All Stories

  1. Fibroblastic reticular cell–derived HGF orchestrates sympathetic nerves in tumor-induced lymph node remodeling and metastasis
  2. Phosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer
  3. Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake
  4. Modeling of cancer-related body-wide effects identifies LTB4 as a diagnostic biomarker for pancreatic cancer
  5. Spatiotemporal Quantification of Metastatic Tumour Cell Growth and Distribution in Lymph Nodes by Whole-Mount Tissue 3D Imaging
  6. Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness
  7. The physiology, pathology and potential therapeutic application of serotonylation
  8. STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells
  9. MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin
  10. Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer
  11. Signalling entrains the peripheral circadian clock
  12. Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways
  13. Perineural invasion reprograms the immune microenvironment through cholinergic signaling in pancreatic ductal adenocarcinoma
  14. BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma
  15. Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1
  16. Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts
  17. The Diverse Function of PD-1/PD-L Pathway Beyond Cancer
  18. Neurotransmitters: emerging targets in cancer
  19. Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis
  20. GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway
  21. Targeting the tumor microenvironment for pancreatic ductal adenocarcinoma therapy
  22. GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner
  23. NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6
  24. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling
  25. Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma
  26. Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis
  27. THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer
  28. The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway
  29. Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis
  30. Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis
  31. SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway
  32. SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis
  33. PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins
  34. FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling
  35. Integrin α9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling
  36. SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex
  37. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice
  38. miRNA-218-loaded carboxymethyl chitosan - Tocopherol nanoparticle to suppress the proliferation of gastrointestinal stromal tumor growth
  39. Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma
  40. Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10
  41. CCBE1 promotes GIST development through enhancing angiogenesis and mediating resistance to imatinib
  42. Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes
  43. Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer
  44. Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR‐338‐3p‐PKLR axis in hepatocellular carcinoma
  45. Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer
  46. Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal–epithelial transition
  47. Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma
  48. Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin
  49. Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway
  50. Microfilament regulatory protein MENA increases activity of RhoA and promotes metastasis of hepatocellular carcinoma
  51. DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by α3β1 integrin-Rho GTPase signaling
  52. Evaluation of high-risk clinicopathological indicators in gastrointestinal stromal tumors for prognosis and imatinib treatment outcome
  53. Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling
  54. LRG1 is an independent prognostic factor for endometrial carcinoma
  55. miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer
  56. CTHRC1 Acts as a Prognostic Factor and Promotes Invasiveness of Gastrointestinal Stromal Tumors by Activating Wnt/PCP-Rho Signaling
  57. Lumican Accelerates Wound Healing by Enhancing α2β1 Integrin-Mediated Fibroblast Contractility
  58. Xiamenmycin Attenuates Hypertrophic Scars by Suppressing Local Inflammation and the Effects of Mechanical Stress
  59. Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study
  60. MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells
  61. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump
  62. Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis
  63. Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling
  64. Migration of epithelial cells on laminins: RhoA antagonizes directionally persistent migration
  65. Integrin α3 subunit regulates events linked to epithelial repair, including keratinocyte migration and protein expression
  66. Epigenetic silencing of WIF-1 in hepatocellular carcinomas
  67. Kindlin-1 Is Required for RhoGTPase-Mediated Lamellipodia Formation in Keratinocytes
  68. Establishment of stable human fibroblast cell lines constitutively expressing active Rho-GTPases
  69. Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of  2 1 integrin
  70. Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cells
  71. Effects of constitutively active GTPases on fibroblast behavior
  72. Evidence for Serine/Threonine and Histidine Kinase Activity in the Tobacco Ethylene Receptor Protein NTHK2