All Stories

  1. Structural insights into choline-O-sulfatase reveal the molecular determinants for ligand binding

    Article • Acta Crystallographica Section D Structural Biology, April 2022, International Union of Crystallography

    Dr. Jose A. Gavira

  2. Attaining atomic resolution from in situ data collection at room temperature using counter-diffusion-based low-cost microchips

    Article • Acta Crystallographica Section D Structural Biology, July 2020, International Union of Crystallography

    Dr. Jose A. Gavira

  3. Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Dr. Jose A. Gavira

  4. Resurrection of efficient Precambrian endoglucanases for lignocellulosic biomass hydrolysis

    Article • Communications Chemistry, July 2019, Springer Science + Business Media

    Dr. Jose A. Gavira

  5. Enhanced Stability against Radiation Damage of Lysozyme Crystals Grown in Fmoc-CF Hydrogels

    Article • Crystal Growth & Design, June 2019, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  6. Extending the pool of compatible peptide hydrogels for protein crystallization

    Article • Crystals, May 2019, MDPI AG

    Dr. Jose A. Gavira

  7. A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography

    Article • IUCrJ, April 2019, International Union of Crystallography

    Dr. Jose A. Gavira

  8. Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation

    Article • Scientific Reports, February 2019, Springer Science + Business Media

    Dr. Jose A. Gavira

  9. The Molecular Mechanism of Nitrate Chemotaxis via Direct Ligand Binding to the PilJ Domain of McpN

    Article • mBio, February 2019, ASM Journals

    Dr. Jose A. Gavira

  10. A novel cysteine carbamoyl-switch is responsible for the inhibition of formamidase, a nitrilase superfamily member

    Article • Archives of Biochemistry and Biophysics, February 2019, Elsevier

    Dr. Jose A. Gavira

  11. Catalytic and Electron Conducting Carbon Nanotube–Reinforced Lysozyme Crystals

    Article • Advanced Functional Materials, December 2018, Wiley

    Dr. Jose A. Gavira, Dr Juan J Diaz-Mochon

  12. Seeding from silica-reinforced lysozyme crystals for neutron crystallography

    Article • Acta Crystallographica Section D Structural Biology, November 2018, International Union of Crystallography

    Dr. Jose A. Gavira

  13. Functional Annotation of Bacterial Signal Transduction Systems: Progress and Challenges

    Article • International Journal of Molecular Sciences, November 2018, MDPI AG

    Dr. Jose A. Gavira

  14. High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human PathogenPseudomonas aeruginosa

    Article • mBio, November 2018, ASM Journals

    Dr. Jose A. Gavira

  15. Structural Basis for Polyamine Binding at the dCACHE Domain of the McpU Chemoreceptor from Pseudomonas putida

    Article • Journal of Molecular Biology, May 2018, Elsevier

    Dr. Jose A. Gavira

  16. Protein separation under a microfluidic regime

    Article • The Analyst, January 2018, Royal Society of Chemistry

    Dr. Jose A. Gavira

  17. Efficient Screening Methodology for Protein Crystallization Based on the Counter-Diffusion Technique

    Article • Crystal Growth & Design, November 2017, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  18. De novo active sites for resurrected Precambrian enzymes

    Article • Nature Communications, July 2017, Nature

    Dr. Jose A. Gavira

  19. Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

    Article • Human Molecular Genetics, July 2017, Oxford University Press (OUP)

    Dr. Jose A. Gavira

  20. Continuous Sensing Photonic Lab-on-a-Chip Platform Based on Cross-Linked Enzyme Crystals

    Article • Analytical Chemistry, December 2016, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  21. Bioinspired Calcium Phosphate Coated Mica Sheets by Vapor Diffusion and Its Effects on Lysozyme Assembly and Crystallization

    Article • Crystal Growth & Design, September 2016, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  22. Current trends in protein crystallization

    Article • Archives of Biochemistry and Biophysics, July 2016, Elsevier

    Dr. Jose A. Gavira

  23. Macromolecular crystallography: An old science with new perspectives

    Article • Archives of Biochemistry and Biophysics, July 2016, Elsevier

    Dr. Jose A. Gavira, Ana Camara-Artigas

  24. Bacterial rhyaluronidase id and production

    Article • FEBS Letters, July 2016, Wiley

    Dr. Jose A. Gavira, Luciano Messina, Dr Juan J Diaz-Mochon

  25. A multiple path photonic lab on a chip for parallel protein concentration measurements

    Article • Lab on a Chip, January 2015, Royal Society of Chemistry

    Dr. Jose A. Gavira

  26. Influence of the chirality of short peptide supramolecular hydrogels in protein crystallogenesis

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Dr Juan M Cuerva, Dr Luis Alvarez de Cienfuegos, Dr Juan J Diaz-Mochon, Dr. Jose A. Gavira

