All Stories

  1. Synchronization of the ovulation and copulation timings increased the number of in vivo fertilized oocytes in superovulated female mice

    Article • PLoS ONE, February 2023, PLOS

    Dr Toru Takeo

  2. History of cryobiology, with special emphasis in evolution of mouse sperm cryopreservation

    Article • Cryobiology, April 2018, Elsevier

    Dr Toru Takeo

  3. Dimethyl sulfoxide and quercetin prolong the survival, motility, and fertility of cold-stored mouse sperm for 10 days†

    Article • Biology of Reproduction, November 2017, Oxford University Press (OUP)

    Dr Toru Takeo

  4. Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice

    Article • Biology Open, April 2017, The Company of Biologists

    Dr Toru Takeo

  5. Fertility of cold-stored mouse sperm is recovered by promoting acrosome reaction and hyperactivation after cholesterol efflux by methyl-beta-cyclodextrin

    Article • Biology of Reproduction, January 2017, Oxford University Press (OUP)

    Dr Toru Takeo

  6. Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

    Article • Scientific Reports, December 2016, Nature

    Dr Toru Takeo

  7. Genome-editing using mouse oocytes derived from ultrasuperovulation technique

    Article • Biology Open, July 2016, The Company of Biologists

    Dr Toru Takeo

  8. N-acetyl cysteine prolongs the survival term of mouse embryos at cold temperatures

    Article • Cryobiology, June 2016, Elsevier

    Dr Toru Takeo

  9. Ultrasupeovulation techniques is effective in various strains of mice

    Article • Theriogenology, May 2016, Elsevier

    Dr Toru Takeo

  10. GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development

    Article • Cancer Science, February 2016, Wiley

    Dr Toru Takeo

  11. Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gangliosidosis

    Article • Asian Journal of Pharmaceutical Sciences, February 2016, Elsevier

    Dr Toru Takeo

  12. Ultrasuperovulation technique produces 100 oocytes from one female mouse

    Article • PLoS ONE, May 2015, PLOS

    Dr Toru Takeo

  13. Effects of cyclodextrins on GM1-gangliosides in fibroblasts from GM1-gangliosidosis patients

    Article • Journal of Pharmacy and Pharmacology, April 2015, Wiley

    Dr Toru Takeo

  14. Thiol compounds increase fertilizing ability of oocytes in mice

    Article • Biology of Reproduction, February 2015, Society for the Study of Reproduction

    Dr Toru Takeo

  15. Efficacy of 2-Hydroxypropyl-β-cyclodextrin in Niemann–Pick Disease Type C Model Mice and Its Pharmacokinetic Analysis in a Patient with the Disease

    Article • Biological and Pharmaceutical Bulletin, January 2015, Pharmaceutical Society of Japan

    Dr Toru Takeo

  16. Protocol of embryo cryopreservation in mice

    Article • Current Protocols in Mouse Biology, December 2014, Wiley

    Dr Toru Takeo

  17. Protocol of sperm cryopreservation in mice

    Article • Current Protocols in Mouse Biology, September 2014, Wiley

    Dr Toru Takeo

  18. Protocol of in vitro fertilization for cryopreserved sperm in mice

    Article • Current Protocols in Mouse Biology, June 2014, Wiley

    Dr Toru Takeo

  19. Protocol of transportation of GM mice using fresh and frozen reproductive cells

    Article • Current Protocols in Mouse Biology, June 2014, Wiley

    Dr Toru Takeo

  20. Lipocalin 2 induces sperm activation in female reproductive tract

    Article • Development, May 2014, The Company of Biologists

    Dr Toru Takeo

  21. Cryopreservation of mouse sperm after cold storage

    Article • Cryobiology, February 2014, Elsevier

    Dr Toru Takeo

  22. Protocol of in vitro fertilization for cryopreserved sperm with poor motiilty

    Article • Journal of Reproduction and Development, January 2014, Japanese Society of Animal Reproduction

    Dr Toru Takeo

  23. Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann–Pick Type C disease models

    Article • Molecular Genetics and Metabolism Reports, January 2014, Elsevier

    Dr Toru Takeo

  24. Plolonged exposure to hyaluronidase decreases the fertilizing ability of mouse oocytes

    Article • Journal of Reproduction and Development, January 2014, Japanese Society of Animal Reproduction

    Dr Toru Takeo

  25. Vitrification of mouse oocyte

    Article • Cryobiology, December 2013, Elsevier

    Dr Toru Takeo

  26. Oocyte cryopreservation and in vitro fertilization in mice

    Article • Cryobiology, October 2013, Elsevier

    Dr Toru Takeo

  27. Reduced glutathione improves fertilizing ability of in-vitro matured oocytes in mice

    Article • Theriogenology, September 2013, Elsevier

    Dr Toru Takeo

  28. Shipment of GM mice using cold-storage technique of sperm

    Article • Cryobiology, December 2012, Elsevier

    Dr Toru Takeo

  29. Akt1-Mediated Skeletal Muscle Growth Attenuates Cardiac Dysfunction and Remodeling After Experimental Myocardial Infarction

    Article • Circulation Heart Failure, December 2011, Wolters Kluwer Health

    Dr Toru Takeo

  30. Reduced glutathione enhances fertilizing ability of oocyte in vitro

    Article • Biology of Reproduction, July 2011, Society for the Study of Reproduction

    Dr Toru Takeo

  31. Novel migrating mouse neural crest cell assay system utilizing P0-Cre/EGFP fluorescent time-lapse imaging

    Article • BMC Developmental Biology, January 2011, Springer Science + Business Media

    Dr Toru Takeo

  32. Overview of sperm cryopreservation and in vitro fertilization in mice

    Article • Journal of Mammalian Ova Research, October 2010, Japanese Society of Mammalian Ova Research

    Dr Toru Takeo

  33. Mouse sperm cryoprotectant containing raffinose, skim milk and glutamine

    Article • Laboratory Animals, April 2010, SAGE Publications

    Dr Toru Takeo

  34. 165. The in vitro fertilization rate of cryopreserved C57BL/6 strain mouse sperm

    Article • Cryobiology, December 2009, Elsevier

    Dr Toru Takeo

  35. Shipment of GM mice using cold-storage technique of mouse two-cell embryos

    Article • Cryobiology, April 2009, Elsevier

    Dr Toru Takeo

  36. Cyclodextrin improves fertilizing ability of frozen-thawed sperm

    Article • Biology of Reproduction, November 2007, Society for the Study of Reproduction

    Dr Toru Takeo

  37. LGR4 Regulates the Postnatal Development and Integrity of Male Reproductive Tracts in Mice

    Article • Biology of Reproduction, November 2006, Society for the Study of Reproduction

    Dr Toru Takeo

  38. Membrane injuries decrease fertilizing ability of frozen-thawed sperm

    Article • Biology of Reproduction, September 2004, Society for the Study of Reproduction

    Dr Toru Takeo