 2017, Nature

    Dr Laurent Kremer

  12. Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport

    Article • Frontiers in Cellular and Infection Microbiology, September 2017, Frontiers

    Dr Laurent Kremer

  13. Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish

    Article • Antimicrobial Agents and Chemotherapy, August 2017, ASM Journals

    Dr Laurent Kremer

  14. Natural and Synthetic Flavonoids as Potent Mycobacterium tuberculosis UGM Inhibitors

    Article • Chemistry - A European Journal, July 2017, Wiley

    Dr Laurent Kremer

  15. Organometallic tosyl hydrazones: Synthesis, characterization, crystal structures and in vitro evaluation for anti- Mycobacterium tuberculosis and antiproliferative activities

    Article • Polyhedron, July 2017, Elsevier

    Dr Laurent Kremer

  16. Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

    Article • Journal of Medicinal Chemistry, June 2017, American Chemical Society (ACS)

    Dr Laurent Kremer

  17. The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments

    Article • Molecular Microbiology, April 2017, Wiley

    Dr Laurent Kremer, Professor Jean-Louis Herrmann

  18. The Diverse Cellular and Animal Models to Decipher the Physiopathological Traits of Mycobacterium abscessus Infection

    Article • Frontiers in Cellular and Infection Microbiology, April 2017, Frontiers

    Dr Laurent Kremer

  19. Acid-Fast Positive and Acid-Fast Negative Mycobacterium tuberculosis: The Koch Paradox

    Article • Microbiology Spectrum, April 2017, ASM Journals

    Dr Laurent Kremer

  20. Characterization of a mycobacterial cellulase and its impact on biofilm- and drug-induced cellulose production

    Article • Glycobiology, March 2017, Oxford University Press (OUP)

    Dr Laurent Kremer

  21. The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium

    Article • Scientific Reports, February 2017, Nature

    Dr Laurent Kremer

  22. Binding of NADP + triggers an open-to-closed transition in a mycobacterial FabG β-ketoacyl-ACP reductase

    Article • Biochemical Journal, January 2017, Portland Press Ltd.

    Dr Laurent Kremer

  23. Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384

    Article • Antimicrobial Agents and Chemotherapy, January 2017, ASM Journals

    Dr Laurent Kremer

  24. Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea

    Article • European Journal of Medicinal Chemistry, January 2017, Elsevier

    Dr Laurent Kremer

  25. 1H -1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation

    Article • Chemical Biology & Drug Design, November 2016, Wiley

    Dr Laurent Kremer

  26. Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking

    Article • PLoS Pathogens, November 2016, PLOS

    Dr Laurent Kremer

  27. Current perspectives on the families of glycoside hydrolases of Mycobacterium tuberculosis : their importance and prospects for assigning function to unknowns

    Article • Glycobiology, October 2016, Oxford University Press (OUP)

    Dr Laurent Kremer

  28. MAB_3551cencodes the primary triacylglycerol synthase involved in lipid accumulation inMycobacterium abscessus

    Article • Molecular Microbiology, September 2016, Wiley

    Dr Laurent Kremer

  29. A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence ofMycobacterium marinumin multiple hosts

    Article • Cellular Microbiology, June 2016, Wiley

    Dr Laurent Kremer

  30. Use of the Salmonella MgtR peptide as an antagonist of the Mycobacterium MgtC virulence factor

    Article • Future Microbiology, February 2016, Future Medicine

    Dr Laurent Kremer

  31. Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

    Article • Journal of Visualized Experiments, September 2015, MyJove Corporation

    Dr Jean-Louis Herrmann, Dr Laurent Kremer

  32. Regard à travers le danio pour mieux comprendre les interactions hôte/pathogène

    Article • médecine/sciences, June 2015, EDP Sciences

    Dr Laurent Kremer

  33. Palladium (II) and platinum (II) complexes containing organometallic thiosemicarbazone ligands: Synthesis, characterization, X-ray structures and antitubercular evaluation

