All Stories

  1. Unlocking a Simpler Path to Nitrogen Fixation

    Article • Proceedings of the National Academy of Sciences, November 2024, Proceedings of the National Academy of Sciences

    Lucia Payá Tormo, Zhiyong Yang

  2. Ancient nitrogenases are ATP dependent

    Article • mBio, July 2024, ASM Journals

    Zhiyong Yang

  3. The Origins of ATP Dependence in Biological Nitrogen Fixation

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Zhiyong Yang

  4. Low-temperature trapping of N2 reduction reaction intermediates in nitrogenase MoFe protein–CdS quantum dot complexes

    Article • The Journal of Chemical Physics, December 2023, American Institute of Physics

    Zhiyong Yang

  5. High Affinity Electrostatic Interactions Support the Formation of CdS Quantum Dot:Nitrogenase MoFe Protein Complexes

    Article • Nano Letters, November 2023, American Chemical Society (ACS)

    Zhiyong Yang

  6. Cryo-annealing of Photoreduced CdS Quantum Dot–Nitrogenase MoFe Protein Complexes Reveals the Kinetic Stability of the E4(2N2H) Intermediate

    Article • Journal of the American Chemical Society, September 2023, American Chemical Society (ACS)

    Zhiyong Yang

  7. The Fe Protein Cycle Associated with Nitrogenase Catalysis Requires the Hydrolysis of Two ATP for Each Single Electron Transfer Event

    Article • Journal of the American Chemical Society, March 2023, American Chemical Society (ACS)

    Zhiyong Yang

  8. A conformational equilibrium in the nitrogenase MoFe protein with an α-V70I amino acid substitution illuminates the mechanism of H2 formation

    Article • Faraday Discussions, January 2023, Royal Society of Chemistry

    Zhiyong Yang

  9. 13C ENDOR Characterization of the Central Carbon within the Nitrogenase Catalytic Cofactor Indicates That the CFe6Core Is a Stabilizing “Heart of Steel”

    Article • Journal of the American Chemical Society, September 2022, American Chemical Society (ACS)

    Zhiyong Yang

  10. The One-Electron Reduced Active-Site FeFe-Cofactor of Fe-Nitrogenase Contains a Hydride Bound to a Formally Oxidized Metal-Ion Core

    Article • Inorganic Chemistry, March 2022, American Chemical Society (ACS)

    Zhiyong Yang

  11. Exploring the Role of the Central Carbide of the Nitrogenase Active-Site FeMo-cofactor through Targeted13C Labeling and ENDOR Spectroscopy

    Article • Journal of the American Chemical Society, June 2021, American Chemical Society (ACS)

    Zhiyong Yang

  12. The electronic structure of FeV-cofactor in vanadium-dependent nitrogenase

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Zhiyong Yang

  13. Electron Redistribution within the Nitrogenase Active Site FeMo-Cofactor During Reductive Elimination of H2 to Achieve N≡N Triple-Bond Activation

    Article • Journal of the American Chemical Society, December 2020, American Chemical Society (ACS)

    Zhiyong Yang

  14. Correction to “Establishing a Thermodynamic Landscape for the Active Site of Mo-Dependent Nitrogenase”

    Article • Journal of the American Chemical Society, March 2020, American Chemical Society (ACS)

    Zhiyong Yang, Shelley Minteer

  15. Reduction of Substrates by Nitrogenases

    Article • Chemical Reviews, March 2020, American Chemical Society (ACS)

    Zhiyong Yang

  16. An Efficient Viologen-Based Electron Donor to Nitrogenase

    Article • Biochemistry, November 2019, American Chemical Society (ACS)

    Zhiyong Yang

  17. Establishing a Thermodynamic Landscape for the Active Site of Mo-Dependent Nitrogenase

    Article • Journal of the American Chemical Society, October 2019, American Chemical Society (ACS)

    Zhiyong Yang, Shelley Minteer

  18. Spectroscopic Description of the E1State of Mo Nitrogenase Based on Mo and Fe X-ray Absorption and Mössbauer Studies

    Article • Inorganic Chemistry, August 2019, American Chemical Society (ACS)

