All Stories

  1. Quantitative determination of intracellular Asulacrine in MCF-7 breast cancer cells by liquid chromatography-mass spectrometry and its application to cellular pharmacokinetic studies of P188 modified liposomes
  2. Integrated scientific data bases review on asulacrine and associated toxicity
  3. Identification and characterization of in vivo metabolites of asulacrine using advanced mass spectrophotometry technique in combination with improved data mining strategy
  4. A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliablein vitroinhibitory drug–drug interaction evaluation
  5. Bioavailability and pharmacokinetics profile of helicid in beagle dogs using gradient elution high performance liquid chromatography electrospray ionization mass spectrometry
  6. A novel CYP2D6 inhibitor was found which could be used as positive inhibitor of CYP2D6
  7. Strategies to Maximize Liposomal Drug Loading for a Poorly Water-soluble Anticancer Drug
  8. A logistic equation to determine the validity of tramadol from related gene polymorphisms and psychological factors
  9. Prediction of Human Pharmacokinetics from Preclinical Information of Rhein, an Antidiabetic Nephropathy Drug, Using a Physiologically Based Pharmacokinetic Model
  10. Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1,6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS
  11. 10.1016/j.jchromb.2004.12.028
  12. Stereoselective Regulations of P-Glycoprotein by Ginsenoside Rh2 Epimers and the Potential Mechanisms From the View of Pharmacokinetics
  13. Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells
  14. The formulation and preparation process of Aconitum coreanum film-coating tablets
  15. Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line
  16. Differences in metabolite profile between blood plasma and serum
  17. Activation of CYP3A-mediated testosterone 6β-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes
  18. Development and validation of a liquid chromatography–mass spectrometry method for the determination of verticinone in rat plasma and its application to pharmacokinetic study
  19. Quantitative determination of helicid in rat biosamples by liquid chromatography electrospray ionization mass spectrometry
  20. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers
  21. Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1′-hydroxylation and 4-hydroxylation of midazolam
  22. Metabonomic characterization of early atherosclerosis in hamsters with induced cholesterol
  23. Simultaneous Quantification of Benazepril, Gliclazide and Valsartan in Human Plasma by LC–MS–MS and Application for Rapidly Measuring Protein Binding Interaction between Rhein and These Three Drugs
  24. Global analysis of metabolites in rat and human urine based on gas chromatography/time-of-flight mass spectrometry
  25. LC–MS–MS Study of the Pharmacokinetics of a 9-β-Dihydro-9,10-O-acetal Derivative of Docetaxel in Rats and Beagle Dogs
  26. Simultaneous determination of multiple angiotensin type 1 receptor antagonists and its application to high-throughput pharmacokinetic study: Cassette dosing versus cassette analysis
  27. LC–MS–MS Study of the Pharmacokinetics of a 9-β-Dihydro-9,10-O-acetal Derivative of Docetaxel in Rats and Beagle Dogs
  28. Chiral separation of ibuprofen and chiral pharmacokinetics in healthy chinese volunteers
  29. Simultaneous determination of ginsenoside Rg1, Re, Rd, Rb1 and ophiopogonin D in rat plasma by liquid chromatography/electrospray ionization mass spectrometric method and its application to pharmacokinetic study of ‘SHENMAI’ injection
  30. Effect of danshen extract on pharmacokinetics of theophylline in healthy volunteers
  31. LC-ESI-MS Determination of Roxithromycin in Tissues of Beagle Dogs after Multiple Dosing of Roxithromycin Sustained Release Tablets
  32. Pharmacokinetic Study of Triptolide, a Constituent of Immunosuppressive Chinese Herb Medicine, in Rats
  33. Determination of secnidazole in human plasma by high-performance liquid chromatography with UV detection and its application to the bioequivalence studies
  34. Quantitative analysis of 23-hydroxybetulinic acid, a novel anticancer substance, in the cellular environment of a human colon adenocarcinoma cell line for cellular pharmacokinetic studies
  35. Liquid chromatographic–mass spectrometry analysis and pharmacokinetic studies of a novel rabeprazole formulation, sterile powder for injection, in dogs and rats
  36. Simultaneous determination of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 in rat plasma by HPLC/ESI/MS: platform for the pharmacokinetic evaluation of total panax notoginsenoside, a typical kind of multiple constituent traditional Chinese...
  37. Pharmacokinetic and Absolute Bioavailability Study of Total Panax Notoginsenoside, a Typical Multiple Constituent Traditional Chinese Medicine (TCM) in Rats
  38. Identification of the major metabolites of 5-n-butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichloridephenyl)-3H-1,2,4-triazol-3-one, a new angiotensin type 1 receptor antagonist, in rat bile by HPLC–diode array det...
  39. Construction of the Fingerprints of Ginseng Stem and Leaf Saponin Reference Substances and Spiked Plasma Sample by LC-ESI/MS and Its Application to Analyzing the Compounds Absorbed into Blood after Oral Administration of Ginseng Stem and Leaf Saponin i...
  40. HPLC Assay of Levamisole and Abamectin in Sheep Plasma for Application to Pharmacokinetic Studies
  41. Development of a sensitive LC-ESI-MS assay for 20(R)-ginsenoside Rh2 and its pharmacokinetic application in dogs: A case for the influence of micronization on traditional Chinese medicine
  42. Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study
  43. Simultaneous determination of MHD and DMD in dog plasma by high-performance liquid chromatography with fluorescence detection and its application to pharmacokinetic studies
  44. Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma
  45. Simultaneous determination of erythromycin ethylsuccinate and its metabolite erythromycin in human plasma using liquid chromatography–electrospray ionization mass spectrometry for clinical study
  46. Liquid chromatographic/mass spectrometric assay of rabprazole in dog plasma for a pharmacokinetic study
  47. In Vitro Assessment of Plasma Protein Binding of 20(R)-Ginsenoside Rh2 by Equilibrium Dialysis and LC-MS Analysis: A Case of Species Differences
  48. Sensitive and selective liquid chromatography–electrospray ionization mass spectrometry analysis of ginkgolide B in dog plasma
  49. Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography–electrospray mass spectrometry for pharmacokinetic studies
  50. Simultaneous rapid quantification of ginsenoside Rg1 and its secondary glycoside Rh1 and aglycone protopanaxatriol in rat plasma by liquid chromatography–mass spectrometry after solid-phase extraction
  51. High performance liquid chromatographic–mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies
  52. Simultaneous determination of oxymatrine and its active metabolite matrine in dog plasma by liquid chromatography–mass spectrometry and its application to pharmacokinetic studies
  53. Enantioselective Pharmacokinetics of Ibuprofen and Involved Mechanisms
  54. Pharmacokinetics of Guanfu Base I, an Active Metabolite of Guanfu Base A, in Rats
  55. Unidirectional Inversion of Ibuprofen in Caco-2 Cells: Developing a Suitable Model for Presystemic Chiral Inversion Study
  56. Transport and Bioavailability Studies of Astragaloside IV, an Active Ingredient in Radix Astragali