    Article • Inorganic Chemistry Communications, May 2015, Elsevier

    Dr Laurent Kremer

  34. Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

    Article • Antimicrobial Agents and Chemotherapy, March 2015, ASM Journals

    Dr Laurent Kremer

  35. Mycobacterium marinum MgtC Plays a Role in Phagocytosis but is Dispensable for Intracellular Multiplication

    Article • PLoS ONE, December 2014, PLOS

    Dr Laurent Kremer

  36. Overexpression of theSalmonellaKdpF membrane peptide modulates expression ofkdpgenes and intramacrophage growth

    Article • FEMS Microbiology Letters, September 2014, Oxford University Press (OUP)

    Dr Laurent Kremer

  37. The Molecular Genetics of Mycolic Acid Biosynthesis

    Article • Microbiology Spectrum, August 2014, ASM Journals

    Dr Laurent Kremer

  38. Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis

    Article • PLoS Pathogens, May 2014, PLOS

    Dr Laurent Kremer

  39. Les cordes mycobactériennes

    Article • médecine/sciences, May 2014, EDP Sciences

    Dr Jean-Louis Herrmann, Dr Laurent Kremer

  40. Antibiotics and New Inhibitors of the Cell Wall

    Article • April 2014, ASM Journals

    Dr Laurent Kremer

  41. Synthesis, characterization and in vitro anti-Trypanosoma cruzi and anti-Mycobacterium tuberculosis evaluations of cyrhetrenyl and ferrocenyl thiosemicarbazones

    Article • Journal of Organometallic Chemistry, April 2014, Elsevier

    Dr Laurent Kremer

  42. The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation

    Article • Biochemical and Biophysical Research Communications, April 2014, Elsevier

    Dr Laurent Kremer

  43. 7-Chloroquinoline-isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation

    Article • Chemical Biology & Drug Design, March 2014, Wiley

    Dr Laurent Kremer

  44. Extraction and Purification of Mycobacterial Mycolic Acids

    Article • BIO-PROTOCOL, January 2014, Bio-Protocol, LLC

    Dr Laurent Kremer

  45. Base-Promoted Expedient Access to Spiroisatins: Synthesis and Antitubercular Evaluation of 1H-1,2,3-Triazole-Tethered Spiroisatin–Ferrocene and Isatin–Ferrocene Conjugates

    Article • Organometallics, November 2013, American Chemical Society (ACS)

    vipan kumar, Dr Laurent Kremer

  46. 4-Aminoquinoline-β-Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation

    Article • Chemical Biology & Drug Design, October 2013, Wiley

    Dr Laurent Kremer

  47. Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia

    Article • International Journal of Antimicrobial Agents, July 2013, Elsevier

    Professor Anil Kumar Saxena, Dr Laurent Kremer

  48. Overexpression of the KdpF Membrane Peptide in Mycobacterium bovis BCG Results in Reduced Intramacrophage Growth and Altered Cording Morphology

    Article • PLoS ONE, April 2013, PLOS

    Dr Laurent Kremer

  49. 1H-1,2,3-Triazole-Tethered Isatin–Ferrocene and Isatin–Ferrocenylchalcone Conjugates: Synthesis and in Vitro Antitubercular Evaluation

    Article • Organometallics, March 2013, American Chemical Society (ACS)

    vipan kumar, Dr Laurent Kremer

  50. Synthesis, Antitubercular Activity and Mechanism of Resistance of Highly Effective Thiacetazone Analogues

    Article • PLoS ONE, January 2013, PLOS

    Dr Laurent Kremer

  51. Azide–alkynecycloadditionen route towards 1H-1,2,3-triazole-tethered β-lactam–ferrocene and β-lactam–ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation

    Article • Dalton Transactions, January 2013, Royal Society of Chemistry

    vipan kumar, Dr Laurent Kremer

  52. Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation

    Article • Biochemical and Biophysical Research Communications, January 2013, Elsevier