    Zhiyong Yang

  19. Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism To Achieve N2Reduction

    Article • Biochemistry, July 2019, American Chemical Society (ACS)

    Zhiyong Yang

  20. (Invited) Electrocatalytic N2 Reduction to NH3 Using the Enzyme Nitrogenase

    Article • ECS Meeting Abstracts, June 2019, The Electrochemical Society

    Zhiyong Yang

  21. A Voltammetric Study of Nitrogenase Catalysis Using Electron Transfer Mediators

    Article • ACS Catalysis, January 2019, American Chemical Society (ACS)

    Zhiyong Yang

  22. Kinetic Understanding of N2Reduction versus H2Evolution at the E4(4H) Janus State in the Three Nitrogenases

    Article • Biochemistry, September 2018, American Chemical Society (ACS)

    Zhiyong Yang

  23. Hydride Conformers of the Nitrogenase FeMo-cofactor Two-Electron Reduced State E2(2H), Assigned Using Cryogenic Intra Electron Paramagnetic Resonance Cavity Photolysis

    Article • Inorganic Chemistry, March 2018, American Chemical Society (ACS)

    Zhiyong Yang

  24. A pathway for biological methane production using bacterial iron-only nitrogenase

    Article • Nature Microbiology, January 2018, Springer Science + Business Media

    Zhiyong Yang

  25. Light-driven carbon dioxide reduction to methane by nitrogenase in a photosynthetic bacterium

    Article • Proceedings of the National Academy of Sciences, August 2016, Proceedings of the National Academy of Sciences

    Zhiyong Yang

  26. Reductive Elimination of H2 Activates Nitrogenase to Reduce the N≡N Triple Bond: Characterization of the E4(4H) Janus Intermediate in Wild-Type Enzyme

    Article • Journal of the American Chemical Society, August 2016, American Chemical Society (ACS)

    Zhiyong Yang

  27. Exploring Electron/Proton Transfer and Conformational Changes in the Nitrogenase MoFe Protein and FeMo-cofactor Through Cryoreduction/EPR Measurements

    Article • Israel Journal of Chemistry, July 2016, Wiley

    Zhiyong Yang

  28. Evidence That the Pi Release Event Is the Rate-Limiting Step in the Nitrogenase Catalytic Cycle

    Article • Biochemistry, June 2016, American Chemical Society (ACS)

    Zhiyong Yang

  29. Reversible Photoinduced Reductive Elimination of H2 from the Nitrogenase Dihydride State, the E4(4H) Janus Intermediate

    Article • Journal of the American Chemical Society, January 2016, American Chemical Society (ACS)

    Zhiyong Yang

  30. Identification of a Key Catalytic Intermediate Demonstrates That Nitrogenase Is Activated by the Reversible Exchange of N2 for H2

    Article • Journal of the American Chemical Society, March 2015, American Chemical Society (ACS)

    Zhiyong Yang

  31. A Confirmation of the Quench-Cryoannealing Relaxation Protocol for Identifying Reduction States of Freeze-Trapped Nitrogenase Intermediates

    Article • Inorganic Chemistry, March 2014, American Chemical Society (ACS)

    Zhiyong Yang

  32. Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage

    Article • Chemical Reviews, January 2014, American Chemical Society (ACS)

    Zhiyong Yang

  33. On reversible H 2 loss upon N 2 binding to FeMo-cofactor of nitrogenase

    Article • Proceedings of the National Academy of Sciences, September 2013, Proceedings of the National Academy of Sciences

    Zhiyong Yang

  34. Nitrogenase reduction of carbon-containing compounds

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, August 2013, Elsevier

    Zhiyong Yang

  35. Carbon dioxide reduction to methane and coupling with acetylene to form propylene catalyzed by remodeled nitrogenase

    Article • Proceedings of the National Academy of Sciences, November 2012, Proceedings of the National Academy of Sciences

    Zhiyong Yang

  36. The Nitrogenase Regulatory Enzyme Dinitrogenase Reductase ADP-Ribosyltransferase (DraT) Is Activated by Direct Interaction with the Signal Transduction Protein GlnB

