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  1. Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

    Article • Cell Metabolism, August 2023, Elsevier

    Dr María Ángeles Pajares

  2. Vimentin single cysteine residue acts as a tunable sensor for network organization and as a key for actin remodeling in response to oxidants and electrophiles

    Article • Redox Biology, August 2023, Elsevier

    Dr María Ángeles Pajares

  3. Amino Acid Metabolism and Disease

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Dr María Ángeles Pajares

  4. Appraising the Role of Astrocytes as Suppliers of Neuronal Glutathione Precursors

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Dr María Ángeles Pajares

  5. Alexander disease: the road ahead

    Article • Neural Regeneration Research, January 2023, Medknow

    Dr María Ángeles Pajares

  6. Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia

    Article • Brain Communications, January 2023, Oxford University Press (OUP)

    Dr María Ángeles Pajares

  7. Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress

    Article • Redox Biology, September 2022, Elsevier

    Dr María Ángeles Pajares

  8. Vimentin Tail Segments Are Differentially Exposed at Distinct Cellular Locations and in Response to Stress

    Article • Frontiers in Cell and Developmental Biology, June 2022, Frontiers

    Dr María Ángeles Pajares

  9. Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary cilia

    Article • Scientific Reports, April 2022, Springer Science + Business Media

    Dr María Ángeles Pajares

  10. Amoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation

    Article • Frontiers in Pharmacology, January 2022, Frontiers

    Dr María Ángeles Pajares

  11. Polar Interactions at the Dimer–Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization

    Article • International Journal of Molecular Sciences, December 2021, MDPI AG

    Dr María Ángeles Pajares

  12. Molecular Insight into the Regulation of Vimentin by Cysteine Modifications and Zinc Binding

    Article • Antioxidants, June 2021, MDPI AG

    Dr María Ángeles Pajares

  13. Immunolocalization studies of vimentin and ACE2 on the surface of cells exposed to SARS-CoV-2 Spike proteins

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr María Ángeles Pajares

  14. Oxidative and Electrophilic Stress Aggravate GFAP Dysfunction in Alexander Disease

    Article • Free Radical Biology and Medicine, November 2020, Elsevier

    Dr María Ángeles Pajares

  15. Type III intermediate filaments as targets and effectors of electrophiles and oxidants

    Article • Redox Biology, September 2020, Elsevier

    Dr María Ángeles Pajares

  16. Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

    Article • Frontiers in Pharmacology, March 2020, Frontiers

    Dr María Ángeles Pajares

  17. Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism

    Article • Biochimie, February 2020, Elsevier

    Dr María Ángeles Pajares

  18. Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division

    Article • Nature Communications, September 2019, Springer Science + Business Media

    Dr María Ángeles Pajares

  19. Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia

    Article • The FASEB Journal, May 2019, Federation of American Societies For Experimental Biology (FASEB)

    Dr María Ángeles Pajares, Isabel Varela-Nieto, Steven Zeisel

  20. Integrated approaches to unravel the impact of protein lipoxidation on macromolecular interactions

    Article • Free Radical Biology and Medicine, April 2019, Elsevier

    Dr María Ángeles Pajares

  21. Vimentin disruption by lipoxidation and electrophiles: Role of the cysteine residue and filament dynamics

    Article • Redox Biology, January 2019, Elsevier

    Dr María Ángeles Pajares

  22. The relationship between what we eat and hearing

    Article • Nutrients, December 2018, MDPI AG

    Dr María Ángeles Pajares

  23. Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase

    Article • PLoS ONE, June 2018, PLOS

    Dr María Ángeles Pajares

  24. Asthma and allergic rhinitis associate with the rs2229542 variant that induces a p.Lys90Glu mutation and compromises AKR1B1 protein levels

