All Stories

  1. Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis

    Article • Cell Reports Medicine, February 2026, Elsevier

    Zhihui Feng

  2. USP32 promotes temporomandibular joint osteoarthritis by modulating PKM2 stability and glycolytic metabolism in chondrocytes

    Article • Cell Death and Disease, November 2025, Springer Science + Business Media

    Zhihui Feng

  3. Enhanced mitochondrial biogenesis facilitates the development of cutaneous squamous cell carcinoma

    Article • Cancer Letters, May 2025, Elsevier

    Zhihui Feng

  4. Allantoin Serves as a Novel Risk Factor for the Progression of MASLD

    Article • Antioxidants, April 2025, MDPI AG

    Zhihui Feng

  5. Genetic and Functional Changes in Mitochondria in the Pituitary Adenoma: The Pathogenesis and Its Therapy

    Article • Antioxidants, December 2024, MDPI AG

    Zhihui Feng

  6. Mitochondria as a sensor, a central hub and a biological clock in psychological stress-accelerated aging

    Article • Ageing Research Reviews, January 2024, Elsevier

    Zhihui Feng

  7. Comparative Study of Hydroxytyrosol Acetate and Hydroxytyrosol in Activating Phase II Enzymes

    Article • Antioxidants, October 2023, MDPI AG

    Zhihui Feng

  8. Assembly of mitochondrial succinate dehydrogenase in human health and disease

    Article • Free Radical Biology and Medicine, October 2023, Elsevier

    Zhihui Feng

  9. Role of Oxidative Stress in Mitochondrial Function: Relevance for Liver Function

    Article • Antioxidants, September 2023, MDPI AG

    Zhihui Feng

  10. High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes

    Article • The American Journal of Human Genetics, August 2023, Elsevier

    Zhihui Feng

  11. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy

    Article • Nature Communications, July 2022, Springer Science + Business Media

    Zhihui Feng

  12. Hepatic Suppression of Mitochondrial Complex II Assembly Drives Systemic Metabolic Benefits

    Article • Advanced Science, January 2022, Wiley

    Zhihui Feng

  13. Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases

    Article • Antioxidants, December 2021, MDPI AG

    Zhihui Feng

  14. Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status

    Article • Antioxidants, November 2021, MDPI AG

    Zhihui Feng

  15. Integrative Analyses Reveal Tstd1 as a Potential Modulator of HDL Cholesterol and Mitochondrial Function in Mice

    Article • Cells, November 2021, MDPI AG

    Zhihui Feng

  16. Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance

    Article • Advanced Science, May 2021, Wiley

    Zhihui Feng

  17. Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes

    Article • Redox Biology, May 2021, Elsevier

    Zhihui Feng

  18. Punicalagin Activates AMPK/PGC‐1α/Nrf2 Cascade in Mice: The Potential Protective Effect against Prenatal Stress

    Article • Molecular Nutrition & Food Research, June 2020, Wiley

    Zhihui Feng

  19. Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade

    Article • Nutrients, January 2020, MDPI AG

    Zhihui Feng

  20. Modulation of HIF-2α PAS-B domain contributes to physiological responses

    Article • Proceedings of the National Academy of Sciences, December 2018, Proceedings of the National Academy of Sciences

    Zhihui Feng

  21. Combination of β-glucan and Morus alba L. Leaf Extract Promotes Metabolic Benefits in Mice Fed a High-Fat Diet

    Article • Nutrients, October 2017, MDPI AG

    Zhihui Feng

  22. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress

    Article • Cell Death and Differentiation, September 2017, Springer Science + Business Media

    Zhihui Feng

  23. Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury

    Article • Frontiers in Molecular Neuroscience, September 2017, Frontiers

    Zhihui Feng

  24. Oxidative damage of mitochondrial respiratory chain in different organs of a rat model of diet-induced obesity

    Article • Zeitschrift für Ernährungswissenschaft, June 2017, Springer Science + Business Media

