All Stories

  1. Ring opening, conformational analysis and NagZ inhibition of a GlcNAc-configured iminosugar-derived aziridine
  2. Evaluation of GlcNAc-Configured Glycomimetics as Pharmacological Chaperones of NAGLU for the Treatment of Mucopolysaccharidosis IIIB
  3. Petasis-mediated exo-iminoglycals synthesis from glyconolactams allows access to unprecedented 1-spirocyclopropyl deoxynojirimycin
  4. Ring opening, conformational analysis and NagZ inhibition of a GlcNAc-configured iminosugar-derived aziridine
  5. Introduction of Structural Diversity at the C2 Position of Unsaturated Iminosugars through Palladium‐Catalyzed Cross‐Coupling Reactions
  6. Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues
  7. Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions
  8. Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors
  9. Stereoselective Access to Iminosugar C,C-Glycosides from 6-Azidoketopyranoses
  10. Stereoselective Synthesis of 1-C-Diethylphosphonomethyl and -difluoromethyl Iminosugars from Sugar Lactams
  11. Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition and Applications
  12. Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors
  13. Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif
  14. Iminosugar C‐Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease**
  15. Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions
  16. Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure
  17. The Oxocarbenium Ion Intermediate
  18. Contributing to the Study of Enzymatic and Chemical Glycosyl Transfer Through the Observation and Mimicry of Glycosyl Cations
  19. Insight into the Ferrier Rearrangement by Combining Flash Chemistry and Superacids
  20. Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog
  21. Structural and Computational Analysis of 2‐Halogeno‐Glycosyl Cations in the Presence of a Superacid: An Expansive Platform
  22. Structural and Computational Analysis of 2-Halogeno-Glycosyl Cations in the Presence of a Superacid: An Expansive Platform
  23. Site-Selective Debenzylation of C-Allyl Iminosugars Enables Their Stereocontroled Structure Diversification at the C-2 Position
  24. Defining the SN1 Side of Glycosylation Reactions: Stereoselectivity of Glycopyranosyl Cations
  25. Bi(OTf)3-mediated intramolecular epoxide opening for bicyclic azepane synthesis
  26. Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C-allyl iminosugar
  27. Lewis acid-catalysed nucleophilic opening of a bicyclic hemiaminal followed by ring contraction: Access to functionalized L-idonojirimycin derivatives
  28. Cover Feature: 2-Acetamido-2-deoxy-l -iminosugar C -Alkyl and C -Aryl Glycosides: Synthesis and Glycosidase Inhibition (Eur. J. Org. Chem. /2018)
  29. 2-Acetamido-2-deoxy-l -iminosugar C -Alkyl and C -Aryl Glycosides: Synthesis and Glycosidase Inhibition
  30. Catalyst‐Free Synthesis of Alkylpolyglycosides Induced by High‐Frequency Ultrasound
  31. Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens
  32. Multivalency To Inhibit and Discriminate Hexosaminidases
  33. Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance
  34. HF-Induced Intramolecular C-Arylation and C-Alkylation/Fluorination of 2-Aminoglycopyranoses
  35. In silicoanalyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay–Sachs disease
  36. Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics
  37. 4′-Methoxyphenacyl-Assisted Synthesis of β-Kdo Glycosides
  38. Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid
  39. Synthesis of the Tetrasaccharide Repeating Unit of the β-Kdo-Containing Exopolysaccharide from Burkholderia pseudomallei and B. cepacia Complex
  40. Burkholderia pseudomallei Capsular Polysaccharide Recognition by a Monoclonal Antibody Reveals Key Details toward a Biodefense Vaccine and Diagnostics against Melioidosis
  41. Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings
  42. Synthesis of pyrrolidine-based analogues of 2-acetamidosugars as N-acetyl-d-glucosaminidase inhibitors
  43. γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP
  44. Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors
  45. Site-selective hexa-hetero-functionalization of α-cyclodextrin an archetypical C6-symmetric concave cycle
  46. Synthesis of 1,2-trans-2-Acetamido-2-deoxyhomoiminosugars
  47. Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement
  48. gem-Difluorocarbadisaccharides: Restoring theexo-Anomeric Effect
  49. Intramolecular Aglycon Delivery Enables the Synthesis of 6-Deoxy-β-d-manno-heptosides as Fragments of Burkholderia pseudomallei and Burkholderia mallei Capsular Polysaccharide
  50. N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors
  51. Chapter 20. Conformationally restricted glycoside derivatives as mechanistic probes and/or inhibitors of sugar processing enzymes and receptors
  52. Non-specific accumulation of glycosphingolipids in GNE myopathy
  53. Conformational Selection in Glycomimetics: Human Galectin‐1 Only Recognizes syn‐Ψ‐Type Conformations of β‐1,3‐Linked Lactose and Its C‐Glycosyl Derivative
  54. Novel imino sugar α-glucosidase inhibitors as antiviral compounds
  55. Skeletal rearrangement of seven-membered iminosugars: Synthesis of (−)-adenophorine, (−)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors
