All Stories

  1. In Vitro and In Vivo Stimulation of Toll-Like Receptor 9 by CpG Oligodeoxynucleotides Incorporated Into Polypod-Like DNA Nanostructures

    Article • Journal of Pharmaceutical Sciences, September 2017, Elsevier

    Ph.D. Yuki Takahashi

  2. Pharmacokinetics of Exosomes—An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics

    Article • Journal of Pharmaceutical Sciences, September 2017, Elsevier

    Ph.D. Yuki Takahashi

  3. Accelerated growth of B16 BL 6 tumor in mice through efficient uptake of their own exosomes by B16 BL 6 cells

    Article • Cancer Science, July 2017, Wiley

    Ph.D. Yuki Takahashi

  4. Using size-controlled multicellular spheroids of murine adenocarcinoma cells to efficiently establish pulmonary tumors in mice

    Article • Biotechnology Journal, May 2017, Wiley

    Ph.D. Yuki Takahashi

  5. Amelioration of Experimental Autoimmune Encephalomyelitis in Mice by Interferon-Beta Gene Therapy, Using a Long-Term Expression Plasmid Vector

    Article • Molecular Pharmaceutics, March 2017, American Chemical Society (ACS)

    Ph.D. Yuki Takahashi

  6. Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot–Binding Peptide With Interferon Gamma for Cancer Gene Therapy

    Article • Journal of Pharmaceutical Sciences, March 2017, Elsevier

    Ph.D. Yuki Takahashi

  7. Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

    Article • European Journal of Pharmaceutical Sciences, January 2017, Elsevier

    Ph.D. Yuki Takahashi

  8. Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan

    Article • International Journal of Pharmaceutics, January 2017, Elsevier

    Ph.D. Yuki Takahashi

  9. Optimization of Albumin Secretion and Metabolic Activity of Cytochrome P450 1A1 of Human Hepatoblastoma HepG2 Cells in Multicellular Spheroids by Controlling Spheroid Size

    Article • Biological and Pharmaceutical Bulletin, January 2017, Pharmaceutical Society of Japan

    Ph.D. Yuki Takahashi

  10. Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

    Article • Journal of Pharmaceutical Sciences, January 2017, Elsevier

    Ph.D. Yuki Takahashi

  11. Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

    Article • Biomaterials, December 2016, Elsevier

    Ph.D. Yuki Takahashi

  12. Interferon-Inducible Mx Promoter-Driven, Long-Term Transgene Expression System of Interferon-β for Cancer Gene Therapy

    Article • Human Gene Therapy, November 2016, Mary Ann Liebert Inc

    Ph.D. Yuki Takahashi

  13. Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

    Article • Scientific Reports, July 2016, Nature

    Ph.D. Yuki Takahashi

  14. Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer

    Article • Gene Therapy, March 2016, Nature

    Ph.D. Yuki Takahashi

  15. Application of Magnesium Pyrophosphate–Based Sponge-Like Microparticles to Enhance the Delivery Efficiency and Adjuvant Effects of Polyriboinosinic-Polyribocytidylic Acid in Immune Cells

    Article • Journal of Pharmaceutical Sciences, February 2016, Elsevier

    Ph.D. Yuki Takahashi

  16. Erratum: Corrigendum: Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion

    Article • Scientific Reports, January 2016, Nature

    Ph.D. Yuki Takahashi

  17. Analysis and Control of in Vivo Kinetics of Exosomes for the Development of Exosome-based DDS

    Article • YAKUGAKU ZASSHI, January 2016, Pharmaceutical Society of Japan

    Ph.D. Yuki Takahashi

  18. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation

    Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2016, Elsevier

    Ph.D. Yuki Takahashi

  19. Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells

    Article • Nanomedicine Nanotechnology Biology and Medicine, January 2016, Elsevier

    Ph.D. Yuki Takahashi

  20. Atomic force microscopy analysis of orientation and bending of oligodeoxynucleotides in polypod-like structured DNA

    Article • Nano Research, October 2015, Tsinghua University Press

    Ph.D. Yuki Takahashi

  21. Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion

    Article • Scientific Reports, October 2015, Nature

    Ph.D. Yuki Takahashi

  22. Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells

    Article • Nucleic Acid Therapeutics, October 2015, Mary Ann Liebert Inc

    Ph.D. Yuki Takahashi

  23. Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids

    Article • Pharmaceutical Research, September 2015, Springer Science + Business Media

    Ph.D. Yuki Takahashi

  24. Induction of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a DNA-Based Hydrogel with Adjuvant Activity

    Article • Advanced Functional Materials, August 2015, Wiley

    Ph.D. Yuki Takahashi

  25. Contribution of Epigenetic Modifications to the Decline in Transgene Expression from Plasmid DNA in Mouse Liver

    Article • Pharmaceutics, August 2015, MDPI AG

    Ph.D. Yuki Takahashi

  26. Self-Assembling DNA Dendrimer for Effective Delivery of Immunostimulatory CpG DNA to Immune Cells

    Article • Biomacromolecules, April 2015, American Chemical Society (ACS)