  27. Protein crystallization in short-peptide supramolecular hydrogels: a versatile strategy towards biotechnological composite materials

    Article • CrystEngComm, January 2015, Royal Society of Chemistry

    Dr Juan J Diaz-Mochon, Dr Luis Alvarez de Cienfuegos, Dr. Jose A. Gavira

  28. McCLEC, a robust and stable enzymatic based microreactor platform

    Article • Lab on a Chip, January 2015, Royal Society of Chemistry

    Dr. Jose A. Gavira

  29. Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences throughout Evolutionary History

    Article • Molecular Biology and Evolution, November 2014, Oxford University Press (OUP)

    Dr. Jose A. Gavira

  30. Cloning, expression, purification, crystallization and preliminary X-ray characterization of allantoinase fromBacillus licheniformisATCC 14580

    Article • Acta Crystallographica Section F Structural Biology Communications, October 2014, International Union of Crystallography

    Dr. Jose A. Gavira

  31. Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme

    Article • Molecular Biology and Evolution, October 2014, Oxford University Press (OUP)

    Dr. Jose A. Gavira

  32. Use of Cross-Linked Poly(ethylene glycol)-Based Hydrogels for Protein Crystallization

    Article • Crystal Growth & Design, July 2014, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  33. Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins

    Article • Proteins Structure Function and Bioinformatics, April 2014, Wiley

    Dr. Jose A. Gavira

  34. Mechanistic Insights of β-Lactmases Evolution

    Article • Biophysical Journal, January 2014, Elsevier

    Dr. Jose A. Gavira

  35. Introduction to protein crystallization

    Article • Acta Crystallographica Section F Structural Biology Communications, December 2013, International Union of Crystallography

    Dr. Jose A. Gavira

  36. Purification, crystallization and preliminary crystallographic analysis of the ligand-binding regions of the PctA and PctB chemoreceptors fromPseudomonas aeruginosain complex with amino acids

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2013, International Union of Crystallography

    Dr. Jose A. Gavira

  37. Thermostable and promiscuous Precambrian proteins

    Article • Environmental Microbiology, November 2013, Wiley

    Dr. Jose A. Gavira

  38. Conservation of Protein Structure over Four Billion Years

    Article • Structure, September 2013, Elsevier

    Dr. Jose A. Gavira

  39. Correction to “Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases”

    Article • Journal of the American Chemical Society, July 2013, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  40. Heterogeneous Crystallization of Proteins: Is it a Prenucleation Clusters Mediated Process?

    Article • Crystal Growth & Design, July 2013, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  41. Growth of Ultrastable Protein–Silica Composite Crystals

    Article • Crystal Growth & Design, June 2013, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  42. Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

    Article • Journal of the American Chemical Society, February 2013, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  43. In situX-ray data collection from highly sensitive crystals ofPseudomonas putidaPtxS in complex with DNA

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, October 2012, International Union of Crystallography

    Dr. Jose A. Gavira

  44. Evidence for chemoreceptors with bimodular ligand-binding regions harboring two signal-binding sites

    Article • Proceedings of the National Academy of Sciences, October 2012, Proceedings of the National Academy of Sciences

    Dr. Jose A. Gavira

  45. Mutational and Structural Analysis of L-N-Carbamoylase Reveals New Insights into a Peptidase M20/M25/M40 Family Member

    Article • Journal of Bacteriology, August 2012, ASM Journals

    Dr. Jose A. Gavira

  46. Protein Experiment: Scientific Data Processing Platform for On-Flight Experiment Tuning

    Article • Microgravity Science and Technology, July 2012, Springer Science + Business Media

    Professor Dominique Maes, Dr. Jose A. Gavira

  47. Monitoring and Scoring Counter-Diffusion Protein Crystallization Experiments in Capillaries by in situ Dynamic Light Scattering

    Article • PLoS ONE, June 2012, PLOS

    Dr. Jose A. Gavira

  48. Crystallization and crystallographic analysis of the ligand-binding domain of thePseudomonas putidachemoreceptor McpS in complex with malate and succinate

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, March 2012, International Union of Crystallography

    Dr. Jose A. Gavira

  49. Optimization of Protein Crystallization: The OptiCryst Project

    Article • Crystal Growth & Design, June 2011, American Chemical Society (ACS)

    Mr Patrick D Shaw Stewart, Dr. Jose A. Gavira

  50. Combining Counter-Diffusion and Microseeding to Increase the Success Rate in Protein Crystallization

    Article • Crystal Growth & Design, June 2011, American Chemical Society (ACS)