  56. C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB–l-isoDMDP Compared to Miglitol and Miglustat
  57. Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams
  58. An “Against the Rules” Double Bank Shot with Diisobutylaluminum Hydride To Allow Triple Functionalization of α‐Cyclodextrin
  59. Synthesis and conformational analysis of bicyclic mimics of α- and β-d-glucopyranosides adopting the biologically relevant 2,5B conformation
  60. Cyclodextrins selectively modified on both rims using an O-3-debenzylative post-functionalisation, a consequence of the Sorrento meeting
  61. Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors
  62. Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy
  63. Conformational analysis of seven-membered 1-N-iminosugars by NMR and molecular modelling
  64. Towards a stable noeuromycin analog with a d-manno configuration: Synthesis and glycosidase inhibition of d-manno-like tri- and tetrahydroxylated azepanes
  65. Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether-Bridged Iminosugars
  66. Direct Experimental Evidence for the High Chemical Reactivity of α‐ and β‐Xylopyranosides Adopting a 2,5B Conformation in Glycosyl Transfer
  67. Cavitand supported tetraphosphine: cyclodextrin offers a useful platform for Suzuki-Miyaura cross-coupling
  68. Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain
  69. 2- C -Hydroxymethyl-2,3- O -isopropylidene- D -ribono-1,5-lactam. Corrigendum
  70. Synthesis and Electrochemical Study of an Original Copper(II)‐Capped Salen–Cyclodextrin Complex
  71. Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars
  72. Can Hetero‐Polysubstituted Cyclodextrins be Considered as Inherently Chiral Concave Molecules?
  73. Diisobutylaluminium Hydride (DIBAL‐H) Promoted Secondary Rim Regioselective Demethylations of Permethylated β‐Cyclodextrin: A Mechanistic Proposal
  74. μ-Waves avoid large excesses of diisobutylaluminium-hydride (DIBAL-H) in the debenzylation of perbenzylated α-cyclodextrin
  75. Analysis of the Reaction Coordinate of α- l -Fucosidases: A Combined Structural and Quantum Mechanical Approach
  76. Cyclodextrin tetraplexes: first syntheses and potential as cross-linking agent
  77. Duplex of capped-cyclodextrins, synthesis and cross-linking behaviour with a biopolymer
  78. Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: Potent and selective β-N-acetylhexosaminidase inhibitors
  79. Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase
  80. Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion
  81. Total Synthesis of the Epimer at C-6′ of the Miharamycin B Framework
  82. Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells
  83. Stereochemical Assignment and First Synthesis of the Core of Miharamycin Antibiotics
  84. ChemInform Abstract: Phenylenediamine Catalysis of “Click Glycosylations” in Water: Practical and Direct Access to Unprotected Neoglycoconjugates.
  85. Structural and biochemical evidence for a boat-like transition state in β-mannosidases
  86. New Synthetic Seven‐Membered 1‐Azasugars Displaying Potent Inhibition Towards Glycosidases and Glucosylceramide Transferase
  87. Phenylenediamine catalysis of “click glycosylations” in water: practical and direct access to unprotected neoglycoconjugates
  88. Conformational behaviour of glycomimetics: NMR and molecular modelling studies of the C-glycoside analogue of the disaccharide methyl β-d-galactopyranosyl-(1→3)-β-d-glucopyranoside
  89. Synthesis of a bicyclic analog of l-iduronic acid adopting the biologically relevant 2 S 0 conformation
  90. The conformation of the C-glycosyl analogue of N-acetyl-lactosamine in the free state and bound to a toxic plant agglutinin and human adhesion/growth-regulatory galectin-1
  91. Access to Homoglyconojirimycins via Ring Isomerization of Penta‐Hydroxylated Azepanes.
  92. Tandem Staudinger—azaWittig Mediated Ring Expansion: Rapid Access to New Isofagomine-Tetrahydroxyazepane Hybrids.
  93. Access to Homoglyconojirimycins via Ring Isomerisation of Penta­hydroxylated Azepanes
  94. Tandem Staudinger–azaWittig mediated ring expansion: rapid access to new isofagomine-tetrahydroxyazepane hybrids
  95. RCM as a tool to freeze conformation of monosaccharides: synthesis of a β-mannopyranoside mimic adopting a conformation close to the biologically relevant B2,5 boat
  96. Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-l-lyxofuranose
  97. Looking forward: a glance into the future of organic chemistry
  98. Alchimies futures : compte rendu de l'expérience ESYOP
  99. Nucleophilic opening of epoxyazepanes: expanding the family of polyhydroxyazepane-based glycosidase inhibitors
  100. Looking glass inhibitors: efficient synthesis and biological evaluation of d-deoxyfuconojirimycin
  101. New 1-amino-1-deoxy- and 2-amino-2-deoxy-polyhydroxyazepanes: synthesis and inhibition of glycosidases
  102. The Conformational Behavior of Novel Glycosidase Inhibitors with Substituted Azepan Structures: An NMR and Modeling Study
  103. (2S,3R,4R,5S)-3,4-O-Isopropylidene-2-methyl-1-oxa-6,9-diazaspiro[4.5]decane-7,10-dione
  104. The First Synthesis of Substituted Azepanes Mimicking Monosaccharides: A New Class of Potent Glycosidase Inhibitors.