    Article • Journal of Bacteriology, November 2012, ASM Journals

    Zhiyong Yang

  37. Unification of reaction pathway and kinetic scheme for N 2 reduction catalyzed by nitrogenase

    Article • Proceedings of the National Academy of Sciences, March 2012, Proceedings of the National Academy of Sciences

    Zhiyong Yang

  38. ENDOR/HYSCORE Studies of the Common Intermediate Trapped during Nitrogenase Reduction of N2H2, CH3N2H, and N2H4Support an Alternating Reaction Pathway for N2Reduction

    Article • Journal of the American Chemical Society, August 2011, American Chemical Society (ACS)

    Zhiyong Yang

  39. Molybdenum Nitrogenase Catalyzes the Reduction and Coupling of CO to Form Hydrocarbons*

    Article • Journal of Biological Chemistry, June 2011, Elsevier

    Zhiyong Yang

  40. Steric Control of the Hi‐CO MoFe Nitrogenase Complex Revealed by Stopped‐Flow Infrared Spectroscopy

    Article • Angewandte Chemie, November 2010, Wiley

    Zhiyong Yang

  41. Is Mo Involved in Hydride Binding by the Four-Electron Reduced (E4) Intermediate of the Nitrogenase MoFe Protein?

    Article • Journal of the American Chemical Society, March 2010, American Chemical Society (ACS)

    Zhiyong Yang

  42. Synthesis and Characterization of Diiron Thiadithiolate Complexes Related to the Active Site of [FeFe]-Hydrogenases

    Article • European Journal of Inorganic Chemistry, March 2010, Wiley

    Zhiyong Yang

  43. Synthesis and structural characterization of the mono- and diphosphine-containing diiron propanedithiolate complexes related to [FeFe]-hydrogenases. Biomimetic H2 evolution catalyzed by (μ-PDT)Fe2(CO)4[(Ph2P)2N(n-Pr)]

    Article • Journal of Inorganic Biochemistry, November 2008, Elsevier

    Zhiyong Yang

  44. Synthesis, Structural Characterization, and Some Properties of New N-Functionally Substituted Diiron Azadithiolate Complexes as Biomimetic Models of Iron-Only Hydrogenases

    Article • Organometallics, September 2007, American Chemical Society (ACS)

    Zhiyong Yang

  45. Diiron Thiadithiolates as Active Site Models for the Iron-Only Hydrogenases:  Synthesis, Structures, and Catalytic H2Production

    Article • Organometallics, April 2007, American Chemical Society (ACS)

    Zhiyong Yang

  46. Diiron Oxadithiolate Type Models for the Active Site of Iron-Only Hydrogenases and Biomimetic Hydrogen Evolution Catalyzed by Fe2(μ-SCH2OCH2S-μ)(CO)6

    Article • Organometallics, December 2005, American Chemical Society (ACS)

    Zhiyong Yang

  47. Novel Single and Double Diiron Oxadithiolates as Models for the Active Site of [Fe]-Only Hydrogenases

    Article • Organometallics, June 2004, American Chemical Society (ACS)

    Zhiyong Yang

  48. Formation and Chemical Reactivities of a New Type of Double-Butterfly [{Fe2(-CO)(CO)6}2(-SZS-)]2: Synthetic and Structural Studies on Novel Linear and Macrocyclic Butterfly Fe/E (E=S, Se) Cluster Complexes

    Article • Chemistry - A European Journal, January 2003, Wiley

    Zhiyong Yang

  49. Reactions of Butterfly Complex Anions of the Type [(μ-RTe)(μ-CO)Fe2(CO)6]-with Electrophiles. A New Route toμ4-Se-Containing Double-Butterfly Clusters. Crystal Structures of (μ-p-MeC6H4Te)(μ-PhCH2SCS)Fe2(CO)6and [(μ-RTe)Fe2(CO)6]2(μ4-Se) (R = Ph,p-BrC6H4)

    Article • Organometallics, June 2002, American Chemical Society (ACS)

    Zhiyong Yang