    Article • Human Mutation, May 2018, Wiley

    Dr María Ángeles Pajares

  25. Mammalian Sulfur Amino Acid Metabolism: A Nexus Between Redox Regulation, Nutrition, Epigenetics, and Detoxification

    Article • Antioxidants & Redox Signaling, January 2018, Mary Ann Liebert Inc

    Dr María Ángeles Pajares

  26. Alterations in Nucleocytoplasmic Localization of the Methionine Cycle Induced by Oxidative Stress During Liver Disease

    Article • January 2018, Elsevier

    Dr María Ángeles Pajares

  27. PDRG1 at the interface between intermediary metabolism and oncogenesis

    Article • World Journal of Biological Chemistry, November 2017, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Dr María Ángeles Pajares

  28. Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

    Article • Frontiers in Molecular Neuroscience, April 2017, Frontiers

    Dr María Ángeles Pajares

  29. Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, March 2017, Elsevier

    Dr María Ángeles Pajares

  30. Correction: The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases

    Article • PLoS ONE, September 2016, PLOS

    Dr María Ángeles Pajares

  31. Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice

    Article • Frontiers in Aging Neuroscience, August 2016, Frontiers

    Dr María Ángeles Pajares

  32. The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases

    Article • PLoS ONE, August 2016, PLOS

    Dr María Ángeles Pajares

  33. Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase

    Article • Frontiers in Pharmacology, August 2016, Frontiers

    Dr María Ángeles Pajares

  34. Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice

    Article • The Journal of Nutritional Biochemistry, December 2015, Elsevier

    Dr María Ángeles Pajares

  35. Regulación redox del ciclo de la metionina

    Article • May 2015, Sociedad Espanola de Bioquimica y Biologia Molecular (SEBBM)

    Dr María Ángeles Pajares

  36. The deficit in folic acid accelerates hearing loss

    Article • The FASEB Journal, November 2014, Federation of American Societies For Experimental Biology (FASEB)

    Isabel Varela-Nieto, Dr María Ángeles Pajares

  37. Acute Liver Injury Induces Nucleocytoplasmic Redistribution of Hepatic Methionine Metabolism Enzymes

    Article • Antioxidants & Redox Signaling, June 2014, Mary Ann Liebert Inc

    Dr María Ángeles Pajares

  38. Modulation of GSTP1-1 Oligomerization by Electrophilic Inflammatory Mediators and Reactive Drugs

    Article • Inflammation & Allergy - Drug Targets, June 2013, Bentham Science Publishers

    Dr María Ángeles Pajares

  39. Redox stress regulates production of the main cellular methyl donor S-adenosylmethionine

    Article • FEBS Letters, May 2013, Wiley

    Dr María Ángeles Pajares

  40. Structural Studies of Betaine Homocysteine Methyl Transferase (BHMT) and a Dimeric Mutant by Conventional and 2DCOS Moving Lapse IR Spectroscopy

    Article • Biophysical Journal, January 2013, Elsevier

    Dr María Ángeles Pajares

  41. NADP+ Binding to the Regulatory Subunit of Methionine Adenosyltransferase II Increases Intersubunit Binding Affinity in the Hetero-Trimer

    Article • PLoS ONE, November 2012, PLOS

    Dr María Ángeles Pajares

  42. Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase)

    Article • October 2011, Wiley

    Dr María Ángeles Pajares

  43. Refolding and characterization of methionine adenosyltransferase from Euglena gracilis

    Article • Protein Expression and Purification, September 2011, Elsevier

    Dr María Ángeles Pajares

  44. Structural basis for the stability of a thermophilic methionine adenosyltransferase against guanidinium chloride

    Article • Amino Acids, December 2010, Springer Science + Business Media

    Dr María Ángeles Pajares

  45. Las otras utilidades de los aminoácidos

    Article • September 2010, Sociedad Espanola de Bioquimica y Biologia Molecular (SEBBM)

    Dr María Ángeles Pajares

  46. Cyclopentenone Prostaglandins with Dienone Structure Promote Cross-Linking of the Chemoresistance-Inducing Enzyme Glutathione Transferase P1-1