    Ph.D. Yuki Takahashi

  27. Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

    Article • Journal of Pharmaceutical Sciences, February 2015, Elsevier

    Ph.D. Yuki Takahashi

  28. Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice

    Article • Journal of Controlled Release, February 2015, Elsevier

    Ph.D. Yuki Takahashi

  29. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

    Article • Journal of Extracellular Vesicles, January 2015, Taylor & Francis

    Ph.D. Yuki Takahashi

  30. DNA nanotechnology-based development of delivery systems for bioactive compounds

    Article • European Journal of Pharmaceutical Sciences, July 2014, Elsevier

    Ph.D. Yuki Takahashi

  31. Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice

    Article • Molecular Therapy — Methods & Clinical Development, June 2014, Nature

    Ph.D. Yuki Takahashi

  32. Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity

    Article • Gene Therapy, June 2014, Nature

    Ph.D. Yuki Takahashi

  33. Enhancement of Anticancer Effect of Interferon-γ Gene Transfer against Interferon-γ-Resistant Tumor by Depletion of Tumor-Associated Macrophages

    Article • Molecular Pharmaceutics, May 2014, American Chemical Society (ACS)

    Ph.D. Yuki Takahashi

  34. Efficient delivery of immunostimulatory DNA to mouse and human immune cells through the construction of polypod-like structured DNA

    Article • Nanomedicine Nanotechnology Biology and Medicine, May 2014, Elsevier

    Ph.D. Yuki Takahashi

  35. Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery

    Article • Journal of Controlled Release, April 2014, Elsevier

    Ph.D. Yuki Takahashi

  36. Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-γ Gene Transfer

    Article • Human Gene Therapy Clinical Development, March 2014, Mary Ann Liebert Inc

    Ph.D. Yuki Takahashi

  37. Removal of transgene-expressing cells by a specific immune response induced by sustained transgene expression

    Article • The Journal of Gene Medicine, March 2014, Wiley

    Ph.D. Yuki Takahashi

  38. In vivo fate of exogenously-administered exosomes

    Article • Drug Delivery System, January 2014, Japan Society of Drug Delivery System

    Ph.D. Yuki Takahashi

  39. Transplantation of insulin-secreting multicellular spheroids for the treatment of type 1 diabetes in mice

    Article • Journal of Controlled Release, January 2014, Elsevier

    Ph.D. Yuki Takahashi

  40. Expression Profile-Dependent Improvement of Insulin Sensitivity by Gene Delivery of Interleukin-6 in a Mouse Model of Type II Diabetes

    Article • Molecular Pharmaceutics, October 2013, American Chemical Society (ACS)

    Ph.D. Yuki Takahashi

  41. Gene delivery of albumin binding peptide-interferon-gamma fusion protein with improved pharmacokinetic properties and sustained biological activity

    Article • Journal of Pharmaceutical Sciences, September 2013, Elsevier

    Ph.D. Yuki Takahashi

  42. Poly(N-isopropylacrylamide)-coated microwell arrays for construction and recovery of multicellular spheroids

    Article • Journal of Bioscience and Bioengineering, June 2013, Elsevier

    Ph.D. Yuki Takahashi

  43. Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

    Article • Journal of Biotechnology, May 2013, Elsevier

    Ph.D. Yuki Takahashi

  44. Development of multicellular spheroid for cell-based therapy

    Article • Drug Delivery System, January 2013, Japan Society of Drug Delivery System

    Ph.D. Yuki Takahashi

  45. Increased immunostimulatory activity of polypod-like structured DNA by ligation of the terminal loop structures

    Article • Journal of Controlled Release, November 2012, Elsevier

    Ph.D. Yuki Takahashi

  46. Fibronectin inhibits cytokine production induced by CpG DNA in macrophages without direct binding to DNA

    Article • Cytokine, October 2012, Elsevier

    Ph.D. Yuki Takahashi

  47. Controlling the kinetics of interferon transgene expression for improved gene therapy

    Article • Journal of Drug Targeting, September 2012, Informa Healthcare

    Ph.D. Yuki Takahashi

  48. Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice

    Article • Gene Therapy, August 2012, Nature

    Ph.D. Yuki Takahashi

  49. Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells

    Article • ACS Nano, July 2012, American Chemical Society (ACS)

    Ph.D. Yuki Takahashi

  50. Near-Infrared Fluorescence Probes for Enzymes Based on Binding Affinity Modulation of Squarylium Dye Scaffold

    Article • Analytical Chemistry, May 2012, American Chemical Society (ACS)