  105. Synthesis and acid catalyzed hydrolysis of B2,5 type conformationally constrained glucopyranosides: incorporation into a cellobiose analogue
  106. Trimethylaluminum-Promoted Rearrangements of Unsaturated Sugars into Cyclohexanes.
  107. 2- C -Hydroxymethyl-2,3- O -isopropylidene- D -ribono-1,5-lactam
  108. Trimethylaluminium promoted rearrangements of unsaturated sugars into cyclohexanes
  109. The first synthesis of substituted azepanes mimicking monosaccharides: a new class of potent glycosidase inhibitors
  110. Synthesis of B2,5 Type Conformationally Constrained Glucopyranosides.
  111. Synthesis of B2,5 type conformationally constrained glucopyranosides
  112. Synthesis of Methoxy‐Substituted Exocyclic (E)‐ and (Z)‐Unsaturated Methyl Pyranosides and a Study of Their Reactivity towards Lewis Acids
  113. Synthesis of Seven‐ and Eight‐Membered Carbasugar Analogues via Ring‐Closing Metathesis and Their Inhibitory Activities Toward Glycosidases.
  114. Synthesis of seven- and eight-membered carbasugar analogs via ring-closing metathesis and their inhibitory activities toward glycosidases
  115. ChemInform Abstract: Total Synthesis of Calditol: Structural Clarification of This Typical Component of Archaea Order Sulfolobales.
  116. ChemInform Abstract: Synthesis of Several Members of a New Family of Carbasugars: The Cyclooctane Mimetics.
  117. Total Synthesis of Calditol: Structural Clarification of this Typical Component of Archaea OrderSulfolobales
  118. Synthesis of Several Members of a New Family of Carbasugars: The Cyclooctane Mimetics
  119. ChemInform Abstract: Tetrahydrofuran α‐Azido Esters: Precursors of Anomeric α‐Amino Acid Monomers via Radical Bromination.
  120. The structure of calditol isolated from the thermoacidophilic archaebacterium Sulfolobus acidocaldarius
  121. Photobromination of a bicyclic mimic of α-L-fucose; components for a combinatorial library of rigid fucose analogues
  122. Solid-phase enzyme-linked assay for the screening of glycosidase activities and inhibitors
  123. Sugar mimics from sugar lactones
  124. ChemInform Abstract: (6R)‐, and (6S)‐6‐C‐Methylglucose from D‐Glucuronolactone: Efficient Synthesis of a Seven Carbon Fucose Analogue: Inhibition of Some Enzymes of Primary Metabolism.
  125. ChemInform Abstract: 6C‐Butylglucoses from Glucuronolactone: Suppression of Silyl Migration During Borohydride Reduction of Lactols by Cerium(III) Chloride: Inhibition of Phosphoglucomutase.
  126. 6C-Butylglucoses from glucuronolactone: Suppression of silyl migration during borohydride reduction of lactols by cerium (III) chloride: Inhibition of phosphoglucomutase
  127. 6R-, and 6S, -6C-methylglucose from D-glucuronolactone: Efficient synthesis of a seven carbon fucose analogue: Inhibition of some enzymes of primary metabolism
  128. ChemInform Abstract: The First Example of a 6‐C‐Aryl‐D‐glucose: Inhibition of Glucokinase.
  129. ChemInform Abstract: 7‐Carbon Mimics of D‐Glucose and L‐Fucose: Activation by 6R‐, and Inactivation by 6S, ‐6C‐Methylglucose of Glycogen Synthase: Inhibition of Glucokinase and/or Glucose‐6‐phosphatase.
  130. Structure and Conformation of Mannoamidines by Nmr and Molecular Modeling: are They Good Transition State Mimics?
  131. 7-Carbon mimics of D-glucose and L-fucose: Activation by 6R-, and inactivation by 6S, -6C-methylglucose of glycogen synthase: Inhibition of glucokinase and/or glucose-6-phosphatase
  132. The first example of a : Inhibition of glucokinase
  133. Inhibition of glycosidases by substituted amidines
  134. ChemInform Abstract: Synthesis of a Benzylamidine Derived from D‐Mannose. A Potent Mannosidase Inhibitor.
  135. Synthesis of a benzylamidine derived from D-mannose. A potent mannosidase inhibitor