    Zhihui Feng

  25. The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain

    Article • Anesthesia & Analgesia, April 2017, Wolters Kluwer Health

    Zhihui Feng

  26. The regulatory roles of O-GlcNAcylation in mitochondrial homeostasis and metabolic syndrome

    Article • Free Radical Research, October 2016, Taylor & Francis

    Zhihui Feng

  27. Pomegranate extract and exercise provide additive benefits on improvement of immune function by inhibiting inflammation and oxidative stress in high-fat-diet-induced obesity in rats

    Article • The Journal of Nutritional Biochemistry, June 2016, Elsevier

    Zhihui Feng

  28. Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system

    Article • Molecular Nutrition & Food Research, April 2016, Wiley

    Zhihui Feng

  29. O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity in mice through the modulation of mitochondrial homeostasis

    Article • Diabetologia, March 2016, Springer Science + Business Media

    Zhihui Feng

  30. Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer

    Article • Biochemical Pharmacology, March 2016, Elsevier

    Prof Xuejun Sun, Zhihui Feng

  31. Hydroxytyrosol protects against acrolein induced preosteoblast cell toxicity: Involvement of Nrf2/Keap1 pathway

    Article • Journal of Functional Foods, December 2015, Elsevier

    Zhihui Feng

  32. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation

    Article • Scientific Reports, September 2015, Springer Science + Business Media

    Zhihui Feng

  33. Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells

    Article • PLOS One, June 2015, PLOS

    Zhihui Feng

  34. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation

    Article • British Journal Of Nutrition, April 2015, Cambridge University Press

    Zhihui Feng

  35. Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring

    Article • The Journal of Nutritional Biochemistry, February 2015, Elsevier

    Zhihui Feng

  36. Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice

    Article • Neural Plasticity, January 2015, Hindawi Publishing Corporation

    Zhihui Feng

  37. Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate

    Article • Cell Death and Disease, November 2014, Springer Science + Business Media

    Zhihui Feng

  38. Mitochondrial Dysfunction in Obesity-Associated Nonalcoholic Fatty Liver Disease: The Protective Effects of Pomegranate with Its Active Component Punicalagin

    Article • Antioxidants & Redox Signaling, October 2014, Mary Ann Liebert Inc

    Zhihui Feng

  39. AMPK activation prevents prenatal stress-induced cognitive impairment: Modulation of mitochondrial content and oxidative stress

    Article • Free Radical Biology and Medicine, October 2014, Elsevier

    Zhihui Feng

  40. Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: Regulation by a polyphenol -(−)-epigallocatechin-3-gallate

    Article • Metabolism, October 2014, Elsevier

    Zhihui Feng

  41. LL-37 attenuates inflammatory impairment via mTOR signaling-dependent mitochondrial protection

    Article • The International Journal of Biochemistry & Cell Biology, September 2014, Elsevier

    Zhihui Feng

  42. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats

    Article • Experimental Gerontology, August 2014, Elsevier

    Zhihui Feng

  43. (–)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto–Kakizaki rats

    Article • Free Radical Research, June 2014, Taylor & Francis

    Zhihui Feng

  44. 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic Acid (C75), an Inhibitor of Fatty-acid Synthase, Suppresses the Mitochondrial Fatty Acid Synthesis Pathway and Impairs Mitochondrial Function

    Article • Journal of Biological Chemistry, May 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Zhihui Feng

  45. Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death

    Article • Cell Death and Disease, May 2014, Springer Science + Business Media

    Zhihui Feng

  46. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients

    Article • Free Radical Biology and Medicine, April 2014, Elsevier

    Zhihui Feng

  47. Anticancer Effect of a Curcumin Derivative B63: ROS Production and Mitochondrial Dysfunction

    Article • Current Cancer Drug Targets, March 2014, Bentham Science Publishers

    Zhihui Feng

  48. Aerobic Interval Training Attenuates Mitochondrial Dysfunction in Rats Post-Myocardial Infarction: Roles of Mitochondrial Network Dynamics

    Article • International Journal of Molecular Sciences, March 2014, MDPI AG

    Zhihui Feng

  49. Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis

    Article • Clinical and Experimental Pharmacology and Physiology, March 2014, Wiley

    Zhihui Feng

  50. Bitter Gourd Inhibits the Development of Obesity-Associated Fatty Liver in C57BL/6 Mice Fed a High-Fat Diet

    Article • Journal of Nutrition, February 2014, Oxford University Press (OUP)