    Dr Takuya Terai, Ph.D. Yuki Takahashi

  51. Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy

    Article • The Journal of Gene Medicine, April 2012, Wiley

    Ph.D. Yuki Takahashi

  52. Comparison of antigen expression from plasmid DNA in tumor-free and antigen-expressing tumor-bearing mice

    Article • Human Vaccines & Immunotherapeutics, February 2012, Taylor & Francis

    Ph.D. Yuki Takahashi

  53. Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice

    Article • Free Radical Biology and Medicine, August 2011, Elsevier

    Professor Yasuyoshi SAKAI, Ph.D. Yuki Takahashi

  54. Prolonged Circulation Half-life of Interferon γ Activity by Gene Delivery of Interferon γ–Serum Albumin Fusion Protein in Mice

    Article • Journal of Pharmaceutical Sciences, June 2011, Elsevier

    Ph.D. Yuki Takahashi

  55. Saturation of transgene protein synthesis from mRNA in cells producing a large number of transgene mRNA

    Article • Biotechnology and Bioengineering, May 2011, Wiley

    Ph.D. Yuki Takahashi

  56. Inhibition of nuclear delivery of plasmid DNA and transcription by interferon γ: hurdles to be overcome for sustained gene therapy

    Article • Gene Therapy, March 2011, Nature

    Ph.D. Yuki Takahashi

  57. Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice

    Article • Biomaterials, January 2011, Elsevier

    Ph.D. Yuki Takahashi

  58. Positive Correlation Between the Generation of Reactive Oxygen Species and Activation/Reactivation of Transgene Expression After Hydrodynamic Injections into Mice

    Article • Pharmaceutical Research, November 2010, Springer Science + Business Media

    Ph.D. Yuki Takahashi

  59. Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors

    Article • The Journal of Gene Medicine, September 2010, Wiley

    Ph.D. Yuki Takahashi

  60. Sustained Exogenous Expression of Therapeutic Levels of IFN-  Ameliorates Atopic Dermatitis in NC/Nga Mice via Th1 Polarization

    Article • The Journal of Immunology, January 2010, The American Association of Immunologists

    Ph.D. Yuki Takahashi

  61. Optimization of Gene Therapy Effect by Spaciotemporal Control of Expressed Proteins

    Article • YAKUGAKU ZASSHI, January 2010, Pharmaceutical Society of Japan

    Ph.D. Yuki Takahashi

  62. Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice

    Article • Molecular Therapy, September 2009, Nature

    Ph.D. Yuki Takahashi

  63. Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy

    Article • Advanced Drug Delivery Reviews, July 2009, Elsevier

    Ph.D. Yuki Takahashi

  64. Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression

    Article • The Journal of Gene Medicine, May 2009, Wiley

    Ph.D. Yuki Takahashi

  65. Quantitative and Temporal Analysis of Gene Silencing in Tumor Cells Induced by Small Interfering RNA or Short Hairpin RNA Expressed from Plasmid Vectors

    Article • Journal of Pharmaceutical Sciences, January 2009, Elsevier

    Ph.D. Yuki Takahashi

  66. Gene silencing ofβ-cateninin melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice

    Article • International Journal of Cancer, November 2008, Wiley

    Ph.D. Yuki Takahashi

  67. Erratum

    Article • Cancer Science, October 2008, Wiley

    Ph.D. Yuki Takahashi

  68. Reactivation of Silenced Transgene Expression in Mouse Liver by Rapid, Large-Volume Injection of Isotonic Solution

    Article • Human Gene Therapy, October 2008, Mary Ann Liebert Inc

    Ph.D. Yuki Takahashi

  69. Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing ofSOCSgene expression in tumor cells

    Article • Cancer Science, August 2008, Wiley

    Ph.D. Yuki Takahashi

  70. Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1α expression in tumor cells and hepatocytes

    Article • Gene Therapy, February 2008, Nature

    Ph.D. Yuki Takahashi

  71. Design of PCR‐amplified DNA fragments for in vivo gene delivery: Size‐dependency on stability and transgene expression

    Article • Journal of Pharmaceutical Sciences, September 2007, Elsevier

    Ph.D. Yuki Takahashi

  72. Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA

    Article • International Journal of Cancer, January 2007, Wiley

    Ph.D. Yuki Takahashi

  73. In vivo siRNA Delivery to Tumor Cells and Its Application to Cancer Gene Therapy

    Article • YAKUGAKU ZASSHI, January 2007, Pharmaceutical Society of Japan

    Ph.D. Yuki Takahashi

  74. Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting β-catenin or hypoxia-inducible factor 1α

    Article • Journal of Controlled Release, November 2006, Elsevier

    Ph.D. Yuki Takahashi

  75. Moment analysis for kinetics of gene silencing by RNA interference

    Article • Biotechnology and Bioengineering, January 2006, Wiley

    Ph.D. Yuki Takahashi

  76. Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: Quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases

    Article • Journal of Controlled Release, July 2005, Elsevier

    Ph.D. Yuki Takahashi

  77. Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice

    Article • Clinical & Experimental Metastasis, January 2004, Springer Science + Business Media

    Ph.D. Yuki Takahashi