    Article • Molecular Pharmacology, July 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr María Ángeles Pajares

  47. Subunit association as the stabilizing determinant for archaeal methionine adenosyltransferases

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, July 2009, Elsevier

    Dr María Ángeles Pajares

  48. Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution

    Article • The FASEB Journal, June 2009, Federation of American Societies For Experimental Biology (FASEB)

    Dr María Ángeles Pajares

  49. Structure-function relationships in methionine adenosyltransferases

    Article • Cellular and Molecular Life Sciences, October 2008, Springer Science + Business Media

    Dr María Ángeles Pajares

  50. Early effects of copper accumulation on methionine metabolism

    Article • Cellular and Molecular Life Sciences, June 2008, Springer Science + Business Media

    Dr María Ángeles Pajares

  51. Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?

    Article • Cellular and Molecular Life Sciences, November 2006, Springer Science + Business Media

    Dr María Ángeles Pajares

  52. Rat liver betaine–homocysteine S-methyltransferase equilibrium unfolding: insights into intermediate structure through tryptophan substitutions

    Article • Biochemical Journal, November 2005, Portland Press Ltd.

    Dr María Ángeles Pajares

  53. Methionine Adenosyltransferase α-Helix Structure Unfolds at Lower Temperatures than β-Sheet: A 2D-IR Study

    Article • Biophysical Journal, June 2004, Elsevier

    Dr María Ángeles Pajares

  54. BHMT from rat liver

    Article • May 2004, Protein Data Bank, Rutgers University

    Dr María Ángeles Pajares

  55. Crystal Structure of Rat Liver Betaine Homocysteine S-Methyltransferase Reveals New Oligomerization Features and Conformational Changes Upon Substrate Binding

    Article • Journal of Molecular Biology, May 2004, Elsevier

    Dr María Ángeles Pajares

  56. Methionine Adenosyltransferase as a Useful Molecular Systematics Tool Revealed by Phylogenetic and Structural Analyses

    Article • Journal of Molecular Biology, January 2004, Elsevier

    Dr María Ángeles Pajares

  57. Cu2+binding triggers αBoPrP assembly into insoluble laminar polymers

    Article • FEBS Letters, December 2003, Wiley

    Dr María Ángeles Pajares

  58. Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights into the Catalytic Mechanism

    Article • Journal of Molecular Biology, August 2003, Elsevier

    Dr María Ángeles Pajares

  59. Methionine Adenosyltransferase complexed with ADP and a L-methionine analogous

    Article • August 2003, Protein Data Bank, Rutgers University

    Dr María Ángeles Pajares

  60. Methionine adenosyltransferase complexed with both substrates ATP and methionine

    Article • August 2003, Protein Data Bank, Rutgers University

    Dr María Ángeles Pajares

  61. Methionine Adenosyltransferase complexed with a L-methionine analogous

    Article • August 2003, Protein Data Bank, Rutgers University

    Dr María Ángeles Pajares

  62. Active-site-mutagenesis study of rat liver betaine-homocysteine S-methyltransferase

    Article • Biochemical Journal, March 2003, Portland Press Ltd.

    Dr María Ángeles Pajares

  63. Role of an Intrasubunit Disulfide in the Association State of the Cytosolic Homo-oligomer Methionine Adenosyltransferase

    Article • Journal of Biological Chemistry, December 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr María Ángeles Pajares, Juan Calvete

  64. Leishmania donovanimethionine adenosyltransferase

    Article • European Journal of Biochemistry, December 2002, Wiley

    Dr María Ángeles Pajares

  65. Crystallization and preliminary X-ray study of recombinant betaine–homocysteineS-methyltransferase from rat liver

    Article • Acta Crystallographica Section D Biological Crystallography, August 2002, International Union of Crystallography

    Dr María Ángeles Pajares

  66. Prion Protein Interaction with Glycosaminoglycan Occurs with the Formation of Oligomeric Complexes Stabilized by Cu(II) Bridges

    Article • Journal of Molecular Biology, May 2002, Elsevier

    Dr María Ángeles Pajares

  67. Equilibrium unfolding studies of the rat liver methionine adenosyltransferase III, a dimeric enzyme with intersubunit active sites

    Article • Biochemical Journal, January 2002, Portland Press Ltd.