    Dr Laurent Kremer

  53. Mycobacterial lipolytic enzymes: A gold mine for tuberculosis research

    Article • Biochimie, January 2013, Elsevier

    Dr Laurent Kremer

  54. Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue

    Article • Journal of Proteomics, October 2012, Elsevier

    Dr Laurent Kremer

  55. MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth

    Article • PLoS ONE, September 2012, PLOS

    Dr Laurent Kremer

  56. CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan

    Article • Immunology Letters, April 2012, Elsevier

    Dr Laurent Kremer

  57. Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG

    Article • Tuberculosis, November 2011, Elsevier

    Dr Laurent Kremer

  58. Mycobacterium tuberculosis Lipolytic Enzymes as Potential Biomarkers for the Diagnosis of Active Tuberculosis

    Article • PLoS ONE, September 2011, PLOS

    Dr Laurent Kremer

  59. Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system

    Article • Biochemical and Biophysical Research Communications, September 2011, Elsevier

    Dr Laurent Kremer

  60. Fatty Acyl Chains of Mycobacterium marinum Lipooligosaccharides: STRUCTURE, LOCALIZATION AND ACYLATION BY PapA4 (MMAR_2343) PROTEIN

    Article • Journal of Biological Chemistry, July 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Laurent Kremer

  61. Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones

    Article • Bioorganic & Medicinal Chemistry Letters, May 2011, Elsevier

    Dr Laurent Kremer

  62. A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos

    Article • Molecular Microbiology, April 2011, Wiley

    Jeffrey Cirillo, Dr Laurent Kremer

  63. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

    Article • Molecular Microbiology, November 2010, Wiley

    Dr Laurent Kremer

  64. An improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substrates

    Article • PROTEOMICS, October 2010, Wiley

    Dr Laurent Kremer

  65. Division and cell envelope regulation by Ser/Thr phosphorylation:Mycobacteriumshows the way

    Article • Molecular Microbiology, March 2010, Wiley

    Dr Laurent Kremer

  66. Division and Cell Envelope Regulation by Ser/Thr Phosphorylation:MycobacteriumShows the Way

    Article • Molecular Microbiology, January 2010, Wiley

    Dr Laurent Kremer

  67. The Mycobacterium tuberculosis GroEL1 Chaperone Is a Substrate of Ser/Thr Protein Kinases

    Article • Journal of Bacteriology, February 2009, ASM Journals

    Dr Laurent Kremer

  68. pETPhos: A customized expression vector designed for further characterization of Ser/Thr/Tyr protein kinases and their substrates

    Article • Plasmid, September 2008, Elsevier

    Dr Laurent Kremer

  69. Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis

    Article • Protein Expression and Purification, April 2008, Elsevier

    Dr Laurent Kremer

  70. Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages

    Article • FEBS Letters, January 2008, Wiley

    Dr Laurent Kremer

  71. Mycobacterium tuberculosis FabD

    Article • September 2007, Protein Data Bank, Rutgers University

    Dr Laurent Kremer

  72. Polysaccharide structural variability in mycobacteria: identification and characterization of phosphorylated mannan and arabinomannan