    Mr Patrick D Shaw Stewart, Dr. Jose A. Gavira

  51. Hetero- vs Homogeneous Nucleation of Protein Crystals Discriminated by Supersaturation

    Article • Crystal Growth & Design, May 2011, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  52. Understanding the polymorphic behaviour of a mutant of the α-spectrin SH3 domain by means of two 1.1 Å resolution structures

    Article • Acta Crystallographica Section D Biological Crystallography, February 2011, International Union of Crystallography

    Dr. Jose A. Gavira, Ana Camara-Artigas

  53. Crystallization in gels: a practical workshop

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 2010, International Union of Crystallography

    Dr. Jose A. Gavira

  54. Atomic resolution studies of haloalkane dehalogenases DhaA04, DhaA14 and DhaA15 with engineered access tunnels

    Article • Acta Crystallographica Section D Biological Crystallography, August 2010, International Union of Crystallography

    Dr. Jose A. Gavira

  55. Biophysical and atomic force microscopy characterization of the RNA from satellite tobacco mosaic virus

    Article • Nucleic Acids Research, August 2010, Oxford University Press (OUP)

    Dr. Jose A. Gavira

  56. Toward the Crystallization of Photosystem II Core Complex from Pisum sativum L.

    Article • Crystal Growth & Design, August 2010, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  57. Novel conformational aspects of the third PDZ domain of the neuronal post-synaptic density-95 protein revealed from two 1.4Å X-ray structures

    Article • Journal of Structural Biology, June 2010, Elsevier

    Dr. Jose A. Gavira, Ana Camara-Artigas

  58. Two-step counterdiffusion protocol for the crystallization of haemoglobin II fromLucina pectinatain the pH range 4–9

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2010, International Union of Crystallography

    Dr. Jose A. Gavira

  59. Modulation of Buried Ionizable Groups in Proteins with Engineered Surface Charge

    Article • Journal of the American Chemical Society, February 2010, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  60. Structure of dihydropyrimidinase from Sinorhizobium meliloti CECT4114: New features in an amidohydrolase family member

    Article • Journal of Structural Biology, February 2010, Elsevier

    Dr. Jose A. Gavira

  61. Counterdiffusion methods applied to protein crystallization

    Article • Progress in Biophysics and Molecular Biology, November 2009, Elsevier

    Dr. Jose A. Gavira

  62. Direct Observation of Adsorption Sites of Protein Impurities and Their Effects on Step Advancement of Protein Crystals †

    Article • Crystal Growth & Design, July 2009, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  63. Effects of a Magnetic Field on Lysozyme Crystal Nucleation and Growth in a Diffusive Environment

    Article • Crystal Growth & Design, June 2009, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  64. Precise protein solubility determination by Laser confocal differential interference contrast microscopy

    Article • Journal of Crystal Growth, June 2009, Elsevier

    Dr. Jose A. Gavira

  65. Crystallization and diffraction patterns of the oxy and cyano forms of theLucina pectinatahaemoglobins complex

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, December 2008, International Union of Crystallography

    Dr. Jose A. Gavira

  66. Toward a Definition of X-ray Crystal Quality †

    Article • Crystal Growth & Design, December 2008, American Chemical Society (ACS)

    Professor Dominique Maes, Dr. Jose A. Gavira

  67. Granada Crystallization Facility-2: A Versatile Platform for Crystallization in Space †

    Article • Crystal Growth & Design, December 2008, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  68. Comparison of Different Experimental Techniques for the Measurement of Crystal Growth Kinetics †

    Article • Crystal Growth & Design, December 2008, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  69. Crystallization and preliminary crystallographic studies of the recombinantL-N-carbamoylase fromGeobacillus stearothermophilusCECT43

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2008, International Union of Crystallography

    Dr. Jose A. Gavira

  70. Is Agarose an Impurity or an Impurity Filter? In Situ Observation of the Joint Gel/Impurity Effect on Protein Crystal Growth Kinetics

    Article • Crystal Growth & Design, October 2008, American Chemical Society (ACS)

    Dr. Jose A. Gavira

  71. Crystallization of proteins on functionalized surfaces

    Article • Acta Crystallographica Section D Biological Crystallography, September 2008, International Union of Crystallography

    Dr. Jose A. Gavira

  72. Force-Clamp Spectroscopy Detects Residue Co-evolution in Enzyme Catalysis

    Article • Journal of Biological Chemistry, August 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Jose A. Gavira

  73. Structure and Ligand Selection of Hemoglobin II from Lucina pectinata

    Article • Journal of Biological Chemistry, January 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Jose A. Gavira, Ana Camara-Artigas