    Dr María Ángeles Pajares

  68. Equilibrium unfolding studies of the rat liver methionine adenosyltransferase III, a dimeric enzyme with intersubunit active sites

    Article • Biochemical Journal, January 2002, Portland Press Ltd.

    Dr María Ángeles Pajares

  69. METHIONINE ADENOSYLTRANSFERASE COMPLEXED WITH A L-METHIONINE ANALOGOUS

    Article • September 2000, Protein Data Bank, Rutgers University

    Dr María Ángeles Pajares

  70. The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site 1 1Edited by R. Huber

    Article • Journal of Molecular Biology, July 2000, Elsevier

    Dr María Ángeles Pajares

  71. Refolding and Characterization of Rat Liver Methionine Adenosyltransferase from Escherichia coli Inclusion Bodies

    Article • Protein Expression and Purification, July 2000, Elsevier

    Dr María Ángeles Pajares

  72. Assignment of a single disulfide bridge in rat liver methionine adenosyltransferase

    Article • European Journal of Biochemistry, January 2000, Wiley

    Dr María Ángeles Pajares

  73. Characterization of Rat Liver-specific Methionine Adenosyltransferase Gene Promoter: ROLE OF DISTAL UPSTREAM cis-ACTING ELEMENTS IN THE REGULATION OF THE TRANSCRIPTIONAL ACTIVITY

    Article • Journal of Biological Chemistry, September 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jesús Mingorance, Dr María Ángeles Pajares

  74. Recombinant rat liver S-adenosyl-l-methionine synthetase tetramers and dimers are in equilibrium

    Article • The International Journal of Biochemistry & Cell Biology, March 1997, Elsevier

    Dr Jesús Mingorance, Dr María Ángeles Pajares

  75. Glucocorticoid Regulation of Hepatic S-Adenosylmethionine Synthetase Gene Expression

    Article • Endocrinology, March 1997, Endocrine Society

    Dr María Ángeles Pajares

  76. Glucocorticoid Regulation of HepaticS-Adenosylmethionine Synthetase Gene Expression1

    Article • Endocrinology, March 1997, Endocrine Society

    Dr María Ángeles Pajares

  77. S-adenosylmethionine synthesis: Molecular mechanisms and clinical implications

    Article • Pharmacology & Therapeutics, January 1997, Elsevier

    Dr María Ángeles Pajares

  78. Role of thioltransferases on the modulation of rat liver S-adenosylmethionine synthetase activity by glutathione

    Article • FEBS Letters, November 1996, Wiley

    Dr María Ángeles Pajares

  79. Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA

    Article • Biochemical Journal, November 1996, Portland Press Ltd.

    Dr María Ángeles Pajares

  80. Differential expression pattern of S-adenosylmethionine synthetase isoenzymes during rat liver development

    Article • Hepatology, October 1996, Wiley

    Dr María Ángeles Pajares, Lisardo Bosca

  81. Differential expression pattern ofS-adenosylmethionine synthetase isoenzymes during rat liver development

    Article • Hepatology, October 1996, Wiley

    Dr María Ángeles Pajares

  82. Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis

    Article • Journal of Hepatology, August 1996, Elsevier

    Professor Albert Pares, Dr María Ángeles Pajares

  83. Study of the rat liverS-adenosylmethionine synthetase active site with 8-azido ATP

    Article • Biochemical Journal, June 1995, Portland Press Ltd.

    Dr María Ángeles Pajares

  84. Expression of rat liverS-adenosylmethionine synthetase inEscherichia coliresults in two active oligomeric forms

    Article • Biochemical Journal, July 1994, Portland Press Ltd.