    Zhihui Feng

  51. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice

    Article • Free Radical Biology and Medicine, February 2014, Elsevier

    Zhihui Feng

  52. A Signal Transduction Pathway from TGF-β1 to SKP2 via Akt1 and c-Myc and its Correlation with Progression in Human Melanoma

    Article • Journal of Investigative Dermatology, January 2014, Elsevier

    Zhihui Feng

  53. Aging Leads to Elevation of O-GlcNAcylation and Disruption of Mitochondrial Homeostasis in Retina

    Article • Oxidative Medicine and Cellular Longevity, January 2014, Hindawi Publishing Corporation

    Zhihui Feng

  54. Coexpression within Integrated Mitochondrial Pathways Reveals Different Networks in Normal and Chemically Treated Transcriptomes

    Article • International Journal of Genomics, January 2014, Hindawi Publishing Corporation

    Zhihui Feng

  55. A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells

    Article • APOPTOSIS, December 2013, Springer Science + Business Media

    Zhihui Feng

  56. Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity

    Article • Toxicology and Applied Pharmacology, November 2013, Elsevier

    Zhihui Feng

  57. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells

    Article • Biogerontology, September 2013, Springer Science + Business Media

    Zhihui Feng

  58. Adhesive protein-free synthetic hydrogels for retinal pigment epithelium cell culture with low ROS level

    Article • Journal of Biomedical Materials Research Part A, August 2013, Wiley

    Zhihui Feng

  59. Hydroxytyrosol Promotes Superoxide Production and Defects in Autophagy Leading to Anti-proliferation and Apoptosis on Human Prostate Cancer Cells

    Article • Current Cancer Drug Targets, June 2013, Bentham Science Publishers

    Zhihui Feng

  60. Mitochondrial accumulation under oxidative stress is due to defects in autophagy

    Article • Journal of Cellular Biochemistry, November 2012, Wiley

    Zhihui Feng

  61. Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways

    Article • The Journal of Nutritional Biochemistry, August 2012, Elsevier

    Zhihui Feng

  62. Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto–Kakizaki (GK) rats: ameliorating effects of (−)-epigallocatechin-3-gallate

    Article • The Journal of Nutritional Biochemistry, July 2012, Elsevier

    Zhihui Feng

  63. Maternal Docosahexaenoic Acid Feeding Protects Against Impairment of Learning and Memory and Oxidative Stress in Prenatally Stressed Rats: Possible Role of Neuronal Mitochondria Metabolism

    Article • Antioxidants & Redox Signaling, February 2012, Mary Ann Liebert Inc

    Zhihui Feng

  64. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol

    Article • Free Radical Biology and Medicine, May 2011, Elsevier

    Zhihui Feng

  65. Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway

    Article • British Journal of Pharmacology, January 2011, Wiley

    Zhihui Feng

  66. α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells

    Article • The Journal of Nutritional Biochemistry, December 2010, Elsevier

    Zhihui Feng

  67. Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

    Article • The Journal of Nutritional Biochemistry, November 2010, Elsevier

    Zhihui Feng

  68. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes

    Article • The Journal of Nutritional Biochemistry, July 2010, Elsevier

    Zhihui Feng

  69. Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model

    Article • Neurobiology of Aging, April 2010, Elsevier

    Zhihui Feng

  70. A Milk-Based Wolfberry Preparation Prevents Prenatal Stress-Induced Cognitive Impairment of Offspring Rats, and Inhibits Oxidative Damage and Mitochondrial Dysfunction In Vitro

    Article • Neurochemical Research, February 2010, Springer Science + Business Media

    Zhihui Feng

  71. Polyhydroxylated fullerene derivative C60(OH)24prevents mitochondrial dysfunction and oxidative damage in an MPP+-induced cellular model of Parkinson's disease

    Article • Journal of Neuroscience Research, December 2008, Wiley

    Zhihui Feng

  72. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in aDrosophilamodel of Parkinson's disease

    Article • Journal of Neuroscience Research, July 2008, Wiley

    Zhihui Feng