    Article • Glycoconjugate Journal, May 2007, Springer Science + Business Media

    Dr Laurent Kremer

  73. X-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)

    Article • Journal of Molecular Biology, February 2007, Elsevier

    Dr Laurent Kremer

  74. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid

    Article • Nature Reports Stem Cells, August 2006, Nature

    Dr Laurent Kremer

  75. pH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissection

    Article • Molecular Microbiology, August 2006, Wiley

    Dr Laurent Kremer

  76. GroEL1: A Dedicated Chaperone Involved in Mycolic Acid Biosynthesis during Biofilm Formation in Mycobacteria

    Article • Cell, December 2005, Elsevier

    Dr Laurent Kremer

  77. X-ray crystal structure of W42A,R161A double mutant of Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III

    Article • August 2005, Protein Data Bank, Rutgers University

    Dr Laurent Kremer

  78. X-ray crystal structure of R46A,R161A mutant of Mycobacterium tuberculosis FabH

    Article • August 2005, Protein Data Bank, Rutgers University

    Dr Laurent Kremer

  79. A Waxy Tale, by Mycobacterium tuberculosis

    Article • January 2005, ASM Journals

    Dr Laurent Kremer

  80. Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response

    Article • Molecular Microbiology, June 2004, Wiley

    Volker Briken, Dr Laurent Kremer

  81. The Structure of Mycobacterium tuberculosis MPT51 (FbpC1) Defines a New Family of Non-catalytic α/β Hydrolases

    Article • Journal of Molecular Biology, January 2004, Elsevier

    Dr Laurent Kremer

  82. The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds

    Article • Tuberculosis, January 2004, Elsevier

    Dr Laurent Kremer

  83. The crystal structure of Mycobacterium tuberculosis MPT51 (FbpC1)

    Article • December 2003, Protein Data Bank, Rutgers University

    Dr Laurent Kremer

  84. Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis

    Article • Biochemical and Biophysical Research Communications, September 2003, Elsevier

    Dr Laurent Kremer

  85. Lipomannans, But Not Lipoarabinomannans, Purified from Mycobacterium chelonae and Mycobacterium kansasii Induce TNF-  and IL-8 Secretion by a CD14-Toll-Like Receptor 2-Dependent Mechanism

    Article • The Journal of Immunology, August 2003, The American Association of Immunologists

    Dr Laurent Kremer

  86. Immune Response Induced by Recombinant Mycobacterium bovis BCG Producing the Cholera Toxin B Subunit

    Article • Infection and Immunity, May 2003, ASM Journals

    Dr Laurent Kremer

  87. Mycobacterium bovis BCG Producing Interleukin-18 Increases Antigen-Specific Gamma Interferon Production in Mice

    Article • Infection and Immunity, December 2002, ASM Journals

    Dr Laurent Kremer

  88. Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile

    Article • Microbiology, October 2002, Society for General Microbiology

    Dr Laurent Kremer

  89. Current status and future development of antitubercular chemotherapy

    Article • Expert Opinion on Investigational Drugs, August 2002, Informa Healthcare

    Dr Laurent Kremer

  90. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis

    Article • Biochemical Journal, July 2002, Portland Press Ltd.

    Dr Laurent Kremer

  91. Mycolic acid biosynthesis and enzymic characterization of the β-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis

    Article • Biochemical Journal, June 2002, Portland Press Ltd.

    Dr Laurent Kremer

  92. The Methyl-Branched Fortifications of Mycobacterium tuberculosis

    Article • Chemistry & Biology, May 2002, Elsevier

    Dr Laurent Kremer

  93. Characterization of a putative α-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis

    Article • Biochemical Journal, May 2002, Portland Press Ltd.

    Dr Laurent Kremer

  94. Characterization of a putative α-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis

    Article • Biochemical Journal, May 2002, Portland Press Ltd.

    Dr Laurent Kremer

  95. Re-emergence of tuberculosis: strategies and treatment

    Article • Expert Opinion on Investigational Drugs, February 2002, Informa Healthcare

    Dr Laurent Kremer

  96. Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens

    Article • Journal of Molecular Medicine, December 2001, Springer Science + Business Media

    Dr Laurent Kremer

  97. Biochemical Characterization of Acyl Carrier Protein (AcpM) and Malonyl-CoA:AcpM Transacylase (mtFabD), Two Major Components of Mycobacterium tuberculosis Fatty Acid Synthase II

    Article • Journal of Biological Chemistry, May 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Laurent Kremer

  98. Thiolactomycin and Related Analogues as Novel Anti-mycobacterial Agents Targeting KasA and KasB Condensing Enzymes in Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, March 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Laurent Kremer

  99. Mycobacterium bovis Bacillus Calmette Guérin infection prevents apoptosis of resting human monocytes

    Article • European Journal of Immunology, September 1997, Wiley

    Dr Laurent Kremer

  100. Analysis of the Mycobacterium tuberculosis 85A antigen promoter region.

    Article • Journal of Bacteriology, January 1995, ASM Journals

    Dr Laurent Kremer