    Dr María Ángeles Pajares

  85. S-Adenosyl-L-Methionine Synthetase and Methionine Metabolism Deficiencies in Cirrhosis

    Article • January 1994, Springer Science + Business Media

    Dr Jesús Mingorance, Dr María Ángeles Pajares

  86. S-adenosylmethionine treatment prevents carbon tetrachloride—inducedS-adenosylmethionine synthetase inactivation and attenuates liver injury

    Article • Hepatology, October 1992, Wolters Kluwer Health

    Professor Albert Pares, Dr María Ángeles Pajares

  87. How is rat liver S -adenosylmethionine synthetase regulated?

    Article • FEBS Letters, August 1992, Wiley

    Dr María Ángeles Pajares

  88. Impairment of Methionine Metabolism in Liver Disease

    Article • Drug Investigation, January 1992, Springer Science + Business Media

    Dr María Ángeles Pajares

  89. Analysis of the 5′ non-coding region of rat liver S -adenosylmethionine synthetase mRNA and comparison of the M r deduced from the cDNA sequence and the purified enzyme

    Article • FEBS Letters, September 1991, Wiley

    Dr María Ángeles Pajares

  90. Inhibition of glutathione synthesis in the liver leads toS-adenosyl-L-methionine synthetase reduction

    Article • Hepatology, September 1991, Wiley

    Dr María Ángeles Pajares

  91. Fourier transform infrared studies of active-site-methylated rhodopsin. Implications for chromophore-protein interaction, transducin activation, and the reaction pathway

    Article • Biophysical Journal, March 1991, Elsevier

    Dr María Ángeles Pajares

  92. Reduced S-adenosylmethionine synthetase mRNA levels in liver biopsies from cirrhotic subjects

    Article • Journal of Hepatology, January 1991, Elsevier

    Dr María Ángeles Pajares

  93. Inactivation and dissociation ofs-adenosylmethionine synthetase by modification of sulfhydryl groups and its possile occurrence in cirrhosis

    Article • Hepatology, February 1990, Wiley

    Dr María Ángeles Pajares

  94. Mechanisms and Consequences of the Impaired Trans-Sulphuration Pathway in Liver Disease

    Article • Drugs, January 1990, Springer Science + Business Media

    Dr María Ángeles Pajares

  95. Structural basis of protein kinase C activation by tumor promoters.

    Article • Proceedings of the National Academy of Sciences, December 1989, Proceedings of the National Academy of Sciences

    Dr María Ángeles Pajares

  96. Calcium-dependent binding between calmodulin and lysozyme

    Article • FEBS Letters, April 1989, Wiley

    Dr José F Fierro, Dr María Ángeles Pajares

  97. Purification of phospholipid methyltransferase from rat liver microsomal fraction

    Article • Biochemical Journal, August 1986, Portland Press Ltd.

    Dr María Ángeles Pajares

  98. Regulation of Phospholipid Methylation by Reversible Phosphorylation

    Article • January 1986, Springer Science + Business Media

    Dr María Ángeles Pajares

  99. Modulation by the ratio S-adenosylmethionineS-adenosylhomocysteine of cyclic AMP-dependent phosphorylation of the 50 kDa protein of rat liver phospholipid methyltransferase

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 1985, Elsevier

    Dr María Ángeles Pajares

  100. How many phospholipid methyltransferases are there in mammalian cells?

    Article • Trends in Biochemical Sciences, November 1984, Elsevier

    Dr María Ángeles Pajares

  101. Purification and photoaffinity labelling of lipid methyltransferase from rat liver

    Article • Biochemical Journal, October 1984, Portland Press Ltd.

    Dr María Ángeles Pajares

  102. Activation of partially purified rat liver lipid methyltransferase by phosphorylation

    Article • Biochemical and Biophysical Research Communications, August 1984, Elsevier

    Dr María Ángeles Pajares