All Stories

  1. Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

    Article • Biochemical and Biophysical Research Communications, October 2022, Elsevier

    Dr. JEFFERY S TESSEM

  2. Ca2+ Sensors Assemble: Function of the MCU Complex in the Pancreatic Beta Cell

    Article • Cells, June 2022, MDPI AG

    Dr. JEFFERY S TESSEM

  3. 1446-P: Sex-Specific Effects of Nr4a1 in the Pancreatic Beta Cell

    Article • Diabetes, June 2022, American Diabetes Association

    Dr. JEFFERY S TESSEM

  4. Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study

    Article • January 2022, MDPI AG

    Dr. JEFFERY S TESSEM

  5. Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions

    Article • Biomolecules, December 2021, MDPI AG

    Dr. JEFFERY S TESSEM

  6. Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study

    Article • December 2021, MDPI AG

    Dr. JEFFERY S TESSEM

  7. Decreased proliferation of aged rat beta cells corresponds with enhanced expression of the cell cycle inhibitor p27 KIP1

    Article • Biology of the Cell, September 2021, Wiley

    Dr. JEFFERY S TESSEM

  8. The Accumulation and Molecular Effects of Trimethylamine N-Oxide on Metabolic Tissues: It’s Not All Bad

    Article • Nutrients, August 2021, MDPI AG

    Dr. JEFFERY S TESSEM

  9. Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional β-Cell Mass

    Article • Metabolites, November 2020, MDPI AG

    Dr. JEFFERY S TESSEM

  10. Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, August 2020, Elsevier

    Dr. JEFFERY S TESSEM

  11. Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues

    Article • Cells, November 2019, MDPI AG

    Dr. JEFFERY S TESSEM

  12. HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27

    Article • Biochemical Journal, December 2018, Portland Press Ltd.

    Dr. JEFFERY S TESSEM

  13. Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells

    Article • The Journal of Nutritional Biochemistry, December 2018, Elsevier

    Dr. JEFFERY S TESSEM

  14. β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle

    Article • International Journal of Molecular Sciences, August 2018, MDPI AG

    Dr. JEFFERY S TESSEM

  15. Nr4a1 and Nr4a3 Knock Out Mice Have Impaired Glucose Clearance and Beta-Cell Function under High-Fat Feeding

    Article • Diabetes, July 2018, American Diabetes Association

    Dr. JEFFERY S TESSEM

  16. High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

    Article • Journal of Visualized Experiments, January 2018, MyJove Corporation

    Dr. JEFFERY S TESSEM

  17. Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration

    Article • The Journal of Nutritional Biochemistry, November 2017, Elsevier

    Dr. JEFFERY S TESSEM

  18. β-Hydroxybutyrate improves β-cell mitochondrial function and survival

    Article • Journal of Insulin Resistance, August 2017, AOSIS Open Journals

    Dr. JEFFERY S TESSEM

  19. Mechanisms by which cocoa flavanols improve metabolic syndrome and related disorders

    Article • The Journal of Nutritional Biochemistry, September 2016, Elsevier

    Dr. JEFFERY S TESSEM

  20. β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion

    Article • AJP Endocrinology and Metabolism, July 2016, American Physiological Society

    Dr. JEFFERY S TESSEM

  21. Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos

    Article • FEBS Letters, May 2016, Wiley

    Dr. JEFFERY S TESSEM

  22. Cdk5r1 Overexpression Induces Primaryβ-Cell Proliferation

    Article • Journal of Diabetes Research, January 2016, Hindawi Publishing Corporation

    Dr. JEFFERY S TESSEM

  23. Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway

    Article • Islets, January 2015, Taylor & Francis

    Dr. JEFFERY S TESSEM

  24. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

    Article • Proceedings of the National Academy of Sciences, March 2014, Proceedings of the National Academy of Sciences

    Dr. JEFFERY S TESSEM

  25. Macrophages in Pancreatic Degeneration and Diabetes Prevention

    Article • Diabetes, June 2008, American Diabetes Association

    Dr. JEFFERY S TESSEM

  26. Stimulation of Human and Rat Islet β-Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1

    Article • Molecular and Cellular Biology, March 2008, ASM Journals

    Dr. JEFFERY S TESSEM

  27. A CRITICAL ROLE FOR MACROPHAGES IN PREVENTING PANCREATITIS ASSOCIATED DIABETES

    Article • Pancreas, November 2007, Wolters Kluwer Health

    Dr. JEFFERY S TESSEM

  28. Roles for bone-marrow-derived cells in β-cell maintenance

    Article • Trends in Molecular Medicine, November 2004, Elsevier

    Dr. JEFFERY S TESSEM

  29. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss

    Article • Proceedings of the National Academy of Sciences, October 2003, Proceedings of the National Academy of Sciences

    Dr. JEFFERY S TESSEM