  74. Crystallization and preliminary crystallographic studies of an active-site mutant hydantoin racemase fromSinorhizobium melilotiCECT4114

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, December 2007, International Union of Crystallography

    Dr. Jose A. Gavira

  75. Structure of the mexicain–E-64 complex and comparison with other cysteine proteases of the papain family

    Article • Acta Crystallographica Section D Biological Crystallography, April 2007, International Union of Crystallography

    Dr. Jose A. Gavira

  76. Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand

    Article • Acta Crystallographica Section D Biological Crystallography, April 2007, International Union of Crystallography

    Dr. Jose A. Gavira, Ana Camara-Artigas, Dr Andrés Palencia

  77. New techniques for membrane protein crystallization tested on photosystem II core complex of Pisum sativum

    Article • Photosynthesis Research, February 2007, Springer Science + Business Media

    Dr. Jose A. Gavira

  78. Crystallization and preliminary crystallographic studies of the recombinant dihydropyrimidinase fromSinorhizobium melilotiCECT4114

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2006, International Union of Crystallography

    Dr. Jose A. Gavira

  79. Capillary crystallization and molecular-replacement solution of haemoglobin II from the clamLucina pectinata

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2006, International Union of Crystallography

    Dr. Jose A. Gavira, Ana Camara-Artigas

  80. Binding curves by continuous gradient flow-mix calorimetry

    Article • Thermochimica Acta, October 2005, Elsevier

    Dr. Jose A. Gavira

  81. Life in the fast lane for protein crystallization and X-ray crystallography

    Article • Progress in Biophysics and Molecular Biology, July 2005, Elsevier

    Dr. Jose A. Gavira

  82. Purification, crystallization and preliminary X-ray analysis of mexicain

    Article • Acta Crystallographica Section D Biological Crystallography, October 2004, International Union of Crystallography

    Dr. Jose A. Gavira

  83. Protein crystallization by capillary counterdiffusion for applied crystallographic structure determination

    Article • Journal of Structural Biology, April 2003, Elsevier

    Dr. Jose A. Gavira

  84. Purification, crystallization and preliminary X-ray analysis ofCaenorhabditis elegansubiquitin-conjugation enzyme M7.1

    Article • Acta Crystallographica Section D Biological Crystallography, February 2003, International Union of Crystallography

    Dr. Jose A. Gavira

  85. Protein crystal quality in diffusive environments and its evaluation

    Article • Journal of Crystal Growth, January 2003, Elsevier

    Dr. Jose A. Gavira

  86. Granada Crystallisation Box: a new device for protein crystallisation by counter-diffusion techniques

    Article • Acta Crystallographica Section D Biological Crystallography, September 2002, International Union of Crystallography

    Dr. Jose A. Gavira

  87. Agarose as crystallisation media for proteins II: Trapping of gel fibres into the crystals

    Article • Acta Crystallographica Section D Biological Crystallography, September 2002, International Union of Crystallography

    Dr. Jose A. Gavira

  88. Ab initiocrystallographic structure determination of insulin from protein to electron density without crystal handling

    Article • Acta Crystallographica Section D Biological Crystallography, June 2002, International Union of Crystallography

    Dr. Jose A. Gavira

  89. Agarose as crystallization media for proteins

    Article • Journal of Crystal Growth, November 2001, Elsevier

    Dr. Jose A. Gavira

  90. A supersaturation wave of protein crystallization

    Article • Journal of Crystal Growth, November 2001, Elsevier

    Dr. Jose A. Gavira

  91. Structure of tetragonal hen egg-white lysozyme at 0.94 Å from crystals grown by the counter-diffusion method

    Article • Acta Crystallographica Section D Biological Crystallography, July 2001, International Union of Crystallography

    Dr. Jose A. Gavira

  92. Crystallization and cryocrystallography inside X-ray capillaries

    Article • Journal of Applied Crystallography, May 2001, International Union of Crystallography

    Dr. Jose A. Gavira

  93. Experimental evidence for the stability of the depletion zone around a growing protein crystal under microgravity

    Article • Acta Crystallographica Section D Biological Crystallography, March 2001, International Union of Crystallography

    Dr. Jose A. Gavira

  94. In-situmeasurement of rocking curves during lysozyme crystal growth

    Article • Acta Crystallographica Section D Biological Crystallography, March 1999, International Union of Crystallography

    Dr. Jose A. Gavira

  95. Topography and high resolution diffraction studies in tetragonal lysozyme

    Article • Journal of Crystal Growth, January 1999, Elsevier

    Dr. Jose A. Gavira

  96. Reinforced protein crystals

    Article • Materials Research Bulletin, November 1998, Elsevier

    Dr. Jose A. Gavira